Schizophrenia And Genetics

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Psychiatric Genetics and Genomics

Author : Peter McGuffin
Publisher : Oxford University Press
ISBN 13 : 9780198564867
Total Pages : 508 pages
Book Rating : 4.5/5 (648 download)

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Book Synopsis Psychiatric Genetics and Genomics by : Peter McGuffin

Download or read book Psychiatric Genetics and Genomics written by Peter McGuffin and published by Oxford University Press. This book was released on 2004-09-23 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews of the hardback:'It is timely to see such an excellent textbook... Aimed at graduate level students, this book is complex enough to be thorough, but clear with enough background to be accessible... the coverage is comprehensive and the flow logical... The text is uniformly well written and achieves a successful integration.' -The Lancet'A good introduction and reference book for professionals interested in psychiatric genetics such as psychiatrists, clinical psychologists and neuroscientists... the book you want to have on your bookshelf to look up material and obtain a complete and balanced picture of the field.' -Psychological MedicineRevised for paperback edition, with new appendicesGenetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations.The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future.The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors.Readership: Psychiatrists, clinical psychologists, geneticists, neuroscientists and neurologists

Principles of Psychiatric Genetics

Author : John I. Nurnberger
Publisher : Cambridge University Press
ISBN 13 : 0521896495
Total Pages : 415 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Principles of Psychiatric Genetics by : John I. Nurnberger

Download or read book Principles of Psychiatric Genetics written by John I. Nurnberger and published by Cambridge University Press. This book was released on 2012-09-13 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.

Neuroimaging in Schizophrenia

Author : Marek Kubicki
Publisher : Springer Nature
ISBN 13 : 3030352064
Total Pages : 432 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Neuroimaging in Schizophrenia by : Marek Kubicki

Download or read book Neuroimaging in Schizophrenia written by Marek Kubicki and published by Springer Nature. This book was released on 2020-02-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book explains the importance of imaging techniques in exploring and understanding the role of brain abnormalities in schizophrenia. The findings obtained using individual imaging modalities and their biological interpretation are reviewed in detail, and updates are provided on methodology, testable hypotheses, limitations, and new directions for research. The coverage also includes important recent applications of neuroimaging to schizophrenia, for example in relation to non-pharmacological interventions, brain development, genetics, and prediction of treatment response and outcome. Written by world renowned experts in the field, the book will be invaluable to all who wish to learn about the newest and most important developments in neuroimaging research in schizophrenia, how these developments relate to the last 30 years of research, and how they can be leveraged to bring us closer to a cure for this devastating disorder. Neuroimaging in Schizophrenia will assist clinicians in navigating what is an extremely complex field and will be a source of insight and stimulation for researchers.

The Gene

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
ISBN 13 : 1476733538
Total Pages : 624 pages
Book Rating : 4.4/5 (767 download)

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Book Synopsis The Gene by : Siddhartha Mukherjee

Download or read book The Gene written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2016-05-17 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

Schizophrenia

Author : Irving I. Gottesman
Publisher : CUP Archive
ISBN 13 : 9780521295598
Total Pages : 276 pages
Book Rating : 4.2/5 (955 download)

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Book Synopsis Schizophrenia by : Irving I. Gottesman

Download or read book Schizophrenia written by Irving I. Gottesman and published by CUP Archive. This book was released on 1982-06-30 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Schizophrenia Genesis

Author : Irving I. Gottesman
Publisher : W. H. Freeman
ISBN 13 : 9780716721475
Total Pages : 296 pages
Book Rating : 4.7/5 (214 download)

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Book Synopsis Schizophrenia Genesis by : Irving I. Gottesman

Download or read book Schizophrenia Genesis written by Irving I. Gottesman and published by W. H. Freeman. This book was released on 1990-09-15 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sorting out fact from fiction, one of the world's leading experts presents an absorbing account of what is actually know about the complex subject of schizophrenia.

The New Genetics of Mental Illness

Author : Peter McGuffin
Publisher : Butterworth-Heinemann
ISBN 13 : 1483164276
Total Pages : 317 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The New Genetics of Mental Illness by : Peter McGuffin

Download or read book The New Genetics of Mental Illness written by Peter McGuffin and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Genetics of Mental Illness is a collection of papers that discusses the advancement of molecular biology in the context of psychiatry. The book presents papers that are organized thematically. The text first discusses the basics of biology and quantitative models, and then proceeds to covering linkage analysis. Next, the book deals with various mental disorders, including schizophrenia, eating disorders, and developmental disorders. The remaining materials turn their attention to dementia and Huntington's disease. The book will be of great use to researchers and practitioners of behavioral sciences, such as psychology and psychiatry.

Models of Madness

Author : Dr John Read
Publisher : Routledge
ISBN 13 : 1134055021
Total Pages : 489 pages
Book Rating : 4.1/5 (34 download)

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Book Synopsis Models of Madness by : Dr John Read

Download or read book Models of Madness written by Dr John Read and published by Routledge. This book was released on 2013-06-19 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are hallucinations and delusions really symptoms of an illness called ‘schizophrenia’? Are mental health problems really caused by chemical imbalances and genetic predispositions? Are psychiatric drugs as effective and safe as the drug companies claim? Is madness preventable? This second edition of Models of Madness challenges those who hold to simplistic, pessimistic and often damaging theories and treatments of madness. In particular it challenges beliefs that madness can be explained without reference to social causes and challenges the excessive preoccupation with chemical imbalances and genetic predispositions as causes of human misery, including the conditions that are given the name 'schizophrenia'. This edition updates the now extensive body of research showing that hallucinations, delusions etc. are best understood as reactions to adverse life events and that psychological and social approaches to helping are more effective and far safer than psychiatric drugs and electroshock treatment. A new final chapter discusses why such a damaging ideology has come to dominate mental health and, most importantly, how to change that. Models of Madness is divided into three sections: Section One provides a history of madness, including examples of violence against the ‘mentally ill’, before critiquing the theories and treatments of contemporary biological psychiatry and documenting the corrupting influence of drug companies. Section Two summarises the research showing that hallucinations, delusions etc. are primarily caused by adverse life events (eg. parental loss, bullying, abuse and neglect in childhood, poverty, etc) and can be understood using psychological models ranging from cognitive to psychodynamic. Section Three presents the evidence for a range of effective psychological and social approaches to treatment, from cognitive and family therapy to primary prevention. This book brings together thirty-seven contributors from ten countries and a wide range of scientific disciplines. It provides an evidence-based, optimistic antidote to the pessimism of biological psychiatry. Models of Madness will be essential reading for all involved in mental health, including service users, family members, service managers, policy makers, nurses, clinical psychologists, psychiatrists, psychotherapists, counsellors, psychoanalysts, social workers, occupational therapists, art therapists.

Hidden Valley Road

Author : Robert Kolker
Publisher : Anchor
ISBN 13 : 0385543778
Total Pages : 427 pages
Book Rating : 4.3/5 (855 download)

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Book Synopsis Hidden Valley Road by : Robert Kolker

Download or read book Hidden Valley Road written by Robert Kolker and published by Anchor. This book was released on 2020-04-07 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease. "Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah Winfrey Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family? What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations. With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

Neurodevelopment and Schizophrenia

Author : Matcheri S. Keshavan
Publisher : Cambridge University Press
ISBN 13 : 9780521823319
Total Pages : 576 pages
Book Rating : 4.8/5 (233 download)

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Book Synopsis Neurodevelopment and Schizophrenia by : Matcheri S. Keshavan

Download or read book Neurodevelopment and Schizophrenia written by Matcheri S. Keshavan and published by Cambridge University Press. This book was released on 2004-11-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

The Origins of Schizophrenia

Author : Alan S. Brown
Publisher : Columbia University Press
ISBN 13 : 0231521928
Total Pages : 445 pages
Book Rating : 4.2/5 (315 download)

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Book Synopsis The Origins of Schizophrenia by : Alan S. Brown

Download or read book The Origins of Schizophrenia written by Alan S. Brown and published by Columbia University Press. This book was released on 2011-11-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Origins of Schizophrenia synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade. Advances in epidemiology, translational neuroscience technology, and molecular and statistical genetics have recast schizophrenia's neurobiological nature, identifying new putative environmental risk factors and candidate susceptibility genes. Providing the latest clinical and neuroscience research developments in a comprehensive volume, this collection by world-renowned investigators answers a pressing need for balanced, thorough information, while pointing to future directions in research and interdisciplinary collaboration. The book, featuring a foreword by Robert Freedman, M.D., thoroughly examines these topics from the vantage points of epidemiologic, clinical, and basic neuroscience approaches, making it an essential resource for researchers in psychiatry, psychology, and neuroscience and for clinical mental health professionals.

The Neurobiological Basis of Suicide

Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Behavioral Genetics in the Postgenomic Era

Author : Robert Plomin
Publisher : Amer Psychological Assn
ISBN 13 : 9781557989260
Total Pages : 608 pages
Book Rating : 4.9/5 (892 download)

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Book Synopsis Behavioral Genetics in the Postgenomic Era by : Robert Plomin

Download or read book Behavioral Genetics in the Postgenomic Era written by Robert Plomin and published by Amer Psychological Assn. This book was released on 2003 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Genome Project-which has provided a working draft of the sequence of DNA in the human genome - is a remarkable scientific achievement. In this postgenomic world, it appears that all genes and all DNA variation will eventually be known. For behavioral researchers, this is especially exciting because behavioral dimensions and disorders are the most complex traits of all. To understand these traits, we need to understand the roles of many genes and many environmental influences.

Embodying the Self: Neurophysiological Perspectives on the Psychopathology of Anomalous Bodily Experiences

Author : Mariateresa Sestito
Publisher : Frontiers Media SA
ISBN 13 : 2889454568
Total Pages : 174 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Embodying the Self: Neurophysiological Perspectives on the Psychopathology of Anomalous Bodily Experiences by : Mariateresa Sestito

Download or read book Embodying the Self: Neurophysiological Perspectives on the Psychopathology of Anomalous Bodily Experiences written by Mariateresa Sestito and published by Frontiers Media SA. This book was released on 2018-04-12 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of the 20th Century, phenomenology has developed a distinction between lived body (Leib) and physical body (Koerper), a distinction well known as body-subject vs. body-object (Hanna and Thompson 2007). The lived body is the body experienced from within - my own direct experience of my body lived in the first-person perspective, myself as a spatiotemporal embodied agent in the world. The physical body on the other hand, is the body thematically investigated from a third person perspective by natural sciences as anatomy and physiology. An active topic affecting the understanding of several psychopathological disorders is the relatively unknown dynamic existing between aspects related to the body-object (that comprises the neurobiological substrate of the disease) and the body-subject (the experiences reported by patients) (Nelson and Sass 2017). A clue testifying the need to better explore this dynamic in the psychopathological context is the marked gap that still exists between patients’ clinical reports (generally entailing disturbing experiences) and etiopathogenetic theories and therapeutic practices, that are mainly postulated at a bodily/brain level of description and analysis. The phenomenological exploration typically targets descriptions of persons’ lived experience. For instance, patients suffering from schizophrenia may describe their thoughts as alien (‘‘thoughts are intruding into my head’’) and the world surrounding them as fragmented (‘‘the world is a series of snapshots’’) (Stanghellini et al., 2015). The result is a rich and detailed collection of the patients’ qualitative self-descriptions (Stanghellini and Rossi, 2014), that reveal fundamental changes in the structure of experiencing and can be captured by using specific assessment tools (Parnas et al. 2005; Sass et al. 2017; Stanghellini et al., 2014). The practice of considering the objective and the subjective levels of analysis as separated in the research studies design has many unintended consequences. Primarily, it has the effect of limiting actionable neuroscientific progress within clinical practice. This holds true both in terms of availability of evidence-based treatments for the disorders, as well as for early diagnosis purposes. In response to this need, this collection of articles aims to promote an interdisciplinary endeavor to better connect the bodily, objective level of analysis with its experiential corollary. This is accomplished by focusing on the convergence between (neuro) physiological evidence and the phenomenological manifestations of anomalous bodily experiences present in different disorders.

The Biology of Twinning in Man

Author : M. G. Bulmer
Publisher : Clarendon Press
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Biology of Twinning in Man by : M. G. Bulmer

Download or read book The Biology of Twinning in Man written by M. G. Bulmer and published by Clarendon Press. This book was released on 1970 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twins are probably by no means unknown to most people - for instance in the sporting world of my Australian homeland there are quite a number of cases of note - yet very few people understand the biology behind twins. Although this book suffers a good deal from its age - people like Tim Flannery, Tom McMahon, John Rushton, and Michael Laker clearly give evidence that there is something much more "designed" than randomness involved in dizygotic twin frequencies around the world - if you want a basic introduction to the facts about twinning in humans you will get it here without any doubt. Bulmer deals with every aspects of twinning from the frequency of twinning in humans to the liabilities mothers of twins face vis-à-vis those of single children. He also goes into less common detail about the extreme difficulties of higher order multiple births - and provides little-known but easily understandable details about their frequency. Bulmer shows that for most of human history mothers of twins were at huge disadvantages both in terms of their much greater health risks and the low birth mass and short gestation of their children. For this reason, Bulmer shows that only when major health improvements were made could twins compete with singleton children, and he shows this had and has major consequences culturally. Another very interesting sidelight is Bulmer's look at how single birthing evolved as the most productive strategy in humans and other primates (except for the primitive tree shrews). Bulmer compares this with the situation in animals that typically give birth to multiple young. He should, however, have looked at the environmental conditions that encourage singleton births and compare with those animals that give birth to multiple, highly precocial offspring. All in all, though it is certainly dated, "Biology of Twinning in Man" is a simple and useful overview of what most people should know about multiple births in humans.

The American Psychiatric Association Publishing Textbook of Schizophrenia, Second Edition

Author : Jeffrey A. Lieberman, M.D.
Publisher : American Psychiatric Pub
ISBN 13 : 1615371729
Total Pages : 322 pages
Book Rating : 4.6/5 (153 download)

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Book Synopsis The American Psychiatric Association Publishing Textbook of Schizophrenia, Second Edition by : Jeffrey A. Lieberman, M.D.

Download or read book The American Psychiatric Association Publishing Textbook of Schizophrenia, Second Edition written by Jeffrey A. Lieberman, M.D. and published by American Psychiatric Pub. This book was released on 2020-01-30 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Schizophrenia remains the most challenging of mental disorders confronted by psychiatrists and other mental health providers. Its primary manifestations-psychotic symptoms and cognitive impairment-profoundly affect the functioning of individuals with schizophrenia. This is an updated textbook covering the current state of knowledge about schizophrenia, including its causes, nature, presentation, and treatment. Chapters are written by a roster of experts in "--

Madness and Genetic Determinism

Author : Patrick D. Hahn
Publisher : Springer
ISBN 13 : 303021866X
Total Pages : 196 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Madness and Genetic Determinism by : Patrick D. Hahn

Download or read book Madness and Genetic Determinism written by Patrick D. Hahn and published by Springer. This book was released on 2019-07-11 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers important topics in the psychiatric genetics (PG) field. Many of these have been overlooked in mainstream accounts, and many contemporary PG researchers have omitted or whitewashed the eugenic and “racial hygiene” origins of the field. The author critically analyzes PG evidence in support of genetic claims which, given the lack of gene discoveries, are based mainly on the results of psychiatric twin and adoption studies. Given that the evidence in favor of genetic influences is much weaker than mainstream sources report, due to serious issues in twin and adoption research, the author points to environmental factors, including trauma, as the main causes of conditions such as schizophrenia.