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Author : Rolf Hoigné
Publisher : Birkhauser
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.3/5 (91 download)
Download or read book Risk Factors for Adverse Drug Reactions written by Rolf Hoigné and published by Birkhauser. This book was released on 1990 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Weber
Publisher : Birkhäuser
ISBN 13 : 9783764323721
Total Pages : 152 pages
Book Rating : 4.3/5 (237 download)
Download or read book Risk Factors for Adverse Drug Reactions — Epidemiological Approaches written by Weber and published by Birkhäuser. This book was released on 1990-01-01 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The benzodiazepines are among the most widely-used of drugs. However, in many countries their popularity is waning as prescribers become more aware of problems with unwanted effects and with rebound and withdrawal syndromes. The earlier benzodiazepines were long-acting, and it was thought that their shorter-acting successors would have important advantages. Other developments include partial agonists and partial inverse agonists, compounds acting on the benzodiazepine-GABA macro molecular site although not as a typical benzodiazepine, and anxiolytic agents acting on 5-HT pathways directly. I shall review the problems of unwanted effects and dependence, mainly from an epidemiological view point, and then relate the pharmacological properties of the newer com pounds to possible differences in their clinical profile of adverse effects. Adverse behavioural effects Benzodiazepines are used, inter alia, as anxiolytics and hyp notics. The latter use exploits the sedative actions which occur at higher than anxiolytic doses. The sedation should disappear by the time the patient wakes up. Hypnotics are thus unique in that their wanted effect and unwanted effect are identical - sedation - but separated in time by about 8 hours.
Author : Weber
Publisher : Birkhäuser
ISBN 13 : 9783034872928
Total Pages : 0 pages
Book Rating : 4.8/5 (729 download)
Download or read book Risk Factors for Adverse Drug Reactions — Epidemiological Approaches written by Weber and published by Birkhäuser. This book was released on 2014-01-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The benzodiazepines are among the most widely-used of drugs. However, in many countries their popularity is waning as prescribers become more aware of problems with unwanted effects and with rebound and withdrawal syndromes. The earlier benzodiazepines were long-acting, and it was thought that their shorter-acting successors would have important advantages. Other developments include partial agonists and partial inverse agonists, compounds acting on the benzodiazepine-GABA macro molecular site although not as a typical benzodiazepine, and anxiolytic agents acting on 5-HT pathways directly. I shall review the problems of unwanted effects and dependence, mainly from an epidemiological view point, and then relate the pharmacological properties of the newer com pounds to possible differences in their clinical profile of adverse effects. Adverse behavioural effects Benzodiazepines are used, inter alia, as anxiolytics and hyp notics. The latter use exploits the sedative actions which occur at higher than anxiolytic doses. The sedation should disappear by the time the patient wakes up. Hypnotics are thus unique in that their wanted effect and unwanted effect are identical - sedation - but separated in time by about 8 hours.
Author : Weber
Publisher : Birkhäuser
ISBN 13 : 9783764323721
Total Pages : 160 pages
Book Rating : 4.3/5 (237 download)
Download or read book Risk Factors for Adverse Drug Reactions — Epidemiological Approaches written by Weber and published by Birkhäuser. This book was released on 1990-01-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The benzodiazepines are among the most widely-used of drugs. However, in many countries their popularity is waning as prescribers become more aware of problems with unwanted effects and with rebound and withdrawal syndromes. The earlier benzodiazepines were long-acting, and it was thought that their shorter-acting successors would have important advantages. Other developments include partial agonists and partial inverse agonists, compounds acting on the benzodiazepine-GABA macro molecular site although not as a typical benzodiazepine, and anxiolytic agents acting on 5-HT pathways directly. I shall review the problems of unwanted effects and dependence, mainly from an epidemiological view point, and then relate the pharmacological properties of the newer com pounds to possible differences in their clinical profile of adverse effects. Adverse behavioural effects Benzodiazepines are used, inter alia, as anxiolytics and hyp notics. The latter use exploits the sedative actions which occur at higher than anxiolytic doses. The sedation should disappear by the time the patient wakes up. Hypnotics are thus unique in that their wanted effect and unwanted effect are identical - sedation - but separated in time by about 8 hours.
Author : Arthur J. Atkinson Jr.
Publisher : Elsevier
ISBN 13 : 0080466427
Total Pages : 567 pages
Book Rating : 4.0/5 (84 download)
Download or read book Principles of Clinical Pharmacology written by Arthur J. Atkinson Jr. and published by Elsevier. This book was released on 2011-04-28 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry Expanded coverage of pharmacogenetics Expanded coverage of drug transporters and their role in interactions Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions A new chapter on drug discovery that focuses on oncologic agents Inclusion of therapeutic antibodies in chapter on biotechnology products
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1024 pages
Book Rating : 4.3/5 (91 download)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Author : Raj S. Bhopal
Publisher : Oxford University Press
ISBN 13 : 0198739680
Total Pages : 481 pages
Book Rating : 4.1/5 (987 download)
Download or read book Concepts of Epidemiology written by Raj S. Bhopal and published by Oxford University Press. This book was released on 2016 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: First edition published in 2002. Second edition published in 2008.
Author : Jean-Michel Metry
Publisher : CRC Press
ISBN 13 : 9780471971221
Total Pages : 216 pages
Book Rating : 4.9/5 (712 download)
Download or read book Drug Regimen Compliance written by Jean-Michel Metry and published by CRC Press. This book was released on 1998-01-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable work comprehensively covers all issues of drug regimen compliance. In three sections--Clinical Trials, Patient Management, and Future Aspects--it deals with a topic of debate and interest.
Author : John Talbot
Publisher : John Wiley & Sons
ISBN 13 : 9780470845523
Total Pages : 776 pages
Book Rating : 4.8/5 (455 download)
Download or read book Stephens' Detection of New Adverse Drug Reactions written by John Talbot and published by John Wiley & Sons. This book was released on 2004-03-08 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: A key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate new adverse drug reactions, discussing all elements from the scientific background and animal toxicology through to worldwide regulatory and ethical issues. Stephens' Detection of New Adverse Drug Reactions provides comprehensive and up-to-date coverage of material fundamentally important to all those active in the field, whether they work in the pharmaceutical industry, drug regulatory authorities or in academia. The fifth edition of this classic reference work includes new chapters on: * vaccine safety surveillance * managing drug safety issues with marketed products * operational aspects of drug safety function * safety of biotechnology products * future of pharmacovigilance Reviews of previous editions: "This book surpasses all its educational aims. Not only is the subject matter covered comprehensively but the material is presented in a very user-friendly manner. The editors have succeeded in producing a highly-specific, definitive reference book which doubles as a most enjoyable read." Commended by the 1999 BMA Medical Book Competition "For anyone entering the field of adverse reaction monitoring one could not wish for a better primer" International Journal of Risk and Safety in Medicine
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309049393
Total Pages : 636 pages
Book Rating : 4.3/5 (9 download)
Download or read book Reducing Risks for Mental Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1032 pages
Book Rating : 4.:/5 (319 download)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1990 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1796 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Springer Publishing Company
ISBN 13 : 0826164897
Total Pages : 233 pages
Book Rating : 4.8/5 (261 download)
Download or read book Annual Review of Gerontology and Geriatrics, Volume 12, 1992 written by and published by Springer Publishing Company. This book was released on 1992-11-15 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition of the Annual Review of Gerontology and Geriatrics brings together, in one convenient volume, the results of many of the studies supported by the Hartford Foundation. The first two chapters of this volume set the stage for the specific research reports that follow. In the first chapter, Burke, Jolson, Goetsch, and Ahronheim review current information on medication use and the adverse drug events in the elderly from two natioanl data bases: The National Disease and Therapeutic Index and the Food and Drug Administration's Spontaneous Reporting System. The second chapters present the recent work of Beers in development of explicit criteria defining inappropriate medication use in the elderly.
Author : World Health Organization
Publisher :
ISBN 13 : 9789290360742
Total Pages : 381 pages
Book Rating : 4.3/5 (67 download)
Download or read book Current Challenges in Pharmacovigilance written by World Health Organization and published by . This book was released on 2001-01-01 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of recent progress in the harmonization of terminology and processes affecting work on the clinical safety of medicines consensus is needed on standards for many difficult aspects of day-to-day pharmacovigilance that continue to pose problems for both the pharmaceutical industry and drug regulators. The CIOMS V Working Group has generated proposals for pragmatic approaches to dealing with such issues as: classification and handling of individual safety case reports from a variety of sources (spontaneous consumer reports solicited reports literature the Internet observational studies and secondary data bases disease and other registries regulatory ADR databases and licensor-licensee interactions); new approaches to case management and regulatory reporting practices (proper clinical evaluation of cases incidental vs other events patient and reporter identifiability seriousness criteria expectedness criteria case follow-up criteria and the role and structure of case narratives); improvements and efficiencies in the format content and reporting of periodic safety update reports (PSURs) (including results of an industry survey on PSUR workloads and practices; proposals for high case volume and long time-period reports simplification of certain PSURs summary bridging reports addendum reports license renewal reports for EU and Japan dealing with old products and other technical details); determination and use of population exposure (denominator) data (sources of data and a guide to analytical approaches for a variety of circumstances).The Group has also taken stock of the current state of expedited and periodic clinical safety reporting requirements around the world with summary data on regulations from more than 60 countries. Recommendations are made for enhancing the harmonization steps already taken as a result of previous CIOMS publications and the ICH process. In addition to dealing with unfinished and unresolved issues from previous CIOMS initiatives the report covers many emerging topics such as those involving new technologies. Its 20 Appendices provide a wealth of detailed explanations and reference information. It is the most comprehensive and recent treatment of difficult pharmacovigilance issues affecting the working practices and systems of drug safety and other pharmaceutical professionals.
Author : Simon Y Mills
Publisher : Elsevier Health Sciences
ISBN 13 : 0443071713
Total Pages : 704 pages
Book Rating : 4.4/5 (43 download)
Download or read book The Essential Guide to Herbal Safety written by Simon Y Mills and published by Elsevier Health Sciences. This book was released on 2004-12-23 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of American Botanical Council's 2005 James A. Duke Botanical Literature Award, the Essential Guide to Herbal Safety offers a balanced and objective perspective on the principles of herbal medicine safety as well as the complex challenges relating to self-prescribed or professionally prescribed herbal medications and supplements. With contributions from leading international practitioners and authorities, it contains comprehensive reviews, in monograph format, of the published safety data for 125 common herbs. You'll also find coverage of issues of quality, interactions, adverse reactions, toxicity, allergy, contact sensitivity, and idiosyncratic reactions. Provides the most current information on safety issues in herbal medicine. Presents authoritative and credible safety information from two experienced herbal practitioners. Combines theoretical chapters with 125 well-researched monographs, making it the most thorough and comprehensive text on the market for herbal safety in practice. Provides clear information using the most current evidence-based reviews, covering factors that influence herb safety, including the negative placebo effects (nocebo), various types of unpredictable effects, the basis for interactions between herbs and drugs, and quality issues. Uses an established grading system for assessing safety in pregnancy and lactation that is realistic and appropriate to herb use. Thoroughly critiques the dominant misinformation in the media and medical journals on herb safety issues. Contains 83 documented case studies on hepatoxicity and the effects in relation to kava. Kava safety is a hot topic. Includes two useful appendices detailing herbal references for pregnancy and lactation considerations.
Author : F. Michael Gloth III
Publisher : Springer Science & Business Media
ISBN 13 : 1592596681
Total Pages : 330 pages
Book Rating : 4.5/5 (925 download)
Download or read book Handbook of Pain Relief in Older Adults written by F. Michael Gloth III and published by Springer Science & Business Media. This book was released on 2003-12-17 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive assessment of the clinical, psychological, legal, and cultural aspects of dealing with unnecessary pain in the elderly. The authors explore pharmacotherapy (nonopioids, opioids, and adjuvants), interventional strategies, the role of rehabilitation in managing pain in seniors, and the problems of pain management in long-term care. Supplementary features include continuing medical education (CME) certification, a CME posttest and evaluation to be completed and submitted for credit, and an appendix of analgesics that details starting oral doses, maximum daily oral doses, and special considerations for the elderly. 6.5 AMA/PRA category 1 CME credits with completion of included test.
Author : Tinsley Randolph Harrison
Publisher :
ISBN 13 :
Total Pages : 1370 pages
Book Rating : 4.3/5 (91 download)
Download or read book Harrison's Principles of Internal Medicine written by Tinsley Randolph Harrison and published by . This book was released on 1994 with total page 1370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
