Reflectance Confocal Microscopy of Cutaneous Tumors

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Publisher : CRC Press
ISBN 13 : 1498757626
Total Pages : 849 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Reflectance Confocal Microscopy of Cutaneous Tumors by : Salvador Gonzalez

Download or read book Reflectance Confocal Microscopy of Cutaneous Tumors written by Salvador Gonzalez and published by CRC Press. This book was released on 2017-07-06 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflectance confocal microscopy enables lesions in skin to be examined without excision, but with improved diagnostic accuracy, assessment of dermoscopic-histologic correlation, assessment of surgical margins, as well as speed and convenience for the physician and patient. This extensively enlarged and updated text reviews the current and future state of the art for those involved with the diagnosis and treatment of skin tumors, with a greatly increased amount of material on the expected normal patterns of skin throughout life and on non-melanocytic tumors.

Reflectance Confocal Microscopy of Cutaneous Tumors

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Author :
Publisher : CRC Press
ISBN 13 : 9780415451048
Total Pages : 280 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Reflectance Confocal Microscopy of Cutaneous Tumors by : Salvador Gonzalez

Download or read book Reflectance Confocal Microscopy of Cutaneous Tumors written by Salvador Gonzalez and published by CRC Press. This book was released on 2008-03-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: With 1.4 million cases of skin cancer reported in the USA each year there is increasing emphasis on early and accurate diagnosis. In Vivo Reflectance Confocal Microscopy is the latest technology being developed to meet these needs: it allows optical sectioning of an area of skin without the need for physical sectioning and could thus be ideal for dermatologists wishing to examine detailed features of a skin lesion without troubling the patient for a biopsy specimen. It has further potential also, for dermatopathologists needing to determine the best location for a section and for dermatological surgeons needing to determine the margins of a lesion to be excised. This comprehensive full-colour atlas – the first available – sets out the potential of the technology and its possible applications for the clinical practitioners involved in the diagnosis and treatment of skin cancers.

Reflectance Confocal Microscopy for Skin Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 3642219977
Total Pages : 484 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Reflectance Confocal Microscopy for Skin Diseases by : Rainer Hofmann-Wellenhof

Download or read book Reflectance Confocal Microscopy for Skin Diseases written by Rainer Hofmann-Wellenhof and published by Springer Science & Business Media. This book was released on 2012-02-07 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the use and significance of in vivo reflectance confocal microscopy (RCM) for non-invasive high-resolution imaging of the skin. All of the chapters in this hands-on guide are generously illustrated with numerous confocal images and structured in a reader-friendly way. The contents include detailed information on the most relevant and up-to-date aspects of RCM, schematic drawings summarizing and explaining the most important RCM criteria, and a chapter specifically devoted to bridging the gap between dermoscopy, RCM, and histopathology. At the end of each chapter, core messages recapitulate the most pertinent aspects. Reflectance Confocal Microscopy for Skin Diseases will be a valuable resource for all physicians involved in the diagnosis and treatment of neoplastic and inflammatory skin diseases.

Technology in Practical Dermatology

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Publisher : Springer Nature
ISBN 13 : 3030453510
Total Pages : 484 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Technology in Practical Dermatology by : Michele Fimiani

Download or read book Technology in Practical Dermatology written by Michele Fimiani and published by Springer Nature. This book was released on 2020-06-27 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a complete overview on the latest available technologies in dermatology, while discussing future trends of this ever-growing field. This handy guide provides clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today. It also includes a section on imaging techniques for the evaluation of skin tumors, with chapters devoted to dermoscopy, in vivo and ex vivo reflectance confocal microscopy, high frequency ultrasound, optical coherence tomography, and a closing part on latest approaches to wound management. Completed by over 200 clinical images, Current Technology in Practical Dermatology: Non-Invasive Imaging, Lasers and Ulcer Management is both a valuable tool for the inpatient dermatologist and for physicians, residents, and medical students in the field.

Atlas of Dermatology, Dermatopathology and Venereology

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Author :
Publisher : Springer
ISBN 13 : 9783319538105
Total Pages : 0 pages
Book Rating : 4.5/5 (381 download)

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Book Synopsis Atlas of Dermatology, Dermatopathology and Venereology by : Bruce Smoller

Download or read book Atlas of Dermatology, Dermatopathology and Venereology written by Bruce Smoller and published by Springer. This book was released on 2021-10-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together thousands of the best dermatologic clinical and pathological photographs and figures from researchers and scientists around the world, this volume focuses on the most prevalent dermatologic disorders as they relate to cutaneous infectious and neoplastic conditions and procedural dermatology. It includes atypical presentations of various disorders, giving insight into differential diagnoses, helping to familiarize the reader with some of the rarest dermatologic disorders. Atlas of Dermatology, Dermatopathology and Venereology Volume 3 is written for dermatologists, dermatopathologists, and residents and summarizes data regarding any dermatologic disorder and syndrome. Each entry includes an introduction, clinical and pathological manifestations, diagnosis, differential diagnosis, and treatment and prognosis. div>/div/div/div

Imaging in Dermatology

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Publisher : Academic Press
ISBN 13 : 0128028599
Total Pages : 562 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Imaging in Dermatology by : Michael R. Hamblin

Download or read book Imaging in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-07-29 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging in Dermatology covers a large number of topics in dermatological imaging, the use of lasers in dermatology studies, and the implications of using these technologies in research. Written by the experts working in these exciting fields, the book explicitly addresses not only current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today, along with the cellular and molecular effects of these technologies. Outlines the fundamentals of imaging and lasers for dermatology in clinical and research settings Provides knowledge of current and future applications of dermatological imaging and lasers Coherently structured book written by the experts working in the fields covered

Usefulness of in Vivo Reflectance Confocal Microscopy and Automated Videomosaics in the Treatment and Management of Skin Cancers

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Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (122 download)

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Book Synopsis Usefulness of in Vivo Reflectance Confocal Microscopy and Automated Videomosaics in the Treatment and Management of Skin Cancers by : Oriol Yélamos i Pena

Download or read book Usefulness of in Vivo Reflectance Confocal Microscopy and Automated Videomosaics in the Treatment and Management of Skin Cancers written by Oriol Yélamos i Pena and published by . This book was released on 2019 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Skin cancer is major health problem due to its increased incidence in the last decades. Standard treatment of skin cancer is still surgery, which can be challenging to perform since most skin cancers are located in visible areas such as the face. Hence, methods to improve skin cancer treatment and minimize scarring are crucial. In this sense, non-invasive imaging technologies can be of great help in determining the margins of skin cancers prior to their treatment, as well as they offer a great opportunity to monitor its treatment and detect early relapses. Reflectance confocal microscopy (RCM) is one of this non-invasive imaging technologies which has cellular resolution and has shown to have high diagnostic accuracy for different types of skin cancers such as keratinocyte carcinomas, melanomas or Paget disease. Currently two RCM microscopes are commercially available: 1) a wide-probe microscope which requires attaching a metal/plastic ring on the skin to obtain image mosaics up to 8 x 8 mm; 2) a handheld RCM (HRCM) microscope which allows free imaging along the skin with a field of view which ranges from 0.75 to 1 mm. HRCM has the advantage that permits imaging areas larger than 8 x 8 mm by navigating over the skin but lacks mosaicking capabilities in its native software, making orientation complicated. However, it is intuitive to think that HRCM is the ideal tool to predefine the margins of skin cancers and to monitor its responses to treatment due to its versatility, especially when the size of tumor is larger than 8 mm. The goal of the current thesis was to develop a computer algorithm to obtain static 2D mosaics obtained from dynamic videos obtained with HRCM, and to apply this technique to address some of the challenges that physicians encounter when managing skin cancers, such as defining the skin cancer margins prior to surgery (particularly important in some skin cancers such as lentigo maligna [LM] which have ill-defined margins), identifying residual tumor directly in the surgical wound, and identifying small foci of tumor in recurrent or persistent skin cancers which present in a patchy fashion such as extramammary Paget's disease (EMPD). The research for this thesis resulted in 5 publications summarized herein. The first publication describes the videomosaicking algorithm as well as clinical to showcase how this algorithm can be used not only in RCM but in other microscopic imaging systems. The second publication applies the videomosaicking algorithm to delineate the preoperative margins in a consecutive series of 23 LM/LM melanoma, showing that the HRCM with videomosaicking can correctly predict the surgical defect after staged excision with minimal variations. In the third publication, HRCM was used to identify persistence or recurrence of EMPD after different treatments. Here, the videomosaicking algorithm was used in some of the patients and showed that the diagnostic accuracy improved when videomosaics were added to the conventional HRCM examination. In the fourth and fifth publications HRCM and videomosaics were used to image directly in the surgical wound after treating keratinocyte carcinomas (after laser ablation in the 4th publication, and after Mohs surgery in the 5th publication), showing it is possible to identify residual tumor using HRCM and videomosaics directly inside the surgical wound.In summary, this thesis shows how videomosaics expand the usefulness of HRCM in skin cancer management and overcome its main challenges by expanding the field of view and obtaining architectural information which is crucial when evaluating microscopic images." -- TDX.

Confocal Microscopy, An Issue of Dermatologic Clinics

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Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323463096
Total Pages : 242 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Confocal Microscopy, An Issue of Dermatologic Clinics by : Jane M. Grant-Kels

Download or read book Confocal Microscopy, An Issue of Dermatologic Clinics written by Jane M. Grant-Kels and published by Elsevier Health Sciences. This book was released on 2016-10-03 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Dermatologic Clinics, guest edited by Jane M. Grant-Kels, Giovanni Pellacani, and Caterina Longo, is devoted to Confocal Microscopy. Articles in this timely issue include: Basics of Confocal Microscopy and the Complexity of Diagnosing Skin Tumors: New Imaging Tools in Clinical Practice, Diagnostic Workflows, Cost-estimate and New Trends; Opening a Window Into Living Tissue: Histopathologic Features of Confocal Microscopic Findings in Skin Tumors; Addressing the Issue of Discriminating Nevi from Early Melanomas: Dues and Pitfalls; Melanoma Types and Melanoma Progression: The Different Faces; Lentigo Maligna, Macules of the Face and Lesions on Sun-damaged Skin: Confocal makes the Difference; Glowing in the dark: use of confocal microscopy in dark pigmented lesions; Enlightening the Pink: Use of Confocal Microscopy in Pink Lesions; Shining into the White: The Spectrum of Epithelial Tumors from Actinic Keratosis to SCC; Application of Wide-probe and Handy-probe for Skin Cancer Diagnosis: Pros and Cons; Confocal Microscopy for Special Sites and Special Uses; Confocal Algorithms for Inflammatory Skin Diseases and Hair Diseases; In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs’ Surgeons; Telediagnosis with Confocal Microscopy: A Reality or a Dream?; “Well-aging": Early Detection of Skin Aging Signs; The Role of Confocal Microscopy in Clinical Trials for Treatment Monitoring; and Fluorescence (multiwave) Confocal Microscopy.

Dermoscopy in General Dermatology

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Publisher : CRC Press
ISBN 13 : 1351782886
Total Pages : 719 pages
Book Rating : 4.3/5 (517 download)

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Book Synopsis Dermoscopy in General Dermatology by : Aimilios Lallas

Download or read book Dermoscopy in General Dermatology written by Aimilios Lallas and published by CRC Press. This book was released on 2018-09-03 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: This lavishly illustrated guide from experts will enable practitioners to get the most out of dermoscopy for investigations and treatments in general dermatology.

Handbook of Dermoscopy

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Publisher : CRC Press
ISBN 13 : 0203090349
Total Pages : 106 pages
Book Rating : 4.2/5 (3 download)

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Book Synopsis Handbook of Dermoscopy by : Josep Malvehy

Download or read book Handbook of Dermoscopy written by Josep Malvehy and published by CRC Press. This book was released on 2006-01-17 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise in popularity of dermoscopy has meant that more and more practitioners need a ready reference to consult in a clinical setting where larger atlases are less practical. The Handbook of Dermoscopy features a wealth of photographs, checklists, and algorithms to assist in spot diagnoses. Coverage includes melanocytic lesions, seborrheic kerato

Image Guided Dermatologic Treatments

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Publisher : Springer Nature
ISBN 13 : 3030292363
Total Pages : 147 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Image Guided Dermatologic Treatments by : Robert L. Bard

Download or read book Image Guided Dermatologic Treatments written by Robert L. Bard and published by Springer Nature. This book was released on 2019-11-05 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book showcases the latest digital skin imaging, optical/laser systems and advanced immunologic therapies including topics ranging from the basic dermatologic sciences to advanced microscopic and laser optics. The addition of radiologic breakthroughs serves as comprehensive source for the dermatologic community, helping them access sonographic, CT, MRI and nuclear medicine procedures refined for dermatologic and subcutaneous pathologies. In addition, it assists radiologists determine the appropriate imaging technologies for specific clinical dermal disorders. A detailed and up-to-date overview of image-guided treatments is provided. The initial chapters on benign and inflammatory diseases are precursors to advanced chapters on hidradenitis suppurativa and pigmented lesion analysis. A dedicated chapter on melanoma skin cancer and malignant melanoma is followed by updated concepts of melanoma treatment, including genetic markers and PET/CT to monitor therapeutic success. Further chapters address such topics as dermal trauma from foreign bodies and burns, scar imaging, fillers complications and podiatric imaging. Chapters on optical coherence tomography and reflectance confocal microscopy complete the coverage. All chapters were written by dermatologists trained in ultrasound diagnosis, interventional radiologists, dermatopathologists and specialists in advanced optical and microscopic dermatologic analysis, providing a reference guide to noninvasive diagnosis techniques and image guided minimally invasive treatment options. As such, Image Guided Dermatologic Treatments will be an invaluable asset for clinicians in medical and allied fields where dermatologic diagnosis using the least invasive option is required.

Eyelid and Conjunctival Tumors

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Publisher : Springer Nature
ISBN 13 : 3030366065
Total Pages : 134 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Eyelid and Conjunctival Tumors by : Mathilde Kaspi

Download or read book Eyelid and Conjunctival Tumors written by Mathilde Kaspi and published by Springer Nature. This book was released on 2020-03-28 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas gives the complete expert opinion on the diagnostic features of eyelid and conjunctival tumors (benign and malignant): a state-of-the-art guide with numerous images, useful for both dermatologists and ophthalmologists. This invaluable resource, illustrating clinical, histological and re fectance confocal microscopy features, first addresses the normal conditions of the ocular surface, then reviews lesions due to epidermal, melanocytic and adnexal tumors. A final part is devoted to conjunctiva conditions, from normal to malignant conjunctival tumors. The high number of illustrations and their description of many ocular surface lesions with in vivo confocal microscopy make this atlas an essential guide for the practitioners of both specialities.

Application of Reflectance Confocal Microscopy in the Evaluation of Murine Healthy and Lesional Skin

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Application of Reflectance Confocal Microscopy in the Evaluation of Murine Healthy and Lesional Skin by : Jose Luis Egea

Download or read book Application of Reflectance Confocal Microscopy in the Evaluation of Murine Healthy and Lesional Skin written by Jose Luis Egea and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflectance confocal microscopy (RCM) is a non-invasive imaging technology that allows real-time examination of the skin at nearly histologic resolution. It has been proved to be valuable in the clinics, but its application in animal models is limited. The main objectives were to identify characteristic confocal features in healthy murine skin, and evaluate the cutaneous alterations in the mouse model of oxazolone-induced dermatitis.A VivaScopeu00ae microscope was used to take horizontal optical sections of the skin from the stratum corneum to the dermis, up to the maximum optical depth of 250 u00b5m. Imaging was performed on healthy or lesional skin of male C57BL/6 mice. The dermatitis was induced in the depilated nape of sensitized mice by repeated topical challenges with oxazolone, and imaged 24 hours after each challenge.The major architectural and cellular features of each stratum of the epidermis and dermis were identified in healthy skin. However, the patterns were not as pronounced as those described in humans, and the dermo-epidermal junction was indistinct.Features of spongiotic dermatitis were visualized in the model. In the acute stage, there were areas of increased intercellular brightness (spongiosis), circumscribed oval hyporefractive areas (vesicles), and single or clusters of refractile round cells at the level of the stratum spinosum (exocytosis) and dermis. With chronicity, the honeycomb pattern was increased in thickness (acanthosis), and inflammatory cells were often observed with haphazardly arranged, highly refractile fibrilar fibers (fibrosis).RCM represents a powerful tool to analyze skin changes in animal models, and complements histopathology when studying dynamic processes (blood flow), or structures and lesions usually altered by histological processing. Additionally, its non-invasive nature enables the monitoring of skin lesions in the same animal, which is particularly useful in models intended to mimic a chronic disease.

Nanoscience in Dermatology

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Publisher : Academic Press
ISBN 13 : 0128029455
Total Pages : 404 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Nanoscience in Dermatology by : Michael R. Hamblin

Download or read book Nanoscience in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-08-13 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology Coherently structured book written by experts working in the fields covered

Cutaneous Melanoma

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Publisher : Academic Press
ISBN 13 : 0128040319
Total Pages : 254 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Cutaneous Melanoma by : Giuseppe Argenziano

Download or read book Cutaneous Melanoma written by Giuseppe Argenziano and published by Academic Press. This book was released on 2017-08-15 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous Melanoma: A Pocket Guide for Diagnosis and Management serves as an easy-to-consult, short, and schematic reference providing guidelines for diagnosing and managing melanoma in the context of various clinical scenarios. In the daily routine of a busy clinician, there is a need for schematic reference tools that allow quick consultation for immediate decisions. Melanoma is a deadly disease that should be promptly managed following precise and evidence-based guidelines. The guide contains many schematics and figures, vastly outnumbering the pages dedicated to text. This guide follows the sequence of a real clinical setting, going from the first screening visit to the final stages of terminal patients. Provides a quick-access resource for diagnosis and treatment of melanoma patients at all stages Includes succinct guidelines, schematics, and figures for busy clinicians Concludes with a section addressing special clinical situations, including melanoma in pregnancy, pediatric melanoma, familial melanoma and MPM, atypical Spitz tumor, occult primary melanoma, and the histopathologic gray zone

Non Invasive Diagnostic Techniques in Clinical Dermatology

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642321097
Total Pages : 464 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Non Invasive Diagnostic Techniques in Clinical Dermatology by : Enzo Berardesca

Download or read book Non Invasive Diagnostic Techniques in Clinical Dermatology written by Enzo Berardesca and published by Springer Science & Business Media. This book was released on 2013-12-02 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive but compact guide to the latest technical and technological developments in the growing field of non invasive diagnosis in clinical dermatology. Information is provided on the practical and technical characteristics of a wide range of equipment and methods for in vivo measurements that aid in the investigation of skin function, the evaluation of topically applied products and the monitoring of skin disease. Individual sections are devoted to imaging techniques, skin analysis, superficial skin analysis, skin mechanics, water and stratum corneum hydration and erythema and blood flow. All of the authors are experts in the field, with detailed knowledge of the techniques they describe. Non Invasive Diagnostic Techniques in Clinical Dermatology will be of value for all dermatologists, whether they are engaged in delivering patient care or in research programs, for cosmetic scientists and for biologists involved in skin research and product assessment.

The Melanocytic Proliferations

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Publisher : John Wiley & Sons
ISBN 13 : 1118488962
Total Pages : 936 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis The Melanocytic Proliferations by : A. Neil Crowson

Download or read book The Melanocytic Proliferations written by A. Neil Crowson and published by John Wiley & Sons. This book was released on 2014-01-06 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough updating of the best-selling, vital reference and textbook on melanocytic proliferations PRAISE FOR THE FIRST EDITION: “Well-written and entertaining” —Modern Pathology “An extremely helpful guide for the practicing dermatopathologist or general pathologist” —Archives of Pathology and Laboratory Medicine “An incredibly relevant clinical-histopathologic text” —Doody’s Melanocytic proliferations comprise a large number of pigmented lesions of the skin and muscosa. Of these, melanoma is of particular interest to clinicians and their patients. The rising number of incidences of melanoma has led to increased interest in the disease from diagnostic, management, and basic science perspectives. The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions is the most complete single-source treatment of the subject available—thoroughly updated to reflect the very latest studies and clinical experience in diagnosing and treating melanocytic proliferation. This new edition of the bestseller presents an experience- and evidence-based review of pigmented lesions that encompasses the biology, diagnosis, and treatment of melanocytic proliferations and disorders, including melanoma. It comes with over 300 new color images—bringing the total to over 600—and contains two completely new chapters: Dermatoscopic Diagnosis of Melanoma; and Reflectance Confocal Microscopy. Chapter coverage includes: • An approach to the clinical diagnosis of melanoma, its precursors, and its clinical mimics • Freckles and lentigines • Benign acquired nevi • Dermal dendritic melanocytic proliferations/dermal melanocytoses • Spitz nevus • Combined nevus, deep penetrating nevus, plexiform spindle cell nevus, and borderline tumors of the deep penetrating nevus variant • Recurrent melanocytic nevus • Congenital nevi • Dysplastic melanocytic nevi, de novo intradermal epithelioid and lentiginous melanocytic dysplasias, and nevi at specific anatomic sites • Melanoma • Conjunctival melanocytic proliferations • Use of adjunctive immunoperoxidase, molecular, and ultrastructural studies in the diagnosis of melanocytic proliferations • Biology of melanoma • Borderline melanocytic proliferation • Dermatoscopic diagnosis of melanoma • Reflectance confocal microscopy • Therapy of melanoma The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions is an incredibly important text for all clinical pathologists, dermatopathologists, surgical pathologists, dermatologists, cosmetic physicians, and surgeons.