Silicon In A One Dimensional Porous Nanotube Structure And Its Evaluation As Drug Delivery Vector In Vitro

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Silicon in a One-dimensional Porous Nanotube Structure and Its Evaluation as Drug Delivery Vector in Vitro

Author : Tan Khanh Le Nguyen
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Silicon in a One-dimensional Porous Nanotube Structure and Its Evaluation as Drug Delivery Vector in Vitro by : Tan Khanh Le Nguyen

Download or read book Silicon in a One-dimensional Porous Nanotube Structure and Its Evaluation as Drug Delivery Vector in Vitro written by Tan Khanh Le Nguyen and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery is a promising therapeutic approach to achieve sustainable drug release while minimizing adverse side effects triggered by non-specificity of the free drugs. Among delivery vectors, biodegradable nanomaterials are of utmost interest for minimizing deleterious consequences stemming from long-term carrier accumulation. With regard to inorganic nanomaterials, porous silicon (pSi) is among a few that can degrade and release non-toxic byproducts (i.e. orthosilicic acid), and dissolution kinetics of the materials can readily be controlled via modulating structural morphology as well as surface chemistry. To date, a great number of pSi-based delivery vectors with intricate designs have been presented to address multiple challenges in therapeutic delivery. Since the shape of the nanocarriers have been shown to influence interactions with multiple biological components, pSi with various geometrical shapes (i.e. discoidal, hemisphere and platelet shapes) have been introduced in recent years, and promising therapeutic efficacy has also been demonstrated in various disease models. Recently, via a sacrificial ZnO template method developed by our group, we have shown that one-dimensional (1D) porous nanotube structure of Si (pSiNTs) with well-defined shell thickness, inner diameter and length can readily be achieved. Since the materials can degrade in biological media and exert negligible effects to viability of both normal (e.g. human embryonic kidney, HEK 293) and cancer (e.g. HeLa cervical cancer) human cells, it is of great interest to evaluate pSiNTs as potential therapeutic platforms. Interestingly, we have also demonstrated pSiNTs can also serve as a facile template for facilitating formation of a secondary nanostructure, so called platinum nanocrystals (Pt NCs) with potential anti-cancer properties. Evaluation of in vitro anti-cancer activity of this novel nanohybrid revealed the viability of HeLa cells was reduced in a time-dependent manner as a consequence of a "Trojan horse" mechanism, in which a high concentration of Pt NCs are internalized within cells assisted by pSiNTs and subsequently released via dissolution of the nanotube matrix. In addition, pSiNTs are also evaluated as potential therapeutic delivery vectors for nucleic acids. Preliminary in vitro studies suggest the materials can deliver reporter plasmids DNA (circular DNA) encoding green fluorescent proteins (eGFP) into HEK 293 cells. In another study, downregulations of eGFP (in HeLa) and estrogen receptors (ER) (in MCF-7 breast cancer cells) are also demonstrated via delivery of small interfering RNA (siRNAs) targeting eGFP-mRNA (siGFP) and ER-mRNA (siER) by pSiNTs. All in all, these studies presented herein demonstrate the potential merit of pSiNTs in drug delivery and serve as a foundation for future studies to design pSiNTs-based platforms that can successively address multiple biological barriers encountered upon systemic administration. Such studies expand the library of possible pSi structures in nanomedicine for suitable disease models and associated applications.

Porous Silicon for Biomedical Applications

Author : Hélder A. Santos
Publisher : Woodhead Publishing
ISBN 13 : 0128225246
Total Pages : 646 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Porous Silicon for Biomedical Applications by : Hélder A. Santos

Download or read book Porous Silicon for Biomedical Applications written by Hélder A. Santos and published by Woodhead Publishing. This book was released on 2021-10-23 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy. Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry. This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field. Reviews the fundamental aspects of porous silicon, including the fabrication and unique properties of this useful material. Discusses a broad selection of biomedical applications, offering a detailed insight into the benefits of porous silicon in both research and clinical settings. Includes fully updated content from the previous edition, as well as brand new chapters, covering topics such as porous silicon micro- and nanoneedles, and cancer immunotherapy.

Drug Delivery with Targeted Nanoparticles

Author : Yılmaz Çapan
Publisher : CRC Press
ISBN 13 : 1000375269
Total Pages : 790 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Drug Delivery with Targeted Nanoparticles by : Yılmaz Çapan

Download or read book Drug Delivery with Targeted Nanoparticles written by Yılmaz Çapan and published by CRC Press. This book was released on 2021-11-30 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

Nanoparticulate Drug Delivery Systems

Author : Raj K. Keservani
Publisher : CRC Press
ISBN 13 : 1351137247
Total Pages : 423 pages
Book Rating : 4.3/5 (511 download)

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Book Synopsis Nanoparticulate Drug Delivery Systems by : Raj K. Keservani

Download or read book Nanoparticulate Drug Delivery Systems written by Raj K. Keservani and published by CRC Press. This book was released on 2019-01-23 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Advanced Porous Biomaterials for Drug Delivery Applications

Author : Mahaveer Kurkuri
Publisher : CRC Press
ISBN 13 : 1000783936
Total Pages : 437 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Advanced Porous Biomaterials for Drug Delivery Applications by : Mahaveer Kurkuri

Download or read book Advanced Porous Biomaterials for Drug Delivery Applications written by Mahaveer Kurkuri and published by CRC Press. This book was released on 2022-11-30 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Porous Biomaterials for Drug Delivery Applications probes cutting-edge progress in the application of advanced porous biomaterials in drug delivery fields. These biomaterials offer promise in improving upon the design, cost, and creation of potent novel drug delivery systems. The book focuses on two categories: nature engineered and synthetic advanced porous biomaterials, with a wide range of low-cost porous biomaterial-based systems that have been used for the delivery of diverse drugs through in vitro/in vivo approaches. Details how advanced porous biomaterial-assisted systems improve essential properties in drug delivery applications Explains how advanced porous biomaterials systems are being used and explored to improve overall performances of drug delivery systems in mitigating a variety of diseases Emphasizes major applications in drug delivery such as controlled release, cancer therapy, and targeted delivery, and with focus on oral, topical, and transdermal applications Focuses on both naturally available and synthetic low-cost advanced porous biomaterials and their role in enhancing important parameters in drug delivery applications Accessible to readers with bio and non-bio backgrounds This book is an ideal reference for academics, researchers, and industry professionals in the interdisciplinary fields of biomedicine and biomedical engineering, pharmaceuticals, materials science, and chemistry.

Nanotechnology and Drug Delivery, Volume One

Author : José L. Arias
Publisher : CRC Press
ISBN 13 : 1466599480
Total Pages : 378 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Nanotechnology and Drug Delivery, Volume One by : José L. Arias

Download or read book Nanotechnology and Drug Delivery, Volume One written by José L. Arias and published by CRC Press. This book was released on 2014-08-04 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatfo

Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery

Author : Chia-Chen Wu
Publisher :
ISBN 13 : 9781303527197
Total Pages : 21 pages
Book Rating : 4.5/5 (271 download)

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Book Synopsis Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery by : Chia-Chen Wu

Download or read book Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery written by Chia-Chen Wu and published by . This book was released on 2013 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous materials with engineered surface properties are of interest for molecular separations, catalysis, drug delivery, and chemical sensing. One of the longstanding chemical challenges in the engineering of nanomaterials is to control the placement of different chemistries in spatially distinct regions on a nanoscale object. This thesis focuses on discovering and understanding processes to prepare such spatially differentiated chemistries on porous silicon. For the porous silicon system, the ability to prepare pores of average diameter anywhere from 1 to 200 nm allows the harnessing of surface tension and capillary forces to promote or obstruct the infiltration of reagent for selective modification. The first process investigated involves placing different chemistries on the pore walls by means of microdroplet patterning. In this method, a chemical resist is drop-coated on a porous silicon sample to mask distinct regions across the plane of the chip for subsequent chemical modification. Two chemistries, silicon oxide and silicon-methyl, are demonstrated here. The differential partitioning of test molecules on the resulting hydrophilic/hydrophobic film is achieved by simultaneous optical reflectance measurement of both regions, where the reflectance spectrum contains a convolution of the Fabry-Pérot interference spectrum for both types of surface chemistries. A second approach to engineer porous Si nanostructures that is investigated uses a hydrophobic organic liquid as a chemical resist; it is infiltrated into the pores to mask the interior of the porous silicon film, while the exterior surface and the pore mouths of the film are subjected to an aqueous chemical reaction with HF and subsequent chemical modification by thermal hydrosilylation. When chemically modified with a hydrophobic dodecyl species, the resulting film has a hydrophilic interior and a hydrophobic outer surface. The ability of these core-shell porous nanostructures to admit and release small molecules is assessed and exploited. The last portion of the thesis focuses on an evaluation of chemically modified porous silicon particles as oral drug delivery material, with an emphasis on the ability of the interior of the porous silicon nanostructure to protect physiologically unstable drugs. Partially oxidized porous silicon particles show no toxicity to nematodes at particle concentration up to 1 mg/mL in culture media. In vitro experiments show the particles protect anthelmintic protein-based drug Cry5B from hydrolytic degradation in simulated gastric fluid, and the bioactivity against nematodes is maintained. However, much reduced bioactivity of the therapeutic particles is observed In vivo on hookworm-infected hamsters. The lack of effectiveness in treating the disease In vivo is attributed to the short residence time of the particles in the gut of the animals.

Nanoconjugate Nanocarriers for Drug Delivery

Author : Raj K. Keservani
Publisher : CRC Press
ISBN 13 : 135117102X
Total Pages : 453 pages
Book Rating : 4.3/5 (511 download)

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Book Synopsis Nanoconjugate Nanocarriers for Drug Delivery by : Raj K. Keservani

Download or read book Nanoconjugate Nanocarriers for Drug Delivery written by Raj K. Keservani and published by CRC Press. This book was released on 2018-09-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume presents a plethora of new research on the use of nanoconjugate nanocarriers in drug delivery. Nanotechnology as drug carriers has been observed to increase the level of sophistication through a variety of ways. It helps to alleviate some of the pitfalls of conventional dosage forms, such as few pitfalls such as non-specific drug delivery, dose dumping, poor patient compliance, toxicities linked with higher doses, etc. With chapters from highly skilled, experienced, and renowned scientists and researchers, Nanoconjugate Nanocarriers for Drug Delivery is divided into four sections, providing an introduction to nanocarriers for drug delivery, physicochemical features of nanocarriers, and specific applications dealing with drug delivery in particular. The materials used as well as formulation and characterization have been discussed in detail. The nanocarriers covered in the book include nanoparticles, vesicular carriers, carriers having carbon as the core constituent, dispersed systems, etc. The book also delves into the interaction and associations between drug delivery research and its therapeutic applications in practice. The book integrates a wide variety of case studies, research, and theories in an attempt to reveal the diversity and capture the novel approaches of nanoconjugate nanocarriers for drug delivery employed by developers and content experts in the field. This timely publication will be an essential reference and current awareness source, building on the available literature in the field of pharmacy and biomedical science, while also providing ideas for further research opportunities in this dynamic field.

Lipid-Based Nanocarriers for Drug Delivery and Diagnosis

Author : Muhammad Raza Shah
Publisher : William Andrew
ISBN 13 : 0323527302
Total Pages : 373 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Lipid-Based Nanocarriers for Drug Delivery and Diagnosis by : Muhammad Raza Shah

Download or read book Lipid-Based Nanocarriers for Drug Delivery and Diagnosis written by Muhammad Raza Shah and published by William Andrew. This book was released on 2017-06-07 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid-Based Nanocarriers for Drug Delivery and Diagnosis explores the present state of widely used lipid-based nanoparticulate delivery systems, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanoliposomes, micelles, nanoemulsions, nanosuspensions and lipid nanotubes. The various types of lipids that can be exploited for drug delivery and their chemical composition and physicochemical characteristics are reviewed in detail, along with their characterization aspects and effects of their dimensions on drug delivery systems behavior in-vitro and in-vivo. The book covers the effective utilization of these lipids based systems for controlled and targeted delivery of potential drugs/genes for enhanced clinical efficacy. Provides the present state of widely used lipid-based nanoparticulate delivery systems Explores how lipid-based nanocarriers improve drug delivery safety Describes the nanoformulation design and the preparation methods of lipid-based nanocarriers

Nanocarriers for Organ-Specific and Localized Drug Delivery

Author : Muhammad Raza Shah
Publisher : Elsevier
ISBN 13 : 012821094X
Total Pages : 272 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanocarriers for Organ-Specific and Localized Drug Delivery by : Muhammad Raza Shah

Download or read book Nanocarriers for Organ-Specific and Localized Drug Delivery written by Muhammad Raza Shah and published by Elsevier. This book was released on 2022-04-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ-specific drug delivery is aimed at achieving increased concentration of therapeutic molecules at target sites with minimum side effects on other healthy tissues. Similarly, drug-specific delivery to some vital organs, such as the brain, lungs, heart and kidneys remains a challenging task for the formulation scientists. Oral delivery of most of the commercially available life-saving drugs has also been impeded by various physio-chemical and biological barriers. These advancements in nanotechnology have led to the development of various pharmaceutical nanocarriers.Nanocarriers for Organ-Specific and Localized Drug Delivery summarizes targeted drug delivery systems and approaches to the major organs of the body. The book shows how drugs can be specifically targeted to the pathological area within an organ in a viable way. Employing pharmaceutical nanocarriers for drug delivery targeted to specific organs of the body requires a comprehensive knowledge of the disease site’s pathophysiology as well as physical, chemical and pharmaceutical techniques for modification or functionalization of the nanocarriers.Combining theoretical principles and practical applications of various nanocarriers for organ-specific drug delivery, this is an important reference source for all those seeking to increase their understanding of how pharmaceutical nanocarriers are being used to create more efficient drug delivery systems. Outlines the underlying principles for the design of advanced pharmaceutical nanocarriers for organ specific drug delivery Includes guidance on how to exploit the pathophysiology and microenvironment of the diseased sites for targeted drug delivery Assesses the major challenges for creating pharmaceutical nanocarriers on a mass scale

Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device

Author : Emily Jessica Anglin
Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (187 download)

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Book Synopsis Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device by : Emily Jessica Anglin

Download or read book Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device written by Emily Jessica Anglin and published by . This book was released on 2007 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the fabrication, chemical modification, drug release, and toxicity studies of nanostructured porous silicon for the purposes of developing a smart drug delivery device. The first chapter is an introductory chapter, presenting the chemical and physical properties of porous silicon, the concepts and issues of current drug delivery devices and materials, and how porous silicon can address the issues regarding localized and controlled drug therapies. The second chapter discusses chemical modifications of nanostructured porous Si for stabilizing the material in biologically relevant media while providing an extended release of a therapeutic in vitro. This chapter also demonstrates the utility of the porous silicon optical signatures for effectively monitoring drug release from the system and its applications for development of a self-reporting drug delivery device. In chapter three, the concept of providing a triggered release of a therapeutic from porous silicon microparticles through initiation by an external stimulus is demonstrated. The microparticles are chemically modified, and the release is enhanced by a short application of ultrasound to the particulate system. The effect of ultrasound on the drug release and particle size is discussed. Chapter four presents a new method for sustaining the release of a monoclonal antibody from the porous matrix of porous SiO2. The therapeutic is incorporated into the films through electrostatic adsorption and a slow release is observed in vitro. A new method of quantifying the extent of drug loading is monitored with interferometry. The last chapter of the thesis provides a basic in vivo toxicity study of various porous Si microparticles for intraocular applications. Three types of porous Si particles are fabricated and studied in a rabbit eye model. The toxicity studies were conducted by collaborators at the Shiley Eye Center, La Jolla, CA. This work, demonstrates the feasibility of developing a self-reporting, extended release drug delivery system using porous Si microparticles for intraocular applications.

Nanostructures for Drug Delivery

Author : Ecaterina Andronescu
Publisher : Elsevier
ISBN 13 : 0323461492
Total Pages : 1026 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanostructures for Drug Delivery by : Ecaterina Andronescu

Download or read book Nanostructures for Drug Delivery written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-03-24 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial

Intracellular Delivery

Author : Aleš Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400712480
Total Pages : 871 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Intracellular Delivery by : Aleš Prokop

Download or read book Intracellular Delivery written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.

Micro- and Nanotechnologies-Based Product Development

Author : Neelesh Kumar Mehra
Publisher : CRC Press
ISBN 13 : 1000421600
Total Pages : 327 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Micro- and Nanotechnologies-Based Product Development by : Neelesh Kumar Mehra

Download or read book Micro- and Nanotechnologies-Based Product Development written by Neelesh Kumar Mehra and published by CRC Press. This book was released on 2021-09-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive information of the nanotechnology-based pharmaceutical product development including a diverse range of arenas such as liposomes, nanoparticles, fullerenes, hydrogels, thermally responsive externally activated theranostics (TREAT), hydrogels, microspheres, micro- and nanoemulsions and carbon nanomaterials. It covers the micro- and nanotechnological aspects for pharmaceutical product development with the product development point of view and also covers the industrial aspects, novel technologies, stability studies, validation, safety and toxicity profiles, regulatory perspectives, scale-up technologies and fundamental concept in the development of products. Salient Features: Covers micro- and nanotechnology approaches with current trends with safety and efficacy in product development. Presents an overview of the recent progress of stability testing, reverse engineering, validation and regulatory perspectives as per regulatory requirements. Provides a comprehensive overview of the latest research related to micro- and nanotechnologies including designing, optimisation, validation and scale-up of micro- and nanotechnologies. Is edited by two well-known researchers by contribution of vivid chapters from renowned scientists across the globe in the field of pharmaceutical sciences. Dr. Neelesh Kumar Mehra is working as an Assistant Professor of Pharmaceutics & Biopharmaceutics at the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He received ‘TEAM AWARD’ for successful commercialisation of an ophthalmic suspension product. He has authored more than 60 peer-reviewed publications in highly reputed international journals and more than 10 book chapter contributions. He has filed patents on manufacturing process and composition to improved therapeutic efficacy for topical delivery. He guided PhD and MS students for their dissertations/research projects. He has received numerous outstanding awards including Young Scientist Award and Team Award for his research output. He recently published one edited book, ‘Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives’, in CRC Press. Currently, he is editing books on nano drug delivery-based products with Elsevier Pvt Ltd. He has rich research and teaching experience in the formulation and development of complex, innovative ophthalmic and injectable biopharmaceutical products including micro- and nanotechnologies for regulated market. Dr. Arvind Gulbake is working as an Assistant Professor at the Faculty of Pharmacy, School of Pharmaceutical & Population Health Informatics, at DIT University, Dehradun, India. He has authored more than 40 peer-reviewed publications in highly reputed international journals, four book chapters and a patent contribution. He has received outstanding awards including Young Scientist Award and BRG Travel Award for his research. He is an assistant editor for IJAP. He guided PhD and MS students for their dissertations/research projects. He has successfully completed extramural project funded by SERB, New Delhi, Government of India. He has more than 12 years of research and teaching experience in the formulation and development of nanopharmaceuticals.

Nanotechnology for Oral Drug Delivery

Author : João Pedro Martins
Publisher : Academic Press
ISBN 13 : 0128180390
Total Pages : 536 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nanotechnology for Oral Drug Delivery by : João Pedro Martins

Download or read book Nanotechnology for Oral Drug Delivery written by João Pedro Martins and published by Academic Press. This book was released on 2020-07-30 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research

Nanotechnology in Drug Delivery

Author : Saurabh Bhatia
Publisher : CRC Press
ISBN 13 : 1315342065
Total Pages : 296 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Nanotechnology in Drug Delivery by : Saurabh Bhatia

Download or read book Nanotechnology in Drug Delivery written by Saurabh Bhatia and published by CRC Press. This book was released on 2017-03-03 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

Smart Materials for Drug Delivery

Author : Carmen Alvarez-Lorenzo
Publisher : Royal Society of Chemistry
ISBN 13 : 1849738785
Total Pages : 419 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Smart Materials for Drug Delivery by : Carmen Alvarez-Lorenzo

Download or read book Smart Materials for Drug Delivery written by Carmen Alvarez-Lorenzo and published by Royal Society of Chemistry. This book was released on 2013 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Materials for Drug Delivery brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems.