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Author : Mary Mann-Jong Chang
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (59 download)
Download or read book Regulation of Interleukin-8 Gene Expression in Airway Epithelium written by Mary Mann-Jong Chang and published by . This book was released on 1999 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Loretta Sparkman
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.:/5 (631 download)
Download or read book Nitric Oxide Regulation of Interleukin-8 (IL-8) Gene Expression in Lung Epithelial Cells written by Loretta Sparkman and published by . This book was released on 2004 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cheng-Yuan Kao
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.:/5 (7 download)
Download or read book Molecular Characterization of Human Airway Epithelium Innate Immunity by IL-17 Regulation written by Cheng-Yuan Kao and published by . This book was released on 2005 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ewa Ostrowska
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (246 download)
Download or read book Synergistic Inflammatory Signaling in Airway Epithelial Cells written by Ewa Ostrowska and published by . This book was released on 2008 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jennifer S. Gray
Publisher :
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.3/5 (129 download)
Download or read book Regulation of Interleukin-8 Expression by Deoxynivalenol in U937 Monocytes written by Jennifer S. Gray and published by . This book was released on 2007 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shiva Kumar Bandari
Publisher :
ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (864 download)
Download or read book Regulation of Interleukin-8 (IL-8) Gene Expresssion in THP-1 Cells by Organic Dust written by Shiva Kumar Bandari and published by . This book was released on 2012 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concentrated animal feeding operation (CAFO) has become a common practice in animal production industry due to its efficiency and cost-effectiveness. Workers in CAFOs are exposed to high levels of air-borne dust containing microbial pathogens and organic and inorganic substances and are at a greater risk of developing acute respiratory symptoms and chronic lung diseases. Interleukin-8 (IL-8), a C-X-C chemokine, functions as chemotactic factor for neutrophils and T-cells and plays pivotal roles in innate immunity and inflammation. The aim of this study was to elucidate molecular mechanisms of IL-8 gene regulation by poultry dust in THP-1 monocytic cells. Results of Northern blotting and enzyme linked immunosorbent assays showed that dust extract induced IL-8 mRNA and protein levels in a time- and concentration dependent manner. Nuclear run-on assays and promoter assay by transient transfection indicated that dust extract enhanced IL-8 gene transcription to increase IL-8 mRNA levels. DNA binding and mutational studies revealed that dust extract increased AP-1 and NF-k̳B binding to IL-8 promoter and both AP-1 and NF-k̳B are necessary for the induction of promoter activity. Dust induction of IL-8 expression was associated with the activations of protein kinase C (PKC) and mitogen activated protein kinases (MAPKs) and sensitive to pharmacological inhibitors indicating the importance of PKC and MAPK signal transduction pathways in the induction. Dust treatment increased reactive oxygen species (ROS) levels in THP-1 cells as revealed by dihydroethidium (DHE) labeling. IL-8 mRNA and protein induction was suppressed by the hydroxyl radical scavenger dimethylthiourea indicating the importance of intracellular ROS for the induction. IL-8 induction was not suppressed by polymyxin B indicating that lipopolysaccharide in dust may not contribute to the induction. Dust extract displayed elastase- and trypsin-like activities and protease inhibitors reduced the IL-8 mRNA and protein levels indicating that proteases might play a role in the induction. In summary these studies have shown a. Poultry dust extract enhances AP-1 and NF-k̳B binding to the promoter to increase IL-8 gene transcription leading to increased IL-8 mRNA and protein levels. b. Increased levels of reactive oxygen species and activation of PKC and MAPK signaling pathways mediate dust extract induction of IL-8 expression. c. Lipopolysaccharide in dust extract is not important for IL-8 induction, but protease activity might be important.
Author : Anning Lin
Publisher : CRC Press
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.F/5 ( download)
Download or read book The JNK Signaling Pathway written by Anning Lin and published by CRC Press. This book was released on 2006-02-15 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecular mechanisms that govern cellular functions. The intracellular signaling network, which is composed of many signaling pathways, regulates most, if not all, fundamental cellular activities, from proliferation to programmed cell death (apoptosis). Over the past decade, many signaling pathways have been “mapped’ out. Nowadays, we know in great detail about how a specific signal is transmitted via specific signaling pathways, from the membrane to the nucleus, to change the functions of a cell. In this book, a group of experts present a comprehensive review of one of such signaling pathways, the JNK signaling pathway.
Author :
Publisher :
ISBN 13 :
Total Pages : 1724 pages
Book Rating : 4.E/5 ( download)
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Leonard J. Schiff
Publisher : Springer
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.3/5 (91 download)
Download or read book IN VITRO MODELS OF RESPIRATORY EPITHELIUM written by Leonard J. Schiff and published by Springer. This book was released on 1986-07 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1844 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A.E. Baue
Publisher : Springer Science & Business Media
ISBN 13 : 8847022134
Total Pages : 288 pages
Book Rating : 4.8/5 (47 download)
Download or read book Sepsis and Organ Dysfunction written by A.E. Baue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if in the last years more information on sepsis and new treatments has become available, mortality rate is however high. In fact, the complexity of the several biohumoral factors involved in this process is difficult to understand. Another major problem is the consequent organ failure, which grows in a sequential way and in relation with the lesion gravity and the functional reserves of the patient. The volume presents the most recent results of research in this field.
Author : Michael B. Sporn
Publisher : Academic Press
ISBN 13 : 0323141617
Total Pages : 441 pages
Book Rating : 4.3/5 (231 download)
Download or read book The Retinoids written by Michael B. Sporn and published by Academic Press. This book was released on 2012-12-02 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring retinoids. A discussion on the relationships between structure and activity of retinoids is included. The last chapter addresses the role of vitamin A in animal and human nutrition. This volume also discusses the metabolism of vitamin A in normal and disease states, as well as its interaction with hormones, micronutrients, drugs, and alcohol. This volume is an ideal source for nutritionists, clinicians, and researchers who are interested in the progressing field of retinoid research.
Author :
Publisher :
ISBN 13 :
Total Pages : 1810 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : D.F. Rogers
Publisher : Springer Science & Business Media
ISBN 13 : 9783764356910
Total Pages : 408 pages
Book Rating : 4.3/5 (569 download)
Download or read book Airway Mucus: Basic Mechanisms and Clinical Perspectives written by D.F. Rogers and published by Springer Science & Business Media. This book was released on 1997-09-23 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of respiratory secretions. The clinical aspects of the topic are then considered, with chapters discussing the involvement of mucus secretions in bacterial infection and in hypersecretory diseases of the airway. The volume concludes with a discussion of the therapeutic aspects of the topic, both in terms of the possible approaches to the treatment of mucus hypersecretion and the interaction of these drugs with airway mucus. Written by leading experts in the field, each contribution provides a comprehensive review of its particular subject. Reflecting the latest advances in this important area of respiratory research, this volume will be of great interest to scientists and clinicians working in the field of airway secretions and related areas.
Author : Gennaro Ciliberto
Publisher : CRC Press
ISBN 13 : 9780203904244
Total Pages : 392 pages
Book Rating : 4.9/5 (42 download)
Download or read book Cytokine Inhibitors written by Gennaro Ciliberto and published by CRC Press. This book was released on 2000-11-14 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of
Author : Surendran Mahalingam
Publisher : Springer Science & Business Media
ISBN 13 : 9780306482342
Total Pages : 140 pages
Book Rating : 4.4/5 (823 download)
Download or read book Chemokines in Viral Infections written by Surendran Mahalingam and published by Springer Science & Business Media. This book was released on 2004-10-14 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past five years, a large number of new chemokines and chemokine receptors have been identified. Alarming progress in the areas of bioinformatics and expressed sequence tag (EST) databases attributed to this development. Recent discoveries provide compelling evidences supporting the roles of these messengers and their receptors in the control of viral infection as well as in aiding virus survival. Chemokines in Viral Infections is the first to provide a comprehensive write up on the various evidences available to date on the interactions between host chemokine system and viral chemokines. This book intends to unravel the chemokine constellation in the context of viral infections, a versatility that was not fully understood five years ago. This book is excellent reading material and will be of interest to research scientists, clinicians and postgraduate students.
Author : John E. Bennett, MD, MACP
Publisher : Elsevier Health Sciences
ISBN 13 : 1455748013
Total Pages : 5094 pages
Book Rating : 4.4/5 (557 download)
Download or read book Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases written by John E. Bennett, MD, MACP and published by Elsevier Health Sciences. This book was released on 2014-08-28 with total page 5094 pages. Available in PDF, EPUB and Kindle. Book excerpt: After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you'll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.
