Recent Advances In Migraine Therapy

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Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

White Matter Diseases

Author : Massimo Filippi
Publisher : Springer Nature
ISBN 13 : 303038621X
Total Pages : 215 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis White Matter Diseases by : Massimo Filippi

Download or read book White Matter Diseases written by Massimo Filippi and published by Springer Nature. This book was released on 2020-02-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.

Pituitary Adenylate Cyclase-Activating Polypeptide

Author : Hubert Vaudry
Publisher : Springer Science & Business Media
ISBN 13 : 9781402073069
Total Pages : 432 pages
Book Rating : 4.0/5 (73 download)

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Book Synopsis Pituitary Adenylate Cyclase-Activating Polypeptide by : Hubert Vaudry

Download or read book Pituitary Adenylate Cyclase-Activating Polypeptide written by Hubert Vaudry and published by Springer Science & Business Media. This book was released on 2003 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.

Migraine in Women

Author : Elizabeth Loder
Publisher : PMPH-USA
ISBN 13 : 9781550091809
Total Pages : 212 pages
Book Rating : 4.0/5 (918 download)

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Book Synopsis Migraine in Women by : Elizabeth Loder

Download or read book Migraine in Women written by Elizabeth Loder and published by PMPH-USA. This book was released on 2004 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fifteen specialists serve as chapter authors, covering sex hormones and genetics, as well as the social, cultural, psychiatric, and psychological factors that contribute to headache disorders. Their approach is evidence-based, but where there are gaps in research, the authors provide advice based on expert consensus and clinical experience. Each chapter opens with a case report that synthesizes the chapter's treatment recommendations, as well as key points listing the chapter's contents. The main body of the chapter features an introductory overview, a closing summary, tables, and an extensive list of suggestive reading.

Headache and Migraine Biology and Management

Author : Seymour Diamond
Publisher : Academic Press
ISBN 13 : 0128011629
Total Pages : 334 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Headache and Migraine Biology and Management by : Seymour Diamond

Download or read book Headache and Migraine Biology and Management written by Seymour Diamond and published by Academic Press. This book was released on 2015-03-13 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy. Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues. This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field. - A practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs - Features chapters from leading physicians and researchers in headache medicine - Full-color text that includes both an overview of multiple disciplines and discusses the measures that can be used to treat headaches

Refractory Migraine

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Author : Elliot A. Schulman, FACP, MD
Publisher : Oxford University Press
ISBN 13 : 0199745560
Total Pages : 495 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Refractory Migraine by : Elliot A. Schulman, FACP, MD

Download or read book Refractory Migraine written by Elliot A. Schulman, FACP, MD and published by Oxford University Press. This book was released on 2010-08-05 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have book for any health professional who treats patients with headache disorders, Refractory Migraine is written by international experts from the world's top headache centers. It describes how they approach the treatment of migraine patients who continue to suffer despite appropriate medical treatment. First, it highlights current ideas about the definition and characterization of refractory migraine, and reviews underlying causes and contributing factors. Then, individual chapters cover every important aspect of migraine treatment with the focus entirely on refractory forms of the disorder. Its many features include detailed algorithms for outpatient and inpatient withdrawal from overused medications, innovative drug therapy and nonpharmacological treatments, a list of questions to ask before deciding to try hormonal therapies, and detailed descriptions of how to recognize and interact with patients who have challenging personality disorders or concomitant psychiatric problems. We're confident you'll often turn to this book for advice about challenges in migraine management. When you do, the bulleted lists and boxes that highlight and condense the main messages of each chapter put the information you need at your fingertips. If you treat patients with migraine, you will recognize many of the challenging situations and topics covered in this book - and you will be encouraged by the innovative and resourceful therapeutic strategies suggested by seasoned headache doctors with a wealth of clinical experience. Readable, comprehensive and up to date, this book gives you access to ingenious treatment approaches developed and refined in specialty headache clinics that regularly - and successfully - treat patients with refractory headache problems. When you meet the next migraine patient who says "I've tried it all, and nothing works", you will know where to go for practical advice about what to do next.

Drug-Induced Headache

Author : Hans-Christoph Diener
Publisher : Springer Science & Business Media
ISBN 13 : 3642733271
Total Pages : 174 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Drug-Induced Headache by : Hans-Christoph Diener

Download or read book Drug-Induced Headache written by Hans-Christoph Diener and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. WILKINSON Patients with frequent or daily headaches pose a very difficult problem for the physician who has to treat them, particularly as many patients think that there should be a medicine or medicines which give them instant relief. In the search for the compound which would meet this very natural desire, many drugs have been manufactured and the temptation for the physician is either to increase the dose of a drug which seems to be, at any rate, partially effective, or to add one or more drugs to those which the patient is already taking. Although there have been some references to the dangers of overdosage of drugs for migraine in the past, it was not until relatively recently that it was recognized that drugs given for the relief of headache, if taken injudiciously, may themselves cause headache. The first drugs to be implicated in this way were ergotamine and phenazone. In the case of ergotamine tartrate, the dangers of ergotism were well known as this was a disorder which had been known and written about for many years. In the treatment of headache, fully blown ergotism is rare and in recent years has usually been due to self-medication in doses much greater than those prescribed although there are a few recorded cases where toxic amounts have been given.

The End of Migraines: 150 Ways to Stop Your Pain

Author : Alexander Mauskop
Publisher : New York Headache Center
ISBN 13 : 1736286811
Total Pages : pages
Book Rating : 4.7/5 (362 download)

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Book Synopsis The End of Migraines: 150 Ways to Stop Your Pain by : Alexander Mauskop

Download or read book The End of Migraines: 150 Ways to Stop Your Pain written by Alexander Mauskop and published by New York Headache Center. This book was released on 2021-01-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Alexander Mauskop, M.D., is the founder and medical director of the New York Headache Center. He is also a Professor of Clinical Neurology at the State University of New York Downstate Medical Center in Brooklyn, New York. A leading authority in the field of headache medicine, Dr. Mauskop has lectured widely throughout the world. The End of Migraine: 150 Ways to Stop Your Pain is a comprehensive resource based on Dr. Mauskop’s extensive experience in treating thousands of patients with migraine. In addition to scientific evidence, clinical observations, and practical suggestions, The End of Migraine describes and evaluates the immense amount of information available about every imaginable option that has been shown to impact the occurrence and treatment of migraines. The 150 approaches to ending migraine pain include non-pharmacologic treatments such as avoidance of triggers, diet, physical and behavioral measures, neuro-modulation, and various supplements. It also describes and ranks a wide range of acute and preventive prescription drugs, from the traditional to all of the latest innovations and treatments. The book is written in a clear, concise, and accessible style. Dr. Mauskop’s warm, reassuring voice enables the reader to feel that they are sitting with him, hearing his advice first-hand. Above all, readers of The End of Migraine: 150 Ways to Stop Your Pain will, perhaps for the first time, feel that they are not alone, because there is hope. The book is directed not only to those suffering from migraines but also to neurologists and other health care providers who treat migraine patients.

Pharmacological Management of Headaches

Author : Dimos D. Mitsikostas
Publisher : Springer
ISBN 13 : 3319199110
Total Pages : 253 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Pharmacological Management of Headaches by : Dimos D. Mitsikostas

Download or read book Pharmacological Management of Headaches written by Dimos D. Mitsikostas and published by Springer. This book was released on 2015-08-26 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, headache experts summarize all the currently available therapies for primary headaches and most importantly, describe the ‘tricks’ that can ensure the success of headache pharmacotherapy. Prevention and acute treatment of migraine and cluster headache receive particular attention and individual chapters are devoted to the treatment of primary headaches in special groups, i.e. children, pregnant women and the elderly. Further chapters focus on selected secondary headache disorders and cranial neuralgias for which pharmacotherapy is available. The book is designed to meet the daily practice needs of general physicians, general neurologists, neurologists in training and medical students. Headache remains a leading reason for people to seek medical consultation, and migraine and other primary headache disorders are classified by the WHO as among the most disabling medical conditions in the general population, often affecting individuals during their most productive years. Unfortunately, under treatment and mismanagement are the fate of many headache patients and this book provides a sound basis for optimizing treatment.

Piperidine-Based Drug Discovery

Author : Ruben Vardanyan
Publisher : Elsevier
ISBN 13 : 0128134283
Total Pages : 359 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Piperidine-Based Drug Discovery by : Ruben Vardanyan

Download or read book Piperidine-Based Drug Discovery written by Ruben Vardanyan and published by Elsevier. This book was released on 2017-06-12 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. - Explores this extremely important heterocycle to a high level of detail - Describes synthesis methods for 70 current drugs based on Piperidine scaffolds - Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine - Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Management of Headache and Headache Medications

Author : Lawrence D. Robbins
Publisher : Springer Science & Business Media
ISBN 13 : 1461221242
Total Pages : 354 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Management of Headache and Headache Medications by : Lawrence D. Robbins

Download or read book Management of Headache and Headache Medications written by Lawrence D. Robbins and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: With full revisions and updates, plus new chapters on herbs and vitamins, "triptans," headache during breast feeding, menstrual migraine, opiate abuse, cervicogenic causes of headache, and exercise and sexual headache, this book presents a full and in-depth range of information for primary care physicians and neurologists.

ABC of Headache

Author : Anne MacGregor
Publisher : John Wiley & Sons
ISBN 13 : 1118682009
Total Pages : 88 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis ABC of Headache by : Anne MacGregor

Download or read book ABC of Headache written by Anne MacGregor and published by John Wiley & Sons. This book was released on 2013-05-20 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its different presentations, headache is one of the most commonsymptoms seen by family practitioners. The difficulty is indiagnosing the cause of the headache so that the appropriatetreatment is provided, or if referral to a specialist is therecommended course of action. The ABC of Headache helps with this dilemma and guidesthe healthcare professional to look for the possible causes ofpresenting symptoms. Based on real case histories, each chapterguides the reader from symptoms through to diagnosis andmanagement. This new ABC is a highly illustrated, informative, andpractical source of knowledge. With links to further informationand resources, it is a valuable text for healthcare professionalsat all levels of practice and training.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 850 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

The Migraine Miracle

Author : Josh Turknett
Publisher : New Harbinger Publications
ISBN 13 : 1608828778
Total Pages : 252 pages
Book Rating : 4.6/5 (88 download)

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Book Synopsis The Migraine Miracle by : Josh Turknett

Download or read book The Migraine Miracle written by Josh Turknett and published by New Harbinger Publications. This book was released on 2013-12-01 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you suffer from migraines, you know from experience that prescription medication can only do so much to help relieve your suffering. You also know that your next headache could still strike at any time, and as a result, you may lead a life of fear and trepidation, never knowing when the responsibilities of work and family will once again fall victim to your throbbing skull. Unfortunately, despite the many advances in medicine, there is still no real cure for the migraine headache. In The Migraine Miracle, a neurologist with a personal history of migraines offers readers the revolutionary dietary cure that has worked for him and continues to work for his patients: a diet low in wheat, sugar, and processed foods, and high in organic, protein-rich animal products. The book also explores the link between inflammation, diet, and migraines, and contains a 21-day meal plan to help readers change the way they eat. By following this easy meal plan, millions of sufferers will discover a life free from symptoms—once and for all. The book includes comprehensive, research-based information that explains what the brain goes through during a migraine headache, the phases of the migraine, and how a diagnosis is made. It also explores the risks and benefits of migraine medication, natural remedies for migraines, dietary migraine triggers, and detailed, specific instructions for a migraine-free eating plan. If you have tried migraine medicine but have not found real relief, it’s time to try something new. By changing the way you eat, and understanding what foods can trigger your migraine, you can start feeling better longer, without the threat of a migraine always looming over everything you do.

The Headaches

Author : Jes Olesen
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0781754003
Total Pages : 1212 pages
Book Rating : 4.7/5 (817 download)

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Book Synopsis The Headaches by : Jes Olesen

Download or read book The Headaches written by Jes Olesen and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established worldwide as the one definitive, encyclopedic reference on headache, The Headaches is now in its thoroughly revised, updated Third Edition. The foremost international authorities examine the mechanisms of over 100 types of headache and provide evidence-based treatment recommendations, including extensive tables of controlled clinical trials. This edition presents the revised International Headache Society classification of headaches and explains how to use this new classification for accurate diagnosis. Many headache entities are discussed for the first time, such as chronic migraines; primary headache attributed to sexual activity; primary stabbing, cough, exertional, and thunderclap headaches; hypnic headaches; and new daily persistent headaches. A new section focuses on childhood headaches. Chapters that focus on headaches in elderly patients and patients with psychiatric or medical diseases are also included.

What Your Doctor May Not Tell You About(TM): Migraines

Author : Alexander Mauskop
Publisher : Grand Central Publishing
ISBN 13 : 0446537055
Total Pages : 217 pages
Book Rating : 4.4/5 (465 download)

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Book Synopsis What Your Doctor May Not Tell You About(TM): Migraines by : Alexander Mauskop

Download or read book What Your Doctor May Not Tell You About(TM): Migraines written by Alexander Mauskop and published by Grand Central Publishing. This book was released on 2007-11-01 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing details of the pros and cons of common prescription medications, this text explains Dr. Mauskop's patient-tested, seven-step programme for migraine relief. It includes tips on avoiding migraine triggers in food, the home & the environment.

Managing Your Migraine

Author : Katy Munro
Publisher : Penguin UK
ISBN 13 : 0241514290
Total Pages : 224 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Managing Your Migraine by : Katy Munro

Download or read book Managing Your Migraine written by Katy Munro and published by Penguin UK. This book was released on 2021-08-26 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'A fantastic and much needed resource for all those suffering. Dr Katy Munro's experience and knowledge through this book will help all those who read it' Dr Rupy Aujla, The Doctor's Kitchen 'Dr Katy Munro is the single best migraine expert our family have ever met [...] This book brings hope to every migraineur' Miranda Sawyer, Guardian & Observer Journalist ***** Despite being one of the most common and debilitating conditions in the world, migraine is still widely misunderstood, stigmatised and misdiagnosed. Migraine is much more than 'just a headache', it's a genetic, neurological brain disorder, and it's time patients got the healp they really need. Managing Your Migraine is the practical go-to guide for understanding and treating migraine. In the book, headache Specialist and GP Dr Katy Munro will give you expert advice on: · Understanding your migraine phases and triggers · The impact of food, exercise and sleep on migraine · Rescue plans for acute attacks · Migraine preventers · Migraine in children · Managing your mental health with migraine If you're a person with migraine, or know someone struggling, this book will provide helpful strategies for alleviating your symptoms and managing your migraine. Drawing on her medical expertise, her own personal experience with migraine and the stories of her patients, Dr Munro will empower you to get to know your own migraine and build an effective treatment plan that will help you live your life more fully. Part of the Penguin Life Experts series.