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Red Blood Cell Aging
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Book Synopsis Red Blood Cell Aging by : Antonio De Flora
Download or read book Red Blood Cell Aging written by Antonio De Flora and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.
Book Synopsis Influence of Oxygen Toxicity on the Rate of Red Cell Aging by : D. Danon
Download or read book Influence of Oxygen Toxicity on the Rate of Red Cell Aging written by D. Danon and published by . This book was released on 1967 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Blood Cells, Rheology and Aging by : Dieter Platt
Download or read book Blood Cells, Rheology and Aging written by Dieter Platt and published by Springer. This book was released on 1988 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the third Erlangen-Nuremberg symposium on experimental geronto logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co agulation is a typical thrombophilic tendency with aging.
Book Synopsis Regulation of red cell life-span, erythropoiesis, senescence and clearance by : Lars Kaestner
Download or read book Regulation of red cell life-span, erythropoiesis, senescence and clearance written by Lars Kaestner and published by Frontiers E-books. This book was released on 2014-12-03 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.
Book Synopsis Red Blood Cell Aggregation by : Oguz Baskurt
Download or read book Red Blood Cell Aggregation written by Oguz Baskurt and published by CRC Press. This book was released on 2011-09-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
Book Synopsis Stem Cells and Aging by : Surajit Pathak
Download or read book Stem Cells and Aging written by Surajit Pathak and published by Academic Press. This book was released on 2021-03-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe
Book Synopsis Cellular and Molecular Aspects of Aging by : John Wallace Eaton
Download or read book Cellular and Molecular Aspects of Aging written by John Wallace Eaton and published by . This book was released on 1985 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Hemoglobin Content of Single Erythrocytes in Cell Aging and Hemopoietic Disturbance by : Charles Anderson Sondhaus
Download or read book The Hemoglobin Content of Single Erythrocytes in Cell Aging and Hemopoietic Disturbance written by Charles Anderson Sondhaus and published by . This book was released on 1958 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Anemia in the Elderly by : Lodovico Balducci
Download or read book Anemia in the Elderly written by Lodovico Balducci and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anemia in the elderly has been properly defined as the silent epidemic, representing 3 million people in the United States aged 65 years and older. Incidence and prevalence of this condition increase with age. It differs in its etiology, pathogenesis and treatment from anemia in children and younger adults. Anemia is associated with reduced survival, increased risk of functional dependence and hospitalization, increased risk of congestive heart failure and stage renal disease and cognitive disorders. Approximately 70% of anemia in older individuals is reversible.
Book Synopsis Red Cell Membrane Transport in Health and Disease by : Ingolf Bernhardt
Download or read book Red Cell Membrane Transport in Health and Disease written by Ingolf Bernhardt and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: 51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.
Book Synopsis Blood Cells, Rheology, and Aging by : Dieter Platt
Download or read book Blood Cells, Rheology, and Aging written by Dieter Platt and published by . This book was released on 1987-12-11 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume on experimental gerontology deals with the effects of aging on blood cells and rheology. Since gerontology is an interdisciplinary science, numerous experts engaged in various disciplines present their up-to-date results related to aging. The detailed accounts compiled in this book will augment the knowledge of red cells, immunology, receptors, blood coagulation, and rheology. The volume provides a valuable basis for future scientific work in gerontological research.
Book Synopsis Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity by : Franck Mauvais-Jarvis
Download or read book Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity written by Franck Mauvais-Jarvis and published by Springer. This book was released on 2017-12-08 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
Book Synopsis The Red Cell Life-Cycle From Erythropoiesis to Clearance by : Lars Kaestner
Download or read book The Red Cell Life-Cycle From Erythropoiesis to Clearance written by Lars Kaestner and published by Frontiers Media SA. This book was released on 2019-02-05 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eBook ‘The red cell life-cycle from erythropoiesis to clearance’ continues the discussion of questions like: What are the changes associated with red blood cell maturation, adulthood and senescence? What are the determinants of red blood cell life span and clearance? What are the mechanisms in control of red blood cell mass in healthy humans and patients with various forms of anaemia? Can red blood cells be 'trained' to provide the body with more oxygen during endurance exercises? What are the markers of circulating red blood cell senescence and in cells during storage and transfusion? And what can be learned from various species that developed advanced adaptations to maintain oxygen delivery under stress conditions such as exercising to the limit, diving or living in anaerobic aquatic habitats or at high altitude? Within the approximately 120 days (or 40 in a mouse, or 150-170 in a horse) life span of 'healthy' red blood cells, many cellular properties change leading to aged mixed cell populations in the circulation. Red blood cells seem to be genetically terminated by the time they become red blood cells and the contributions of this eBook increase the understanding of this process. There are surprisingly versatile remodeling processes happening during the red blood cell life span. Numerous disorders are associated with the premature onset of the 'ageing process' of red blood cells. Furthermore, in vitro ageing and/or modifications as well as the slowing down of the modifications is an important issue in transfusion medicine. Many of the molecular mechanisms behind such effects are elucidated in this eBook.
Book Synopsis The Effects of Oxidative Damage on In Vivo Aging, Density, and Survival of Baboon Red Blood Cells by :
Download or read book The Effects of Oxidative Damage on In Vivo Aging, Density, and Survival of Baboon Red Blood Cells written by and published by . This book was released on 1992 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To assess the relationships among density, age, and survival of baboon red blood cells, hydrogen peroxide-treated (oxidized) red blood cells and untreated (non-oxidized) red blood cells were labeled with 51-Cr and auto transfused. Hydrogen peroxide in a final concentration of 339 micro mol/liter was used to treat the baboon red blood cells. Blood samples were collected following autotransfusion of the non-oxidized and oxidized red blood cells. These samples were processed as unfractionated red blood cells and as fractionated top, intermediate, and bottom red blood cells consisting of 6 bands isolated using percoll-hypaque density gradients. Oxidized unfractionated red blood cells and oxidized red blood cells in the bottom fraction consisting of 6 bands exhibited significantly reduced 51-Cr 24-hour posttransfusion survival values. The T-1/2 values in the bottom fraction were significantly lower in the oxidized than in the non-oxidized red blood cells. As the more dense red blood cells were removed from the circulation, the movement of radioactivity from the less dense top red blood cell fraction to the more dense bottom fraction was reduced. In another aspect of this study, non-oxidized and oxidized unfractionated and fractionated red blood cells were labeled with biotin. Percoll hypaque density gradients were used to separate the bottom red blood cell fraction containing 3 bands or 6 bands. Twenty minutes after the autotransfusion of these biotin-labeled non-fractionated and fractionated red blood cells, blood samples were collected. The biotin-labeled red blood cells were recovered on avidin plates, labeled with 51-Cr, and autotransfused. Samples were collected for 24-hour posttransfusion survival and lifespan measurement. The 24-hour posttransfusion survival values of the oxidized non-fractionated red blood cells were only 77% compared to 89% for the non-oxidized non-fractionated red blood cells.
Download or read book RealAge written by Michael F. Roizen and published by Harper Collins. This book was released on 2010-11-16 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is aging? Aging is not a mysterious metaphysical phenomenon. Aging happens in the particulars. Your arteries become clogged. Your arthritis flares up. Age is not just a chronological measurement; it's the rate at which the primary internal guardians of health--your cardiovascular and immune systems--decline. While your chronological age is fixed, your biological age may be years older--or younger--depending on a combination of factors. RealAge offers a revolutionary, systematic program that calculates the aging effect of more than 100 different health behaviors--ranging from diet and medication to stress control and chronic smoking--and enables you to assess your own biological age. Most important, it shows you how to design a specific path to improving or reversing your own aging trajectory. Developed by Dr. Michael F. Roizen, chair of anesthesia and critical care at the University of Chicago and preventive gerontologist, along with four other scientists, the RealAge program is based on cutting-edge scientific research. Dr. Roizen and his team have pored over 25,000 medical studies, evaluating what they tell us about aging and what they tell us about the prevention of aging.In RealAge, they present the complete results of their analysis for the first time. Each chapter covers a broad health topic--for example, how the right vitamins and supplements, exercise, or diet can be used to control how your genes affect you--and calculates the RealAge advantage you will gain by adopting a specific behavior. Charts, fact sheets, and tests give you specific choices to make and describe benefits to be gained so you can measure your success. Suggested behavior changes are rated in order of difficulty so you can decide whether the result is worth the effort. Ultimately, this program is about maintaining your health. The better condition you are in, the better prepared you will be to fight the factors that age you. RealAge demonstrates that you can have more control over the aging process. It makes science simple and its promise is irresistible: You may live as young at seventy as you did at forty-four. Remeber your high school reunion? Even though everyone was the same chronological age, people no longer looked the same. Some wore the years well, staying young and exuberant despite the passage of time, whereas others looked as if they had aged ten years more than everyone else--and probably had. Did you know that: Financial stress can make your RealAge two to thirty-two years older? The difference between having the ideal blood pressure 115/76--and high blood pressure--higher than 140/90--can make a RealAge difference of more than twenty years? A tablet of aspirin a day can make your RealAge 1.9 years younger? Flossing daily and seeing a dentist and dental hygienist every six months can make your RealAge 6.4 years younger? In RealAge you will discover many other easy-to-institute Age Reduction Strategies that will enable you to live longer and younger.
Book Synopsis Lipid metabolism in mammals by : Fred Snyder
Download or read book Lipid metabolism in mammals written by Fred Snyder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade we have witnessed a vast expansion in our knowl edge of lipid metabolism, especially for mammalian tissues. One obvious conclusion arising from these studies is that no single overall scheme of lipid metabolism can be classed as distinctly characteristic of all mamma lian organs. Although certain synthetic and degradative lipid pathways are similar in a variety of organs, I have been impressed by the notable exceptions. I was motivated to organize this work on Lipid Metabolism in Mammals because of the lack of a single reference source containing a comparative organ approach to lipid metabolism in mammals that empha sizes the uniqueness of pathways in the various organs of the body. Because of the escalation in lipid research, I also feel strongly that there is an urgent need for an updated concise account of this field. The group of authors for the chapters in the two volumes of Lipid Metabolism in Mammals were selected for their expertise and personal experience with the lipid metabolism of the organs or blood constituents that are the subjects of the chapters. Sufficient leeway has been given each author to approach the subject matter from a personal viewpoint. How ever, the overall direction of each chapter has been slanted to emphasize the similarities and differences in lipid metabolism among organ systems. The introductory chapter on general pathways provides a convenient refer ence to illustrations of specific reaction sequences that are well established and that occur in a number of organs.
Book Synopsis Rossi's Principles of Transfusion Medicine by : Toby L. Simon
Download or read book Rossi's Principles of Transfusion Medicine written by Toby L. Simon and published by John Wiley & Sons. This book was released on 2016-05-23 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references
