Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition

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Publisher : CABI
ISBN 13 : 1789240212
Total Pages : 433 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition by : Manjit S. Kang

Download or read book Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition written by Manjit S. Kang and published by CABI. This book was released on 2020-04-01 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base.

Quantitative Genetics in Maize Breeding

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Publisher : Springer Science & Business Media
ISBN 13 : 1441907661
Total Pages : 669 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Quantitative Genetics in Maize Breeding by : Arnel R. Hallauer

Download or read book Quantitative Genetics in Maize Breeding written by Arnel R. Hallauer and published by Springer Science & Business Media. This book was released on 2010-09-28 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maize is used in an endless list of products that are directly or indirectly related to human nutrition and food security. Maize is grown in producer farms, farmers depend on genetically improved cultivars, and maize breeders develop improved maize cultivars for farmers. Nikolai I. Vavilov defined plant breeding as plant evolution directed by man. Among crops, maize is one of the most successful examples for breeder-directed evolution. Maize is a cross-pollinated species with unique and separate male and female organs allowing techniques from both self and cross-pollinated crops to be utilized. As a consequence, a diverse set of breeding methods can be utilized for the development of various maize cultivar types for all economic conditions (e.g., improved populations, inbred lines, and their hybrids for different types of markets). Maize breeding is the science of maize cultivar development. Public investment in maize breeding from 1865 to 1996 was $3 billion (Crosbie et al., 2004) and the return on investment was $260 billion as a consequence of applied maize breeding, even without full understanding of the genetic basis of heterosis. The principles of quantitative genetics have been successfully applied by maize breeders worldwide to adapt and improve germplasm sources of cultivars for very simple traits (e.g. maize flowering) and very complex ones (e.g., grain yield). For instance, genomic efforts have isolated early-maturing genes and QTL for potential MAS but very simple and low cost phenotypic efforts have caused significant and fast genetic progress across genotypes moving elite tropical and late temperate maize northward with minimal investment. Quantitative genetics has allowed the integration of pre-breeding with cultivar development by characterizing populations genetically, adapting them to places never thought of (e.g., tropical to short-seasons), improving them by all sorts of intra- and inter-population recurrent selection methods, extracting lines with more probability of success, and exploiting inbreeding and heterosis. Quantitative genetics in maize breeding has improved the odds of developing outstanding maize cultivars from genetically broad based improved populations such as B73. The inbred-hybrid concept in maize was a public sector invention 100 years ago and it is still considered one of the greatest achievements in plant breeding. Maize hybrids grown by farmers today are still produced following this methodology and there is still no limit to genetic improvement when most genes are targeted in the breeding process. Heterotic effects are unique for each hybrid and exotic genetic materials (e.g., tropical, early maturing) carry useful alleles for complex traits not present in the B73 genome just sequenced while increasing the genetic diversity of U.S. hybrids. Breeding programs based on classical quantitative genetics and selection methods will be the basis for proving theoretical approaches on breeding plans based on molecular markers. Mating designs still offer large sample sizes when compared to QTL approaches and there is still a need to successful integration of these methods. There is a need to increase the genetic diversity of maize hybrids available in the market (e.g., there is a need to increase the number of early maturing testers in the northern U.S.). Public programs can still develop new and genetically diverse products not available in industry. However, public U.S. maize breeding programs have either been discontinued or are eroding because of decreasing state and federal funding toward basic science. Future significant genetic gains in maize are dependent on the incorporation of useful and unique genetic diversity not available in industry (e.g., NDSU EarlyGEM lines). The integration of pre-breeding methods with cultivar development should enhance future breeding efforts to maintain active public breeding programs not only adapting and improving genetically broad-based germplasm but also developing unique products and training the next generation of maize breeders producing research dissertations directly linked to breeding programs. This is especially important in areas where commercial hybrids are not locally bred. More than ever public and private institutions are encouraged to cooperate in order to share breeding rights, research goals, winter nurseries, managed stress environments, and latest technology for the benefit of producing the best possible hybrids for farmers with the least cost. We have the opportunity to link both classical and modern technology for the benefit of breeding in close cooperation with industry without the need for investing in academic labs and time (e.g., industry labs take a week vs months/years in academic labs for the same work). This volume, as part of the Handbook of Plant Breeding series, aims to increase awareness of the relative value and impact of maize breeding for food, feed, and fuel security. Without breeding programs continuously developing improved germplasm, no technology can develop improved cultivars. Quantitative Genetics in Maize Breeding presents principles and data that can be applied to maximize genetic improvement of germplasm and develop superior genotypes in different crops. The topics included should be of interest of graduate students and breeders conducting research not only on breeding and selection methods but also developing pure lines and hybrid cultivars in crop species. This volume is a unique and permanent contribution to breeders, geneticists, students, policy makers, and land-grant institutions still promoting quality research in applied plant breeding as opposed to promoting grant monies and indirect costs at any short-term cost. The book is dedicated to those who envision the development of the next generation of cultivars with less need of water and inputs, with better nutrition; and with higher percentages of exotic germplasm as well as those that pursue independent research goals before searching for funding. Scientists are encouraged to use all possible breeding methodologies available (e.g., transgenics, classical breeding, MAS, and all possible combinations could be used with specific sound long and short-term goals on mind) once germplasm is chosen making wise decisions with proven and scientifically sound technologies for assisting current breeding efforts depending on the particular trait under selection. Arnel R. Hallauer is C. F. Curtiss Distinguished Professor in Agriculture (Emeritus) at Iowa State University (ISU). Dr. Hallauer has led maize-breeding research for mid-season maturity at ISU since 1958. His work has had a worldwide impact on plant-breeding programs, industry, and students and was named a member of the National Academy of Sciences. Hallauer is a native of Kansas, USA. José B. Miranda Filho is full-professor in the Department of Genetics, Escola Superior de Agricultura Luiz de Queiroz - University of São Paulo located at Piracicaba, Brazil. His research interests have emphasized development of quantitative genetic theory and its application to maize breeding. Miranda Filho is native of Pirassununga, São Paulo, Brazil. M.J. Carena is professor of plant sciences at North Dakota State University (NDSU). Dr. Carena has led maize-breeding research for short-season maturity at NDSU since 1999. This program is currently one the of the few public U.S. programs left integrating pre-breeding with cultivar development and training in applied maize breeding. He teaches Quantitative Genetics and Crop Breeding Techniques at NDSU. Carena is a native of Buenos Aires, Argentina. http://www.ag.ndsu.nodak.edu/plantsci/faculty/Carena.htm

Quantitative Genetics and Crop Breeding

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Publisher : New India Publishing Agency
ISBN 13 : 9789380235981
Total Pages : 256 pages
Book Rating : 4.2/5 (359 download)

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Book Synopsis Quantitative Genetics and Crop Breeding by : Thirugnanakumar S

Download or read book Quantitative Genetics and Crop Breeding written by Thirugnanakumar S and published by New India Publishing Agency. This book was released on 2012-01-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present work is unique in that sense it gives formulae along with actual data analyzed for the easy understanding. This book is mainly meant for post graduate and research scholars in Quantitative Genetics. A careful perusal of the book will give clear cut idea about the interpretation of the data and formulation of breeding strategies.

Genetic Data Analysis for Plant and Animal Breeding

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Publisher : Springer
ISBN 13 : 3319551779
Total Pages : 409 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Genetic Data Analysis for Plant and Animal Breeding by : Fikret Isik

Download or read book Genetic Data Analysis for Plant and Animal Breeding written by Fikret Isik and published by Springer. This book was released on 2017-09-09 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this book is composed of two sections. The first section (Chapters 1 to 8) covers topics of classical phenotypic data analysis for prediction of breeding values in animal and plant breeding programs. In the second section (Chapters 9 to 13) we provide the concept and overall review of available tools for using DNA markers for predictions of genetic merits in breeding populations. With advances in DNA sequencing technologies, genomic data, especially single nucleotide polymorphism (SNP) markers, have become available for animal and plant breeding programs in recent years. Analysis of DNA markers for prediction of genetic merit is a relatively new and active research area. The algorithms and software to implement these algorithms are changing rapidly. This section represents state-of-the-art knowledge on the tools and technologies available for genetic analysis of plants and animals. However, readers should be aware that the methods or statistical packages covered here may not be available or they might be out of date in a few years. Ultimately the book is intended for professional breeders interested in utilizing these tools and approaches in their breeding programs. Lastly, we anticipate the usage of this volume for advanced level graduate courses in agricultural and breeding courses.

Quantitative Genetics with Special Reference to Plant and Animal Breeding

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Publisher : Wiley-Blackwell
ISBN 13 : 9780813820118
Total Pages : 421 pages
Book Rating : 4.8/5 (21 download)

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Book Synopsis Quantitative Genetics with Special Reference to Plant and Animal Breeding by : Ralph E. Comstock

Download or read book Quantitative Genetics with Special Reference to Plant and Animal Breeding written by Ralph E. Comstock and published by Wiley-Blackwell. This book was released on 1996-04-19 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Plant Breeding

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Publisher : CABI
ISBN 13 : 1845936248
Total Pages : 756 pages
Book Rating : 4.8/5 (459 download)

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Book Synopsis Molecular Plant Breeding by : Yunbi Xu

Download or read book Molecular Plant Breeding written by Yunbi Xu and published by CABI. This book was released on 2010 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in plant genomics and molecular biology have revolutionized our understanding of plant genetics, providing new opportunities for more efficient and controllable plant breeding. Successful techniques require a solid understanding of the underlying molecular biology as well as experience in applied plant breeding. Bridging the gap between developments in biotechnology and its applications in plant improvement, Molecular Plant Breeding provides an integrative overview of issues from basic theories to their applications to crop improvement including molecular marker technology, gene mapping, genetic transformation, quantitative genetics, and breeding methodology.

Principles of Plant Genetics and Breeding

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Publisher : John Wiley & Sons
ISBN 13 : 1119626323
Total Pages : 855 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Principles of Plant Genetics and Breeding by : George Acquaah

Download or read book Principles of Plant Genetics and Breeding written by George Acquaah and published by John Wiley & Sons. This book was released on 2020-12-14 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised edition of the bestselling textbook, covering both classical and molecular plant breeding Principles of Plant Genetics and Breeding integrates theory and practice to provide an insightful examination of the fundamental principles and advanced techniques of modern plant breeding. Combining both classical and molecular tools, this comprehensive textbook describes the multidisciplinary strategies used to produce new varieties of crops and plants, particularly in response to the increasing demands to of growing populations. Illustrated chapters cover a wide range of topics, including plant reproductive systems, germplasm for breeding, molecular breeding, the common objectives of plant breeders, marketing and societal issues, and more. Now in its third edition, this essential textbook contains extensively revised content that reflects recent advances and current practices. Substantial updates have been made to its molecular genetics and breeding sections, including discussions of new breeding techniques such as zinc finger nuclease, oligonucleotide directed mutagenesis, RNA-dependent DNA methylation, reverse breeding, genome editing, and others. A new table enables efficient comparison of an expanded list of molecular markers, including Allozyme, RFLPs, RAPD, SSR, ISSR, DAMD, AFLP, SNPs and ESTs. Also, new and updated “Industry Highlights” sections provide examples of the practical application of plant breeding methods to real-world problems. This new edition: Organizes topics to reflect the stages of an actual breeding project Incorporates the most recent technologies in the field, such as CRSPR genome edition and grafting on GM stock Includes numerous illustrations and end-of-chapter self-assessment questions, key references, suggested readings, and links to relevant websites Features a companion website containing additional artwork and instructor resources Principles of Plant Genetics and Breeding offers researchers and professionals an invaluable resource and remains the ideal textbook for advanced undergraduates and graduates in plant science, particularly those studying plant breeding, biotechnology, and genetics.

Molecular Genetics, Genomics and Biotechnology of Crop Plants Breeding

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Publisher : MDPI
ISBN 13 : 3039288776
Total Pages : 238 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Molecular Genetics, Genomics and Biotechnology of Crop Plants Breeding by : Søren K. Rasmussen

Download or read book Molecular Genetics, Genomics and Biotechnology of Crop Plants Breeding written by Søren K. Rasmussen and published by MDPI. This book was released on 2020-05-27 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue on molecular genetics, genomics, and biotechnology in crop plant breeding seeks to encourage the use of the tools currently available. It features nine research papers that address quality traits, grain yield, and mutations by exploring cytoplasmic male sterility, the delicate control of flowering in rice, the removal of anti-nutritional factors, the use and development of new technologies for non-model species marker technology, site-directed mutagenesis and GMO regulation, genomics selection and genome-wide association studies, how to cope with abiotic stress, and an exploration of fruit trees adapted to harsh environments for breeding purposes. A further four papers review the genetics of pre-harvest spouting, readiness for climate-smart crop development, genomic selection in the breeding of cereal crops, and the large numbers of mutants in straw lignin biosynthesis and deposition.

Genetics and Exploitation of Heterosis in Crops

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Publisher :
ISBN 13 : 9780891185499
Total Pages : 0 pages
Book Rating : 4.1/5 (854 download)

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Book Synopsis Genetics and Exploitation of Heterosis in Crops by : J. G. Coors

Download or read book Genetics and Exploitation of Heterosis in Crops written by J. G. Coors and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the momentous contributions of hybrid crop varieties with worldwide experts. Topics include an overview, quantitative genetics, genetic diversity, biochemistry and molecular biology, methodologies, commercial strategies, and examples from numerous crops.

Quantitative Genetics and Selection in Plant Breeding

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Publisher : Walter de Gruyter
ISBN 13 : 9783110075618
Total Pages : 428 pages
Book Rating : 4.0/5 (756 download)

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Book Synopsis Quantitative Genetics and Selection in Plant Breeding by : Günter Wricke

Download or read book Quantitative Genetics and Selection in Plant Breeding written by Günter Wricke and published by Walter de Gruyter. This book was released on 1986 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Genetics and Molecular Breeding

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Publisher : MDPI
ISBN 13 : 3039211757
Total Pages : 626 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Plant Genetics and Molecular Breeding by : Pedro Martínez-Gómez

Download or read book Plant Genetics and Molecular Breeding written by Pedro Martínez-Gómez and published by MDPI. This book was released on 2019-07-11 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new plant varieties is a long and tedious process involving the generation of large seedling populations for the selection of the best individuals. While the ability of breeders to generate large populations is almost unlimited, the selection of these seedlings is the main factor limiting the generation of new cultivars. Molecular studies for the development of marker-assisted selection (MAS) strategies are particularly useful when the evaluation of the character is expensive, time-consuming, or with long juvenile periods. The papers published in the Special Issue “Plant Genetics and Molecular Breeding” report highly novel results and testable new models for the integrative analysis of genetic (phenotyping and transmission of agronomic characters), physiology (flowering, ripening, organ development), genomic (DNA regions responsible for the different agronomic characters), transcriptomic (gene expression analysis of the characters), proteomic (proteins and enzymes involved in the expression of the characters), metabolomic (secondary metabolites), and epigenetic (DNA methylation and histone modifications) approaches for the development of new MAS strategies. These molecular approaches together with an increasingly accurate phenotyping will facilitate the breeding of new climate-resilient varieties resistant to abiotic and biotic stress, with suitable productivity and quality, to extend the adaptation and viability of the current varieties.

Quantitative Genetics

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Publisher : Springer Nature
ISBN 13 : 3030839400
Total Pages : 419 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Quantitative Genetics by : Shizhong Xu

Download or read book Quantitative Genetics written by Shizhong Xu and published by Springer Nature. This book was released on 2022-01-19 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intended audience of this textbook are plant and animal breeders, upper-level undergraduate and graduate students in biological and agricultural science majors. Statisticians who are interested in understanding how statistical methods are applied to genetics and agriculture can benefit substantially by reading this book. One characteristic of this textbook is represented by three chapters of technical reviews for Mendelian genetics, population genetics and preliminary statistics, which are prerequisites for studying quantitative genetics. Numerous examples are provided to illustrate different methods of data analysis and estimation of genetic parameters. Along with each example of data analyses is the program code of SAS (statistical analysis system).

Handbook of Formulas and Software for Plant Geneticists and Breeders

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Publisher : CRC Press
ISBN 13 : 9781560229490
Total Pages : 368 pages
Book Rating : 4.2/5 (294 download)

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Book Synopsis Handbook of Formulas and Software for Plant Geneticists and Breeders by : Manjit S. Kang

Download or read book Handbook of Formulas and Software for Plant Geneticists and Breeders written by Manjit S. Kang and published by CRC Press. This book was released on 2003-05-28 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A simple solution to complicated statistical techniques and formulas! The Handbook of Formulas and Software for Plant Geneticists and Breeders is an up-to-date reference source that eliminates the need for hand calculations of complicated genetic formulas and equations. Contributions from members of the C1 Division of the Crop Science Society of America include computer program codes not found in Statistical Analysis System (SAS) and other commonly available statistical packages. The book provides an invaluable shortcut to sorting through piles of literature in search of programs that may have been published in abbreviated forms or never at all. The Handbook of Formulas and Software for Plant Geneticists and Breeders puts full-fledged program codes of specialized statistical and genetics-related software programs at your fingertips. It shows practicing geneticists, breeders, and students how to use specialized software through practical examples. The book is an excellent research and teaching tool in quantitative genetics and plant breeding, providing definitions of key terms and information on how to obtain desired software and key references. It also includes an extensive listing of programs available for linkage and mapping software that can be accessed through the Internet. The Handbook of Formulas and Software for Plant Geneticists and Breeders presents, among others, programs related to: genotype-by-environmental interaction (GEI) and stability analysis genetic diversity estimation best linear unbiased predictors (BLUPs) principal component and additive main effects and multiplicative interaction (AMMI) analyses quantitative trait loci -by-environment (QTL x E) analysis GGE biplot analysis diallel analyses path analysis trend analysis field plot technique The Handbook of Formulas and Software for Plant Geneticists and Breeders is essential for academics and researchers working in genetics, breeding, and genomics, and as a supplement for coursework in quantitative genetics and plant breeding.

Selection Methods in Plant Breeding

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Publisher : Springer Science & Business Media
ISBN 13 : 1402063709
Total Pages : 462 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Selection Methods in Plant Breeding by : Izak Bos

Download or read book Selection Methods in Plant Breeding written by Izak Bos and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for plant breeders, researchers and post-graduate students, this excellent new book provides a comprehensive review of the methods and underlying theoretical foundations used for selection in plant breeding programs. The authors review basic elements of population and quantitative genetic theory, moving on to consider in a unique way the tackling of the problems presented by soil heterogeneity and intergenotypic competition when selecting quantitative characters.

Breeding for Quantitative Traits in Plants

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Publisher :
ISBN 13 : 9780972072434
Total Pages : 422 pages
Book Rating : 4.0/5 (724 download)

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Book Synopsis Breeding for Quantitative Traits in Plants by : Rex Novero Bernardo

Download or read book Breeding for Quantitative Traits in Plants written by Rex Novero Bernardo and published by . This book was released on 2019 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Temperate Fruit Crop Breeding

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Publisher : Springer Science & Business Media
ISBN 13 : 1402069073
Total Pages : 459 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Temperate Fruit Crop Breeding by : Jim F. Hancock

Download or read book Temperate Fruit Crop Breeding written by Jim F. Hancock and published by Springer Science & Business Media. This book was released on 2008-02-21 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fully integrates the conventional and biotechnological approaches to fruit crop breeding. Individual chapters are written on a wide variety of species covering all the major fruit crops in one volume. For each crop, there is a discussion of their taxonomy and evolution, history of improvement, crossing techniques, evaluation methods, and heritability of major traits and germplasm resources. Also discussed are the most recent advances in genetic mapping and QTL (quantitative trait loci) analysis, marker assisted breeding, gene cloning, gene expression analysis, regeneration and transformation. Patenting and licensing issues are also covered.

Handbook of Statistical Genomics

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Publisher : John Wiley & Sons
ISBN 13 : 1119429250
Total Pages : 1740 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Handbook of Statistical Genomics by : David J. Balding

Download or read book Handbook of Statistical Genomics written by David J. Balding and published by John Wiley & Sons. This book was released on 2019-07-09 with total page 1740 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.