Redox Signaling And Regulation In Biology And Medicine

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Redox Signaling and Regulation in Biology and Medicine

Author : Claus Jacob
Publisher : John Wiley & Sons
ISBN 13 : 3527627596
Total Pages : 514 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Redox Signaling and Regulation in Biology and Medicine by : Claus Jacob

Download or read book Redox Signaling and Regulation in Biology and Medicine written by Claus Jacob and published by John Wiley & Sons. This book was released on 2009-05-06 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Redox Signaling

Author :
Publisher : Elsevier
ISBN 13 : 0443294453
Total Pages : 184 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Redox Signaling by :

Download or read book Redox Signaling written by and published by Elsevier. This book was released on 2024-08-01 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 162 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the ACR series Updated release includes the latest information on the Advances in Cancer Research

Oxidative Stress and Redox Regulation

Author : Ursula Jakob
Publisher : Springer Science & Business Media
ISBN 13 : 9400757875
Total Pages : 488 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Oxidative Stress and Redox Regulation by : Ursula Jakob

Download or read book Oxidative Stress and Redox Regulation written by Ursula Jakob and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Redox Regulation of Differentiation and De-differentiation

Author : Carsten Berndt
Publisher : CRC Press
ISBN 13 : 1000435385
Total Pages : 544 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Redox Regulation of Differentiation and De-differentiation by : Carsten Berndt

Download or read book Redox Regulation of Differentiation and De-differentiation written by Carsten Berndt and published by CRC Press. This book was released on 2021-08-26 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)

Peroxiporins

Author : Iria Medraño-Fernandez
Publisher : CRC Press
ISBN 13 : 1000927784
Total Pages : 245 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Peroxiporins by : Iria Medraño-Fernandez

Download or read book Peroxiporins written by Iria Medraño-Fernandez and published by CRC Press. This book was released on 2023-10-11 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emitters to receptors. Thus, these channels are strategically situated in the thin line between life and death, guaranteeing adequate but safe signaling. Key Features: - Provides a brief history of the discovery and characterization of peroxiporins - Reviews key findings on hydrogen peroxide transport across biological membranes - Discusses the cartography of redox signaling in crowded cells - Includes lavish illustrations and comprehensive images to facilitate teaching - Highlights recent findings, outstanding controversies and open questions

Oxidative Stress

Author : Helmut Sies
Publisher : Academic Press
ISBN 13 : 0128196963
Total Pages : 876 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Oxidative Stress by : Helmut Sies

Download or read book Oxidative Stress written by Helmut Sies and published by Academic Press. This book was released on 2019-11-07 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: A conceptual framework for studying oxidative stress. Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies. Features contributions from international leaders in oxidative stress and redox biology research.

Cellular Implications Of Redox Signaling

Author : Avihai Danon
Publisher : World Scientific
ISBN 13 : 1783261153
Total Pages : 441 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Cellular Implications Of Redox Signaling by : Avihai Danon

Download or read book Cellular Implications Of Redox Signaling written by Avihai Danon and published by World Scientific. This book was released on 2003-07-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells.

Redox Regulation of Cell Signaling and Its Clinical Application

Author : Junji Yodoi
Publisher : CRC Press
ISBN 13 : 9780824719616
Total Pages : 366 pages
Book Rating : 4.7/5 (196 download)

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Book Synopsis Redox Regulation of Cell Signaling and Its Clinical Application by : Junji Yodoi

Download or read book Redox Regulation of Cell Signaling and Its Clinical Application written by Junji Yodoi and published by CRC Press. This book was released on 1999-03-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult T-cell leukemia-derived factor (ADF).

Antioxidant and Redox Regulation of Genes

Author : Chandan K. Sen
Publisher : Academic Press
ISBN 13 : 0080527299
Total Pages : 591 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Antioxidant and Redox Regulation of Genes by : Chandan K. Sen

Download or read book Antioxidant and Redox Regulation of Genes written by Chandan K. Sen and published by Academic Press. This book was released on 1999-11-08 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses oxidant-reduction or redox and antioxidant sensitive molecular mechanisms and how they are implicated in different disease processes. Possible strategies to pharmacologically and/or nutritionally manipulate such redox-sensitive molecular responses are emphasized. Reactive species as intracellular messengers Redox regulation of cellular responses Clinical implications of redox signaling and antioxidant therapy

Redox-Active Therapeutics

Author : Ines Batinić-Haberle
Publisher : Springer
ISBN 13 : 3319307053
Total Pages : 709 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Redox-Active Therapeutics by : Ines Batinić-Haberle

Download or read book Redox-Active Therapeutics written by Ines Batinić-Haberle and published by Springer. This book was released on 2016-10-13 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.

Pulmonary Vasculature Redox Signaling in Health and Disease

Author : Yong-Xiao Wang
Publisher : Springer
ISBN 13 : 3319632450
Total Pages : 429 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Pulmonary Vasculature Redox Signaling in Health and Disease by : Yong-Xiao Wang

Download or read book Pulmonary Vasculature Redox Signaling in Health and Disease written by Yong-Xiao Wang and published by Springer. This book was released on 2017-10-18 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.

Platelets in Cardiovascular Disease

Author : Deepak L. Bhatt
Publisher : Imperial College Press
ISBN 13 : 1860948529
Total Pages : 235 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis Platelets in Cardiovascular Disease by : Deepak L. Bhatt

Download or read book Platelets in Cardiovascular Disease written by Deepak L. Bhatt and published by Imperial College Press. This book was released on 2008 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine. Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease. Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful. Sample Chapter(s). Chapter 1: Platelet Biology the Role of Platelets in Hemostasis, Thrombosis and Inflammation (274 KB). Contents: Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation (R C Becker); Thromboxane Antagonists (B R Dulin & S R Steinhubl); Glycoprotein IIb/IIIa Inhibitors (S J Lehman et al.); ADP Receptor Antagonists (J Karha & C P Cannon); Monitoring Antiplatelet Therapy (P Harrison & A D Michelson); Platelet Genomics (B K Jefferson et al.); Future Strategies for the Development of Antiplatelet Drugs (R A Harrington). Readership: Physicians: cardiologists, vascular medicine specialists, hematologists; physicians in training: fellows, residents, interns; pharmacists; pharmaceutical industry: scientists, sales representatives.

Hydrogen Sulfide in Redox Biology Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128016221
Total Pages : 382 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Hydrogen Sulfide in Redox Biology Part B by :

Download or read book Hydrogen Sulfide in Redox Biology Part B written by and published by Academic Press. This book was released on 2015-03-03 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation

Methods in Redox Signaling

Author : Dipak Kumar Das
Publisher :
ISBN 13 : 9781934854068
Total Pages : 0 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Methods in Redox Signaling by : Dipak Kumar Das

Download or read book Methods in Redox Signaling written by Dipak Kumar Das and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Redox Signaling is the first and only comprehensive handbook on the experimental methods used to study redox signaling. Formerly recognized as destructive mechanisms, reactive oxygen species (ROS) have now been recognized as saviors by protecting the cells through redox signaling. This evolving science involves the pathobiology of various disease processes including cancer, cardiovascular diseases, wound healing, and many other degenerative diseases. Although the concept of reactive oxygen species has been known to some for decades, their potential role in the biological system has only been recognized in recent years. With the identification of these new mechanisms and their potential, the exploration in this area is expanding rapidly and the scientific articles are pouring in. Being relatively young, a vast majority of the mechanisms of redox signaling, especially those related to disease processes still remain unknown. Methods in Redox Signaling provides a valuable tool for the growing number of scientists engaging in the research and investigation involving redox regulation of degenerative diseases.

Hydrogen Sulfide in Redox Biology Part A

Author :
Publisher : Academic Press
ISBN 13 : 012801623X
Total Pages : 351 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Hydrogen Sulfide in Redox Biology Part A by :

Download or read book Hydrogen Sulfide in Redox Biology Part A written by and published by Academic Press. This book was released on 2015-02-25 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation

Oxidants and Antioxidants

Author : Lester Packer
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121822019
Total Pages : 574 pages
Book Rating : 4.8/5 (22 download)

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Book Synopsis Oxidants and Antioxidants by : Lester Packer

Download or read book Oxidants and Antioxidants written by Lester Packer and published by Gulf Professional Publishing. This book was released on 1999 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Total Antioxidant Activity * Vitamin C * Polyphenols and Flavanoids * Thiols * Vitamin E and Coenzyme Q10 * Carotenoids and Retinoids.

Oxidative Stress

Author : Canhua Huang
Publisher : Springer Nature
ISBN 13 : 981160522X
Total Pages : 323 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Oxidative Stress by : Canhua Huang

Download or read book Oxidative Stress written by Canhua Huang and published by Springer Nature. This book was released on 2021-05-27 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.