Role Of Epidermal Growth Factor Receptors And Their Ligands In Normal Mammary Epithelial And Breast Cancer Cells

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Role of Epidermal Growth Factor Receptors and Their Ligands in Normal Mammary Epithelial and Breast Cancer Cells

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Role of Epidermal Growth Factor Receptors and Their Ligands in Normal Mammary Epithelial and Breast Cancer Cells by :

Download or read book Role of Epidermal Growth Factor Receptors and Their Ligands in Normal Mammary Epithelial and Breast Cancer Cells written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidermal growth factor (EGF) and transforming growth factor a (TGFalpha) acting through EGF receptors (EGFR) regulate the development of normal mammary epithelial cells (MEC) and breast cancer. Primary culture studies examined the effects of EGF and TGFalpha in MEC. PD158780, a selective inhibitor of the tyrosine kinase domain of EGFR, helped demonstrate that EGFR signaling was required for the proliferation and functional differentiation of immature MEC from days 0-7 of culture, and survival of terminally differentiated MEC from days 17.5-21 of the study. EGFR levels were expressed at high levels in non-functional MEC and MEC undergoing apoptosis whereas functionally differentiated MEC expressed relatively low levels of EGFR. In EGF medium, cultured MEC expressed peak levels of erbB2 and erbB3 from day 7-14 of culture, whereas erbB4 levels were only detected within MEC cultured for 7 and 10.5 days. MEC isolated from mammary glands expressed high levels of erbB2 and erbB3 in virgin rats and rats during pregnancy and involution, and relatively low levels during lactation, whereas erbB4 appeared to be uniformly expressed throughout the developmental stages analyzed. These findings will help in the development of therapies to treat aggressive human breast cancers that often overexpress EGFR and/or other erbB receptors.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Epidermal Growth Factor-Like Ligands in Breast Cancer

Author : Eileen Adamaon
Publisher :
ISBN 13 :
Total Pages : 69 pages
Book Rating : 4.:/5 (453 download)

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Book Synopsis Epidermal Growth Factor-Like Ligands in Breast Cancer by : Eileen Adamaon

Download or read book Epidermal Growth Factor-Like Ligands in Breast Cancer written by Eileen Adamaon and published by . This book was released on 1997 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cripto-1 (Cr-1) and Amphiregulin (Ar) are two EGF-like growth factors that occur at higher levels than normal in breast cancer cells and tissues. They occur during mammary cell proliferation in normal virgin, pregnant and lactating mouse mammary glands, and in early embryo cells. To test the roles of Cr-1, we infected normal mouse mammary cells with retroviruses over-expressing Cr-1, or an antisense version, in order to inhibit the production of this polypeptide. Cr-1 stimulated proliferation and was inhibitory to differentiation (lactation). Reduction of Cr-1 did not affect differentiation but decreased growth rate and increased apoptosis. Cr-1 overexpression transforms cells but appears not to be tumorigenic. We completely inactivated the Cr-1 genes in order to produce mice that expressed no Cr-1 in mammary glands as well as in all other tissues. To this end, we inactivated Cr-1 in embryo stem (ES) cells by homologous recombination and produced Cr-1 gene-targeted mice. Studies on these Cr-1 ( -/- ) cells showed that ES cell differentiation to cardiac myocytes was prevented. The "knockout" animals demonstrate that Cr-1 is essential for axis formation and embryonic development. Cr-1 absence causes aberrant proliferation of mesoderm cells, loss of migratory signals and absence of heart development.

Molecular Targeting and Signal Transduction

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1402078226
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Molecular Targeting and Signal Transduction by : Rakesh Kumar

Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells

Author : Jennifer J. Gavinski
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (891 download)

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Book Synopsis The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells by : Jennifer J. Gavinski

Download or read book The Effects of Soluble Epidermal Growth Factor Receptor in Mammary Epithelial Cells written by Jennifer J. Gavinski and published by . This book was released on 2008 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Growth Factors and Oncogenes in Breast Cancer

Author : Mels Sluyser
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Growth Factors and Oncogenes in Breast Cancer by : Mels Sluyser

Download or read book Growth Factors and Oncogenes in Breast Cancer written by Mels Sluyser and published by Wiley-VCH. This book was released on 1987 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

EGFR Signaling Networks in Cancer Therapy

Author : John D. Haley
Publisher : Springer Science & Business Media
ISBN 13 : 1597453560
Total Pages : 393 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis EGFR Signaling Networks in Cancer Therapy by : John D. Haley

Download or read book EGFR Signaling Networks in Cancer Therapy written by John D. Haley and published by Springer Science & Business Media. This book was released on 2009-03-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

EGF Receptor in Tumor Growth and Progression

Author : R.B. Lichtner
Publisher : Springer Science & Business Media
ISBN 13 : 3662033917
Total Pages : 303 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis EGF Receptor in Tumor Growth and Progression by : R.B. Lichtner

Download or read book EGF Receptor in Tumor Growth and Progression written by R.B. Lichtner and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut from cell surface to nuclear signaling. Sequencing of these oncogenes revealed that they were mutated forms of captured cellular genes and displayed tyrosine kinase activity. The epidermal growth factor (EGF) receptor was the first of 40-50 transmembrane tyrosine kinase receptors to be cloned and sequenced. Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.

Sturkie's Avian Physiology

Author : G. Causey Whittow
Publisher : Elsevier
ISBN 13 : 0080542085
Total Pages : 701 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Sturkie's Avian Physiology by : G. Causey Whittow

Download or read book Sturkie's Avian Physiology written by G. Causey Whittow and published by Elsevier. This book was released on 1999-10-14 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Fifth Edition is thoroughly revised and updated, and includes new chapters on the physiology of incubation and growth. Chapters on the nervous system and sensory organs have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds. The Fifth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds. Thoroughly updated and revised Coverage of both domestic and wild birds New larger format Only comprehensive, single volume devoted to birds

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Author : G V Sherbet
Publisher : Elsevier
ISBN 13 : 0123878195
Total Pages : 368 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy by : G V Sherbet

Download or read book Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy written by G V Sherbet and published by Elsevier. This book was released on 2011-07-14 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.

Pancreatic Cancer

Author : Douglas B. Evans
Publisher : Springer Science & Business Media
ISBN 13 : 0387216006
Total Pages : 413 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Pancreatic Cancer by : Douglas B. Evans

Download or read book Pancreatic Cancer written by Douglas B. Evans and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.

Control of Growth Factors and Prevention of Cancer

Author : Michael B. Sporn
Publisher : Springer Science & Business Media
ISBN 13 : 3642773834
Total Pages : 177 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Control of Growth Factors and Prevention of Cancer by : Michael B. Sporn

Download or read book Control of Growth Factors and Prevention of Cancer written by Michael B. Sporn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now apparent that several fields of investigation are converging upon each other as the goal of finding a practical way to prevent cancer is pursued. The present monograph represents the efforts of an interdisciplinary ESO Task Force that was convened to assess interactions of peptide growth factors and steroid-like molecules in the prevention of cancer. Each of the participants in the Task Force represents a differentscientific discipline, and the monogrph is intended to be a synthesis of their different approaches to the common problem of cancer prevention. It is hoped that the reader will find this monograph to be of use in the evaluation of both preclinical and clinical approaches to the major issues that face us in chemoprevention. It is clear that prevention of cancer is an idea whose time has come, and the problem now is to implement the most effective approaches toward achieving the desired goals.

Hormones and Growth Factors in Development and Neoplasia

Author : Robert B. Dickson
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hormones and Growth Factors in Development and Neoplasia by : Robert B. Dickson

Download or read book Hormones and Growth Factors in Development and Neoplasia written by Robert B. Dickson and published by Wiley-Liss. This book was released on 1998-05-06 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones and Growth Factors in Development and Neoplasia Edited by Robert B. Dickson, Lombardi Cancer Research Center, Georgetown University David S. Salomon, Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH The study of hormones is critical to our understanding of developmental aberrations leading to cancer, and the discovery of polypeptide growth factors has led to profound insights into the duality of control of development and cancer by hormones at the tissue and cellular levels. In this book, leading researchers in the field present a cohesive overview of several important growth factor systems and how they interact with endocrine hormones in the context of tissue-tissue interactions; control of cellular growth, differentiation, and death; and reciprocal control of receptors and ligands at the molecular level. In its first two sections, Hormones and Growth Factors in Development and Neoplasia introduces important growth factors and hormonal systems in invertebrate and amphibian model systems, highlights early evolutionary and developmental functions for the classes of molecules later shown to be important in human cancer, establishes the roles of growth factors and hormones in mammalian development, and focuses on early embryonic events and later events leading to sexual dimorphism. The book's third section discusses in detail the control of postnatal developmental processes in male and female reproductive tracts, focusing on the prostate and mammary glands as well as the female reproductive tract, all of which are of special importance in hormonally driven cancers. Finally, the book takes a direct look at cancers and the molecular mechanisms of hormone-growth factor interactions. Among the many topics covered in this timely volume are: * Ecdysone in development of Drosophila * The progesterone receptor in mammalian development * Regulation of cell survival and apoptosis in the reproductive tracts and the breast * Hormones, growth factors, oncogenes, and prostate cancer With its novel approach, authoritative coverage, and broad scope, Hormones and Growth Factors in Development and Neoplasia is informative and relevant for researchers across a spectrum of disciplines, including cancer research, endocrinology, developmental biology, and cell biology.

The Role of Epidermal Growth Factor Receptor in Hepatocyte Growth Factor Signaling in Mammary Epithelial Cells

Author : Alyssa Rowena Bonine-Summers
Publisher :
ISBN 13 : 9781109918908
Total Pages : 109 pages
Book Rating : 4.9/5 (189 download)

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Book Synopsis The Role of Epidermal Growth Factor Receptor in Hepatocyte Growth Factor Signaling in Mammary Epithelial Cells by : Alyssa Rowena Bonine-Summers

Download or read book The Role of Epidermal Growth Factor Receptor in Hepatocyte Growth Factor Signaling in Mammary Epithelial Cells written by Alyssa Rowena Bonine-Summers and published by . This book was released on 2006 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deregulated hepatocyte growth factor (HGF) and c-Met signaling leads to increased tumor cell invasion and growth that is observed in mammary carcinogenesis. Determining the specific role of HGF/c-Met signaling in breast cancer has been compounded by the fact that c-Met communicates with a number other receptor pathways that lead to various pathological outcomes. In the present study we show that the epidermal growth factor receptor (EGFR) plays a direct role in HGF/c-Met mediated biological activities. We used the clinically relevant EGFR inhibitors gefitinib and erlotinib to determine the role of EGFR in mediating HGF signaling. Inhibition of EGFR through these small molecule inhibitors significantly reduces the ability of HGF to induce proliferation, cell motility and invasion as well as cell scattering in various mammary epithelial cells. Furthermore, our data indicate that gefitinib and erlotinib negatively regulate the ability of HGF to activate its cognate receptor c-Met and that this action is EGFR-dependent. Our results provide a novel mechanism of action for EGFR as a mediator of HGF signaling thereby linking EGFR to the oncogenic potential of c-Met in mammary carcinomas cells.

HER2-Positive Breast Cancer

Author : Sara Hurvitz
Publisher : Elsevier Health Sciences
ISBN 13 : 0323581234
Total Pages : 264 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis HER2-Positive Breast Cancer by : Sara Hurvitz

Download or read book HER2-Positive Breast Cancer written by Sara Hurvitz and published by Elsevier Health Sciences. This book was released on 2018-07-26 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.

Growth Factors and their Receptors in Cancer Metastasis

Author : Wen G. Jiang
Publisher : Springer Science & Business Media
ISBN 13 : 0306483998
Total Pages : 310 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Growth Factors and their Receptors in Cancer Metastasis by : Wen G. Jiang

Download or read book Growth Factors and their Receptors in Cancer Metastasis written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer

Author : David Salomon
Publisher :
ISBN 13 :
Total Pages : 37 pages
Book Rating : 4.:/5 (455 download)

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Book Synopsis The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer by : David Salomon

Download or read book The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer written by David Salomon and published by . This book was released on 1997 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family which binds to and activates the EGF receptor. Its role in breast cancer, however, is unclear. We have studied the mechanism of induction of HB-EGF(by EGF(in the spontaneously immortalized mammary epithelial cell line MCF-10A and in MCF-10A cells that have been transformed with oncogenic Ha-ras. The levels of EGFR, erbB-2 and erbB-3 were very similar in the nontransformed and in the transformed MCF-10A cells. However, the levels of mitogen- activated protein kinase (MAPK) were elevated in the MCF-10A cells transformed with the Ha-ras oncogene. Neutralizing antibodies and inhibitors against the EGFR were able to inhibit the induction of HE-EUF mRNA levels in the nontransformed MCF-10A cells but not in the MCF- lOA cells transfected with oncogenic Ha-ras. However, an inhibitor of MAPK kinase (MEK) completely blocked the EOF induction of HB-EOF mRNA levels in the parental MCF-10A cells as well as in transformed MCF-10A cells, which suggests that EUF may be operating through other erbB receptors such as erbB-2/erbB-3 heterodimers and that MAPK is involved in the i, of induction in nontransformed and transformed human mammary.