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Small Molecule Dna And Rna Binders
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Book Synopsis Small Molecule DNA and RNA Binders by : Martine Demeunynck
Download or read book Small Molecule DNA and RNA Binders written by Martine Demeunynck and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
Book Synopsis Small Molecule DNA and RNA Binders by : Martine Demeunynck
Download or read book Small Molecule DNA and RNA Binders written by Martine Demeunynck and published by . This book was released on 2003 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis RNA as a Drug Target by : John Schneekloth
Download or read book RNA as a Drug Target written by John Schneekloth and published by John Wiley & Sons. This book was released on 2024-10-07 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover a new paradigm in drug discovery that greatly expands the space of addressable drug targets and potential novel drugs Existing paradigms for drug discovery have focused largely on enzymes and other proteins as drug targets. In recent years, however, different varieties of ribonucleic acids have emerged as a viable focus for target-based drug discovery, with the potential to revolutionize the strategy and approach for this essential step in the drug development process. RNA as a Drug Target: The Next Frontier for Medicinal Chemistry offers a practice-oriented introduction to developing drug-like small molecules that selectively modulate both coding and non-coding RNAs. Beginning with a description and characterization of existing druggable RNAs, the book discusses how to approach different RNA targets for drug discovery. The result is a crucial resource for targeting RNAs and creating the next generation of life-saving pharmaceuticals. RNA as a Drug Target readers will also find: A complete “toolbox” for working with RNA, from structure determination to screening and lead generation techniques A wide range of addressable targets and mechanisms, including splicing modulation, riboswitches, targeted degradation, and more Authoritative discussion of the potential of RNA-targeted small molecule therapeutics for drugging the epitranscriptome RNA as a Drug Target provides an expert introduction to a new frontier in pharmaceutical research for medicinal chemists, biochemists, molecular biologists, and members of the pharmaceutical industry.
Book Synopsis Exploring the Dynamic Landscape of Small Molecule-DNA Binding by : Lennart Alexander Ingmar Ramakers
Download or read book Exploring the Dynamic Landscape of Small Molecule-DNA Binding written by Lennart Alexander Ingmar Ramakers and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deoxyribonucleic acid (DNA) is a fundamental component in all living organisms found in Nature. Although both the double-helix structure of this biomolecule and the fact that it stores all the genetic information required by the organism to survive are well understood there are still aspects related to this molecule which are not as clear. Particularly the interactions underpinning the formation of complexes between other molecules, such as proteins, and DNA remain unclear. One of these is the process underlying the formation of small molecule-DNA complexes. Such complexes are known to form via interactions between these small molecules and the DNA minor groove, it has proven to be complicated to develop a set of rational rules for the synthesis of binders to target particular DNA sequences. Such rules are complicated by the complex molecular environment found within the DNA minor groove as well as the role of the spine of hydration found within this groove. Another aspect of the behaviour of DNA which has attracted a lot of attention is related to the mechanism underlying the melting of short DNA sequence. It is important to gain a better understanding of these mechanisms as this process is thought to be important in DNA transcription, replication and repair as well as being important for the application and development of DNA scaffolds. Additionally, it is thought that understanding the impact of binding on this transition could be used to gain further insights into the interactions underpinning these complexes.
Book Synopsis RNA-small Molecule Interactions by : Sarah Ruth Kirk
Download or read book RNA-small Molecule Interactions written by Sarah Ruth Kirk and published by . This book was released on 2000 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Small Molecule Microarrays: Methods and Protocols by : Mahesh Uttamchandani
Download or read book Small Molecule Microarrays: Methods and Protocols written by Mahesh Uttamchandani and published by Methods in Molecular Biology. This book was released on 2018-12-05 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Small Molecules Targeting RNA by : Qi Liu
Download or read book Synthesis of Small Molecules Targeting RNA written by Qi Liu and published by . This book was released on 2004 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Artificial Assemblies with Cooperative DNA Recognition by : Zutao YU
Download or read book Artificial Assemblies with Cooperative DNA Recognition written by Zutao YU and published by Springer Nature. This book was released on 2020-05-09 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole–imidazole polyamides (PIPs). PIPs represent the best-characterized class of small molecule DNA binders that can be modified to bind with any predetermined DNA sequence and regulate gene expression patterns in a transgene-free and cost-effective manner. PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability. In recent years, there have been numerous novel studies on the applications of these biological tools; this research is thoroughly reviewed in the first chapter. There are several critical issues, however, that impede the further broad study of PIPs, which greatly concern the author. For instance, the short PIP version has an excessively hi^10 bp; this significantly decreases cell permeability. Moreover, the conventional binding strategy for PIP design cannot apply to flexible DNA binding—for example, the DNA-binding mode of a transcription factor pair. In this book, the author describes the development of three kinds of cooperative DNA-binding systems that help resolve the current highly problematic issues concerning PIPs. These three systems offer a range of significant advantages, such as favorable sequence selectivity, long recognition sequence, higher binding affinity, and a flexible gap distance. Released at a critical juncture in the application of PIPs, this book will greatly facilitate their use as therapeutic drugs in the treatment of cancer and hereditary diseases, and in regenerative medicine.
Book Synopsis Targeting Unique Nucleic Acid Structures with Small Molecules by : Victor Kin-man Tam
Download or read book Targeting Unique Nucleic Acid Structures with Small Molecules written by Victor Kin-man Tam and published by . This book was released on 2007 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Long Non Coding RNA Biology by : M.R.S. Rao
Download or read book Long Non Coding RNA Biology written by M.R.S. Rao and published by Springer. This book was released on 2017-08-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
Download or read book Drug-Nucleic Acid Interactions written by and published by Elsevier. This book was released on 2001-07-31 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.
Book Synopsis Design, Synthesis and Evaluation of Small Molecules that Recognize RNA by : Martin Hendrix
Download or read book Design, Synthesis and Evaluation of Small Molecules that Recognize RNA written by Martin Hendrix and published by . This book was released on 1997 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting specific RNA sequences with small molecules has promising applications for the development of cell permeable probes that can selectively interfere with RNA function and could lead to novel therapeutics acting at sites of RNA protein interactions or interferine with catalytic events involving RNA. Aminoglycoside antibiotics provide the largest class of lead structures found in nature to develop such RNA binders. They target a variety of sites within the ribosomal RNA of bacteria and interfere with the catalytic function of the ribosome. To gain insight into the RNA recognition properties of aminoglycosides, the interaction with one of their natural targets, the ribosomal A-site decoding region, has been studied with a series of model RNA hairpins. A new analytical method to measure small molecule-RNA binding based on surface plasmon resonance (SPR) was developed for these studies. It was found that in particular neomycin B and related aminoglycosides bind the A-site model RNA with high specificity and nanomolar affinity. This contrasts with the lack of specificity observed for the interaction of neomycin B with another putative RNA target, the Rev Responsive Element (RRE). The structures of naturally occurring aminoglycosides were examined in search of general RNA recognition motifs. This led to the identification of hydroxyamines as a new recognition motif for phosphodiesters and the Hoogsteen face of guanosine. Model studies in DMSO showed that the 1,3-hydroxyamine motif is particularly suitable for the strong complexation of phosphodiesters. Using this motif as a core structure, a parallel solution phase approach was developed for the construction of combinatorial libraries of small molecules that target RNA.
Book Synopsis Methods for Studying Nucleic Acid/Drug Interactions by : Meni Wanunu
Download or read book Methods for Studying Nucleic Acid/Drug Interactions written by Meni Wanunu and published by CRC Press. This book was released on 2016-04-19 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff
Book Synopsis Handbook of Single-Molecule Biophysics by : Peter Hinterdorfer
Download or read book Handbook of Single-Molecule Biophysics written by Peter Hinterdorfer and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.
Book Synopsis Completion of a Programmable DNA-binding Small Molecule Library by : Carey Frank Hsu
Download or read book Completion of a Programmable DNA-binding Small Molecule Library written by Carey Frank Hsu and published by . This book was released on 2009 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Methodology in the Determination of Sequence-selectivity in Small Molecule-DNA Binding by : Michael Brennan Pickup
Download or read book New Methodology in the Determination of Sequence-selectivity in Small Molecule-DNA Binding written by Michael Brennan Pickup and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Use of a Small Molecule to Improve the Thermostability of DNA Junctions by : Arik Shams
Download or read book The Use of a Small Molecule to Improve the Thermostability of DNA Junctions written by Arik Shams and published by . This book was released on 2014 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The short-term goal of this research project is to employ small molecules as a means to stabilize four-way DNA junctions (4WJs) composed of natural DNA and chimeric nucleic acids. The long-term goal of the project is utilizing the 4WJs as extracellular therapeutic inhibitors of DNA binding proteins [i.e. Histones and High Mobility Group Protein B (HMGB1b)]. A number of studies have shown that classical intracellular DNA-binding proteins have a variety of deleterious side-effects when present in the extracellular milieu. In order to develop a successful 4WJ therapeutic, we are focused on using modified nucleic acids to enhance the stability of the resulting 4WJ. The nucleic acid of interest is PNA (peptide nucleic acid). PNA was selected because it is known to form DNA-PNA duplex/triplex structures with elevated thermoand nuclease stability. 4WJs are prepared using fluorescently labeled DNA strands and a single PNA strand. Small molecules are currently being investigated as tools to potentially link the PNA-DNA strands to form 4WJs composed of multiple PNA strands. One molecule of interest is [Ru(bpy)2(dpp)PtCl2]Cl2. Electrophoretic mobility shift assays (EMSAs) have shown that stable 4WJs form in the presence of this molecule. The junctions were visualized using polyacrylamide gels. Circular dichroism studies will be employed to characterize the structural properties of hybrid of interest. Once a stable 4WJ structure is identified, the hybrid was used to study binding and inhibition of HMGB1 in cell-based assays. --Page iv.
