Role Of Signaling Pathways In Brain Tumorigenesis

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Role of Signaling Pathways in Brain Tumorigenesis

Author : Mehdi Hayat Shahi
Publisher : Springer Nature
ISBN 13 : 9811584737
Total Pages : 215 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Role of Signaling Pathways in Brain Tumorigenesis by : Mehdi Hayat Shahi

Download or read book Role of Signaling Pathways in Brain Tumorigenesis written by Mehdi Hayat Shahi and published by Springer Nature. This book was released on 2023-11-20 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.

Glioma Signaling

Author : Jolanta Barańska
Publisher : Springer Nature
ISBN 13 : 3030306518
Total Pages : 311 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Glioma Signaling by : Jolanta Barańska

Download or read book Glioma Signaling written by Jolanta Barańska and published by Springer Nature. This book was released on 2020-02-07 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.

Glioma Signaling

Author : Jolanta Barańska
Publisher : Springer Science & Business Media
ISBN 13 : 9400747195
Total Pages : 227 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Glioma Signaling by : Jolanta Barańska

Download or read book Glioma Signaling written by Jolanta Barańska and published by Springer Science & Business Media. This book was released on 2012-08-10 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nucleotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration changes, cellular growth, progression and invasion, as well as presents perspective concerning potential targets for glioma therapy.

Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

Author : Terry Lichtor
Publisher : BoD – Books on Demand
ISBN 13 : 9535109898
Total Pages : 652 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications by : Terry Lichtor

Download or read book Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications written by Terry Lichtor and published by BoD – Books on Demand. This book was released on 2013-02-27 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Signal Transduction in Cancer

Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Signal Transduction in Cancer by : David A. Frank

Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Brain Tumors

Author : Francis Ali-Osman
Publisher : Springer Science & Business Media
ISBN 13 : 1592598439
Total Pages : 393 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Brain Tumors by : Francis Ali-Osman

Download or read book Brain Tumors written by Francis Ali-Osman and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.

Neurologic Complications of Cancer

Author : Lisa M. DeAngelis
Publisher : OUP USA
ISBN 13 : 0195366743
Total Pages : 652 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Neurologic Complications of Cancer by : Lisa M. DeAngelis

Download or read book Neurologic Complications of Cancer written by Lisa M. DeAngelis and published by OUP USA. This book was released on 2009 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviewing the impact of cancer on the nervous system, this text examines the diagnosis and management of neurological complications of specific types of cancer, as well as the side effects of oncological treatments. This edition has been updated with new material and diagnostic techniques and treatments.

Webster's New World Medical Dictionary

Author :
Publisher :
ISBN 13 : 9781784027834
Total Pages : pages
Book Rating : 4.0/5 (278 download)

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Book Synopsis Webster's New World Medical Dictionary by :

Download or read book Webster's New World Medical Dictionary written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Webster's New World Medical Dictionary, Third Edition will help you understand and communicate your medical needs when it matters the most. Written by doctors and the experts at WebMD, this edition includes 8500 entries, including 500 new terms, a vitamin appendix, and a companion website to give you access to medical language.

Glioma Cell Biology

Author : Aleksi Sedo
Publisher : Springer
ISBN 13 : 3709114314
Total Pages : 468 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Glioma Cell Biology by : Aleksi Sedo

Download or read book Glioma Cell Biology written by Aleksi Sedo and published by Springer. This book was released on 2014-11-14 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology.

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Oncoimmunology

Author : Laurence Zitvogel
Publisher : Springer
ISBN 13 : 3319624318
Total Pages : 724 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Oncoimmunology by : Laurence Zitvogel

Download or read book Oncoimmunology written by Laurence Zitvogel and published by Springer. This book was released on 2017-12-13 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.

Current Understanding and Treatment of Gliomas

Author : Jeffrey Raizer
Publisher : Springer
ISBN 13 : 3319120484
Total Pages : 184 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Current Understanding and Treatment of Gliomas by : Jeffrey Raizer

Download or read book Current Understanding and Treatment of Gliomas written by Jeffrey Raizer and published by Springer. This book was released on 2014-12-02 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer Nature
ISBN 13 : 303065768X
Total Pages : 283 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer Nature. This book was released on 2021-05-20 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Molecular Targets of CNS Tumors

Author : Miklos Garami
Publisher :
ISBN 13 : 9789535164968
Total Pages : 688 pages
Book Rating : 4.1/5 (649 download)

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Book Synopsis Molecular Targets of CNS Tumors by : Miklos Garami

Download or read book Molecular Targets of CNS Tumors written by Miklos Garami and published by . This book was released on 2011 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Targets of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on signaling pathway of the most common CNS tumor types. To develop drugs which specifically attack the cancer cells requires an understanding of the distinct characteristics of those cells. Additional detailed information is provided on selected signal pathways in CNS tumors.

Tumor Progression and Therapeutic Resistance

Author : Wafik S. El-Deiry
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.X/5 (3 download)

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Book Synopsis Tumor Progression and Therapeutic Resistance by : Wafik S. El-Deiry

Download or read book Tumor Progression and Therapeutic Resistance written by Wafik S. El-Deiry and published by . This book was released on 2005 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the entire breadth of translational cancer research and brings together members of academia and industry in the expectation of accelerating interactions and progress in the field. A variety of key topics are presented, beginning with discovery of molecular targets and pathways (oncogene, cell survival, tumor suppression, cell death), host-neoplasm interactions (cell adhesion, matrix proteases), early detection, monitoring progression, understanding tumor progression and metastasis, immune surveillance, in vivo molecular imaging, animal models, drug discovery including chemistry, high-throughput assays, mechanism determination, target validation, therapeutic window and some progress in clinical trials for more advanced agents and targets.

CNS Cancer

Author : Erwin G. Van Meir
Publisher : Springer Science & Business Media
ISBN 13 : 1603275533
Total Pages : 1294 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis CNS Cancer by : Erwin G. Van Meir

Download or read book CNS Cancer written by Erwin G. Van Meir and published by Springer Science & Business Media. This book was released on 2009-08-15 with total page 1294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

Cancer Therapeutic Targets

Author : John L. Marshall
Publisher : Springer
ISBN 13 : 9781441907165
Total Pages : 0 pages
Book Rating : 4.9/5 (71 download)

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Book Synopsis Cancer Therapeutic Targets by : John L. Marshall

Download or read book Cancer Therapeutic Targets written by John L. Marshall and published by Springer. This book was released on 2017-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, we have experienced an explosion of new information about cancer therapeutic targets. Many of the targets have been validated by the discovery and approval of new medicines which have been approved for the treatment of cancer. On the heels of these successes, innumerable new targets and new potential therapeutics are being developed by many different groups including government agencies, pharmaceutical companies, biotechnology companies, academic institutions, and individual investigators. Understanding the expanding "universe" of cancer therapies is therefore becoming impossible and no single source exists which serves as a reference for the involved parties. Further, the interested parties have vastly different areas of expertise, from focused laboratory based science, to clinical research, to corporate and regulatory oversight. The text would be updated every two years, more often depending on pace of change, interest and sales. While useful online, this reference book would likely be kept in hard copy as well.