Radioimmunoassays For Insulin C Peptide And Proinsulin

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Radioimmunoassays for Insulin, C-Peptide and Proinsulin

Author : L. Heding
Publisher : Springer Science & Business Media
ISBN 13 : 9401170940
Total Pages : 85 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Radioimmunoassays for Insulin, C-Peptide and Proinsulin by : L. Heding

Download or read book Radioimmunoassays for Insulin, C-Peptide and Proinsulin written by L. Heding and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

The Discovery of Insulin

Author : Michael Bliss
Publisher : University of Toronto Press
ISBN 13 : 1487516746
Total Pages : 524 pages
Book Rating : 4.4/5 (875 download)

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Book Synopsis The Discovery of Insulin by : Michael Bliss

Download or read book The Discovery of Insulin written by Michael Bliss and published by University of Toronto Press. This book was released on 2017-06-22 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.

Diabetes & C-Peptide

Author : Anders A.F. Sima
Publisher : Springer Science & Business Media
ISBN 13 : 1617793914
Total Pages : 176 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Diabetes & C-Peptide by : Anders A.F. Sima

Download or read book Diabetes & C-Peptide written by Anders A.F. Sima and published by Springer Science & Business Media. This book was released on 2011-11-04 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide’s physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

Diabetes Mellitus in Children

Author : Mark A. Sperling
Publisher :
ISBN 13 : 9781416027539
Total Pages : 0 pages
Book Rating : 4.0/5 (275 download)

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Book Synopsis Diabetes Mellitus in Children by : Mark A. Sperling

Download or read book Diabetes Mellitus in Children written by Mark A. Sperling and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Unveiling Diabetes - Historical Milestones in Diabetology

Author : V. Jörgens
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318067342
Total Pages : 318 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Unveiling Diabetes - Historical Milestones in Diabetology by : V. Jörgens

Download or read book Unveiling Diabetes - Historical Milestones in Diabetology written by V. Jörgens and published by Karger Medical and Scientific Publishers. This book was released on 2020-08-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: A history of diabetology told by renowned contributors, many have themselves already become a part of diabetes history. A must-have for every diabetologist! Diabetologists, diabetes educators, and many interested readers will appreciate this book. What is more, countless celebrations are planned for the 100th anniversary of the discovery of insulin: this book provides numerous illustrations, accounts of personal experiences, and critical remarks on the history of diabetology – in addition to the history of insulin. It spans an arc from antiquity to the work of Claude Bernard, Paul Langerhans, Josef von Mering, Apollinaire Bouchardat, Oskar Minkowski, E.P. Joslin, and F.M. Allen. The history of insulin is presented from the perspective of diabetologists from Scotland, Spain, Germany, and Poland. The history of oral antidiabetics is told by Harald Lebovitz, and the chapter about glitazones by Edwin Gale reads like a spy novel! Pierre Lefèbvre describes the work of the diabetologist Jean Pirart and the history of glucagon. Sir George Alberti has provided a chapter about the therapy of ketoacidosis, to which he himself made groundbreaking contributions. Nephropathy is presented by Hans-Henrik Parving, and Eva Kohner, Ronald Klein and Barbara E.K. Klein have contributed a chapter on retinopathy. Other contemporary topics such diabetes in pregnancy, diabetes technology, psychosocial aspects of diabetes, and the history of the EASD and ADA are also included in this book.

Joslin's Diabetes Mellitus

Author : Elliott Proctor Joslin
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781727969
Total Pages : 1244 pages
Book Rating : 4.7/5 (279 download)

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Book Synopsis Joslin's Diabetes Mellitus by : Elliott Proctor Joslin

Download or read book Joslin's Diabetes Mellitus written by Elliott Proctor Joslin and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 1244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "bible" on diabetes mellitus is now in its Fourteenth Edition—thoroughly revised and updated by more than 80 noted experts from the Joslin Diabetes Center and other leading institutions worldwide. This edition includes a new eleven-chapter section on hormone action and the regulation of metabolism. The section on definition and pathogenesis now includes chapters on genetics, diabetes in Asia and Africa, and diabetes in U.S. minority groups. Other new chapters cover retinopathy, cardiovascular disease, wound healing, and treatment of women with diabetes. All of the Fourteenth Edition's figures have been completely updated.

Insulin Murders

Author : Vincent Marks
Publisher : CRC Press
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.7/5 (637 download)

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Book Synopsis Insulin Murders by : Vincent Marks

Download or read book Insulin Murders written by Vincent Marks and published by CRC Press. This book was released on 2007-04-26 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book ever to describe real life cases of murder, and purported murder, using insulin as a weapon. Covers cases from the USA, UK, Europe, Japan and New Zealand, including the well known Claus von Bulow case, the first criminal trial to be broadcast in its entirety on US TV (later the subject of a Hollywood movie, Reversal of Fortune). Written by Vincent Marks, coauthor of the critically acclaimed book Panic Nation: Exposing the Lies We're Told About Food and Health (John Blake Publishing) and a world authority on insulin, and Caroline Richmond, a medical journalist and writer, this gripping account is intended for doctors and laypeople alike, especially those with an interest in forensic medicine or true life crime.

Handbook of Immunoassay Technologies

Author : Sandeep K. Vashist
Publisher : Academic Press
ISBN 13 : 012811794X
Total Pages : 498 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of Immunoassay Technologies by : Sandeep K. Vashist

Download or read book Handbook of Immunoassay Technologies written by Sandeep K. Vashist and published by Academic Press. This book was released on 2018-01-02 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Immunoassay Technologies: Approaches, Performances, and Applications unravels the role of immunoassays in the biochemical sciences. During the last four decades, a wide range of immunoassays has been developed, ranging from the conventional enzyme-linked immunosorbent assays, to the smartphone-based point-of-care formats. The advances in rapid biochemical procedures, novel biosensing schemes, fully integrated lab-on-a-chip platforms, prolonged biomolecular storage strategies, device miniaturization and interfacing, and emerging smart system technologies equipped with personalized mobile healthcare tools are paving the way to next-generation immunoassays, and are all discussed in this comprehensive text. Immunoassays play a prominent role in clinical diagnostics as they are the eyes of healthcare professionals, helping them make informed clinical decisions via confirmed disease diagnosis, and thus enabling favorable health outcomes. The faster and reliable diagnosis of infections will further control their spread to uninfected persons. Similarly, immunoassays play a prominent role in veterinary diagnostics, food analysis, environmental monitoring, defense and security, and other bioanalytical settings. Therefore, they enable the detection of a plethora of analytes, which includes disease biomarkers, pathogens, drug impurities, environmental contaminants, allergens, food adulterants, drugs of abuse and various biomolecules. - Provides a valuable increase of understanding of cellular and biomedical functions - Gives the most updated resource in the field of immunoassays, providing the comprehensive details of various types of immunoassays that need to be performed in healthcare, and in industrial, environmental and other biochemical settings - Discusses all multifarious aspects of immunoassays - Describes the immunoassay formats, along with their principle of operation, characteristics, pros and cons, and potential biochemical and bioanalytical applications - Provides extensive knowledge and guided insights as detailed by experienced, renowned experts and key opinion makers in the field of immunoassays

Tietz Clinical Guide to Laboratory Tests - E-Book

Author : Alan H. B. Wu
Publisher : Elsevier Health Sciences
ISBN 13 : 1437719872
Total Pages : 1857 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Tietz Clinical Guide to Laboratory Tests - E-Book by : Alan H. B. Wu

Download or read book Tietz Clinical Guide to Laboratory Tests - E-Book written by Alan H. B. Wu and published by Elsevier Health Sciences. This book was released on 2006-06-08 with total page 1857 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of Norbert Tietz's classic handbook presents information on common tests as well as rare and highly specialized tests and procedures - including a summary of the utility and merit of each test. Biological variables that may affect test results are discussed, and a focus is placed on reference ranges, diagnostic information, clinical interpretation of laboratory data, interferences, and specimen types. New and updated content has been added in all areas, with over 100 new tests added. - Tests are divided into 8 main sections and arranged alphabetically. - Each test includes necessary information such as test name (or disorder) and method, specimens and special requirements, reference ranges, chemical interferences and in vivo effects, kinetic values, diagnostic information, factors influencing drug disposition, and clinical comments and remarks. - The most current and relevant tests are included; outdated tests have been eliminated. - Test index (with extensive cross references) and disease index provide the reader with an easy way to find necessary information - Four new sections in key areas (Preanalytical, Flow Cytometry, Pharmacogenomics, and Allergy) make this edition current and useful. - New editor Alan Wu, who specializes in Clinical Chemistry and Toxicology, brings a wealth of experience and expertise to this edition. - The Molecular Diagnostics section has been greatly expanded due to the increased prevalence of new molecular techniques being used in laboratories. - References are now found after each test, rather than at the end of each section, for easier access.

Immunotherapy of Type 1 Diabetes

Author : Domenico Andreani
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunotherapy of Type 1 Diabetes by : Domenico Andreani

Download or read book Immunotherapy of Type 1 Diabetes written by Domenico Andreani and published by John Wiley & Sons. This book was released on 1989 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent national, European and international diabetes meetings have seen controversial discussions on the potential benefit and also on ethical aspects of immune intervention in patients with Type 1 diabetes or in persons with a high risk of developing the disease.

Understanding Insulin and Insulin Resistance

Author : Anil Gupta
Publisher : Elsevier
ISBN 13 : 012820379X
Total Pages : 321 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Understanding Insulin and Insulin Resistance by : Anil Gupta

Download or read book Understanding Insulin and Insulin Resistance written by Anil Gupta and published by Elsevier. This book was released on 2021-11-17 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Insulin and Insulin Resistance is written in a simple and clear language illustrated with diagrams that show the complex interplay of various factors in the initiation of insulin resistance. The design is systematic and meticulous, portraying topics in a flow from simple to complex. This resource is intended for a broad audience spanning across biochemistry, medicine, dentistry, academia, physicians, and research scholars. It extends the approach to biochemistry, physiology, metabolism of insulin along with the coverage of pathophysiology of insulin resistance, its effects on the body tissues, and its analysis on insulin resistance syndrome.

Ghrelin

Author : Ezio Ghigo
Publisher : Springer Science & Business Media
ISBN 13 : 140207770X
Total Pages : 259 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Ghrelin by : Ezio Ghigo

Download or read book Ghrelin written by Ezio Ghigo and published by Springer Science & Business Media. This book was released on 2004-06-18 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ghrelin is a 28-amino acid acylated peptide predominatntly produced by the stomach. Highlights the impact and function of the hormone ghrelin and provides insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.

Principles of Diabetes Mellitus

Author : Leonid Poretsky
Publisher : Springer Science & Business Media
ISBN 13 : 9781402071140
Total Pages : 788 pages
Book Rating : 4.0/5 (711 download)

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Book Synopsis Principles of Diabetes Mellitus by : Leonid Poretsky

Download or read book Principles of Diabetes Mellitus written by Leonid Poretsky and published by Springer Science & Business Media. This book was released on 2002 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.

Galenics of Insulin

Author : Jens Brange
Publisher : Springer Science & Business Media
ISBN 13 : 3662025264
Total Pages : 108 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Galenics of Insulin by : Jens Brange

Download or read book Galenics of Insulin written by Jens Brange and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Galenical pharmacy or galenics is the science dealing with the pro duction of drug substances from raw materials, the purity of such substances, their formulation into pharmaceutical preparations with the desired effects and safety in use, and the quality control, stability and storage of the preparations. The field has taken its name from the Greek physician Galen (131-201 A.D.), who had a profound influence on medicine for many centuries because he collected and systematized the medicinal knowledge of his time. The discovery of insulin is attributed to Banting and Best who, in 1921, prepared an extract of the pancreas of the fetal calf and showed that the extract was capable of reducing the blood sugar level of a diabetic dog. This outstanding discovery gave rise to the rapid develop ment of the manufacture of insulin of bovine and porcine origin. By 1925, two Danish manufacturers of insulin preparations were established; both have since been in the forefront ofthe development of insulin preparations, the latest achievement being the marketing of human insulin by Novo in 1982. The development of highly purified human insulin produced semisynthetically from porcine insulin or by DNA recombinant methods are significant contributions to safe and efficient insulin therapy. Insulin is a protein which is destroyed in the gastrointestinal tract.

Biotechnology for Beginners

Author : Reinhard Renneberg
Publisher : Academic Press
ISBN 13 : 0323855709
Total Pages : 476 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Biotechnology for Beginners by : Reinhard Renneberg

Download or read book Biotechnology for Beginners written by Reinhard Renneberg and published by Academic Press. This book was released on 2023-01-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology for Beginners, Third Edition presents the latest developments in the evolving field of biotechnology which has grown to such an extent over the past few years that increasing numbers of professional's work in areas that are directly impacted by the science. This book offers an exciting and colorful overview of biotechnology for professionals and students in a wide array of the life sciences, including genetics, immunology, biochemistry, agronomy and animal science. This book will also appeals to lay readers who do not have a scientific background but are interested in an entertaining and informative introduction to the key aspects of biotechnology. Authors Renneberg and Loroch discuss the opportunities and risks of individual technologies and provide historical data in easy-to-reference boxes, highlighting key topics. The book covers all major aspects of the field, from food biotechnology to enzymes, genetic engineering, viruses, antibodies, and vaccines, to environmental biotechnology, transgenic animals, analytical biotechnology, and the human genome. - Covers the whole of biotechnology - Presents an extremely accessible style, including lavish and humorous illustrations throughout - Includes new chapters on CRISPR cas-9, COVID-19, the biotechnology of cancer, and more

Immunoenzymatic Techniques

Author : S. Avrameas
Publisher : Elsevier Science & Technology
ISBN 13 :
Total Pages : 428 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis Immunoenzymatic Techniques by : S. Avrameas

Download or read book Immunoenzymatic Techniques written by S. Avrameas and published by Elsevier Science & Technology. This book was released on 1983 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aandacht voor de enzymatische-immunocytochemie met de nadruk op intracellulaire penetratie van gelabelde antilichamen en de toepassing van "double staining"-methodes of monoclonale antilichamen in normale en in diverse experimentele of pathologische omstandigheden; kwantitatieve aspecten van immuno-enzymatische technieken, zoals nieuwe technische vindingen en toepassingen op verschillende gebieden, bijvoorbeeld biologie, humane en veterinaire geneeskunde, fytopathologie en experimentele ziekten

The Endocrine System in Sports and Exercise

Author : William J. Kraemer
Publisher : John Wiley & Sons
ISBN 13 : 0470757809
Total Pages : 648 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis The Endocrine System in Sports and Exercise by : William J. Kraemer

Download or read book The Endocrine System in Sports and Exercise written by William J. Kraemer and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable new addition to the Encyclopaedia of Sports Medicine series provides a comprehensive and logical look at the principles and mechanisms of endocrinology as related to sports and exercise. It looks at growth hormone factors involved in exercise and the endocrinology of sport competition. It considers various factors and stresses on the body that may alter sporting performance. It covers topics from the acute responses and chronic adaptations of the human endocrine system to the muscular activity involved in conditioning exercise, physical labor, and sport activities. This book is an essential reference for helping to plan better programs of physical fitness, to prepare for sports competitions, and to manage the medical care of athletes.