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Reproducibility And Sensitivity In Small Animal Imaging
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Book Synopsis Handbook of Small Animal Imaging by : George C. Kagadis
Download or read book Handbook of Small Animal Imaging written by George C. Kagadis and published by CRC Press. This book was released on 2018-09-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.
Book Synopsis Small Animal Imaging by : Fabian Kiessling
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Book Synopsis Molecular Imaging of Small Animals by : Habib Zaidi
Download or read book Molecular Imaging of Small Animals written by Habib Zaidi and published by Springer. This book was released on 2014-05-27 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Book Synopsis Small animal imaging: Technological and methodological advances to improve the translational power by : Monique R. Bernsen
Download or read book Small animal imaging: Technological and methodological advances to improve the translational power written by Monique R. Bernsen and published by Frontiers Media SA. This book was released on 2023-01-13 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Small-Animal SPECT Imaging by : Matthew A. Kupinski
Download or read book Small-Animal SPECT Imaging written by Matthew A. Kupinski and published by Springer Science & Business Media. This book was released on 2007-05-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small-Animal SPECT Imaging is an edited work derived from the first workshop on Small-Animal SPECT Imaging held January 14-16, 2004 at the University of Arizona, Tucson, AZ, USA. The overall goal of the meeting and therefore this volume is to promote information exchange and collaboration between the research groups developing systems for small-animal applications. Topics include the biomedical significance of small-animal imaging, an overview of detector technologies including scintillation cameras and semi-conductor arrays, imager design and data acquisition systems, animal handling and anesthesia issues, objective assessment of image quality, and system modeling and reconstruction algorithms.
Book Synopsis Issues in Biophysics and Geophysics Research and Application: 2011 Edition by :
Download or read book Issues in Biophysics and Geophysics Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 1700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Biophysics and Geophysics Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biophysics and Geophysics Research and Application. The editors have built Issues in Biophysics and Geophysics Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biophysics and Geophysics Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biophysics and Geophysics Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Imaging in CNS Drug Discovery and Development by : David Borsook
Download or read book Imaging in CNS Drug Discovery and Development written by David Borsook and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
Book Synopsis Veterinary Surgery: Small Animal - E-BOOK by : Karen M. Tobias
Download or read book Veterinary Surgery: Small Animal - E-BOOK written by Karen M. Tobias and published by Elsevier Health Sciences. This book was released on 2013-12-26 with total page 2775 pages. Available in PDF, EPUB and Kindle. Book excerpt: With detailed coverage of surgical procedures, Veterinary Surgery: Small Animal is an authoritative, two-volume reference on the art and science of small animal surgery. Expert contributors discuss surgical principles and procedures for topics ranging from surgical biology and perioperative care, to neurosurgery orthopedic surgery, and soft tissue surgery, always supported by evidence-based research and complete surgical instructions. More procedures are covered with greater detail than in comparable books, and a greater emphasis on pathophysiology shows how it relates to diagnosis, treatment, and overall case management. Experienced Coeditors Karen Tobias and Spencer Johnston provide the definitive reference for veterinary surgery, invaluable preparation for the ACVS and ECVS board examinations. Blend of clinical and basic science information provides the best possible understanding of clinical issues surrounding operative situations. Specific procedures are covered in great detail and are brought to life with full-color drawings and photographs. Highly recognized contributors provide authoritative coverage that is useful for surgical specialists as well as practicing veterinarians who perform surgery or refer cases for surgery. Detailed coverage of small animal surgery provides excellent preparation for the written examination of the American College of Veterinary Surgeons, and the European College of Veterinary Surgeons. Comprehensive coverage includes surgical biology, surgical methods and perioperative care, neurosurgery, and orthopedics in Volume I; soft tissue surgery is covered in Volume II. Coverage of anatomy, physiology, and pathophysiology in chapters on specific organs includes information critical to operative procedures and patient management. In-depth chapters on anesthesia and pain provide indispensable resources for practicing surgeons. Treatment of cancers in small animals is covered in chapters on surgical oncology, tumors of the spine, and musculoskeletal neoplasia. Extensive references to published studies show the factual basis for the material. The companion website includes all of the images in the book for convenient access, plus references linked to original abstracts on PubMed.
Book Synopsis Saunders Manual of Small Animal Practice - E-Book by : Stephen J. Birchard
Download or read book Saunders Manual of Small Animal Practice - E-Book written by Stephen J. Birchard and published by Elsevier Health Sciences. This book was released on 2005-12-20 with total page 2024 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meticulously organized by body system for optimal readability and ease of reference, the 3rd edition of this best-selling manual provides quick, comprehensive, and practical guidance on evaluating and managing a full range of common medical and surgical conditions encountered in small animal practice. Medical chapters discuss etiology, clinical signs, diagnoses and treatment, while surgical chapters discuss anatomy, preoperative considerations, procedures and postoperative care. It also contains an entire section devoted to avian and exotic pets and a comprehensive drug formulary. - A consistent outline format provides easy access to information on etiology, clinical signs, diagnosis, and treatment for each disease or disorder, as well as anatomy, preoperative conditions, techniques, and postoperative care for surgical procedures. - Key Points draw attention to helpful tips and key concepts. - Includes a comprehensive section covering diagnosis, treatment, and surgery for avian and exotic pets. - Features new chapters that cover key topics such as physical therapy and rehabilitation, pain management, vaccination guidelines, and syncope. - Includes the latest information on drugs and clinical equipment throughout.
Download or read book Federal Register written by and published by . This book was released on 1998-05-14 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stem Cells in Regenerative Medicine by : Alain A. Vertes
Download or read book Stem Cells in Regenerative Medicine written by Alain A. Vertes and published by John Wiley & Sons. This book was released on 2015-09-14 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.
Book Synopsis Molecular Imaging by : Ralph Weissleder
Download or read book Molecular Imaging written by Ralph Weissleder and published by PMPH-USA. This book was released on 2010 with total page 1384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.
Book Synopsis In Vivo Imaging in Pharmacological Research by : Nicolau Beckmann
Download or read book In Vivo Imaging in Pharmacological Research written by Nicolau Beckmann and published by Frontiers Media SA. This book was released on 2017-08-08 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.
Book Synopsis Molecular Toxicology Protocols by : Phouthone Keohavong
Download or read book Molecular Toxicology Protocols written by Phouthone Keohavong and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.
Book Synopsis Abeloff's Clinical Oncology E-Book by : John E. Niederhuber
Download or read book Abeloff's Clinical Oncology E-Book written by John E. Niederhuber and published by Elsevier Health Sciences. This book was released on 2013-09-12 with total page 2712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.
Book Synopsis Molecular Imaging in Oncology by : Martin G. Pomper
Download or read book Molecular Imaging in Oncology written by Martin G. Pomper and published by CRC Press. This book was released on 2008-10-13 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers:instrumentation and techniquescancer imaging
Download or read book PET Chemistry written by P.A. Schubiger and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.
