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Author : Yanqing Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832522890
Total Pages : 125 pages
Book Rating : 4.8/5 (325 download)
Download or read book Role of p53 in cell metabolism, ferroptosis, and stemness written by Yanqing Liu and published by Frontiers Media SA. This book was released on 2023-05-08 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Massimo Negrini
Publisher : Academic Press
ISBN 13 : 0128232749
Total Pages : 434 pages
Book Rating : 4.1/5 (282 download)
Download or read book MicroRNA in Human Malignancies written by Massimo Negrini and published by Academic Press. This book was released on 2022-02-18 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators. Provides fundamental and translational chapters that facilitate the acquisition of knowledge needed to design and perform innovative miRNA-related research studies Synthesizes current research, with a critical review on the field Offers in-depth research by leading experts in the field
Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832537006
Total Pages : 216 pages
Book Rating : 4.8/5 (325 download)
Download or read book Ferroptosis in malignant brain tumors written by and published by Frontiers Media SA. This book was released on 2023-10-25 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daolin Tang
Publisher : Springer Nature
ISBN 13 : 3031391713
Total Pages : 489 pages
Book Rating : 4.0/5 (313 download)
Download or read book Ferroptosis in Health and Disease written by Daolin Tang and published by Springer Nature. This book was released on 2023-11-29 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated and expanded volume gives new insights on ferroptosis – an iron-dependent form of non-apoptotic cell death. The collection of chapters discusses the two major pathways through which ferroptosis can occur: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Readers will gain an understanding of the multiple levels, on which this special cell death is regulated. Hence, the contributions will take a closer look at epigenetic, transcriptional, posttranscriptional and posttranslational layers. Among the described regulators and transcription factors are GPX4, ACSL4 and NFE2L2. This edited volume collects reviews related to current knowledge on the integrated molecular machinery of ferroptosis, thereby also describing how dysregulated ferroptosis is involved in human diseases.
Author : Arnold Jay Levine
Publisher :
ISBN 13 : 9780879698300
Total Pages : 0 pages
Book Rating : 4.6/5 (983 download)
Download or read book The P53 Family written by Arnold Jay Levine and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, their evolution, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis.
Author : Gerard P. Zambetti
Publisher : Springer
ISBN 13 : 9781489998798
Total Pages : 0 pages
Book Rating : 4.9/5 (987 download)
Download or read book The p53 Tumor Suppressor Pathway and Cancer written by Gerard P. Zambetti and published by Springer. This book was released on 2014-11-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.
Author : Jian-ye Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889761568
Total Pages : 184 pages
Book Rating : 4.8/5 (897 download)
Download or read book Biology and Pharmacological Effects of Extracellular Vesicles in Cancer written by Jian-ye Zhang and published by Frontiers Media SA. This book was released on 2022-05-09 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yanqing Liu
Publisher : Frontiers Media SA
ISBN 13 : 2832513425
Total Pages : 452 pages
Book Rating : 4.8/5 (325 download)
Download or read book Ferroptosis in cancer and beyond written by Yanqing Liu and published by Frontiers Media SA. This book was released on 2023-02-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thorsten Cramer
Publisher : Springer
ISBN 13 : 3319421182
Total Pages : 272 pages
Book Rating : 4.3/5 (194 download)
Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Author : Fatemeh Maghuly
Publisher : Frontiers Media SA
ISBN 13 : 288971568X
Total Pages : 218 pages
Book Rating : 4.8/5 (897 download)
Download or read book Omics Technologies Toward Systems Biology written by Fatemeh Maghuly and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Qiongzhu Dong
Publisher : Frontiers Media SA
ISBN 13 : 288974731X
Total Pages : 401 pages
Book Rating : 4.8/5 (897 download)
Download or read book Cancer Cell Metabolism and Immunomodulation in the Context of Tumor Metastasis written by Qiongzhu Dong and published by Frontiers Media SA. This book was released on 2022-03-18 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sudjit Luanpitpong
Publisher : Frontiers Media SA
ISBN 13 : 2832507727
Total Pages : 188 pages
Book Rating : 4.8/5 (325 download)
Download or read book Adult Stem Cells for Regenerative Medicine: From Cell Fate to Clinical Applications written by Sudjit Luanpitpong and published by Frontiers Media SA. This book was released on 2022-11-30 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chad Brenner
Publisher : MDPI
ISBN 13 : 3039217887
Total Pages : 418 pages
Book Rating : 4.0/5 (392 download)
Download or read book Application of Bioinformatics in Cancers written by Chad Brenner and published by MDPI. This book was released on 2019-11-20 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.
Author : Alexander Birbrair
Publisher : Springer Nature
ISBN 13 : 3030362140
Total Pages : 155 pages
Book Rating : 4.0/5 (33 download)
Download or read book Tumor Microenvironments in Organs written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author : Paula Guedes De Pinho
Publisher : MDPI
ISBN 13 : 3039213458
Total Pages : 184 pages
Book Rating : 4.0/5 (392 download)
Download or read book Cancer Metabolomics 2018 written by Paula Guedes De Pinho and published by MDPI. This book was released on 2019-09-03 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.
Author : Jiayi Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832500242
Total Pages : 199 pages
Book Rating : 4.8/5 (325 download)
Download or read book The Role of Interplay between Metabolism and Chromosomes in Tumorigenesis written by Jiayi Wang and published by Frontiers Media SA. This book was released on 2022-09-22 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
