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Regulation And Function Of Transcription Factor Mef2c In Vascular Development
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Book Synopsis The Growth Plate by : Irving M. Shapiro
Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
Book Synopsis Regulation and Function of Transcription Factor MEF2C in Vascular Development by : Joshua Anderson
Download or read book Regulation and Function of Transcription Factor MEF2C in Vascular Development written by Joshua Anderson and published by . This book was released on 2005 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood vessel development in vertebrates starts early during embryogenesis with the de novo formation of blood vessels through the process of vasculogenesis. During vasculogenesis, endothelial progenitor cells coalesce into tubular structures. Pericytes and smooth muscle cells then surround these tubes to form functioning blood vessels. Myocyte enhancer factor 2 (MEF2) transcription factors have been shown to play a critical role in the differentiation of cardiac and skeletal muscle. MEF2C is also expressed in several other cell types, including smooth muscle and endothelial cells, yet little is known about the transcriptional pathways in which MEF2C participates, particularly during vascular development. Before the research contained within this dissertation, no transcriptional targets of MEF2 proteins had been discovered in smooth muscle. However, we found a completely conserved MEF2 site upstream of the HRC transcriptional start site that proved to be necessary for expression of a lacZ transgene in skeletal, cardiac, and arterial smooth muscle; identifying HRC as the first known target gene of MEF2 in smooth muscle. We also found that this HRC enhancer was unresponsive to serum response factor (SRF), making HRC one of only a few smooth muscle genes known not to be a transcriptional target of SRF. To understand the transcriptional pathways that MEF2C participates in, we initiated an enhancer screen and used evolutionary conservation to identify multiple tissue-specific modular enhancers for mef2c . In this screen, we identified a skeletal muscle enhancer, an anterior heart field enhancer, three neural crest enhancers, and two endothelial enhancers at the mef2c locus. One of the enhancer fragments we discovered was a 5.6 Kb fragment that is sufficient to direct expression to both the neural crest and endothelium. We have subsequently separated the neural crest and endothelial elements into two independent enhancers and pared down the endothelial element to a mere 44 base pairs, which are both necessary and sufficient to direct expression of the lacZ reporter to endothelial cells. Within this 44 bp we have found two ETS factor binding sites and an E-Box that are necessary for endothelial expression, and we continue to search for other regulatory elements.
Book Synopsis Cellular and Molecular Pathobiology of Cardiovascular Disease by : Monte Willis
Download or read book Cellular and Molecular Pathobiology of Cardiovascular Disease written by Monte Willis and published by Academic Press. This book was released on 2013-12-23 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Book Synopsis Muscle Development in Drosophilia by : Helen Sink
Download or read book Muscle Development in Drosophilia written by Helen Sink and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Book Synopsis Genomic Control Process by : Isabelle S. Peter
Download or read book Genomic Control Process written by Isabelle S. Peter and published by Academic Press. This book was released on 2015-01-21 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life - Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework - Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature - Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type - Demonstrates the causal power of system-level understanding of genomic control process - Conceptually organizes a constellation of complex and diverse biological phenomena - Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models - Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
Book Synopsis Genetics of Bone Biology and Skeletal Disease by : Rajesh V. Thakker
Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Book Synopsis Cardiac Regeneration by : Masaki Ieda
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Book Synopsis Stem Cells in Reproductive Medicine by : Carlos Simón
Download or read book Stem Cells in Reproductive Medicine written by Carlos Simón and published by Cambridge University Press. This book was released on 2013-07-04 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.
Book Synopsis Myogenesis in Development and Disease by :
Download or read book Myogenesis in Development and Disease written by and published by Academic Press. This book was released on 2018-01-03 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myogenesis in Development and Disease, Volume 126, the latest volume in the Current Topics in Developmental Biology series, covers major topics of research in myogenesis, with a particular emphasis on regeneration and muscle disease. It includes contributions from an international board of authors, providing a comprehensive set of reviews. Covers major topics of research in myogenesis Contains invaluable contributions from an international board of authors Provides a comprehensive set of reviews
Book Synopsis Molecular and Functional Insights Into the Pulmonary Vasculature by : Kaushik Parthasarathi
Download or read book Molecular and Functional Insights Into the Pulmonary Vasculature written by Kaushik Parthasarathi and published by Springer. This book was released on 2018-01-09 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
Book Synopsis Transcriptional Control of Neural Crest Development by : Brian L. Nelms
Download or read book Transcriptional Control of Neural Crest Development written by Brian L. Nelms and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies
Book Synopsis Development of the Cerebellar System by : Joseph Altman
Download or read book Development of the Cerebellar System written by Joseph Altman and published by CRC Press. This book was released on 1997 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an outstanding presentation of what happens during normal cerebellar development.
Book Synopsis The Development of the Vascular System by : Richard N. Feinberg
Download or read book The Development of the Vascular System written by Richard N. Feinberg and published by S. Karger AG (Switzerland). This book was released on 1991 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heart Development and Disease by : Benoit G. Bruneau
Download or read book Heart Development and Disease written by Benoit G. Bruneau and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved. Topics covered in this essential volume include: - Anatomy of a Developing Heart - Genetic and Epigenetic Control of Heart Development - Development of the Cardiac Conduction System - Genetic Basis of Human Congenital Heart Disease - In Vivo and In Vitro Genetic Models of Congenital Heart Disease
Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Book Synopsis Development of the Cardiac Conduction System by : Derek J. Chadwick
Download or read book Development of the Cardiac Conduction System written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2005-01-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.
Book Synopsis Rutter's Child and Adolescent Psychiatry by : Anita Thapar
Download or read book Rutter's Child and Adolescent Psychiatry written by Anita Thapar and published by John Wiley & Sons. This book was released on 2015-06-15 with total page 1109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rutter's Child and Adolescent Psychiatry is the leading textbook in its field. Both interdisciplinary and international, it provides a coherent appraisal of the current state of the field to help researchers, trainees and practicing clinicians in their daily work. Integrating science and clinical practice, it is a comprehensive reference for all aspects of child and adolescent psychiatry. New to this full color edition are expanded coverage on classification, including the newly revised Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and new chapters on systems neuroscience, relationship-based treatments, resilience, global psychiatry, and infant mental health. From an international team of expert editors and contributors, this sixth edition is essential reading for all professionals working and learning in the fields of child and adolescent mental health and developmental psychopathology as well as for clinicians working in primary care and pediatric settings. Michael Rutter has contributed a number of new chapters and a Foreword for this edition: "I greatly welcome this new edition as providing both a continuity with the past and a substantial new look." —Professor Sir Michael Rutter, extract from Foreword. Reviews of previous editions: "This book is by far the best textbook of Child & Adolescent Psychiatry written to date." —Dr Judith Rapoport, NIH "The editors and the authors are to be congratulated for providing us with such a high standard for a textbook on modern child psychiatry. I strongly recommend this book to every child psychiatrist who wants a reliable, up-to-date, comprehensive, informative and very useful textbook. To my mind this is the best book of its kind available today." —Journal of Child Psychology and Psychiatry
