Quadruplex Nucleic Acids

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G-Quadruplex Nucleic Acids

Author : Danzhou Yang
Publisher : Humana
ISBN 13 : 9781493996681
Total Pages : 437 pages
Book Rating : 4.9/5 (966 download)

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Book Synopsis G-Quadruplex Nucleic Acids by : Danzhou Yang

Download or read book G-Quadruplex Nucleic Acids written by Danzhou Yang and published by Humana. This book was released on 2020-09-07 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.

G-Quadruplex Nucleic Acids

Author : Danzhou Yang
Publisher : Humana
ISBN 13 : 9781493996650
Total Pages : 437 pages
Book Rating : 4.9/5 (966 download)

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Book Synopsis G-Quadruplex Nucleic Acids by : Danzhou Yang

Download or read book G-Quadruplex Nucleic Acids written by Danzhou Yang and published by Humana. This book was released on 2019-08-24 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.

Therapeutic Applications of Quadruplex Nucleic Acids

Author : Stephen Neidle
Publisher : Academic Press
ISBN 13 : 0123751381
Total Pages : 210 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Therapeutic Applications of Quadruplex Nucleic Acids by : Stephen Neidle

Download or read book Therapeutic Applications of Quadruplex Nucleic Acids written by Stephen Neidle and published by Academic Press. This book was released on 2012 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.

G-Quadruplex DNA

Author : Peter Baumann
Publisher : Humana
ISBN 13 : 9781493956395
Total Pages : 276 pages
Book Rating : 4.9/5 (563 download)

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Book Synopsis G-Quadruplex DNA by : Peter Baumann

Download or read book G-Quadruplex DNA written by Peter Baumann and published by Humana. This book was released on 2016-08-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.

Quadruplex Nucleic Acids

Author : Stephen Neidle
Publisher : Royal Society of Chemistry
ISBN 13 : 1847555292
Total Pages : 317 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Quadruplex Nucleic Acids by : Stephen Neidle

Download or read book Quadruplex Nucleic Acids written by Stephen Neidle and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Quadruplex Nucleic Acids

Author : Jonathan B. Chaires
Publisher : Springer
ISBN 13 : 3642347436
Total Pages : 285 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Quadruplex Nucleic Acids by : Jonathan B. Chaires

Download or read book Quadruplex Nucleic Acids written by Jonathan B. Chaires and published by Springer. This book was released on 2014-07-08 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.

The Alkali Metal Ions: Their Role for Life

Author : Astrid Sigel
Publisher : Springer
ISBN 13 : 3319217569
Total Pages : 663 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The Alkali Metal Ions: Their Role for Life by : Astrid Sigel

Download or read book The Alkali Metal Ions: Their Role for Life written by Astrid Sigel and published by Springer. This book was released on 2016-02-09 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Protein-Nucleic Acid Interactions

Author : Phoebe A. Rice
Publisher : Royal Society of Chemistry
ISBN 13 : 0854042725
Total Pages : 417 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Protein-Nucleic Acid Interactions by : Phoebe A. Rice

Download or read book Protein-Nucleic Acid Interactions written by Phoebe A. Rice and published by Royal Society of Chemistry. This book was released on 2008-05-22 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.

Principles of Nucleic Acid Structure

Author : Wolfram Saenger
Publisher : Springer Science & Business Media
ISBN 13 : 1461251907
Total Pages : 574 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Principles of Nucleic Acid Structure by : Wolfram Saenger

Download or read book Principles of Nucleic Acid Structure written by Wolfram Saenger and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Author :
Publisher : Academic Press
ISBN 13 : 0128210184
Total Pages : 564 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Quadruplex Nucleic Acids As Targets For Medicinal Chemistry by :

Download or read book Quadruplex Nucleic Acids As Targets For Medicinal Chemistry written by and published by Academic Press. This book was released on 2020-08-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

DNA Replication

Author : Hisao Masai
Publisher : Springer
ISBN 13 : 9811069557
Total Pages : 581 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis DNA Replication by : Hisao Masai

Download or read book DNA Replication written by Hisao Masai and published by Springer. This book was released on 2018-01-22 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Chemistry of Nucleic Acids

Author : Harri Lönnberg
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311132592X
Total Pages : 553 pages
Book Rating : 4.1/5 (113 download)

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Book Synopsis Chemistry of Nucleic Acids by : Harri Lönnberg

Download or read book Chemistry of Nucleic Acids written by Harri Lönnberg and published by Walter de Gruyter GmbH & Co KG. This book was released on 2024-09-23 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function.

Functional Nucleic Acid Based Biosensors for Food Safety Detection

Author : Yunbo Luo
Publisher : Springer
ISBN 13 : 9811082197
Total Pages : 360 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Functional Nucleic Acid Based Biosensors for Food Safety Detection by : Yunbo Luo

Download or read book Functional Nucleic Acid Based Biosensors for Food Safety Detection written by Yunbo Luo and published by Springer. This book was released on 2018-07-13 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the development of a functional nucleic acid based biosensor detection method in the context of food safety. Although there have been major advances in food processing technology in both developed and developing countries, food safety assurance systems are generally becoming more stringent, in response to growing (both real and perceived) food safety problems. These problems are due in part to foodborne microorganisms, heavy metals, and small chemical molecules (biological toxins, pesticide residues, and veterinary drug residues), etc. In addition, the nucleic acid biomarkers (DNA methylation, microRNA, and circRNA) induced by these risk factors are also closely related to food safety. Accordingly, this book offers a brief guide to targets and strategies in functional nucleic acid based biosensors for food safety detection. Divided into several chapters that focus on various respective targets, it will be a valuable resource for students and researchers in the fields of biosensor detection, food science etc.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Author : Loutfy H. Madkour
Publisher : Academic Press
ISBN 13 : 0128197781
Total Pages : 650 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nucleic Acids as Gene Anticancer Drug Delivery Therapy by : Loutfy H. Madkour

Download or read book Nucleic Acids as Gene Anticancer Drug Delivery Therapy written by Loutfy H. Madkour and published by Academic Press. This book was released on 2019-08-27 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Nucleic Acid Structure and Recognition

Author : Stephen Neidle
Publisher : Oxford University Press, USA
ISBN 13 : 9780198506355
Total Pages : 212 pages
Book Rating : 4.5/5 (63 download)

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Book Synopsis Nucleic Acid Structure and Recognition by : Stephen Neidle

Download or read book Nucleic Acid Structure and Recognition written by Stephen Neidle and published by Oxford University Press, USA. This book was released on 2002 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigation for nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies are analysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent and non-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.

Chemistry and Biology of Non-canonical Nucleic Acids

Author : Naoki Sugimoto
Publisher : John Wiley & Sons
ISBN 13 : 3527817883
Total Pages : 288 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Chemistry and Biology of Non-canonical Nucleic Acids by : Naoki Sugimoto

Download or read book Chemistry and Biology of Non-canonical Nucleic Acids written by Naoki Sugimoto and published by John Wiley & Sons. This book was released on 2021-03-16 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

Aptamers for Medical Applications

Author : Yiyang Dong
Publisher : Springer Nature
ISBN 13 : 9813348380
Total Pages : 470 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Aptamers for Medical Applications by : Yiyang Dong

Download or read book Aptamers for Medical Applications written by Yiyang Dong and published by Springer Nature. This book was released on 2021-03-25 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.