Site And Mechanism Of Action Of Resin Acids On Voltage Gated Ion Channels

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Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels

Author : Malin Silverå Ejneby
Publisher : Linköping University Electronic Press
ISBN 13 : 9176853187
Total Pages : 58 pages
Book Rating : 4.1/5 (768 download)

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Book Synopsis Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels by : Malin Silverå Ejneby

Download or read book Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels written by Malin Silverå Ejneby and published by Linköping University Electronic Press. This book was released on 2018-05-15 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels are pore-forming membrane proteins that open or close their gates when the voltage across the membrane is changed. They underlie the electrical activity that enables the heart to pump blood and the brain to receive and send signals. Changes in expression, distribution, and functional properties of voltage-gated ion channels can lead to diseases, such as epilepsy, cardiac arrhythmia, and pain-related disorders. Drugs that modulate the function of voltage-gated ion channels control these diseases in some patients, but the existing drugs do not adequately help all patients, and some also have severe side effects. Resin acids are common components of pine resins, with a hydrophobic three-ringed motif and a negatively charged carboxyl group. They open big-conductance Ca2+-activated K+ (BK) channels and voltage-gated potassium (KV) channels. We aimed to characterize the binding site and mechanism of action of resin acids on a KV channel and explore the effect of a resin acid by modifying the position and valence of charge of the carboxyl group. We tested the effect on several voltage-gated ion channels, including two KV channels expressed in Xenopus laevis oocytes and several voltage-gated ion channels expressed in cardiomyocytes. For this endeavour different electrophysiological techniques, ion channels, and cell types were used together with chemical synthesis of about 140 resin-acid derivatives, mathematical models, and computer simulations. We found that resin acids bind between the lipid bilayer and the Shaker KV channel, in the cleft between transmembrane segment S3 and S4, on the extracellular side of the voltage-sensor domain. This is a fundamentally new interaction site for small-molecule compounds that otherwise usually bind to ion channels in pockets surrounded by water. We also showed that the resin acids open the Shaker KV channel via an electrostatic mechanism, exerted on the positively charged voltage sensor S4. The effect of a resin acid increased when the negatively charged carboxyl group (the effector) and the hydrophobic three-ringed motif (anchor in lipid bilayer) were separated by three atoms: longer stalks decreased the effect. The length rule, in combination with modifications of the anchor, was used to design new resin-acid derivatives that open the human M-type (Kv7.2/7.3) channel. A naturally occurring resin acid also reduced the excitability of cardiomyocytes by affecting the voltage-dependence of several voltage-gated ion channels. The major finding was that the resin acid inactivated sodium and calcium channels, while it activated KV channels at more negative membrane voltages. Computer simulations confirmed that the combined effect on different ion channels reduced the excitability of a cardiomyocyte. Finally, the resin acid reversed induced arrhythmic firing of the cardiomyocytes. In conclusion, resin acids are potential drug candidates for diseases such as epilepsy and cardiac arrhythmia: knowing the binding site and mechanism of action can help to fine tune the resin acid to increase the effect, as well as the selectivity.

Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel

Author : Nina Ottosson
Publisher : Linköping University Electronic Press
ISBN 13 : 917685521X
Total Pages : 66 pages
Book Rating : 4.1/5 (768 download)

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Book Synopsis Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel by : Nina Ottosson

Download or read book Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel written by Nina Ottosson and published by Linköping University Electronic Press. This book was released on 2017-04-20 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels play fundamental roles in excitable cells, such as neurons, where they enable electric signaling. Normally, this signaling is well controlled, but brain damage, alterations in the ionic composition of the extracellular solution, or dysfunctional ion channels can increase the electrical excitability thereby causing epilepsy. Voltage-gated ion channels are obvious targets for antiepileptic drugs, and, as a rule of thumb, excitability is dampened either by closing voltagegated sodium channels (Nav channels) or by opening voltage-gated potassium channels (Kv channels). For example, several classical antiepileptic drugs block the ion-conducting pore of Nav channels. Despite the large number of existing antiepileptic drugs, one third of the patients with epilepsy suffer from intractable or pharmacoresistant seizures. Our research group has earlier described how different polyunsaturated fatty acids (PUFAs) open a Kv channel by binding close to the voltage sensor and, from this position, electrostatically facilitate the movement of the voltage-sensor, thereby opening the channel. However, PUFAs affect a wide range of ion channels, making it difficult to use them as pharmaceutical drugs; it would be desirable to find smallmolecule compounds with an electrostatic, PUFA-like mechanism of action. The aim of the research leading to this thesis was to find, characterize, and refine drug candidates capable of electrostatically opening a Kv channel. The majority of the experiments were performed on the cloned Shaker Kv channel, expressed in oocytes from the frog Xenopus laevis, and the channel activity was explored with the two-electrode voltage-clamp technique. By systematically mutating the extracellular end of the channel’s voltage sensor, we constructed a highly PUFAsensitive channel, called the 3R channel. Such a channel is a useful tool in the search for electrostatic Kv-channel openers. We found that resin acids, naturally occurring in tree resins, act as electrostatic Shaker Kv channel openers. To explore the structure-activity relationship in detail, we synthesized 120 derivatives, whereof several were potent Shaker Kv channel openers. We mapped a common resin acidbinding site to a pocket formed by the voltage sensor, the channel’s third transmembrane segment, and the lipid membrane, a principally new binding site for small-molecule compounds. Further experiments showed that there are specific interactions between the compounds and the channel, suggesting promises for further drug development. Several of the most potent Shaker Kv channel openers also dampened the excitability in dorsal-root-ganglion neurons from mice, elucidating the pharmacological potency of these compounds. In conclusion, we have found that resin-acid derivatives are robust Kv-channel openers and potential drug candidates against diseases caused by hyperexcitability, such as epilepsy.

Endogenous and Exogenous Molecules Modulating Voltage-Gated Potassium Channels

Author : Damon Frampton
Publisher : Linköping University Electronic Press
ISBN 13 : 9180757529
Total Pages : 148 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Endogenous and Exogenous Molecules Modulating Voltage-Gated Potassium Channels by : Damon Frampton

Download or read book Endogenous and Exogenous Molecules Modulating Voltage-Gated Potassium Channels written by Damon Frampton and published by Linköping University Electronic Press. This book was released on 2024-10-02 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: The superfamily of voltage-gated potassium (KV) channels is crucial for the normal function of several tissues and represents an attractive pharmacological target for treating disorders such as epilepsy and cardiac arrhythmias. However, any drug designed to target a KV channel must be capable of discriminating between different members within the superfamily, lest they plague the user with deleterious side effects. Such rational design requires structural and functional insight into how the selectivity of a molecule can be tailored to suit the intended target. This thesis combines the use of electrophysiological and computational techniques to investigate the molecular basis for how the function of hKV7 and hERG channels can be modulated by different lipophilic compounds with known or suspected effects on ion channels. These include polyunsaturated fatty acids (PUFAs), cannabidiol (CBD), and synthetic cannabinoid receptor agonists (SCRAs). Using the two-electrode voltage clamp technique on Xenopus oocytes, we find that both PUFAs and CBD modulate the function of hKV7 channels in subtype-specific manners. PUFAs facilitated the activation of hKV7 channels, except for hKV7.4 channels which were instead inhibited. Molecular dynamics simulations revealed that structural differences in the voltage-sensing domain of hKV7.4 conferred a unique, inhibitory PUFA interaction site absent in the other hKV7 subtypes. Once this site was neutralised by mutagenesis, PUFAs facilitated hKV7.4 activation. In the case of CBD, we observed three different responses: inhibition of channels with hKV7.1 subunits, potentiated voltage-sensitivity of channels with hKV7.2 or hKV7.3 subunits and enhanced maximum conductance of channels with hKV7.4 or hKV7.5 subunits. However, these responses were evoked from the same interaction site in the pore domain, indicating a more complex subtype-specific mechanism of action. Finally, using an automated patch-clamp system we screened 36 different SCRAs on the cardiac channels responsible for repolarisation: hERG and hKV7.1/KCNE1. We find 28 of the SCRAs to be inhibitors of hERG and 22 to be inhibitors of hKV7.1/KCNE1. Molecular dynamics simulations suggest the increased susceptibility of hERG to SCRA-mediated inhibition may be due to a unique central cavity site that is absent from the pore domain of hKV7.1/KCNE1. In conclusion, structurally diverse lipophilic molecules of endogenous and exogenous origins can interact with KV channels and influence their function by enhancing or interfering with functional domains. In some instances, structural differences in the channel protein can explain the discrepancies in pharmacology. These findings have implications for both pharmacology (informing rational drug design) and toxicology (identifying targets through which adverse effects may occur).

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1492 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1976 with total page 1492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles and Practice of Phytotherapy

Author : Kerry Bone
Publisher : Elsevier Health Sciences
ISBN 13 : 0702052973
Total Pages : 1076 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Principles and Practice of Phytotherapy by : Kerry Bone

Download or read book Principles and Practice of Phytotherapy written by Kerry Bone and published by Elsevier Health Sciences. This book was released on 2013-01-08 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authoritative and comprehensive modern textbook on western herbal medicine - now in its second edition This long-awaited second edition of Principles and Practice of Phytotherapy covers all major aspects of herbal medicine from fundamental concepts, traditional use and scientific research through to safety, effective dosage and clinical applications. Written by herbal practitioners with active experience in clinical practice, education, manufacturing and research, the textbook is both practical and evidence based. The focus, always, is on the importance of tailoring the treatment to the individual case. New insights are given into the herbal management of approxiately 100 modern ailments, including some of the most challenging medical conditions, such as asthma, inflammatory bowel disease and other complex autoimmune and inflammatory conditions, and there is vibrant discussion around the contribution of phytotherapy in general to modern health issues, including health ageing. Fully referenced throughout, with more than 10, 000 citations, the book is a core resource for students and practitioners of phytotherapy and naturopathy and will be of value to all healthcare professionals - pharmacists, doctors, nurses - with an interest in herbal therapeutics. 50 evidence-based monographs, including 7 new herbs Rational guidance to phytotherapeutic strategies in the consulting room New appendices provide useful information on topics such as herbal actions, dosage in children and reading and interpreting herbal clinical trials Comprehensive revision of vital safety data, including an extensive herb-drug interaction chart. 50 evidence-based monographs, including 7 new herbs Rational guidance to phytotherapeutic strategies in the consulting room New appendices provide useful information on topics such as herbal actions, dosage in children and reading and interpreting herbal clinical trials Comprehensive revision of vital safety data, including an extensive herb-drug interaction chart.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1666 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Piezo Channels

Author :
Publisher : Academic Press
ISBN 13 : 0128096217
Total Pages : 350 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Piezo Channels by :

Download or read book Piezo Channels written by and published by Academic Press. This book was released on 2017-07-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piezo Channels, Volume 79, the latest volume in the Current Topics in Membranes series provides the necessary membrane research to assist readers in discovering the current state of a particular field and future directions. New chapters in the updated volume include A Tour de Force: The Discovery, Properties, and Function of Piezo Channels, Piezo1 Channels in Vascular Development and the Sensing of Shear Stress, the Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels, Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction, and The Structural Basis for Sensing by the Piezo1 Protein. Users of this series will find an up-to-date presentation of the current knowledge in the field of Piezo Channels. - Written by leading experts in the field - Contains original material, both textual and illustrative, that make it a very relevant reference - Presented in a very comprehensive manner - Ideal reference for both researchers in the field and general readers who will find this book to be relevant and up-to-date

Biomembrane Electrochemistry

Author : Martin Blank
Publisher :
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.X/5 (4 download)

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Book Synopsis Biomembrane Electrochemistry by : Martin Blank

Download or read book Biomembrane Electrochemistry written by Martin Blank and published by . This book was released on 1994 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: In October 1986, the Office of Naval Research initiated a five-year program for electrochemical research on biological and model membranes. The program explored the physical basis of biological sensory and energy-transducing processes by focusing on the electrochemical properties of integral membrane proteins (i.e., channel structures) associated with ion-transport processes. The major research areas covered were interfaces and lipid layers, channels (structure and function), and signal transduction. This volume contains papers from that program as well as some related studies. Annotation copyright by Book News, Inc., Portland, OR

Voltage Gated Sodium Channels

Author : Peter C. Ruben
Publisher : Springer Science & Business Media
ISBN 13 : 3642415881
Total Pages : 328 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Chemical Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 2720 pages
Book Rating : 4.3/5 (91 download)

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Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2720 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Concise Dictionary of Pharmacological Agents

Author : Dr. Ian Morton
Publisher : Springer Science & Business Media
ISBN 13 : 9780751404999
Total Pages : 356 pages
Book Rating : 4.4/5 (49 download)

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Book Synopsis Concise Dictionary of Pharmacological Agents by : Dr. Ian Morton

Download or read book Concise Dictionary of Pharmacological Agents written by Dr. Ian Morton and published by Springer Science & Business Media. This book was released on 1999-10-31 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dictionary provides a convenient personal reference source, intended to complement more encyclopaedic works. First, there is an alphabetic, fully cross-indexed listing of pharmacologically active agents and their properties, containing details of some 4000 individual chemical agents including medical drugs in current use, experimental agents and toxins used as investigation tools. Over 10,000 alternative names are indexed, including chemical names, abbreviated chemical names, official pharmacological names, proprietary names and research code numbers. A key feature is that the properties of the agents are categorised, according to mechanism and use, into 300 classes -for each of which there are descriptive articles for which key literature and review references are provided. Second, there is an alphabetical glossary explaining the meaning of some 3000 biomedical terms from pharmacology, biochemistry, molecular biology, immunology, pathology, physiology, anatomy and microbiology. Emphasis in explanation is given to terms that can cause confusion, for example those relating to drug receptors and to endogenous mediators. Audience: This work provides indispensable information for researchers in the fields of pharmacology, medicinal chemistry and pharmaceutics, and biochemistry, as well as for medical and science writers and editors and drug regulatory officers.

Blackwell's Five-Minute Veterinary Consult

Author : Hugues Beaufrère
Publisher : John Wiley & Sons
ISBN 13 : 1119870577
Total Pages : 580 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Blackwell's Five-Minute Veterinary Consult by : Hugues Beaufrère

Download or read book Blackwell's Five-Minute Veterinary Consult written by Hugues Beaufrère and published by John Wiley & Sons. This book was released on 2025-02-26 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: BLACKWELL’S FIVE-MINUTE VETERINARY CONSULT: AVIAN Quick reference to essential information on 200 diseases and conditions commonly seen in birds in clinical practice Covering topics ranging from infectious and non-infectious diseases to diseases by organ system, Blackwell’s Five-Minute Veterinary Consult: Avian fills a unique niche by providing comprehensive information on common topics in avian medicine in a highly organized and efficient manner, allowing busy practitioners and students to quickly find much needed information. A companion website provides algorithms, procedure guides, and client education handouts, which can be downloaded, edited, and given to clients. Written by the leading experts in the field, this newly revised Second Edition offers close to 200 identically formatted topics on avian conditions, with updated and expanded information on non-infectious disease topics like neoplasia, beak malocclusion, diseases of the bursa, nails, and tongue, among others, and infectious disease topics such as herpesviruses, helminthiasis, arboviruses and backyard poultry infectious diseases. This latest edition has been expanded by more than 50% and numerous subjects have been restructured and expanded. Other topics covered in Blackwell’s Five-Minute Veterinary Consult: Avian include: Viral Diseases including circovirus, bornavirus, avian influenza, west nile virus, polyomavirus, poxvirus, and herpesviruses Bacterial Diseases including colibacillosis, campylobacteriosis, chlamydiosis, pasteurellosis, clostridiosis, salmonellosis, and mycoplasmosis Fungal Diseases including aspergillosis, candidiasis, and macrorhabdosis Parasites including flagellates, coccidia, myiasis, ectoparasites, helminths, and toxicosis including iatrogenic, ingested, airborne, algal biotoxins, heavy metals, and pesticides Orthopedic and traumatic conditions such as beak injuries, neurologic trauma, fractures, luxations, joint diseases and wounds, with neoplasia by organ system Critical Care including hypotension, respiratory distress, seizures, hemorrhage, pain, and internal medicine including cardiac disease, cloacal diseases, ocular diseases, diabetes insipidus, atherosclerosis and thyroid diseases For veterinary students, busy avian practitioners, practitioners in mixed practice who want quick access to reliable information, and emergency clinicians presented with the occasional bird, Blackwell’s Five-Minute Veterinary Consult: Avian is an invaluable, accessible, and highly practical reference to add to your practice library.

Wiley Encyclopedia of Chemical Biology, Volume 4

Author : Tadhg P. Begley
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 836 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Wiley Encyclopedia of Chemical Biology, Volume 4 by : Tadhg P. Begley

Download or read book Wiley Encyclopedia of Chemical Biology, Volume 4 written by Tadhg P. Begley and published by Wiley-Blackwell. This book was released on 2009-02-03 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Indexes to the Epilepsy Accessions of the Epilepsy Information System

Author : J. Kiffin Penry
Publisher :
ISBN 13 :
Total Pages : 1366 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Indexes to the Epilepsy Accessions of the Epilepsy Information System by : J. Kiffin Penry

Download or read book Indexes to the Epilepsy Accessions of the Epilepsy Information System written by J. Kiffin Penry and published by . This book was released on 1978 with total page 1366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Atrial Fibrillation

Author : Andrea Natale
Publisher : Springer Science & Business Media
ISBN 13 : 1597451630
Total Pages : 452 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Atrial Fibrillation by : Andrea Natale

Download or read book Atrial Fibrillation written by Andrea Natale and published by Springer Science & Business Media. This book was released on 2008-04-03 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important new book presents advancements in the treatment and prevention of Atrial Fibrillation (AF). The reader is provided with the latest information that is critically important in the daily care and for the potential cure of patients with AF. Each chapter deals with a different aspect of AF and each chapter is authored by internationally recognized experts in the evolving field of cardiac electrophysiology. This book is a single source that provides a multi-perspective look at and approach to AF. Because AF is so prevalent and affects all areas of medicine, the information in this book will be useful to all those in the medical field.

Ion Channel Drug Discovery

Author : Brian Cox
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735085
Total Pages : 385 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Ion Channel Drug Discovery by : Brian Cox

Download or read book Ion Channel Drug Discovery written by Brian Cox and published by Royal Society of Chemistry. This book was released on 2014-09-03 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.

Calcium Entry Channels in Non-Excitable Cells

Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Calcium Entry Channels in Non-Excitable Cells by : Juliusz Ashot Kozak

Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.