Analysis of Clinical Trials Using SAS

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Publisher : SAS Institute
ISBN 13 : 1635261449
Total Pages : 455 pages
Book Rating : 4.6/5 (352 download)

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Book Synopsis Analysis of Clinical Trials Using SAS by : Alex Dmitrienko

Download or read book Analysis of Clinical Trials Using SAS written by Alex Dmitrienko and published by SAS Institute. This book was released on 2017-07-17 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines. This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates: SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST) SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE) macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials) Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.

SAS/STAT 9. 3 User's Guide

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Publisher :
ISBN 13 : 9781607646341
Total Pages : 0 pages
Book Rating : 4.6/5 (463 download)

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Book Synopsis SAS/STAT 9. 3 User's Guide by : Sas Institute

Download or read book SAS/STAT 9. 3 User's Guide written by Sas Institute and published by . This book was released on 2011-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The GLIMMIX procedure fits and analyzes generalized linear mixed models (GLMM), models with random effects for data that can be nonnormally distributed. This title is also available online.

Applied Multivariate Analysis

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Publisher : Springer Science & Business Media
ISBN 13 : 0387227717
Total Pages : 709 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Applied Multivariate Analysis by : Neil H. Timm

Download or read book Applied Multivariate Analysis written by Neil H. Timm and published by Springer Science & Business Media. This book was released on 2007-06-21 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a broad overview of the basic theory and methods of applied multivariate analysis. The presentation integrates both theory and practice including both the analysis of formal linear multivariate models and exploratory data analysis techniques. Each chapter contains the development of basic theoretical results with numerous applications illustrated using examples from the social and behavioral sciences, and other disciplines. All examples are analyzed using SAS for Windows Version 8.0.

Economics Lab

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Publisher : Routledge
ISBN 13 : 1134347731
Total Pages : 248 pages
Book Rating : 4.1/5 (343 download)

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Book Synopsis Economics Lab by : Alessandra Cassar

Download or read book Economics Lab written by Alessandra Cassar and published by Routledge. This book was released on 2004-01-22 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory experiments with human subjects now provide crucial data in most fields of economics and there has been a tremendous upsurge in interest in this relatively new field of economics. This textbook introduces the student to the world of experimental economics. Contributors including Reinhard Selten and Axel Leijonhufvud that s

Statistical Computing in C++ and R

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Publisher : CRC Press
ISBN 13 : 1420066501
Total Pages : 558 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Statistical Computing in C++ and R by : Randall L. Eubank

Download or read book Statistical Computing in C++ and R written by Randall L. Eubank and published by CRC Press. This book was released on 2011-12-01 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advancement of statistical methodology inextricably linked to the use of computers, new methodological ideas must be translated into usable code and then numerically evaluated relative to competing procedures. In response to this, Statistical Computing in C++ and R concentrates on the writing of code rather than the development and study of numerical algorithms per se. The book discusses code development in C++ and R and the use of these symbiotic languages in unison. It emphasizes that each offers distinct features that, when used in tandem, can take code writing beyond what can be obtained from either language alone. The text begins with some basics of object-oriented languages, followed by a "boot-camp" on the use of C++ and R. The authors then discuss code development for the solution of specific computational problems that are relevant to statistics including optimization, numerical linear algebra, and random number generation. Later chapters introduce abstract data structures (ADTs) and parallel computing concepts. The appendices cover R and UNIX Shell programming. Features Includes numerous student exercises ranging from elementary to challenging Integrates both C++ and R for the solution of statistical computing problems Uses C++ code in R and R functions in C++ programs Provides downloadable programs, available from the authors’ website The translation of a mathematical problem into its computational analog (or analogs) is a skill that must be learned, like any other, by actively solving relevant problems. The text reveals the basic principles of algorithmic thinking essential to the modern statistician as well as the fundamental skill of communicating with a computer through the use of the computer languages C++ and R. The book lays the foundation for original code development in a research environment.

Applied Statistical Genetics with R

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Publisher : Springer Science & Business Media
ISBN 13 : 038789554X
Total Pages : 264 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Applied Statistical Genetics with R by : Andrea S. Foulkes

Download or read book Applied Statistical Genetics with R written by Andrea S. Foulkes and published by Springer Science & Business Media. This book was released on 2009-04-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

Base SAS 9.1.3 Procedures Guide

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Publisher : Sas Inst
ISBN 13 : 9781590477540
Total Pages : 1934 pages
Book Rating : 4.4/5 (775 download)

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Book Synopsis Base SAS 9.1.3 Procedures Guide by : SAS Institute

Download or read book Base SAS 9.1.3 Procedures Guide written by SAS Institute and published by Sas Inst. This book was released on 2006 with total page 1934 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Analysis of Gene Expression Data

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Publisher : Springer Science & Business Media
ISBN 13 : 0387216790
Total Pages : 511 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis The Analysis of Gene Expression Data by : Giovanni Parmigiani

Download or read book The Analysis of Gene Expression Data written by Giovanni Parmigiani and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.

SAS 9. 3 Language Reference

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Publisher :
ISBN 13 : 9781612902326
Total Pages : 0 pages
Book Rating : 4.9/5 (23 download)

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Book Synopsis SAS 9. 3 Language Reference by : Sas Institute

Download or read book SAS 9. 3 Language Reference written by Sas Institute and published by . This book was released on 2012-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Documents essential concepts for the DATA step, SAS features, and SAS files. This title is also available online.

Essential Biostatistics

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Publisher : Oxford University Press
ISBN 13 : 0199365067
Total Pages : 209 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Essential Biostatistics by : Harvey Motulsky

Download or read book Essential Biostatistics written by Harvey Motulsky and published by Oxford University Press. This book was released on 2016 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its engaging and conversational tone, Essential Biostatistics: A Nonmathematical Approach provides a clear introduction to statistics for students in a wide range of fields, and a concise statistics refresher for scientists and professionals who need to interpret statistical results. It explains the ideas behind statistics in nonmathematical terms, offers perspectives on how to interpret published statistical results, and points out common conceptual traps to avoid. It can be used as a stand-alone text or as a supplement to a traditional statistics textbook.

Regulatory Toxicology

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Publisher : Springer
ISBN 13 : 9783642353734
Total Pages : 0 pages
Book Rating : 4.3/5 (537 download)

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Book Synopsis Regulatory Toxicology by : Franz-Xaver Reichl

Download or read book Regulatory Toxicology written by Franz-Xaver Reichl and published by Springer. This book was released on 2014-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Multiple Testing Procedures with Applications to Genomics

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Publisher : Springer
ISBN 13 : 9781441923790
Total Pages : 0 pages
Book Rating : 4.9/5 (237 download)

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Book Synopsis Multiple Testing Procedures with Applications to Genomics by : Sandrine Dudoit

Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer. This book was released on 2010-11-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.

Flexible Imputation of Missing Data, Second Edition

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Publisher : CRC Press
ISBN 13 : 0429960352
Total Pages : 444 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Flexible Imputation of Missing Data, Second Edition by : Stef van Buuren

Download or read book Flexible Imputation of Missing Data, Second Edition written by Stef van Buuren and published by CRC Press. This book was released on 2018-07-17 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.

Cardiovascular Genomics

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Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cardiovascular Genomics by : Keith DiPetrillo

Download or read book Cardiovascular Genomics written by Keith DiPetrillo and published by Methods in Molecular Biology. This book was released on 2009-09-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first section of this guide provides methods for cardiovascular phenotyping of rodent models; the second section covers bioinformatic integration of phenotypde data with genome-wide genotype and expression data. Chapters include step-by-step protocols.

Functional Neuroradiology

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Publisher : Springer Science & Business Media
ISBN 13 : 1441903453
Total Pages : 1015 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Functional Neuroradiology by : Scott H. Faro

Download or read book Functional Neuroradiology written by Scott H. Faro and published by Springer Science & Business Media. This book was released on 2011-09-08 with total page 1015 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neuroradiology: Principles and Clinical Applications, is a follow-up to Faro and Mohamed’s groundbreaking work, Functional (BOLD)MRI: Basic Principles and Clinical Applications. This new 49 chapter textbook is comprehensive and offers a complete introduction to the state-of-the-art functional imaging in Neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 9 major sections, including: Physical principles of all key functional techniques, Lesion characterization using Diffusion, Perfusion, Permeability, MR spectroscopy, and Positron Emission Tomography, an overview of BOLD fMRI physical principles and key concepts, including scanning methodologies, experimental research design, data analysis, and functional connectivity, Eloquent Cortex and White matter localization using BOLD fMRI and Diffusion Tensor Imaging, Clinical applications of BOLD fMRI in Neurosurgery, Neurology, Psychiatry, Neuropsychology, and Neuropharmacology, Multi-modality functional Neuroradiology, Beyond Proton Imaging, Functional spine and CSF imaging, a full-color Neuroanatomical Brain atlas of eloquent cortex and key white matter tracts and BOLD fMRI paradigms. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.

Intuitive Biostatistics

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Publisher : Oxford University Press, USA
ISBN 13 : 9780190643560
Total Pages : 608 pages
Book Rating : 4.6/5 (435 download)

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Book Synopsis Intuitive Biostatistics by : Harvey Motulsky

Download or read book Intuitive Biostatistics written by Harvey Motulsky and published by Oxford University Press, USA. This book was released on 2017-11-15 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: " Intuitive Biostatistics takes a non-technical, non-quantitative approach to statistics and emphasizes interpretation of statistical results rather than the computational strategies for generating statistical data. This makes the text especially useful for those in health-science fields who have not taken a biostatistics course before. The text is also an excellent resource for professionals in labs, acting as a conceptually oriented and accessible biostatistics guide. With an engaging and conversational tone, Intuitive Biostatistics provides a clear introduction to statistics for undergraduate and graduate students and also serves as a statistics refresher for working scientists. "--

Situation 77

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Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Situation 77 by :

Download or read book Situation 77 written by and published by . This book was released on 1977 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: