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Receptor Binding Radiotracers 1982
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Book Synopsis Receptor Binding Radiotracers (1982) by : William C. Eckelman
Download or read book Receptor Binding Radiotracers (1982) written by William C. Eckelman and published by CRC Press. This book was released on 2017-11-22 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series of books on Radiotracers in Biology and Medicine is on the one hand an unbelievably expansive enterprise and on the other hand, a most noble one as well. Tools to probe biology have developed at an accelerating rate. Hevesy pioneered the application of radioisotopes to the study of chemical processes, and since that time radioisotopic methodology has probably contributed as much as any other methodology to the analysis of the fine structure of biologic systems. Radioisotopic methodologies represent powerful tools for the determination of virtually any process of biologic interest. It should not be surprising, therefore, that any effort to encompass all aspects of radiotracer methodology is both desirable in the extreme and doomed to at least some degree of inherent failure. The current series is assuredly a success relative to the breadth of topics which range from in depth treatise of fundamental science or abstract concepts to detailed and specific applications, such as those medicine or even to the extreme of the methodology for sacrifice of anaimals as part of a radiotracer distribution study.
Book Synopsis Studies Of Cellular Functions Using Radiotracers (1982) by : Mervyn W Billinghurst
Download or read book Studies Of Cellular Functions Using Radiotracers (1982) written by Mervyn W Billinghurst and published by CRC Press. This book was released on 2017-11-22 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the result of the concerted effeort of a number os scientists to summarize in a succinct way the current understanding of the mechanisms of these localizations. The editors of the book gratefully acknowledge this combined effort.
Book Synopsis Receptor Binding Radiotracers by : William C. Eckelman
Download or read book Receptor Binding Radiotracers written by William C. Eckelman and published by CRC Press. This book was released on 2019-07-17 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1982, this book explores the role of receptor-binding radiotracers. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of radiology, and other practitioners in their respective fields.
Book Synopsis Cardiovascular Molecular Imaging by : Robert J. Gropler
Download or read book Cardiovascular Molecular Imaging written by Robert J. Gropler and published by CRC Press. This book was released on 2007-07-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular Molecular Imaging is based on a groundbreaking NIH symposium sponsored by the American Society of Nuclear Cardiology. The first all-inclusive guide to the targeted molecular imaging of the cardiovascular system, it includes color illustrations throughout and is packaged with a user-friendly CD-ROM with supplemental material.This refe
Book Synopsis Tracer Kinetics and Physiologic Modeling by : R.M. Lambrecht
Download or read book Tracer Kinetics and Physiologic Modeling written by R.M. Lambrecht and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Animal Models in Radiotracer Design by : Richard M. Lambrecht
Download or read book Animal Models in Radiotracer Design written by Richard M. Lambrecht and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors have asked me to write this foreword probably for two reasons: First, I have spent 35 years trying to develop radiolabeled compounds that would help diagnose and treat disease. I, and the people from my laboratory, have been much involved with developing Nan'I for the diagnosis and treatment of hyperthyroidism and well-differentiated thyroid cancer. Second, I was a participant throughout the entire symposium upon which this book is based. Our latest '311-labeled compound, [l3lll metaiodobenzylguanidine, took us 13 years to develop. It has succeeded in diagnosing and treating adrenergic tumors '31 under circumstances where Na 1 would have failed for the diagnosis and treatment of thyroid cancer. I therefore hope that more scientists will be attracted to this field. This book is written by intelligent, experienced investigators who are knowl edgeable. It is a must for anyone new in the field. For the experienced, I would like to remind you that I attended the entire symposium; the breadth and timeliness of the update has helped us to redirect some of our current efforts into more scientifically productive channels. William H. Beierwaltes, M.D.
Book Synopsis Bibliography of Agricultural Bibliographies by :
Download or read book Bibliography of Agricultural Bibliographies written by and published by . This book was released on 1983 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Radiopharmaceuticals by : AdrainD. Nunn
Download or read book Radiopharmaceuticals written by AdrainD. Nunn and published by Routledge. This book was released on 2018-04-27 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely resource compares single-photon emission tomography (SPECT), used mainly withTechnetium and iodine for routine clinical examinations, and positron emission tomography(PET) , employing short-lived radionuclides of carbon, oxygen, nitrogen, and fluorine in researchinvestigations.Presenting the logic behind why one approach is better than another in various circumstances,Radio pharmaceuticals details the use of radiolabelled substrates in measuring the effect of diseaseand drugs on regional metabolism and receptor concentration/occupancy .. . discusses factorsaffecting the selective retention of small metal complexes by various tissues .. . analyzes the interactionof small exogenous metal complexes with enzymes in vivo and the critical role of stereochemistry. . . explores the use of radio labelled compounds in the study of neuroactive compounds,neurotransmitters, enzyme inhibitors, and substrates in vivo .. . covers the design and pharmacologyof radiolabelled drugs as probes of site of action , selectivity and specificity, and pharmacokineticsin vivo .. . and more.Extensively referenced with over l 050 bibliographic citations, Radiopharmaceuticals is a state-ofthe-art guide for pharmacists; organic, medicinal , and radiopharmaceutical chemists; pharmacokineticists;nuclear medicine physicians and technologists; neurochemists; and governmentregulatory personnel .
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1982 with total page 1174 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1982 with total page 1184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nuclear Imaging in Drug Discovery, Development, and Approval by : BURNS
Download or read book Nuclear Imaging in Drug Discovery, Development, and Approval written by BURNS and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is the purpose and business of the pharmaceutical industry to dis cover, develop, and make available drugs for the care of the sick. The purpose of universities and national laboratories is to provide people and scientific knowledge that can help in the process. This book presents the combined efforts of scientists from the drug in dustry, academic laboratories and national laboratories to describe advances in radiotracer technology in studies on experimental ani mals and living human beings. The authors believe that the technol ogy is now ready for widespread application in the pharmaceutical industry. The goal of this book is to help bring this about. The field of Nuclear Medicine is based on the concept that, if treatment of disease is chemical, the patient's diagnosis should be chemical. Anatomy and histopathology have been the principle ba sis for making a diagnosis. Histopathologic data suffer from being descriptive, subjective, not quantifiable, and based on the study of dead tissue. The era of histopathology as the dominant concept in medical practice is coming to an end. Histopathologic findings are often heterogeneous and a single biopsy will at times not reveal the true nature of the disease, such as the grading of malignancy. Far greater accuracy of staging of disease and in the planning of treat ment is possible through chemistry, as well as by making possible a more suitable selection of a histological biopsy site.
Book Synopsis Antitumor Steroids by : R T Blickenstaff
Download or read book Antitumor Steroids written by R T Blickenstaff and published by Academic Press. This book was released on 2012-12-02 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antitumor Steroids examines the use of steroids, along with nonsteroidal antiestrogens and some benzo[a]carbazoles, in the treatment of cancer. It explains the mechanism by which steroids and their receptors work together to affect their physiological functions in general and their antitumor activity in particular. It also describes the systematic screening of antitumor compounds isolated from natural sources. Organized into nine chapters, this book begins with an overview of the role of steroids in cancer treatment. It then discusses the estrogens, antiestrogens, and compounds (all containing an aromatic A-ring). The next chapters consider androgens, some antiandrogens, derivatives based on C-19 steroids, progestins and corticoids, bile acids, and compounds with a side-chain carboxyl group. The book explains the biogenesis and metabolism of androgens; the pharmacology of medroxyprogesterone acetate; the antitumor properties of naturally occurring corticosteroids; sterols and cucurbitacins; vitamin D and its metabolites; and cardenolides, bufadienolides, and withanolides. The book concludes with a chapter on bile acids, sapogenins and its analogs, and miscellaneous steroids. This book is a valuable resource for organic and medicinal chemists biochemists, and pharmacologists interested in the use of steroids in treating cancer.
Book Synopsis Technetium-99m Pharmaceuticals by : Ilse Zolle
Download or read book Technetium-99m Pharmaceuticals written by Ilse Zolle and published by Springer Science & Business Media. This book was released on 2007-01-28 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.
Book Synopsis Handbook of Radiopharmaceuticals by : Michael J. Welch
Download or read book Handbook of Radiopharmaceuticals written by Michael J. Welch and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States
Book Synopsis Nuclear and Radiochemistry by : Karl Heinrich Lieser
Download or read book Nuclear and Radiochemistry written by Karl Heinrich Lieser and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of the best-selling handbook gives a complete and concise description of the latest knowledge on nuclear and radiochemistry as well as their applications in the various fields of science. It is based on over 40 years experience in teaching courses and research. The book is aimed at all researchers seeking sound knowledge about the properties of matter, whether chemists, physicists, medical doctors, mineralogists or biologists. All of them will find this a valuable source of information. Research in radiochemistry includes: Study of radioactive matter in nature, investigation of radioactive transmutations, chemistry of radioelements etc. Applications include: Radionuclides in geo- and cosmochemistry, dating by nuclear methods, radioanalysis, Mossbauer spectroscopy and related methods, behavior of natural and man-made radionuclides in the environment, dosimetry and radiation protection. All the subjects are presented clearly and comprehensibly, and in a logical sequence, avoiding detailed derivations of equations. The relevant information is compiled in tables and the recent edition of the multi-colored Karlsruhe 'Chart of the Nuclides' has also been included. Clearly a standard work by an author with extensive experience in research and teaching.
Book Synopsis Targeted Molecular Imaging by : Michael J. Welch
Download or read book Targeted Molecular Imaging written by Michael J. Welch and published by Taylor & Francis. This book was released on 2012-02-24 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies t
Book Synopsis Current Directions in Radiopharmaceutical Research and Development by : Steven J. Mather
Download or read book Current Directions in Radiopharmaceutical Research and Development written by Steven J. Mather and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.
