Regulation Of Matrix Accumulation

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Regulation of matrix Accumulation

Author :
Publisher : Academic Press
ISBN 13 : 0323149006
Total Pages : 476 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Regulation of matrix Accumulation by :

Download or read book Regulation of matrix Accumulation written by and published by Academic Press. This book was released on 2012-12-02 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of Matrix Accumulation discusses the development of research and studies on connective tissue. This book emphasizes biochemical characterization of individual connective tissue components and interactions between cells and extracellular macromolecules. Other topics include the intracellular turnover of collagen; biological regulation of collagenase activity; feedback regulation of collagen synthesis; steroid hormone regulation of extracellular matrix proteins; and control of elastin synthesis, including its molecular and cellular aspects. The catalytic and biological properties of elastases; characterization and regulation of lysyl oxidase; and matrix accumulation and the development of form, considering proteoglycans and branching morphogenesis, are explained as well. Included in this text is an autobiography and personal retrospective by Miles Partridge, one of the contributors that greatly influenced the progress in understanding extracellular matrix biology. This publication is a good reference for students and researchers conducting work on biology, specifically on connective tissue.

Extracellular Matrix in Development

Author : Douglas W. DeSimone
Publisher : Springer Science & Business Media
ISBN 13 : 3642359353
Total Pages : 260 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Extracellular Matrix in Development by : Douglas W. DeSimone

Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Capillary Fluid Exchange

Author : Joshua Scallan
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615040668
Total Pages : 86 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Capillary Fluid Exchange by : Joshua Scallan

Download or read book Capillary Fluid Exchange written by Joshua Scallan and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation

The Extracellular Matrix: an Overview

Author : Robert Mecham
Publisher : Springer Science & Business Media
ISBN 13 : 3642165559
Total Pages : 429 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis The Extracellular Matrix: an Overview by : Robert Mecham

Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

The Extracellular Matrix and Ground Regulation

Author : Alfred Pischinger
Publisher : North Atlantic Books
ISBN 13 : 1556436882
Total Pages : 233 pages
Book Rating : 4.5/5 (564 download)

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Book Synopsis The Extracellular Matrix and Ground Regulation by : Alfred Pischinger

Download or read book The Extracellular Matrix and Ground Regulation written by Alfred Pischinger and published by North Atlantic Books. This book was released on 2007-07-17 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The workings of the suitable environment for cells—called the extracellular matrix (ECM) and ground regulation—has occupied the European medical tradition since the early part of the 20th century. As it has become more clear that the origin of disease and its first signals register in the connective tissue, or myofascia, cellular pathologists and biochemists have sought to circumscribe networks of cell communication and microcirculation in the ECM. Alfred Pischinger (1899-1982) continued this line of work by further studying, in work published from 1926 through the late seventies, the connections of the ECM to the hormonal and autonomic systems. In the last twenty years Professor and Doctor of Natural Sciences Hartmut Heine and his colleagues have carried on Pischinger’s work, here summarized in one volume. Part One encompasses theoretical underpinnings; Parts Two and Three address applications and directions for further research. This updated English-language translation not only is an account of the work of Pischinger’s successors—Heine, Otto Bergsmann, and Felix Perger, (the three editors of this volume) and their many colleagues—but notes the positive development of complementary therapies based on this understanding of histology. Acupuncture is referenced directly. Both in Europe and the States the work of manual therapists, including Rolfers, cranio- sacral therapists, and other somatic disciplines have been informed for many years by Pischinger’s outsider model of how changes in the EMC register in the central nervous system and the brain, and are conveyed back to the periphery and connected organs. Heine’s exciting recent work shows that the regulation and construction of the ECM have relationships to cybernetic non-linear systems and phase transitions.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular Matrix: Pathobiology and Signaling

Author : Nikos Karamanos
Publisher : Walter de Gruyter
ISBN 13 : 3110258773
Total Pages : 940 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Extracellular Matrix: Pathobiology and Signaling by : Nikos Karamanos

Download or read book Extracellular Matrix: Pathobiology and Signaling written by Nikos Karamanos and published by Walter de Gruyter. This book was released on 2012-08-31 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

The Tinkerer's Accomplice

Author : J. Scott Turner
Publisher : Harvard University Press
ISBN 13 : 0674057538
Total Pages : 293 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis The Tinkerer's Accomplice by : J. Scott Turner

Download or read book The Tinkerer's Accomplice written by J. Scott Turner and published by Harvard University Press. This book was released on 2010-09-30 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most people, when they contemplate the living world, conclude that it is a designed place. So it is jarring when biologists come along and say this is all wrong. What most people see as design, they say--purposeful, directed, even intelligent--is only an illusion, something cooked up in a mind that is eager to see purpose where none exists. In these days of increasingly assertive challenges to Darwinism, the question becomes acute: is our perception of design simply a mental figment, or is there something deeper at work? Physiologist Scott Turner argues eloquently and convincingly that the apparent design we see in the living world only makes sense when we add to Darwin's towering achievement the dimension that much modern molecular biology has left on the gene-splicing floor: the dynamic interaction between living organisms and their environment. Only when we add environmental physiology to natural selection can we begin to understand the beautiful fit between the form life takes and how life works. In The Tinkerer's Accomplice, Scott Turner takes up the question of design as a very real problem in biology; his solution poses challenges to all sides in this critical debate.

Elastin and Elastases, Volume I

Author : Ladislas Robert
Publisher : CRC Press
ISBN 13 : 1000443426
Total Pages : 325 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Elastin and Elastases, Volume I by : Ladislas Robert

Download or read book Elastin and Elastases, Volume I written by Ladislas Robert and published by CRC Press. This book was released on 2021-05-30 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by internationally known European and American scientists, these volumes systematically present many topics in the elastin and elastases fields. Volume I explains elastin, its biosynthesis, physicochemical properties, and alteration in a variety of pathologies and with aging. Volume II describes elastases, their physiological and pathological roles and their control by natural and synthetic inhibitors. Filled with illustrations and figures, these volumes will benefit researchers, physicians, and industrial scientists.

Biochemistry and Cell Biology of Ageing: Part I Biomedical Science

Author : J. Robin Harris
Publisher : Springer
ISBN 13 : 9811328358
Total Pages : 526 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Biochemistry and Cell Biology of Ageing: Part I Biomedical Science by : J. Robin Harris

Download or read book Biochemistry and Cell Biology of Ageing: Part I Biomedical Science written by J. Robin Harris and published by Springer. This book was released on 2019-02-18 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Extracellular Matrix in Development and Disease

Author : Jeffrey H. Miner
Publisher : Elsevier
ISBN 13 : 9780444518460
Total Pages : 268 pages
Book Rating : 4.5/5 (184 download)

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Book Synopsis Extracellular Matrix in Development and Disease by : Jeffrey H. Miner

Download or read book Extracellular Matrix in Development and Disease written by Jeffrey H. Miner and published by Elsevier. This book was released on 2005-11-18 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules. * Written by leaders in the field * Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer * Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia * Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more

Cell Biology of Extracellular Matrix

Author : E.D. Hay
Publisher : Springer Science & Business Media
ISBN 13 : 9780306439513
Total Pages : 498 pages
Book Rating : 4.4/5 (395 download)

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Book Synopsis Cell Biology of Extracellular Matrix by : E.D. Hay

Download or read book Cell Biology of Extracellular Matrix written by E.D. Hay and published by Springer Science & Business Media. This book was released on 1991-12-31 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Handbook of Proteolytic Enzymes

Author : Alan J. Barrett
Publisher : Academic Press
ISBN 13 : 0123822203
Total Pages : 4097 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Handbook of Proteolytic Enzymes by : Alan J. Barrett

Download or read book Handbook of Proteolytic Enzymes written by Alan J. Barrett and published by Academic Press. This book was released on 2012-10-30 with total page 4097 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. - The only comprehensive book on proteolytic enzymes - Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research - Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases - Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features - Over 1000 peptidases included

Cell-derived Matrices Part A

Author :
Publisher : Academic Press
ISBN 13 : 0128201738
Total Pages : 352 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cell-derived Matrices Part A by :

Download or read book Cell-derived Matrices Part A written by and published by Academic Press. This book was released on 2020-03-26 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-Derived Matrices, Part A, Volume 156, provides a detailed description and step-by-step methods surrounding the use of three-dimensional cell-derived matrices for tissue engineering applications. Biochemical, biophysical and cell biological approaches are presented, along with sample results. Specific chapters cover Anisotropic cell-derived matrices with controlled 3D architecture, Generation of functional fluorescently-labelled cell-derived matrices by means of genetically-modified fibroblasts, Bi-layered cell-derived matrices, Engineering clinically-relevant cell-derived matrices using primary fibroblasts, Decellularized matrices for bioprinting applications, and much more. - Contains contributions from leading experts in the field from across the globe - Covers a wide array of topics on the use of cell-derived matrices for tissue engineering and regenerative medicine applications - Includes relevant, analysis-based topics, such as quantification of the mechanical properties, decellularization protocols, and innovative matrix engineering methods

Plasminogen: Structure, Activation, and Regulation

Author : David M. Waisman
Publisher : Springer Science & Business Media
ISBN 13 : 9780306476990
Total Pages : 322 pages
Book Rating : 4.4/5 (769 download)

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Book Synopsis Plasminogen: Structure, Activation, and Regulation by : David M. Waisman

Download or read book Plasminogen: Structure, Activation, and Regulation written by David M. Waisman and published by Springer Science & Business Media. This book was released on 2003-08-31 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume showcases the most important developments in the area of plasminogen regulation. The book is composed of about 16 chapters dealing with a range of topics including the mechanisms of activation of plasminogen, the structure of plasminogen and plasminogen activators, the role of plasminogen in various physiological and pathological processes (such as tumour growth and progression, wound healing and fibrinolysis) and the interrelationship of the plasmin/MMP proteolytic systems.

Nephrology

Author : Michinobu Hatano
Publisher : Springer
ISBN 13 : 3662351587
Total Pages : 1749 pages
Book Rating : 4.6/5 (623 download)

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Book Synopsis Nephrology by : Michinobu Hatano

Download or read book Nephrology written by Michinobu Hatano and published by Springer. This book was released on 2013-12-01 with total page 1749 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Functional Role for Discoidin Domain Receptor 1 (Ddr1) in the Regulation of Inflammation and Fibrosis During Atherosclerotic Plaque Development

Download A Functional Role for Discoidin Domain Receptor 1 (Ddr1) in the Regulation of Inflammation and Fibrosis During Atherosclerotic Plaque Development PDF Online Free

Author : Christopher Franco
Publisher :
ISBN 13 : 9780494590782
Total Pages : 426 pages
Book Rating : 4.5/5 (97 download)

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Book Synopsis A Functional Role for Discoidin Domain Receptor 1 (Ddr1) in the Regulation of Inflammation and Fibrosis During Atherosclerotic Plaque Development by : Christopher Franco

Download or read book A Functional Role for Discoidin Domain Receptor 1 (Ddr1) in the Regulation of Inflammation and Fibrosis During Atherosclerotic Plaque Development written by Christopher Franco and published by . This book was released on 2009 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagens are abundant components of the extracellular matrix in the atherosclerotic plaque. In addition to contributing to lesion volume and mechanical stability, collagens can influence the behavior of macrophages and smooth muscle cells (SMCs) and have profound effects on both inflammation and fibrosis during lesion development. The aim of this thesis was to define a functional role for the discoidin domain receptor 1 (DDR1), a collagen receptor tyrosine kinase, in murine models of atherogenesis.In our third study, we again utilized bone marrow transplantation to generate mice with deficiency of DDR1 in the host derived tissues such as the vessel wall and uncovered a distinct role for DDR1 expressed on resident vessel wall smooth muscle cells in the regulation of matrix accumulation and fibrous cap formation during atherogenesis. Deficiency of DDR1 in vessel wall cells resulted in robust accumulation of collagen and elastin and resulted in the formation of larger atherosclerotic plaques, with thick fibrous caps.Taken together these studies support a critical role for DDR1 in the development of the atherosclerotic plaque. We demonstrate that DDR1 exerts distinct and opposing effects on lesion size by regulating both monocyte recruitment and matrix accumulation. These studies underscore the importance of collagen signaling during atherogenesis, and identify DDR1 as a key transducer; providing signals that regulate both inflammation and fibrosis during atherogenesis.In our first study, using Ddr1+/+; Ldlr-/- and Ddr1-/-; Ldlr-/- mice fed a high fat diet, we identified DDR1 as a novel positive regulator of atherogenesis. Targeted deletion of DDR1 attenuated atherosclerotic plaque development by limiting inflammation and accelerating matrix accumulation and resulted in the formation of macrophage poor, matrix rich lesions.In the second study, we used bone marrow transplantation to generate chimeric mice with a deficiency of DDR1 in bone marrow derived cells ( Ddr1-/-→+/+) and reveal a central role for macrophage DDR1 in atherogenesis. Deficiency of DDR1 in bone marrow derived cells reduced lesion size by limiting macrophage accumulation in the developing plaque. Moreover using BrdU pulse labeling, we demonstrated reduced monocyte recruitment into the early fatty streak lesions of Ddr1-/-; Ldlr-/- mice.