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Small Molecule Activation With Oxo And Nitridorhenium Complexes Bearing Tridentate Chelate Ligands
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Book Synopsis Small Molecule Activation with Oxo and Nitridorhenium Complexes Bearing Tridentate Chelate Ligands by : Nikola Stevica Lambic
Download or read book Small Molecule Activation with Oxo and Nitridorhenium Complexes Bearing Tridentate Chelate Ligands written by Nikola Stevica Lambic and published by . This book was released on 2018 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ligand Design Considerations for the Activation of Small Molecules by : Sonja Marie Peterson
Download or read book Ligand Design Considerations for the Activation of Small Molecules written by Sonja Marie Peterson and published by . This book was released on 2012 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Nature, the effective control of both the primary and secondary coordination spheres by metal-containing proteins has led to highly efficient and selective catalysts. Much effort has been put forth by the synthetic chemistry community to design complexes that explore the effects of modifying the primary coordination sphere. However, understanding the implications of both coordination spheres together is necessary to ultimately lead to the development of effective synthetic complexes for small molecule activation. For the research described herein, inspiration from biology has led to the design and preparation of ligands, paying special attention to both environments to meet the specific requirements of the small molecules targeted. Chapter 2 discusses the design and synthesis efforts of two new tripodal and tridentate ligands and complexes that feature both a redox-active primary coordination sphere and contain intramolecular H-bond donors in the secondary coordination sphere. This project was in collaboration with the laboratory of Alan Heyduk. Chapter 3 describes the synthesis and characterization of [Co II[superscript] H2bupa]− and [Ni II[superscript] H2bupa]− complexes. The reactivity of both of these complexes with dioxygen was explored in order to detect intermediates during activation yielding proposed Co III[superscript] -superoxo and Ni III[superscript] -hydroxo species. [Co II[superscript] H2bupa]− was also found to reduce dioxygen to water. Water measurements were carried out for [Co II[superscript] H2bupa]− and [Mn II[superscript] H2bupa]− in the presence of an internal standard. The turnover number for these complexes was determined and will also be discussed. Chapter 4 features the synthesis of a new tripodal ligand, H3btspa. It contains the carboxyamidopyridine group reminiscent of H5bupa, but contains two sufonamido groups capable of acting as H-bond acceptors. Upon deprotonation it ready forms complexes with Mn II[superscript], Fe II[superscript], Co II[superscript], and Zn II[superscript] salts. The stability of these complexes will also be described. Chapter 5 discusses nitrogen-containing complexes made from [Fe II[superscript] MST]-. Both the Fe II[superscript] and Fe III[superscript]-ammine complexes were synthesized along with the Fe II[superscript] -hydrazine complex. Attempts to deprotonate the Fe III[superscript]-ammine complex resulted in the reformation of the Fe II[superscript] ammine complex, leading to the proposal of a transient Fe III[superscript]-amido intermediate. Attempts to perform amination chemistry from the Fe II[superscript] and Fe III[superscript]-ammine complexes will also be highlighted.
Book Synopsis Small Molecule Activation and Catalysis by a Cobalt N-heterocyclic Phosphido Complex by : Andrew M. Poitras
Download or read book Small Molecule Activation and Catalysis by a Cobalt N-heterocyclic Phosphido Complex written by Andrew M. Poitras and published by . This book was released on 2020 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to both environmental and economic concerns, there is a demand for the development of more sustainable catalysts and the low cost and greater availability of late first row transition metals make them ideal candidates to replace currently used precious metals. However, one of the main challenges with base metals is the ability to promote two-electron processes needed for most catalytic reactions. Metal-ligand cooperativity has emerged as a viable strategy for promoting s-bond activation. The ligand can participate in two potential ways, ligand-based redox activity or by direct ligand involvement in the s-bond cleavage events, which eliminates the redox requirements of the metal center. N-heterocyclic phosphenium/phosphido ligands (NHP+/-) with chelating diphosphine sidearms can enforce coordination to metal centers while imparting stability on the resulting complex. When incorporated in the tridentate framework (PPP), the NHP+ can be reduced to the anionic NHP- form, which can allow for ligand-based redox processes. This dissertation is focused on the recent exploration of the structural and reactivity studies of cobalt complexes bearing a tridentate ligand with a central NHP+/- moiety. The metal-ligand cooperativity of the cobalt NHP+/- complexes is explored through the rich redox profiles of the monomers and dimers and through the activation of various E-H bonds (E = H, O, S) across the cobalt-PNHP bond. In addition, a highly selective catalytic system for the hydroboration of alkenes is successfully developed using a cobalt NHP+/- complex.
Book Synopsis Chelation Therapy in the Treatment of Metal Intoxication by : Jan Aaseth
Download or read book Chelation Therapy in the Treatment of Metal Intoxication written by Jan Aaseth and published by Academic Press. This book was released on 2016-04-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds
Book Synopsis Organofluorine Compounds in Biology and Medicine by : V Prakash Reddy
Download or read book Organofluorine Compounds in Biology and Medicine written by V Prakash Reddy and published by Newnes. This book was released on 2015-01-25 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry
Book Synopsis The Anomeric Effect by : Eusebio Juaristi
Download or read book The Anomeric Effect written by Eusebio Juaristi and published by CRC Press. This book was released on 1994-10-12 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the structural, conformational, and chemical manifestations of the anomeric effect. In order to present a cogent discussion of this most fundamental and relevant phenomenon, three chapters examine our present understanding of the origin of this conformational effect, based upon a wealth of theoretical and physical data. Equally important, however, are three additional chapters that deal with the general consequences of the stereoelectronic interactions that are associated with the basis of the anomeric effect. The remainder of the book is devoted to new areas of development in the topic-such as differentiation of the endo and exo anomeric interactions, specific analysis of the enthalpic component of anomeric effects, critical evaluation of the kinetics and reverse anomeric effects, discovery of a new substantial effect in second- and lower-row anomeric segments, and others.
Book Synopsis Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells by : Kenneth Kam-Wing Lo
Download or read book Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells written by Kenneth Kam-Wing Lo and published by Academic Press. This book was released on 2016-12-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells Foscuses on the fundamentals and their potential therapeutic and diagnostic applications Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents
Book Synopsis Inhibitors of the Ras Superfamily G-proteins, Part A by :
Download or read book Inhibitors of the Ras Superfamily G-proteins, Part A written by and published by Academic Press. This book was released on 2013-09-10 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Book Synopsis New Look to Phytomedicine by : Mohd Sajjad Ahmad Khan
Download or read book New Look to Phytomedicine written by Mohd Sajjad Ahmad Khan and published by Academic Press. This book was released on 2018-10-23 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research. Compiles up-to-date information on the chemotherapeutics used in the treatment of infective and metabolic disorders Presents advancements in the discovery of new drugs from plants using molecular and nanotechnology tools Examines detailed information on the use of herbals agents in cancer, HIV and other ailments, including diabetes, malaria and neurological disorders
Download or read book Fuel Oxygenates written by Damià Barceló and published by Springer Science & Business Media. This book was released on 2007-08-03 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals mainly with the problems associated with the contamination of groundwater by MTBE and TBA, but ETBE is also considered. The book, written by recognized specialists in the field, is organized in sections covering state-of-the-art analytical methods, including specific isotopic analysis, occurrence in the environment, transport and degradation processes, treatment technologies and human health risks.
Book Synopsis Photochemistry and Photophysics of Coordination Compounds II by : Vincenzo Balzani
Download or read book Photochemistry and Photophysics of Coordination Compounds II written by Vincenzo Balzani and published by Springer. This book was released on 2007-08-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photochemistry (a term that broadly speaking includes photophysics) is abranchofmodernsciencethatdealswiththeinteractionoflightwithmatter and lies at the crossroadsof chemistry, physics, and biology. However, before being a branch of modern science, photochemistry was (and still is today), an extremely important natural phenomenon. When God said: “Let there be light”, photochemistry began to operate, helping God to create the world as wenowknowit.Itislikelythatphotochemistrywasthesparkfortheoriginof life on Earth and played a fundamental role in the evolution of life. Through the photosynthetic process that takes place in green plants, photochemistry is responsible for the maintenance of all living organisms. In the geological past photochemistry caused the accumulation of the deposits of coal, oil, and naturalgasthat wenowuseasfuels.Photochemistryisinvolved inthecontrol ofozoneinthestratosphereandinagreatnumber ofenvironmentalprocesses thatoccurintheatmosphere,inthesea,andonthesoil.Photochemistryisthe essenceoftheprocessofvisionandcausesavarietyofbehavioralresponsesin living organisms. Photochemistry as a science is quite young; we only need to go back less than one century to ?nd its early pioneer [1]. The concept of coordination compound is also relatively young; it was established in 1892, when Alfred Werner conceived his theory of metal complexes [2]. Since then, the terms coordination compound and metal complex have been used as synonyms, even if in the last 30 years, coordination chemistry has extended its scope to the binding ofall kinds of substrates [3, 4].
Book Synopsis Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C by :
Download or read book Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C written by and published by Academic Press. This book was released on 2020-02-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology
Book Synopsis Clinical Ocular Toxicology by : Frederick T. Fraunfelder
Download or read book Clinical Ocular Toxicology written by Frederick T. Fraunfelder and published by Saunders. This book was released on 2008 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by international authorities in ocular toxicology, including the Founder of The National Registry of Drug-Induced Side Effects and its current Director, this essential resource provides the clinically relevant information you need to effectively diagnose and manage herbal, chemical, and drug-related ocular problems. Comprehensive coverage of all drugs' generic and trade drug names, primary uses, ocular and systemic side effects, and clinical significance make this book - like its best-selling predecessor, Drug-Induced Ocular Side Effects - the ideal reference for quick, on-the-spot consultation. Leaders in the field provide need-to-know information on all aspects of ocular toxicology-all in one concise reference. Data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden) help you recognize and avoid drug-induced ocular side effects. A highly templated format makes retrieval of essential knowledge quick and easy. A wealth of full-color photographs provide vivid, visual diagnostic guidance. The latest information on approved medications helps you stay up to date and provide state-of-the-art care. Extensive coverage of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics gives you the knowledge you need to manage any challenge in ocular toxicology Authoritative guidance on ocular drugs and their use in pregnancy helps you safely manage the unique needs of these patients. The inclusion of the WHO classification system helps you determine whether a particular side effect is certain, probable, or likely to occur.
Book Synopsis Comprehensive Heterocyclic Chemistry III by :
Download or read book Comprehensive Heterocyclic Chemistry III written by and published by Elsevier Science. This book was released on 2008-03-27 with total page 12500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Heterocyclic Chemistry III (CHEC-III) is a new 15-volume reference work which provides the first point of entry to the literature for all scientists interested in heterocyclic ring systems. Since publishing in 1984, Comprehensive Heterocyclic Chemistry (CHEC) has become the standard work on the subject, indispensable to all serious readers in the interdisciplinary areas where heterocycles are employed. CHEC-III builds on and complements the material in CHEC and CHEC-II and is designed to be used both alone and in conjunction with these two works. Written by leading scientists who have evaluated and summarized the most important data published over the last decade, Comprehensive Heterocyclic Chemistry III will be an invaluable addition to the reference library of those working with heterocyclic ring systems. Reviews advances in the properties, structure, synthesis, reactivity and applications of the most important heterocyclic ring systems Contains over 250 specialist reviews, logically organized by size and heteroatom content of the heterocyclic ring Saves researchers valuable time and effort through carefully structured critical reviews of the literature by experts
Book Synopsis Three-Membered Rings by : A. Davison
Download or read book Three-Membered Rings written by A. Davison and published by Springer. This book was released on 1973-08-24 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Significant Pharmaceuticals Reported in US Patents by : Thomas F. DeRosa
Download or read book Significant Pharmaceuticals Reported in US Patents written by Thomas F. DeRosa and published by Elsevier. This book was released on 2010-07-07 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents. This "hands-on" title provides explicit laboratory methods for preparing the most recent and effective medications. Each entry documents the biological testing protocols used to evaluate a drug and the significance of the current treatment agent over previous methods. Pharmaceuticals are included in this review only if at least two of the following criteria were met: Effectiveness in treating an illness, Innovative, ease of preparation, synergy with existing Medications. Pharmaceuticals are reported for 27 separate classes of illness, including: AIDS, Alzheimer's Disease, Cardiovascular Disorders, Diabetes, Epilepsy, Hepatitis C, Osteoporosis, Obesity and Sleep Disorders. Significant Pharmaceuticals Reported in US Patents has been designed to be used as both a reference and synthetic guide for pharmaceutical, medicinal and organic chemists and graduate students. Researchers working in other areas will also find the information valuable as in many instances intermediates or the next generation pharmaceutical are readily convertible into other industrial products including: anti-oxidants, chemical additives, herbicides, polymer precursors, water purification agents. Clear structural depictions of reagents and chemical transformations have been supplied to permit the identification of other future applications. Identifies next generation pharmaceuticals Provides practical preparation methods for each active agent and derivatives Documents the analytical characterization and biological testing results of active agents
Book Synopsis Neurofeedback and Neuromodulation Techniques and Applications by : Robert Coben
Download or read book Neurofeedback and Neuromodulation Techniques and Applications written by Robert Coben and published by Academic Press. This book was released on 2010-11-25 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of neurofeedback and neuromodulation offer a window into brain physiology and function, suggesting innovative approaches to the improvement of attention, anxiety, pain, mood and behavior. Resources for understanding what neurofeedback and neuromodulation are, how they are used, and to what disorders and patients they can be applied are scarce, and this volume serves as an ideal tool for clinical researchers and practicing clinicians in both neuroscience and psychology to understand techniques, analysis, and their applications to specific patient populations and disorders. The top scholars in the field have been enlisted, and contributions offer both the breadth needed for an introductory scholar and the depth desired by a clinical professional. Includes the practical application of techniques to use with patients Includes integration of neurofeedback with neuromodulation techniques Discusses what the technique is, for which disorders it is effective, and the evidence basis behind its use Written at an appropriate level for clinicians and researchers
