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Response Relapse Models For Clinical Trials
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Book Synopsis Small Clinical Trials by : Institute of Medicine
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Book Synopsis Pathways of Addiction by : Institute of Medicine
Download or read book Pathways of Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1996-10-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Book Synopsis Addictive Behaviors by : G. Alan Marlatt
Download or read book Addictive Behaviors written by G. Alan Marlatt and published by Amer Psychological Assn. This book was released on 1997-01 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: The destructive power of addiction manifests itself in ill health effects, social and family problems, and economic an and legal troubles. This extensive collection of reprinted articles from American Psychological Association journals provides a current view of psychological research on addictive behaviors.
Book Synopsis Relapse Prevention by : G. Alan Marlatt
Download or read book Relapse Prevention written by G. Alan Marlatt and published by Guilford Press. This book was released on 2007-12-26 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important work elucidates why relapse is so common for people recovering from addictive behavior problems--and what can be done to keep treatment on track. It provides an empirically supported framework for helping people with addictive behavior problems develop the skills to maintain their treatment goals, even in high-risk situations, and deal effectively with setbacks that occur. The expert contributors clearly identify the obstacles that arise in treating specific problem behaviors, review the factors that may trigger relapse at different stages of recovery, and present procedures for teaching effective cognitive and behavioral coping strategies.
Book Synopsis Transforming Clinical Research in the United States by : Institute of Medicine
Download or read book Transforming Clinical Research in the United States written by Institute of Medicine and published by National Academies Press. This book was released on 2010-10-22 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is based on a limited infrastructure. The link between clinical research and medical progress is also frequently misunderstood or unsupported by both patients and providers. The focus of clinical research changes as diseases emerge and new treatments create cures for old conditions. As diseases evolve, the ultimate goal remains to speed new and improved medical treatments to patients throughout the world. To keep pace with rapidly changing health care demands, clinical research resources need to be organized and on hand to address the numerous health care questions that continually emerge. Improving the overall capacity of the clinical research enterprise will depend on ensuring that there is an adequate infrastructure in place to support the investigators who conduct research, the patients with real diseases who volunteer to participate in experimental research, and the institutions that organize and carry out the trials. To address these issues and better understand the current state of clinical research in the United States, the Institute of Medicine's (IOM) Forum on Drug Discovery, Development, and Translation held a 2-day workshop entitled Transforming Clinical Research in the United States. The workshop, summarized in this volume, laid the foundation for a broader initiative of the Forum addressing different aspects of clinical research. Future Forum plans include further examining regulatory, administrative, and structural barriers to the effective conduct of clinical research; developing a vision for a stable, continuously funded clinical research infrastructure in the United States; and considering strategies and collaborative activities to facilitate more robust public engagement in the clinical research enterprise.
Author :Agency for Health Care Research and Quality (U.S.) Publisher :Government Printing Office ISBN 13 :1587634236 Total Pages :236 pages Book Rating :4.5/5 (876 download)
Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Download or read book Mindfulness written by Katie Witkiewitz and published by Hogrefe Publishing GmbH. This book was released on 2018-03-13 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clear and compact guidance on integrating mindfulness into practice This clear and concise book provides practical, evidence-based guidance on the use of mindfulness in treatment: its mechanism of action, the disorders for which there is empirical evidence of efficacy, mindfulness practices and techniques, and how to integrate them into clinical practice. Leading experts describe the concepts and roots of mindfulness, and examine the science that has led to this extraordinarily rich and ancient practice becoming a foundation to many contemporary, evidenced-based approaches in psychotherapy. The efficacy of mindfulness-based interventions in conditions as diverse as borderline personality disorder, post-traumatic stress disorder, depression, alcohol and substance use, emotional dysregulation, attention-deficit hyperactivity disorder, chronic stress, eating disorders, and other medical conditions including type 2 diabetes and rheumatoid arthritis is also described. The book is invaluable reading for all those curious about the current science around mindfulness and about how and when to incorporate it effectively into clinical practice.
Book Synopsis Analysis of Survival Data by : D.R. Cox
Download or read book Analysis of Survival Data written by D.R. Cox and published by CRC Press. This book was released on 1984-06-01 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains many ideas on the analysis of survival data to present a comprehensive account of the field. The value of survival analysis is not confined to medical statistics, where the benefit of the analysis of data on such factors as life expectancy and duration of periods of freedom from symptoms of a disease as related to a treatment applied individual histories and so on, is obvious. The techniques also find important applications in industrial life testing and a range of subjects from physics to econometrics. In the eleven chapters of the book the methods and applications of are discussed and illustrated by examples.
Book Synopsis Psychosocial Treatments by : Elinore McCance-Katz
Download or read book Psychosocial Treatments written by Elinore McCance-Katz and published by Routledge. This book was released on 2004-06-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of this volume have assembled recent articles discussing elements of each of the several commonly used psychosocial interventions -- including relapse prevention therapy, community reinforcement, voucher-based programs, self-help therapies, and motivational enhancement therapy--in addition to research-based articles that demonstrate the efficacy of these approaches. The selections in this book will provide the reader with a broad overview of the field as well as the specific information needed to use these therapies in a variety of clinical settings.
Author :Committee for the Substance Abuse Coverage Study Publisher :National Academies Press ISBN 13 :9780309043960 Total Pages :332 pages Book Rating :4.0/5 (439 download)
Book Synopsis Treating Drug Problems: by : Committee for the Substance Abuse Coverage Study
Download or read book Treating Drug Problems: written by Committee for the Substance Abuse Coverage Study and published by National Academies Press. This book was released on 1992-01-01 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treating Drug Problems, Volume 2 presents a wealth of incisive and accessible information on the issue of drug abuse and treatment in America. Several papers lay bare the relationship between drug treatment and other aspects of drug policy, including a powerful overview of twentieth century narcotics use in America and a unique account of how the federal government has built and managed the drug treatment system from the 1960s to the present. Two papers focus on the criminal justice system. The remaining papers focus on Employer policies and practices toward illegal drugs. Patterns and cycles of cocaine use in subcultures and the popular culture. Drug treatment from a marketing, supply-and-demand perspective, including an analysis of policy options. Treating Drug Problems, Volume 2 provides important information to policy makers and administrators, drug treatment specialists, and researchers.
Book Synopsis Adolescent Substance Abuse by : Yifrah Kaminer
Download or read book Adolescent Substance Abuse written by Yifrah Kaminer and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: `[This] volume provides a unique and advantageous perspective to the trainees and practitioners in the adolescent substance abuse field. It offers a sophisticated perspective on addiction treatment techniques developed in recent years, with a sensitivity to the social and developmental needs of the adolescent.' Marc Galanter, from the Foreword.
Book Synopsis Cognitive-Behavioral Interventions by : Philip C. Kendall
Download or read book Cognitive-Behavioral Interventions written by Philip C. Kendall and published by Academic Press. This book was released on 2013-10-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive-Behavioral Interventions: Theory, Research, and Procedures surveys a variety of areas to which cognitive-behavioral strategies have been applied. The various contributors represent some of the major innovators in the field. Each has developed and systematically evaluated programs which apply sound empirically based procedures to cognitive and behavioral phenomena. The opening chapter traces the short developmental history and describes the current professional environment of the cognitive-behavioral movement. The chapters that follow represent major contributions by the leading investigators across a number of areas of intervention. Each chapter describes a summary of research in the respective area, a description of the actual intervention procedures with supporting empirical data, and a consideration of the theoretical foundations and potential implications associated with the intervention. The chapter contents vary across three dimensions. First, the interventions range from those that focus on the acquisition of new capacities to those that deal with the control and modification of existing processes. Second, several chapters focus on adult populations, several on child populations, and some on both. Finally, whereas a number of the chapters deal with problems that have been areas of traditional clinical concern, several others explore new and interesting applications for cognitive-behavioral interventions.
Book Synopsis Assessing Alcohol Problems by : John P. Allen
Download or read book Assessing Alcohol Problems written by John P. Allen and published by DIANE Publishing. This book was released on 2003 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: A revision of the landmark study by D.J. Lettieri "Alcoholism Treatment Assessment Research Instruments". Assists in locating, examining, and selecting instruments appropriate for use in all stages of the assessment process. Includes state-of-the-art reviews of and recommendations for assessment procedures. Written with the clinician and the less experienced researcher in mind. Includes screening, diagnosis, assessment of drinking behavior, treatment planning, treatment and process assessment, and outcome evaluation. Also Fact Sheets and Sample Instruments.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1980 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309457971 Total Pages :145 pages Book Rating :4.3/5 (94 download)
Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Practical Approaches in the Treatment of Women who Abuse Alcohol and Other Drugs by :
Download or read book Practical Approaches in the Treatment of Women who Abuse Alcohol and Other Drugs written by and published by U.S. Government Printing Office. This book was released on 1994 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mindfulness-Based Cognitive Therapy for Depression, First Edition by : Zindel V. Segal
Download or read book Mindfulness-Based Cognitive Therapy for Depression, First Edition written by Zindel V. Segal and published by Guilford Press. This book was released on 2001-11-14 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an innovative eight-session program that has been clinically proven to bolster recovery from depression and prevent relapse. Developed by leading scientist-practitioners, and solidly grounded in current psychological research, the approach integrates cognitive therapy principles and practice into a mindfulness framework. Clinicians from any background will find vital tools to help clients maintain gains made by prior treatment and to expand the envelope of care to remission and beyond. Illustrative transcripts and a wealth of reproducible materials, including session summaries and participant forms, enhance the clinical utility of the volume. More than 35 reproducibles are also provided in a large-size format on Guilford's website for bookbuyers to download.
