Recent Advances In Nucleosides Chemistry And Chemotherapy

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Recent Advances in Nucleosides: Chemistry and Chemotherapy

Author : C.K. Chu
Publisher : Elsevier
ISBN 13 : 0080540368
Total Pages : 545 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Recent Advances in Nucleosides: Chemistry and Chemotherapy by : C.K. Chu

Download or read book Recent Advances in Nucleosides: Chemistry and Chemotherapy written by C.K. Chu and published by Elsevier. This book was released on 2002-09-11 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.

Antiviral Nucleosides

Author : C.K. Chu
Publisher : Elsevier
ISBN 13 : 0080524540
Total Pages : 269 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Antiviral Nucleosides by : C.K. Chu

Download or read book Antiviral Nucleosides written by C.K. Chu and published by Elsevier. This book was released on 2003-10-15 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Up-to-date review on the chemistry and biology of nucleosides • Modern synthetic methodology • Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.

Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives

Author : Jesús Fernández Lucas
Publisher : John Wiley & Sons
ISBN 13 : 3527343768
Total Pages : 348 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives by : Jesús Fernández Lucas

Download or read book Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives written by Jesús Fernández Lucas and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of innovative tools for creative nucleic acid chemists that open the door to novel probes and therapeutic agents Nucleic acids continue to gain importance as novel diagnostic and therapeutic agents. With contributions from noted scientists and scholars, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practical reference that includes a wide range of approaches for the synthesis of designer nucleic acids and their derivatives. The book covers enzymatic (including chemo-enzymatic) methods, with a focus on the synthesis and incorporation of modified nucleosides. The authors also offer a review of innovative approaches for the non-enzymatic chemical synthesis of nucleic acids and their analogs and derivatives, highlighting especially challenging species. The book offers a concise review of the methods that prepare novel and heavily modified polynucleotides in sufficient amount and purity for most clinical and research applications. This important book: -Presents a timely and topical guide to the synthesis of designer nucleic acids and their derivatives -Addresses the growing market for nucleotide-derived pharmaceuticals used as anti-infectives and chemotherapeutic agents, as well as fungicides and other agrochemicals. -Covers novel methods and the most recent trends in the field -Contains contributions from an international panel of noted scientistics Written for biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practice-oriented guide that reviews innovative methods for the enzymatic as well as non-enzymatic synthesis of nucleic acid species.

Chemical Synthesis of Nucleoside Analogues

Author : Pedro Merino
Publisher : John Wiley & Sons
ISBN 13 : 1118498100
Total Pages : 859 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Chemical Synthesis of Nucleoside Analogues by : Pedro Merino

Download or read book Chemical Synthesis of Nucleoside Analogues written by Pedro Merino and published by John Wiley & Sons. This book was released on 2013-02-12 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects.

Insilico Identification and Optimization of Natural Inhibitors for Drug Target sites in Cryptosporidium parvum

Author : Dr. Pratibha Teotia
Publisher : Manojvm Publishing House
ISBN 13 : 8194885973
Total Pages : pages
Book Rating : 4.1/5 (948 download)

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Book Synopsis Insilico Identification and Optimization of Natural Inhibitors for Drug Target sites in Cryptosporidium parvum by : Dr. Pratibha Teotia

Download or read book Insilico Identification and Optimization of Natural Inhibitors for Drug Target sites in Cryptosporidium parvum written by Dr. Pratibha Teotia and published by Manojvm Publishing House. This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Now day’s computer-aided drug design considered as a powerful method to design very specific lead compounds that can be developed as drug molecules. Using different in-silico tools, a target is selected and then its structure is defined and determined. After that new chemical/ synthetic compounds can be designed in-silico on the basis of combinatorial chemistry or chosen from an already available chemical library of molecules or library of molecules is generated from a subset of small molecules on the basis of docking and scoring against the particular target. In this study, I attempt to generate 2D QSAR model using small pIC50 values for thirty-eight benzoxazole derivatives binding with C. parvum IMPDH protein resulting correlation coefficient value R2/r2 is 0.7948. Docking results show that out of 38 benzoxazole derivatives, four compounds are most active. The present examination may give the data about potential derivatives of Benzoxazole as chemotherapeutic operators to battle against the expanding weight of Cryptosporidiosis infections.

Heterocycles from Carbohydrate Precursors

Author : El Sayed H. El Ashry
Publisher : Springer Science & Business Media
ISBN 13 : 3540729569
Total Pages : 363 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Heterocycles from Carbohydrate Precursors by : El Sayed H. El Ashry

Download or read book Heterocycles from Carbohydrate Precursors written by El Sayed H. El Ashry and published by Springer Science & Business Media. This book was released on 2007-07-30 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Modern Biocatalysis

Author : Wolf-Dieter Fessner
Publisher : John Wiley & Sons
ISBN 13 : 9783527320714
Total Pages : 406 pages
Book Rating : 4.3/5 (27 download)

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Book Synopsis Modern Biocatalysis by : Wolf-Dieter Fessner

Download or read book Modern Biocatalysis written by Wolf-Dieter Fessner and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das Gesamtgebiet der Biokatalyse mit allen seinen Facetten -- Mikrobiologie, Enzymologie, Molekularbiologie, Strukturbiologie, organische Chemie -- wird in diesem interdisziplinär angelegten Werk beleuchtet; insbesondere geht es um enzymatische Katalysen und Ganzzell-Katalysen. Ein Schwerpunkt liegt dabei auf der Entwicklung hochselektiver, umweltfreundlicher Prozesse zur Synthese wichtiger Verbindungsklassen.

Nucleoside Triphosphates and their Analogs

Author : Morteza Vaghefi
Publisher : CRC Press
ISBN 13 : 1420027603
Total Pages : 408 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Nucleoside Triphosphates and their Analogs by : Morteza Vaghefi

Download or read book Nucleoside Triphosphates and their Analogs written by Morteza Vaghefi and published by CRC Press. This book was released on 2016-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: While adenosine triphosphate (ATP) is described as the universal currency of energy in all living organisms at the cellular level, the actual power lies in its phosphate tail. This book is the first dedicated to the field of nucleoside triphosphate (NTP). Its 13 chapters encompass the contributions of twenty scientists from both academia and industry. It provides collective information on the chemical, physiochemical, and biological properties of both natural and modified NTP and their application in life sciences. Three chapters review families of enzymes that depend on nucleotides for assembling DNA and RNA molecules. The appendix includes supporting NMR data.

Nucleic Acids in Chemistry and Biology

Author : G Michael Blackburn
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625771
Total Pages : 503 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

DNA Methylation and Cancer Therapy

Author : Moshe Szyf
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478482
Total Pages : 264 pages
Book Rating : 4.4/5 (784 download)

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Book Synopsis DNA Methylation and Cancer Therapy by : Moshe Szyf

Download or read book DNA Methylation and Cancer Therapy written by Moshe Szyf and published by Springer Science & Business Media. This book was released on 2005-01-20 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

Reagents for Glycoside, Nucleotide, and Peptide Synthesis

Author : David Crich
Publisher : Wiley
ISBN 13 : 9780470023044
Total Pages : 792 pages
Book Rating : 4.0/5 (23 download)

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Book Synopsis Reagents for Glycoside, Nucleotide, and Peptide Synthesis by : David Crich

Download or read book Reagents for Glycoside, Nucleotide, and Peptide Synthesis written by David Crich and published by Wiley. This book was released on 2005-10-21 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook collects together short, informative articles on approximately 250 of the most widely used reagents in the field, into a single volume. Each of the articles, drawn from the e-EROS database, contains a summary of the most pertinent reactions for every reagent, with references to the original literature. This handbook will have a broad appeal and should find a home in every organic chemistry laboratory and library. Compiles all the essential reagents for syntheses on and with biomolecules Gives key information on protection, bond formation and deprotection An essential resource for all synthetic chemists working in drug development and medicinal chemistry Makes use of the leading reagent database e-EROS

Medicinal Chemistry of Nucleic Acids

Author : Lihe Zhang
Publisher : John Wiley & Sons
ISBN 13 : 1118092813
Total Pages : 477 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Medicinal Chemistry of Nucleic Acids by : Lihe Zhang

Download or read book Medicinal Chemistry of Nucleic Acids written by Lihe Zhang and published by John Wiley & Sons. This book was released on 2011-08-10 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Heterocycles

Author :
Publisher :
ISBN 13 :
Total Pages : 580 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Heterocycles by :

Download or read book Heterocycles written by and published by . This book was released on 2004 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Metallodrugs

Author : Shahid Ul Islam
Publisher : John Wiley & Sons
ISBN 13 : 1119640423
Total Pages : 432 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Advances in Metallodrugs by : Shahid Ul Islam

Download or read book Advances in Metallodrugs written by Shahid Ul Islam and published by John Wiley & Sons. This book was released on 2020-07-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Parasitism and Parasitic Control in Animals

Author : Hafiz Muhammad Rizwan
Publisher : CABI
ISBN 13 : 1800621868
Total Pages : 298 pages
Book Rating : 4.8/5 (6 download)

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Book Synopsis Parasitism and Parasitic Control in Animals by : Hafiz Muhammad Rizwan

Download or read book Parasitism and Parasitic Control in Animals written by Hafiz Muhammad Rizwan and published by CABI. This book was released on 2023-07-10 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitism and Parasitic Control in Animals brings together all the details needed to appropriately manage parasites in domestic animals. It provides comprehensive coverage of parasites and factors affecting their transmission, principles of parasite control, diagnosis, and assessment of parasitological information. With numerous new case histories and maps showing the spread of anthelmintic resistance, this textbook forms an essential guide for veterinary practitioners, students and technicians. It is also an invaluable resource for parasitologists, researchers, animal health professionals and anyone working with these parasites in developing countries.

Global Epidemiology of Cancer

Author : Jahangir Moini
Publisher : John Wiley & Sons
ISBN 13 : 1119817447
Total Pages : 676 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Global Epidemiology of Cancer by : Jahangir Moini

Download or read book Global Epidemiology of Cancer written by Jahangir Moini and published by John Wiley & Sons. This book was released on 2022-03-28 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: GLOBAL EPIDEMIOLOGY OF CANCER Cancer is the second highest cause of death in the United States, and a leading cause of death globally. Our goals are to discuss the global epidemiology of various cancers, with detailed information on their prevalence, incidence, and clinical considerations. Epidemiology is the key to understanding the mortality and morbidity of cancer, and how we can prevent, diagnose, and treat the disease. Prevention of cancer is essential for saving lives. Prevalence and incidence of cancer are key factors that each government and population must be aware of. Advances in the study of cancer occur on a regular basis, and this book provides the latest insights about relationships between the disease and stem cells, tumorigenesis, molecular interactions, pathways, channels, and immunity. Global Epidemiology of Cancer: Diagnosis and Treatment meets the needs of readers by providing current information about epidemiology (including molecular epidemiology), diagnosis, and treatment. Providing logical, step-by-step information on various cancers, this book consolidates all of the most up-to-date information and data from verified studies on all different types of cancers in the United States and throughout the world. Chapters are presented so that each includes an overview, clinical manifestations, epidemiology, pathophysiology, etiology and risk factors, diagnosis, treatment, prevention, and prognosis. Global Epidemiology of Cancer: Diagnosis and Treatment will be invaluable to graduate and postgraduate students, including medical students; nurses; physician assistants; residents in oncology; public health students and allied health students.

Current Research on Pre-clinical Aspects of Cancer Therapy

Author : Current Cancer Research Project Analysis Center (U.S.)
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Current Research on Pre-clinical Aspects of Cancer Therapy by : Current Cancer Research Project Analysis Center (U.S.)

Download or read book Current Research on Pre-clinical Aspects of Cancer Therapy written by Current Cancer Research Project Analysis Center (U.S.) and published by . This book was released on 1975 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.