Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Regioselective Iridium Catalyzed C H Activation Borylation Of 2 Substituted Indoles full books in PDF, epub, and Kindle. Read online Regioselective Iridium Catalyzed C H Activation Borylation Of 2 Substituted Indoles ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Sulagna Paul
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.3/5 (129 download)
Download or read book Regioselective Iridium Catalyzed C-H Activation/borylation of 2-substituted Indoles written by Sulagna Paul and published by . This book was released on 2007 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jose Raul Montero Bastidas
Publisher :
ISBN 13 :
Total Pages : 879 pages
Book Rating : 4.5/5 (381 download)
Download or read book Overcoming Regioselectivity Challenges in Iridium Catalyzed C-h Borylation Via Noncovalent Interactions and Advances on Cross Coupling Reactions of Aryl Imidazolylsulfonates written by Jose Raul Montero Bastidas and published by . This book was released on 2021 with total page 879 pages. Available in PDF, EPUB and Kindle. Book excerpt: Direct functionalization of C0́2H bonds reduces the number of synthetic steps for a target molecule enhancing efficiency and avoiding undesired waste material. Iridium catalyzed C-H activation-borylation (CHB) is an established method to access aryl boronic esters. Regioselectivity challenges can arise when multiple hydrogens are present in the molecule. This thesis describes the design of novel strategies to selective direct the CHB to one specific position.Ortho selective CHB has the challenge to go against the traditional CHB selectivity dictated by steric effects. Previously, our group reported a strategy for highly ortho-selective CHB of anilines by using a small B2eg2 (eg = ethanediol) as the borylating reagent. However, the products were unstable and transesterification with pinacol was needed. Chapter 2 builds upon this issue and presents a solution based on the modulation of the size of the boron partner. Small diboron partners retain the high ortho regioselectivity for CHB of aniline but larger borylating reagents generate more stable products. In our estimation, B2bg2 (bg = 1,2-butanediol) represents the best balance of reactivity, regioselectivity and stability.Remote functionalization including para selective reactions are difficult because a potential directing group would be far from the desired reactive site. Chapter 3 details how para CHB of tetraalkylammonium sulfates and sulfamates have been achieved using bipyridine-ligated Ir boryl catalysts. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C8́2H bonds in the counteranions, is proposed to account for para selectivity. The 4,4'-dimethoxy-2,2'-bipyridine ligand gave superior selectivities.The next chapter describes how intramolecular hydrogen bonding (IMHB) can lead to steric shielding effects that can direct CHB regiochemistry. Bpin/arene IMHB can promote remote borylations of N-borylated anilines, 2-amino-N-alkylpyridine, tetrahydroquinolines, indoles and 1-borylated naphthalenes. Our studies support molecular geometries with the Bpin orientation controlled by a C-H0́Ø0́Ø0́ØO IMHB. Calculated rotation barriers to displace the Bpin group are above 4 kcal/mol, suggesting that the planar ground conformation of the borylated arenes is retained during CHB. This study informs researchers to evaluate not only inter- but also intramolecular noncovalent interactions as potential drivers of remote CHB regioselectivity.The borylated products from CHB can be further manipulated in Suzuki-Miyaura cross-coupling (SMC) with aryl halides as the typical electrophilic partner. Aryl imidazolylsulfonates are nongenotoxic electrophiles that can be used in palladium catalyzed SMC to avoid halogenated materials. Chapter 5 shows the efforts towards a nickel-catalyzed SMC of aryl imidazolyl-sulfonates. Results show considerable amounts of the corresponding diarylsulfate formed during the reaction. Interestingly, the diaryl sulfa byproducts were found to be competent electrophilic partners for both palladium and nickel-catalyzed SMC.In summary, this thesis presents novel methodologies to access challenging transformations as the para borylations of phenols, anilines and benzyl alcohols. This was possible by the analysis of the different components of the catalytic system: design of ligands, diboron partners and substrate directing groups and how they interact during the reaction. Finally, the potential of aryl imidazolylsulfonates as nongenotoxic pseudohalides in nickel-catalyzed SMC was evaluated.
Author : Pher G. Andersson
Publisher : Springer Science & Business Media
ISBN 13 : 364215333X
Total Pages : 244 pages
Book Rating : 4.6/5 (421 download)
Download or read book Iridium Catalysis written by Pher G. Andersson and published by Springer Science & Business Media. This book was released on 2011-01-05 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the contents: Robert H Crabtree: Introduction and History. - Montserrat Diéguez, Oscar Pàmies and Carmen Claver: Iridium-catalysed hydrogenation using phosphorous ligands. - David H. Woodmansee and Andreas Pfaltz: Iridium Catalyzed Asymmetric Hydrogenation of Olefins with Chiral N,P and C,N Ligands. - Ourida Saidi and Jonathan M J Williams: Iridium-catalyzed Hydrogen Transfer Reactions. - John F. Bower and Michael J. Krische: Formation of C-C Bonds via Iridium Catalyzed Hydrogenation and Transfer Hydrogenation. - Jongwook Choi, Alan S. Goldman: Ir-Catalyzed Functionalization of CH Bonds. - Mark P. Pouy and John F. Hartwig: Iridium-Catalyzed Allylic Substitution. - Daniel Carmona and Luis A. Oro: Iridium-catalyzed 1.3-dipolar cycloadditions.
Author : Debabrata Maiti
Publisher : John Wiley & Sons
ISBN 13 : 3527346678
Total Pages : 450 pages
Book Rating : 4.5/5 (273 download)
Download or read book Remote C-H Bond Functionalizations written by Debabrata Maiti and published by John Wiley & Sons. This book was released on 2021-04-26 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to contemporary advancements in the field of distal C-H functionalizations An important and dynamic topic within the modern field of organic synthesis, selective functionalization of C-H bonds can be used in a variety of applications across the pharmaceutical and agrochemical industries. Remote C-H Bond Functionalizations presents an inclusive account of the most recent developments and potential applications of performing variegated functionalizations selectively at the distal positions of organic compounds. Featuring contributions by an international team of experts, this authoritative volume provides deep insight into distal functionalizations, including detailed discussion of mechanisms, the engineering of templates, and the design of strategies. The text covers a diverse range of topics including C-H functionalization of palladium/norbornene catalysis, ruthenium-catalyzed remote functionalization, the non-directed distal C(sp2)-H, functionalization, transition metal catalyzed distal para-selective C-H functionalization, and much more. Reviewing contemporary advancements in the field while laying the foundation for future research, this important resource: Provides the most recent research and thorough coverage of the subject available in a single volume Offers practical information on C-H functionalizations in various industries Includes an up-to-date introduction to distal C-H functionalizations Remote C-H Bond Functionalizations is a must-read for every synthetic chemist, including chemists working with organometallics, organic chemists and researchers, and industrial chemists.
Author : Carmen Claver
Publisher : Springer
ISBN 13 : 3319666657
Total Pages : 288 pages
Book Rating : 4.3/5 (196 download)
Download or read book Rhodium Catalysis written by Carmen Claver and published by Springer. This book was released on 2017-12-15 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbrev iated as Top Organomet Chem and cited as a journal.
Author : Fangyi Shen
Publisher :
ISBN 13 : 9781088311219
Total Pages : 163 pages
Book Rating : 4.3/5 (112 download)
Download or read book Allied Studies on Total Sythesis of Cyclic Tripeptide Tmc-95 Via an Iridium Catalyzed Borylation/deborylation Strategy and Teaching Organic Chemistry in "words" written by Fangyi Shen and published by . This book was released on 2019 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arylboronate esters are versatile synthetic building blocks. Iridium catalyzed C-H activation/borylation reactions are a green way of making such building blocks as these reactions often obviate the need for prior functionalization (e.g. halogenation), the use of pyrophoric reagents, cryogenic conditions, etc. Installation of multiple boron substituents about the starting arene and then Ir catalyzed selective deborylation of the individual borons can allow for the formation of an even greater diversity of borylated building blocks.The regioselectivity of Ir-catalyzed borylation is usually driven by sterics, however heterocycles are known to borylated at positions that exhibit heightened C-H acidity through the influence of the heteroatom. The regioselective borylation attained with a tryptophan derivative has been utilized in the development of a novel convergent route to the TMC-95 core. While pursuing a model synthesis of this natural product, the ability of bismuth salts to catalyze deborylations was discovered. These bismuth salts mediated methods can be highly selective in the in the deborylation of di and triborylated indoles. Furthermore, bismuths compounds are safe and less expensive as compared to the Ir-catalysts that facilitated deborylation. Numerous screening experiments on both substrates and other metal salts afforded a better understanding of how these novel deborylations can be applied in various synthetic settings and provided insight into possible mechanisms.Also, while I was a teaching assistant and a fixed-term instructor during my graduate studies at Michigan State University, I gradually realized that teaching is my passion and I am prepared to start my independent career and be an independent thinking teacher for the organic chemistry area.Owing to the nature of the subject, organic chemistry can be very visually distracting, and the image can be overpowering during student's learning. Like it or not students will try memorization first, our hypothesis is that once they know the "organic transformation formula" in words, via memorization or any other method, then introducing them to the structures of these functional groups will come with added context, and once they make that jump from word to structure they will be in a better position to understand reaction mechanisms. More importantly, understanding those reaction mechanisms will enable the student to progress to more complex topics.By introducing functional group transformations without the "clutter" of structures, we predict that once structures are introduced students will prioritize what's important because they will have trained their minds to ask what is the functional group, not "where did I see that structure in my notes".In short, we aim to train students to focus their attention on the reactive functional group of an organic molecule by emphasizing the use of WORDS to describe functional group transformation and teach the organic chemistry as the second language.
Author : Pierre H. Dixneuf
Publisher : Springer
ISBN 13 : 3319246305
Total Pages : 269 pages
Book Rating : 4.3/5 (192 download)
Download or read book C-H Bond Activation and Catalytic Functionalization I written by Pierre H. Dixneuf and published by Springer. This book was released on 2015-12-18 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal.
Author : Uwe Schneider
Publisher : Royal Society of Chemistry
ISBN 13 : 178801118X
Total Pages : 431 pages
Book Rating : 4.7/5 (88 download)
Download or read book Catalysis with Earth-abundant Elements written by Uwe Schneider and published by Royal Society of Chemistry. This book was released on 2020-10-30 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering the limited resources of our planet, earth-abundant elements will have to be explored increasingly in the future. This book highlights the uses of the most earth-abundant elements in catalysis and will be of interest to graduates, academic researchers and practitioners in catalysis.
Author : Françoise Colobert
Publisher : John Wiley & Sons
ISBN 13 : 3527343407
Total Pages : 294 pages
Book Rating : 4.5/5 (273 download)
Download or read book C-H Activation for Asymmetric Synthesis written by Françoise Colobert and published by John Wiley & Sons. This book was released on 2019-11-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Author : Aaron Gabriel Green
Publisher :
ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (869 download)
Download or read book Computational Studies of Iridium-catalyzed Borylation Reactions and Defying Torquoselectivity in Cyclobutene Ring-opening Via Strain-induced Thermal Selectivity written by Aaron Gabriel Green and published by . This book was released on 2013 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The studies reported in this dissertation illustrate a few selected examples of using density functional theory (DFT) calculations to investigate various aspects of iridium-catalyzed reactions and ring-opening of bicyclic cyclobutene rings. These computational predictions not only reproduce and explain experimental results and offer insights to reaction mechanisms, but also provide theoretical models to predict reactivity, regio- and stereoselectivities. Chapter 1 is a review surveying the literature of iridium-catalyzed borylation reactions. Emphasis is placed on iridium-catalyzed borylation of alkenes and arenes. In particular, I discuss the history leading up to the current catalyst systems for iridium-catalyzed borylation reactions, and regioselectivity of borylation for a number of different substrates. Despite the large amount of work on iridium-catalyzed borylation reactions, this review shows that there is still much to be understood regarding the origins of observed regioselectivities. Chapters 2 and 3 describe theoretical investigations of Ir(III)-catalyzed borylation reactions. The origins of regioselectivities observed in the borylation of pyridine are discussed in Chapter 2. The high selectivity for borylation at the 3- and 4- position of pyridine is attributed to the formation of a Lewis acid-base complex between pyridine and either boron species or iridium species in solution. The origins of regioselectivities for the iridium-catalyzed borylation of substituted arenes and 5-membered heterocycles are discussed in Chapter 3. The distortion/interaction model was employed to understand the origins of the selectivities in these reactions. Computations revealed that regioselectivity is mainly controlled by differences in the interaction energies between the iridium catalyst and arene carbon. Chapter 4 illustrates a theoretical study of ring-opening in strained, trans-substituted cyclobutenes. The torquoselectively preferred outward ring-opening products are unable to form due to ring strain inherent in 9- and 10-membered macrocyclic (E, E)-1,3-dienes. As a result of this study, I propose a general methodology for stereoselective synthesis of macrocyclic (Z, Z)-1,3-dienes termed strain-induced thermal selectivity (SITS).
Author : Yasushi Nishihara
Publisher : Springer Science & Business Media
ISBN 13 : 3642323685
Total Pages : 247 pages
Book Rating : 4.6/5 (423 download)
Download or read book Applied Cross-Coupling Reactions written by Yasushi Nishihara and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Author : Ghayoor Abbas Chotana
Publisher :
ISBN 13 :
Total Pages : 596 pages
Book Rating : 4.3/5 (129 download)
Download or read book Iridium Catalyzed Aromatic Borylation and Its Applications in One-pot Preparations of Substituted Aromatic Building Blocks written by Ghayoor Abbas Chotana and published by . This book was released on 2009 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Norio Miyaura
Publisher : Springer
ISBN 13 : 354045313X
Total Pages : 253 pages
Book Rating : 4.5/5 (44 download)
Download or read book Cross-Coupling Reactions written by Norio Miyaura and published by Springer. This book was released on 2003-07-01 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998).
Author : Luis A. Oro
Publisher : Springer Nature
ISBN 13 : 3030690830
Total Pages : 461 pages
Book Rating : 4.0/5 (36 download)
Download or read book Iridium Catalysts for Organic Reactions written by Luis A. Oro and published by Springer Nature. This book was released on 2021-03-29 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume “Iridium Catalysts for Organic Reactions” in the series “Topics in Organometallic Chemistry” intends to update several representative well-known reactions and to introduce other less known or new reactions in particular covering sustainability aspects. Iridium complexes are efficient in many catalytic homogeneous transformations providing high efficiency in both results, activity and selectivity. The interest of the book lies in the presentation of the advances, new perspectives and application in a variety of representative iridium-catalysed reaction. All chapters in the volume are contributed by relevant international experts in the field. The book is aimed at researchers, graduate students and synthetic chemists at all levels in academia and industry.
Author : Dennis G. Hall
Publisher : John Wiley & Sons
ISBN 13 : 3527606823
Total Pages : 571 pages
Book Rating : 4.5/5 (276 download)
Download or read book Boronic Acids written by Dennis G. Hall and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, the whole field of organoboronic acids is presented in one comprehensive handbook. Professor Dennis Hall, a rising star within the community, covers all aspects of this important substance class, including applications in chemistry, biology and medicine. Starting with an introduction to the structure, properties, and preparation of boronic acid derivatives, together with an overview of their reactions and applications, the book goes on to look at metal-catalyzed borylation of alkanes and arenas, coupling reactions and rhodium-catalyzed additions of boronic acids to alkenes and carbonyl compounds. There follows chapters on copper-promoted C-O and C-N cross-coupling of boronic acids, recent applications in organic synthesis, as well as alpha-haloalkylboronic esters in asymmetric synthesis. Later sections deal with cycloadditions, organoboronic acids, oxazaborolidines as asymmetric inducers, and boronic acid based receptors and sensors. The whole is rounded off with experimental procedures, making this invaluable reading for organic, catalytic and medicinal chemists, as well as those working in organometallics.
Author : Venkata Apparao Kallepalli
Publisher :
ISBN 13 : 9781124379562
Total Pages : 157 pages
Book Rating : 4.3/5 (795 download)
Download or read book Iridium Catalyzed C-H Activation/borylation of Aromatic/heteroaromatic Substrates and Its Application in Small Molecule Synthesis written by Venkata Apparao Kallepalli and published by . This book was released on 2010 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kristin Anne Gore
Publisher :
ISBN 13 : 9781369755664
Total Pages : 290 pages
Book Rating : 4.7/5 (556 download)
Download or read book Iridium Catalyzed C-H Borylation written by Kristin Anne Gore and published by . This book was released on 2017 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
