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Quantitative Imaging Tools For Lung Cancer Drug Assessment
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Book Synopsis Quantitative Imaging Tools for Lung Cancer Drug Assessment by : James L. Mulshine
Download or read book Quantitative Imaging Tools for Lung Cancer Drug Assessment written by James L. Mulshine and published by Wiley-OSA. This book was released on 2008-04-14 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents chapters written by leading clinical researchers in the field of lung cancer, where high resolution 3-D imaging technology appears to hold the greatest near-term promise, as well as contributions from recognized experts in CAD, medical information technology systems, regulatory procedure, x-ray standards development, and clinical trial design. These expert contributors discuss the current state of the art and provide a road map for directing further research in lung cancer as well as other organ systems.
Book Synopsis Molecular Imaging Biomarkers in Prostate and Lung Cancers by : Stephanie Anne Harmon
Download or read book Molecular Imaging Biomarkers in Prostate and Lung Cancers written by Stephanie Anne Harmon and published by . This book was released on 2016 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a fundamental need for comprehensive patient characterization and treatment response assessment in clinical oncology. Molecular imaging allows for survey of functional and biological characteristics of a patient's disease throughout treatment. Traditional integration of imaging in clinical care has relied on qualitative evaluation. The overall objective of this dissertation was to evaluate the utility of quantitative molecular imaging in two oncologic malignancies, non-small cell lung cancer (NSCLC) and metastatic castration-resistant prostate cancer (mCRPC). In lung cancer, there is an urgent need to identify early-stage NSCLC patients at risk of post-surgical disease recurrence. We evaluated quantitative metrics from pre-surgical 18F-FDG PET/CT in early-stage NSCLC patients, correlating uptake patterns with outcome intervals. We found metrics describing uptake heterogeneity, including Entropy-GLCM, showed significant, independent associations with 5-year disease-free survival. We also reported significant differences in imaging metrics across squamous cell carcinoma (SCC) and adenocarcinoma (AC) histologies. Our work highlights this phenomenon influences population-level correlation to outcome, with enhanced characterization and predictive ability when accounting for histological differences. Typically characterized by qualitative assessment, i.e. counting of lesions, quantitative biomarkers of mCRPC are in their infancy. We investigated quantitative 18F-NaF PET/CT metrics by evaluating individual lesions throughout treatment for complete disease assessment. Total function burden (SUV[total]) of metastatic bone lesions determined by NaF PET/CT was the strongest correlate of progression-related events in a population of mCRPC patients. Response in SUVtotal assessed within 12 weeks of starting therapy could serve as a surrogate endpoint of progression-related events. mCRPC patients are largely evaluated on appearance of new or worsening lesions, our strong correlation to progression-related events indicates the bias of clinical decisions mediated by a small population of lesions could undersample patient benefit. Finally, we have outlined the development and testing of a novel algorithm to guide clinical biopsies for patients with multiple tumors. Typical workflow of clinical biopsies in these cases are based on physician discretion. Bycombining quantitative imaging information with physician feasibility requirements, robust biopsy site selection in was achieved. This novel algorithm can serve as a basis for automatic site selection in any case of patients with multiple lesions.
Book Synopsis Molecular Imaging Biomarkers in Prostate and Lung Cancers by : Stephanie Anne Harmon
Download or read book Molecular Imaging Biomarkers in Prostate and Lung Cancers written by Stephanie Anne Harmon and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a fundamental need for comprehensive patient characterization and treatment response assessment in clinical oncology. Molecular imaging allows for survey of functional and biological characteristics of a patient's disease throughout treatment. Traditional integration of imaging in clinical care has relied on qualitative evaluation. The overall objective of this dissertation was to evaluate the utility of quantitative molecular imaging in two oncologic malignancies, non-small cell lung cancer (NSCLC) and metastatic castration-resistant prostate cancer (mCRPC). In lung cancer, there is an urgent need to identify early-stage NSCLC patients at risk of post-surgical disease recurrence. We evaluated quantitative metrics from pre-surgical 18F-FDG PET/CT in early-stage NSCLC patients, correlating uptake patterns with outcome intervals. We found metrics describing uptake heterogeneity, including Entropy-GLCM, showed significant, independent associations with 5-year disease-free survival. We also reported significant differences in imaging metrics across squamous cell carcinoma (SCC) and adenocarcinoma (AC) histologies. Our work highlights this phenomenon influences population-level correlation to outcome, with enhanced characterization and predictive ability when accounting for histological differences. Typically characterized by qualitative assessment, i.e. counting of lesions, quantitative biomarkers of mCRPC are in their infancy. We investigated quantitative 18F-NaF PET/CT metrics by evaluating individual lesions throughout treatment for complete disease assessment. Total function burden (SUV[total]) of metastatic bone lesions determined by NaF PET/CT was the strongest correlate of progression-related events in a population of mCRPC patients. Response in SUVtotal assessed within 12 weeks of starting therapy could serve as a surrogate endpoint of progression-related events. mCRPC patients are largely evaluated on appearance of new or worsening lesions, our strong correlation to progression-related events indicates the bias of clinical decisions mediated by a small population of lesions could undersample patient benefit. Finally, we have outlined the development and testing of a novel algorithm to guide clinical biopsies for patients with multiple tumors. Typical workflow of clinical biopsies in these cases are based on physician discretion. Bycombining quantitative imaging information with physician feasibility requirements, robust biopsy site selection in was achieved. This novel algorithm can serve as a basis for automatic site selection in any case of patients with multiple lesions.
Book Synopsis Lung Cancer and Personalized Medicine by : Aamir Ahmad
Download or read book Lung Cancer and Personalized Medicine written by Aamir Ahmad and published by Springer. This book was released on 2015-12-14 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
Book Synopsis DICOM Structured Reporting by : David A. Clunie
Download or read book DICOM Structured Reporting written by David A. Clunie and published by PixelMed Publishing. This book was released on 2000 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lung Cancer Imaging by : James G. Ravenel
Download or read book Lung Cancer Imaging written by James G. Ravenel and published by Springer Science & Business Media. This book was released on 2013-06-22 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their patients is being treated for lung cancer.
Book Synopsis Brain Tumor Imaging by : Elke Hattingen
Download or read book Brain Tumor Imaging written by Elke Hattingen and published by Springer. This book was released on 2015-09-02 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Book Synopsis PET/CT in Lung Cancer by : Archi Agrawal
Download or read book PET/CT in Lung Cancer written by Archi Agrawal and published by Springer. This book was released on 2018-02-16 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, excellently illustrated pocket book provides an up-to-date summary of the science and practice of PET/CT imaging in lung cancer. The coverage encompasses the entire spectrum of lung cancer – pathology, radiological and PET/CT imaging, and management. Readers will also find information on the physics of PET and its use in respiratory gating and radiotherapy planning. The highlights of the book are the exquisite depiction of normal variants, pitfalls, and artifacts and a pictorial atlas of the various types of lung cancer and their manifestations. The contributing authors are well-known and experienced oncologists, pathologists, radiologists, and nuclear physicians. This book has been compiled under the auspices of the British Nuclear Medicine Society. It will be of high value for nuclear physicians, radiologists, referring clinicians and oncologists, and paramedical staff working in these fields
Book Synopsis Pulmonary Functional Imaging by : Yoshiharu Ohno
Download or read book Pulmonary Functional Imaging written by Yoshiharu Ohno and published by Springer Nature. This book was released on 2020-12-11 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the basics of pulmonary functional imaging using new CT and MR techniques and describes the clinical applications of these techniques in detail. The intention is to equip readers with a full understanding of pulmonary functional imaging that will allow optimal application of all relevant techniques in the assessment of a variety of diseases, including COPD, asthma, cystic fibrosis, pulmonary thromboembolism, pulmonary hypertension, lung cancer and pulmonary nodule. Pulmonary functional imaging has been promoted as a research and diagnostic tool that has the capability to overcome the limitations of morphological assessments as well as functional evaluation based on traditional nuclear medicine studies. The recent advances in CT and MRI and in medical image processing and analysis have given further impetus to pulmonary functional imaging and provide the basis for future expansion of its use in clinical applications. In documenting the utility of state-of-the-art pulmonary functional imaging in diagnostic radiology and pulmonary medicine, this book will be of high value for chest radiologists, pulmonologists, pulmonary surgeons, and radiation technologists.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309457971 Total Pages :145 pages Book Rating :4.3/5 (94 download)
Book Synopsis The Drug Development Paradigm in Oncology by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Drug Development Paradigm in Oncology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-02-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Oncologic Imaging by : David G. Bragg
Download or read book Oncologic Imaging written by David G. Bragg and published by Saunders. This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely updated to reflect the latest developments in science and technology, the second edition of this reference presents the diagnostic imaging tools essential to the detection, diagnosis, staging, treatment planning, and post-treatment management of cancer in both adults and children. Organized by major organs and body systems, the text offers comprehensive, abundantly illustrated guidance to enable both the radiologist and clinical oncologist to better appreciate and overcome the challenges of tumor imaging. Features 12 brand-new chapters that examine new imaging techniques, molecular imaging, minimally invasive approaches, 3D and conformal treatment planning, interventional techniques in radiation oncology, interventional breast techniques, and more. Emphasizes practical interactions between oncologists and radiologists. Includes expanded coverage of paediatric tumours as well as thorax, gastrointestinal tract, genitourinary, and musculoskeletal cancers. Offers reorganized and increased content on the brain and spinal cord. Nearly 1,400 illustrations enable both the radiologist and clinical oncologist to better appreciate and overcome the challenges of tumour imaging. - Outstanding Features! Presents internationally renowned authors' insights on recent technological breakthroughs in imaging for each anatomical region, and offers their views on future advances in the field. Discusses the latest advances in treatment planning. Devotes four chapters to the critical role of imaging in radiation treatment planning and delivery. Makes reference easy with a body-system organisation.
Book Synopsis MRI of the Lung by : Hans-Ulrich Kauczor
Download or read book MRI of the Lung written by Hans-Ulrich Kauczor and published by Springer Science & Business Media. This book was released on 2008-11-12 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade significant developments have been achieved in the field of magnetic resonance imaging (MRI), enabling MRI to enter the clinical arena of chest imaging. Standard protocols can now be implemented on up-to-date scanners, allowing MRI to be used as a first-line imaging modality for various lung diseases, including cystic fibrosis, pulmonary hypertension and even lung cancer. The diagnostic benefits stem from the ability of MRI to visualize changes in lung structure while simultaneously imaging different aspects of lung function, such as perfusion, respiratory motion, ventilation and gas exchange. On this basis, novel quantitative surrogates for lung function can be obtained. This book provides a comprehensive overview of how to use MRI for imaging of lung disease. Special emphasis is placed on benign diseases requiring regular monitoring, given that it is patients with these diseases who derive the greatest benefit from the avoidance of ionizing radiation.
Book Synopsis MRI for Radiotherapy by : Gary Liney
Download or read book MRI for Radiotherapy written by Gary Liney and published by Springer. This book was released on 2019-06-20 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides, for the first time, a unified approach to the application of MRI in radiotherapy that incorporates both a physics and a clinical perspective. Readers will find detailed information and guidance on the role of MRI in all aspects of treatment, from dose planning, with or without CT, through to response assessment. Extensive coverage is devoted to the latest technological developments and emerging options. These include hybrid MRI treatment systems, such as MRI-Linac and proton-guided systems, which are ushering in an era of real-time MRI guidance. The past decade has witnessed an unprecedented rise in the use of MRI in the radiation treatment of cancer. The development of highly conformal dose delivery techniques has led to a growing need to harness advanced imaging for patient treatment. With its flexible soft tissue contrast and ability to acquire functional information, MRI offers advantages at all stages of treatment. In documenting the state of the art in the field, this book will be of value to a wide range of professionals. The authors are international experts drawn from the scientific committee of the 2017 MR in RT symposium and the faculty of the ESTRO teaching course on imaging for physicists.
Book Synopsis Magnetic Particle Imaging by : Tobias Knopp
Download or read book Magnetic Particle Imaging written by Tobias Knopp and published by Springer Science & Business Media. This book was released on 2012-05-04 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.
Book Synopsis Radiomics and Radiogenomics by : Ruijiang Li
Download or read book Radiomics and Radiogenomics written by Ruijiang Li and published by CRC Press. This book was released on 2019-07-09 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation
Book Synopsis Quantitative MRI of the Brain by : Paul Tofts
Download or read book Quantitative MRI of the Brain written by Paul Tofts and published by John Wiley & Sons. This book was released on 2005-08-19 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2004 BMA Medical Book Competition Winner (Radiology category) “This is an exciting book, with a new approach to use of the MRI scanner. It bridges the gap between clinical research and general neuro-radiological practice. It is accessible to the clinical radiologist, and yet thorough in its treatment of the underlying physics and of the science of measurement. It is likely to become a classic.” British Medical Association This indispensable 'how to' manual of quantitative MR is essential for anyone who wants to use the gamut of modern quantitative methods to measure the effects of neurological disease, its progression, and its response to treatment. It contains both the methodology and clinical applications, reflecting the increasing interest in quantitative MR in studying disease and its progression. The editor is an MR scientist with an international reputation for high quality research The contributions are written jointly by MR physicists and MR clinicians, producing a practical book for both the research and medical communities A practical book for both the research and medical communities “Paul Tofts has succeeded brilliantly in capturing the essence of what needs to become the future of radiology in particular, and medicine in general – quantitative measurements of disease.” Robert I. Grossman, M.D. New York, University School of Medicine (from the Foreword)
Book Synopsis Helical/spiral CT by : Robert K. Zeman
Download or read book Helical/spiral CT written by Robert K. Zeman and published by McGraw-Hill Incorporated Health Services Division. This book was released on 1995 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text responds to the new era in CT scanning in which the X-ray tube is rotated continuously around the patient. Since helical/spiral CT is superior to conventional CT, it is expected to become the standard technique by the late 1990s.
