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Author : Hui Zhang
Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.3/5 (129 download)
Download or read book Resampling Methods for Adaptive Designs written by Hui Zhang and published by . This book was released on 2005 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jay Bartroff
Publisher : Springer Science & Business Media
ISBN 13 : 1461461146
Total Pages : 250 pages
Book Rating : 4.4/5 (614 download)
Download or read book Sequential Experimentation in Clinical Trials written by Jay Bartroff and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information. Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.
Author : Ioannis Kyriakides
Publisher : Springer Nature
ISBN 13 : 3031015150
Total Pages : 101 pages
Book Rating : 4.0/5 (31 download)
Download or read book Adaptive High-Resolution Sensor Waveform Design for Tracking written by Ioannis Kyriakides and published by Springer Nature. This book was released on 2022-05-31 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent innovations in modern radar for designing transmitted waveforms, coupled with new algorithms for adaptively selecting the waveform parameters at each time step, have resulted in improvements in tracking performance. Of particular interest are waveforms that can be mathematically designed to have reduced ambiguity function sidelobes, as their use can lead to an increase in the target state estimation accuracy. Moreover, adaptively positioning the sidelobes can reveal weak target returns by reducing interference from stronger targets. The manuscript provides an overview of recent advances in the design of multicarrier phase-coded waveforms based on Bjorck constant-amplitude zero-autocorrelation (CAZAC) sequences for use in an adaptive waveform selection scheme for mutliple target tracking. The adaptive waveform design is formulated using sequential Monte Carlo techniques that need to be matched to the high resolution measurements. The work will be of interest to both practitioners and researchers in radar as well as to researchers in other applications where high resolution measurements can have significant benefits. Table of Contents: Introduction / Radar Waveform Design / Target Tracking with a Particle Filter / Single Target tracking with LFM and CAZAC Sequences / Multiple Target Tracking / Conclusions
Author : Gernot Wassmer
Publisher : Springer
ISBN 13 : 3319325620
Total Pages : 310 pages
Book Rating : 4.3/5 (193 download)
Download or read book Group Sequential and Confirmatory Adaptive Designs in Clinical Trials written by Gernot Wassmer and published by Springer. This book was released on 2016-07-04 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population. Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application. The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.
Author : Shelemyahu Zacks
Publisher : John Wiley & Sons
ISBN 13 : 0470466944
Total Pages : 411 pages
Book Rating : 4.4/5 (74 download)
Download or read book Stage-Wise Adaptive Designs written by Shelemyahu Zacks and published by John Wiley & Sons. This book was released on 2009-05-11 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: An expert introduction to stage-wise adaptive designs in all areas of statistics Stage-Wise Adaptive Designs presents the theory and methodology of stage-wise adaptive design across various areas of study within the field of statistics, from sampling surveys and time series analysis to generalized linear models and decision theory. Providing the necessary background material along with illustrative S-PLUS functions, this book serves as a valuable introduction to the problems of adaptive designs. The author begins with a cohesive introduction to the subject and goes on to concentrate on generalized linear models, followed by stage-wise sampling procedures in sampling surveys. Adaptive forecasting in the area of time series analysis is presented in detail, and two chapters are devoted to applications in clinical trials. Bandits problems are also given a thorough treatment along with sequential detection of change-points, sequential applications in industrial statistics, and software reliability. S-Plus functions are available to accompany particular computations, and all examples can be worked out using R, which is available on the book's related FTP site. In addition, a detailed appendix outlines the use of these software functions, while an extensive bibliography directs readers to further research on the subject matter. Assuming only a basic background in statistical topics, Stage-Wise Adaptive Designs is an excellent supplement to statistics courses at the upper-undergraduate and graduate levels. It also serves as a valuable reference for researchers and practitioners in the fields of statistics and biostatistics.
Author : Feifang Hu
Publisher : John Wiley & Sons
ISBN 13 : 0470055871
Total Pages : 234 pages
Book Rating : 4.4/5 (7 download)
Download or read book The Theory of Response-Adaptive Randomization in Clinical Trials written by Feifang Hu and published by John Wiley & Sons. This book was released on 2006-09-29 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures. This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including: How does response-adaptive randomization affect power? Can standard inferential tests be applied following response-adaptive randomization? What is the effect of delayed response? Which procedure is most appropriate and how can "most appropriate" be quantified? How can heterogeneity of the patient population be incorporated? Can response-adaptive randomization be performed with more than two treatments or with continuous responses? The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes: The relationship between power and response-adaptive randomization The general result for determining asymptotically best procedures Procedures based on urn models Procedures based on sequential estimation Implications for the practice of clinical trials Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.
Author : Mark Chang
Publisher : CRC Press
ISBN 13 : 1482256592
Total Pages : 709 pages
Book Rating : 4.4/5 (822 download)
Download or read book Adaptive Design Theory and Implementation Using SAS and R, Second Edition written by Mark Chang and published by CRC Press. This book was released on 2014-12-01 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials. New to the Second Edition Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winners design, biomarker-informed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival modeling, and adaptive treatment switching New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive dose-escalation trials Twenty new SAS macros and R functions Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.
Author :
Publisher : Elsevier
ISBN 13 : 0080932215
Total Pages : 723 pages
Book Rating : 4.0/5 (89 download)
Download or read book Sample Surveys: Design, Methods and Applications written by and published by Elsevier. This book was released on 2009-08-31 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new handbook contains the most comprehensive account of sample surveys theory and practice to date. It is a second volume on sample surveys, with the goal of updating and extending the sampling volume published as volume 6 of the Handbook of Statistics in 1988. The present handbook is divided into two volumes (29A and 29B), with a total of 41 chapters, covering current developments in almost every aspect of sample surveys, with references to important contributions and available software. It can serve as a self contained guide to researchers and practitioners, with appropriate balance between theory and real life applications. Each of the two volumes is divided into three parts, with each part preceded by an introduction, summarizing the main developments in the areas covered in that part. Volume 29A deals with methods of sample selection and data processing, with the later including editing and imputation, handling of outliers and measurement errors, and methods of disclosure control. The volume contains also a large variety of applications in specialized areas such as household and business surveys, marketing research, opinion polls and censuses. Volume 29B is concerned with inference, distinguishing between design-based and model-based methods and focusing on specific problems such as small area estimation, analysis of longitudinal data, categorical data analysis and inference on distribution functions. The volume contains also chapters dealing with case-control studies, asymptotic properties of estimators and decision theoretic aspects. - Comprehensive account of recent developments in sample survey theory and practice - Discusses a wide variety of diverse applications - Comprehensive bibliography
Author : Ying Lu
Publisher : World Scientific
ISBN 13 : 9814583324
Total Pages : 1471 pages
Book Rating : 4.8/5 (145 download)
Download or read book Advanced Medical Statistics (2nd Edition) written by Ying Lu and published by World Scientific. This book was released on 2015-06-29 with total page 1471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch.The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field.Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research.
Author : Patricia Melin
Publisher : Springer Science & Business Media
ISBN 13 : 3540724311
Total Pages : 856 pages
Book Rating : 4.5/5 (47 download)
Download or read book Analysis and Design of Intelligent Systems Using Soft Computing Techniques written by Patricia Melin and published by Springer Science & Business Media. This book was released on 2007-06-05 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises a selection of papers on new methods for analysis and design of hybrid intelligent systems using soft computing techniques from the IFSA 2007 World Congress, held in Cancun, Mexico, June 2007.
Author : Sandeep Menon
Publisher : SAS Institute
ISBN 13 : 1629600849
Total Pages : 364 pages
Book Rating : 4.6/5 (296 download)
Download or read book Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods written by Sandeep Menon and published by SAS Institute. This book was released on 2015-12-09 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods applicable to and used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, it covers topics including: dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs incorporating historical data; adaptive sample size re-estimation and randomization to allocate subjects to effective treatments; population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology and rheumatology. --
Author : Annpey Pong
Publisher : CRC Press
ISBN 13 : 1439810176
Total Pages : 475 pages
Book Rating : 4.4/5 (398 download)
Download or read book Handbook of Adaptive Designs in Pharmaceutical and Clinical Development written by Annpey Pong and published by CRC Press. This book was released on 2016-04-19 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the US FDA's Critical Path Initiative, innovative adaptive designs are being used more and more in clinical trials due to their flexibility and efficiency, especially during early phase development. Handbook of Adaptive Designs in Pharmaceutical and Clinical Development provides a comprehensive and unified presentation of the princip
Author : Frank Bretz
Publisher : CRC Press
ISBN 13 : 1420010905
Total Pages : 202 pages
Book Rating : 4.4/5 (2 download)
Download or read book Multiple Comparisons Using R written by Frank Bretz and published by CRC Press. This book was released on 2016-04-19 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques. Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa. See Dr. Bretz discuss the book.
Author : Maurizio Vichi
Publisher : Springer Science & Business Media
ISBN 13 : 364260126X
Total Pages : 384 pages
Book Rating : 4.6/5 (426 download)
Download or read book Classification and Data Analysis written by Maurizio Vichi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Federation of Classification Societies The International Federation of Classification Societies (IFCS) is an agency for the dissemination of technical and scientific information concerning classification and data analysis in the broad sense and in as wide a· range of applications as possible; founded in 1985 in Cambridge (UK) from the following Scientific Societies and Groups: British Classification Society -BCS; Classification Society of North America -CSNA; Gesellschaft fUr Klassifikation -GfKl; Japanese Classification Society -JCS; Classification Group of Italian Statistical Society - COSIS; Societe Francophone de Classification -SFC. Now the IFCS includes the following Societies: Dutch-Belgian Classification Society - VOC; Polish Classification Section - SKAD; Portuguese Classification Association - CLAD; Group-at-Large; Korean Classification Society -KCS. Biannual Meeting of the Classification and Data Analysis Group of SIS The biannual meeting of the Classification and Data Analysis Group of Societa Italiana di Statistica (SIS) was held in Pescara, July 3 -4, 1997. The 69 papers presented were divided in 17 sessions. Each session was organized by a chairperson with two invited speakers and two contributed papers from a call for papers. All the works were referred. Furthermore, during the meeting a discussant was provided for each session. A short version of the papers (4 pages) was.published before the conference.
Author : Mark Chang
Publisher : CRC Press
ISBN 13 : 1439835934
Total Pages : 566 pages
Book Rating : 4.4/5 (398 download)
Download or read book Monte Carlo Simulation for the Pharmaceutical Industry written by Mark Chang and published by CRC Press. This book was released on 2010-09-29 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to commercialization. It presents the theories and metho
Author : Debasis Kundu
Publisher : Alpha Science Int'l Ltd.
ISBN 13 : 9781842652022
Total Pages : 440 pages
Book Rating : 4.6/5 (52 download)
Download or read book Statistical Computing written by Debasis Kundu and published by Alpha Science Int'l Ltd.. This book was released on 2004 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Computing: Existing Methods and Recent Developments attempts to provide a state of the art account of existing methods and recent developments in the so called new field of Statistical Computing. Fourteen different chapters deal with a wide range of topics. This includes introductory topics such as the basic numerical analysis methods, random number generation, graphical techniques used in statistical data analysis and other areas. It also covers the more specialized techniques such as the EM algorithm, genetic algorithms, nonparametric smoothing techniques, resampling methods, and artificial neural network models, to name a few. In addition, the volume also deals with the computational issues involved in the analysis of mixture models, adaptive designs, weighted distributions, and statistical signal processing, topics which are unlikely to be covered in a standard text on Statistical Computing.
Author : Christopher Jennison
Publisher : CRC Press
ISBN 13 : 9781584888581
Total Pages : 416 pages
Book Rating : 4.8/5 (885 download)
Download or read book Group Sequential Methods with Applications to Clinical Trials written by Christopher Jennison and published by CRC Press. This book was released on 1999-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.
