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Regulation Of Neurite Outgrowth And Growth Cone Motility By Local Calcium Signaling Through Stretch Activated Trpc1 Channels
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Book Synopsis Regulation of Neurite Outgrowth and Growth Cone Motility by Local Calcium Signaling Through Stretch-activated TRPC1 Channels by : Bridget T. Jacques-Fricke
Download or read book Regulation of Neurite Outgrowth and Growth Cone Motility by Local Calcium Signaling Through Stretch-activated TRPC1 Channels written by Bridget T. Jacques-Fricke and published by . This book was released on 2008 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mammalian Transient Receptor Potential (TRP) Cation Channels by : Bernd Nilius
Download or read book Mammalian Transient Receptor Potential (TRP) Cation Channels written by Bernd Nilius and published by Springer. This book was released on 2014-06-24 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Book Synopsis Calcium Signaling by : Md. Shahidul Islam
Download or read book Calcium Signaling written by Md. Shahidul Islam and published by Springer Nature. This book was released on 2019-10-23 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Neuronal Cytoskeleton written by Hirokawa and published by CRC Press. This book was released on 1994-01-12 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Book Synopsis TRP Channels as Therapeutic Targets by : Arpad Szallasi
Download or read book TRP Channels as Therapeutic Targets written by Arpad Szallasi and published by Academic Press. This book was released on 2015-04-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. - Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials - Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more - Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them
Book Synopsis The Glutamate Receptors by : Robert W. Gereau
Download or read book The Glutamate Receptors written by Robert W. Gereau and published by Springer Science & Business Media. This book was released on 2008-02-23 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student. It condenses two previous landmark volumes into one easily accessible volume, and covers the extraordinary research and significant developments in the decade since the previous books were published. This includes the central role glutamate receptors play in neurotransmission.
Book Synopsis Mechanosensitivity and Mechanotransduction by : Irina Kiseleva
Download or read book Mechanosensitivity and Mechanotransduction written by Irina Kiseleva and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.
Book Synopsis Cell Volume Regulation by : Florian Lang
Download or read book Cell Volume Regulation written by Florian Lang and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.
Book Synopsis Calcium Signalling and Disease by : Ernesto Carafoli
Download or read book Calcium Signalling and Disease written by Ernesto Carafoli and published by Springer Science & Business Media. This book was released on 2007-09-29 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Book Synopsis Cellular Migration and Formation of Neuronal Connections by :
Download or read book Cellular Migration and Formation of Neuronal Connections written by and published by Academic Press. This book was released on 2013-05-06 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Download or read book Ion Channels written by Nikita Gamper and published by Humana Press. This book was released on 2016-05-01 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Methods in Molecular Biology book offers strategies and protocols for studying a large group of proteins that form ionic channels in the plasma membrane and intracellular membranes of cells. Includes step-by-step protocols, materials lists, tips and more."
Book Synopsis Mechanosensitive Ion Channels, Part B by :
Download or read book Mechanosensitive Ion Channels, Part B written by and published by Elsevier. This book was released on 2011-09-21 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells;MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.
Book Synopsis Cardiac Mechano-electric Feedback and Arrhythmias by : Peter Kohl
Download or read book Cardiac Mechano-electric Feedback and Arrhythmias written by Peter Kohl and published by Saunders. This book was released on 2005 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kohl (Cardio Mechano-Electric Feedback Lab, Oxford University) documents the role of mechano-electric feedback (MEF) in electrical and mechanical pathological remodeling of cardiac function. Sections cover sub-cellular mechanisms of cardiac MEF, effects of MEF on cardiac cellular electrophysiology, experimental manifestations of MEF in the heart, cardiac MEF in normal physiology, cardiac MEF as a pathogenic mechanism, MEF as a mechanism involved in therapeutic interventions, and the outlook for the future. B&w and color photos and medical images are included. Annotation: 2005 Book News, Inc., Portland, OR (booknews.com).
Book Synopsis Synapse Development and Maturation by : Pasko Rakic
Download or read book Synapse Development and Maturation written by Pasko Rakic and published by Academic Press. This book was released on 2020-05-29 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Includes coverage of mechanisms which regulate synapse formation and maintenance during development - Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity
Book Synopsis Astrocytes and Epilepsy by : Jacqueline A. Hubbard
Download or read book Astrocytes and Epilepsy written by Jacqueline A. Hubbard and published by Academic Press. This book was released on 2016-07-05 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. - Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume - Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions - Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Book Synopsis Calcium Signalling in the Nervous System by : Platon Grigorʹevich Kosti︠u︡k
Download or read book Calcium Signalling in the Nervous System written by Platon Grigorʹevich Kosti︠u︡k and published by . This book was released on 1995 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium ions play an important role in the function of excitable cells, from the triggering of impulses in nerve cells to the regulation of biochemical pathways and basic cellular functions of all cell types in the nervous system. Calcium signalling is the main coupling mechanism linking external stimuli, via the membrane, with intracellular processes. Calcium Signalling in the Nervous System provides an up-to-date account of the most fundamental aspects of calcium signal generation in the nervous system, including pathways for Ca2+ influx, buffering in the cytosol, involvement of intracellular calcium stores and Ca2+ extrusion. The book also gives an overview of the most important aspects of interaction of Ca2+ ions with other messenger systems, the functional meaning of Ca2+ ions, as well as the pharmaceutical tools used for their dissection and modulation. The role of calcium in a variety of neural cell types and implications in brain function are also discussed, including the control of gene expression, cell differentiation and programmed cell death.
