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Pseudomonas And Acinetobacter From Drug Resistance To Pathogenesis
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Book Synopsis Pseudomonas and Acinetobacter: From Drug Resistance to Pathogenesis by : Ghassan M. Matar
Download or read book Pseudomonas and Acinetobacter: From Drug Resistance to Pathogenesis written by Ghassan M. Matar and published by Frontiers Media SA. This book was released on 2018-05-03 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas aeruginosa and Acinetobacter baumannii are among the most common non-lactose-fermenting Gram-negative pathogens responsible for hospital-acquired infections, especially in intensive care units (ICUs). The treatment of infections caused by these bacteria is complicated due to the emergence of multi-drug resistance as the two species are noted for their intrinsic resistance to antimicrobial agents and their ability to acquire genetic elements that encode for resistance determinants. In both species, resistance to multiple classes of antimicrobial agents can seriously compromise the ability to treat infected patients, especially the immunocompromised. Consequently, very few antimicrobials remain as treatment options. Mechanisms of resistance in both of these pathogens include the production of β-lactamases and aminoglycoside-modifying enzymes as well as reduced or lack of expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps. To that purpose, the findings of the studies included in this book deal with the prevalence of resistant isolates to various antimicrobial agents in both P. aeruginosa and A. baumannii, their underlying mechanisms of resistance, their virulence factors, their pathogenesis, and prospective treatment options. Special thanks are due to Mr. Bassam El-Hafi for facilitating procedures involved in this publication.
Book Synopsis Pseudomonas aeruginosa by : Alain Filloux
Download or read book Pseudomonas aeruginosa written by Alain Filloux and published by Springer Nature. This book was released on 2022-10-18 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the wide set of well-regulated virulence factors and defense mechanisms of Pseudomonas aeruginosa focusing on stress responses and the evolution of this opportunistic human pathogen. Pseudomonas aeruginosa is responsible for one out of ten hospital infections. Additionally, this Gram-negative bacterium is accountable for persistent infections in immunocompromised individuals and the leading cause of chronic lung infections in cystic fibrosis patients. This book provides insight on the metabolic versatility of Pseudomonas aeruginosa and its mechanisms for biofilm formation that make this organism highly efficient in causing infections. The book invites the readers to learn more about the intrinsic ability of Pseudomonas aeruginosa to resist a wide variety of antimicrobial agents due to the concerted action of multidrug efflux pumps, antibiotic-degrading enzymes, and the low permeability of bacterial cellular envelopes. Particular focus is put on the evolutionary role of different types of protein-secretion systems in pathogenesis, flagella and their role in chemotaxis and surface sensing, and host-pathogen interactions. This book is a useful introduction to the field for junior scientists interested in the biology and pathogenesis of Pseudomonas aeruginosa. It is also an interesting read for advanced scientists and medical specialists working within this field, providing a broader view of the topic beyond their specific area of specialization.
Book Synopsis Acinetobacter baumannii - The Rise of a Resistant Pathogen by : Karyne Rangel
Download or read book Acinetobacter baumannii - The Rise of a Resistant Pathogen written by Karyne Rangel and published by BoD – Books on Demand. This book was released on 2024-02-07 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acinetobacter baumannii is a formidable global pathogen notorious for its widespread drug-resistant nature. It is a major culprit in various infections, particularly targeting immunocompromised individuals in intensive care units (ICUs). A paramount concern associated with this pathogen lies in its remarkable ability to develop resistance to nearly all clinically utilized antibiotics. Furthermore, it exhibits a concerning propensity to disseminate this resistance rapidly, transcending borders and impacting healthcare facilities across diverse economic strata. Of particular focus is the carbapenem-resistant strain of A. baumannii (CRAb). This strain has garnered the top spot on the World Health Organization's (WHO) list of pathogens, necessitating urgent attention for new treatment development. This book delves into numerous studies underscoring the pivotal role of A. baumannii as one of the most impactful bacteria contributing to Healthcare-Associated Infections (HAIs) within the contemporary healthcare landscape.
Author :Eugénie Bergogne-Bérézin Publisher :Springer Science & Business Media ISBN 13 :0387779442 Total Pages :230 pages Book Rating :4.3/5 (877 download)
Book Synopsis Acinetobacter by : Eugénie Bergogne-Bérézin
Download or read book Acinetobacter written by Eugénie Bergogne-Bérézin and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is currently increasing interest concerning the biology and disease caused by Acinetobacter species. Such interest, however, developed relatively slowly because of the necessity to clarify the confusing taxonomy of these organisms. Much work was needed to identify various species as members of this genus, to recognize their epidemiologic profile, their pathogenic role and their increasing importance as multi-antibiotic resistant organisms. In recent years improvement of genetic approaches, recognition of plasmids, integrons and chromosomal sources of resistance mechanisms aroused interest on the role of Acinetobacters in disease by many microbiologists and clinicians, especially internists and infectious disease specialists. In this regard, physicians are frequently confronted with extremely difficult therapeutic approaches for treatment and prevention of severe nosocomial infections due to multi antibiotic resistant Acinetobacter. Moreover, recent observations of community acquired infections have been reported, especially in patients with various risk factors such as immuno-deficiencies. Also, it is now becoming evident that Acinetobacter infections occur frequently in violent situations such as earthquake or war zones. The mechanisms of Acinetobacter virulence are becoming increasingly clear, providing new insights into their pathogenic role in community acquired infections. It is apparent the time is appropriate for detailed review of the increasing knowledge concerning important new information, both clinical and therapeutic, especially information concerning virulence, resistance mechanisms and typing of Acinetobacter spp. Many new findings are accumulating in almost an exponential manner since publication of previous books on this subject in 1991 and 1996.
Book Synopsis Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight by : Vipin Chandra Kalia
Download or read book Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight written by Vipin Chandra Kalia and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?
Book Synopsis Pseudomonas Aeruginosa by : Theerthankar Das
Download or read book Pseudomonas Aeruginosa written by Theerthankar Das and published by . This book was released on 2021-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antimicrobial Resistance by : Vinay Kumar
Download or read book Antimicrobial Resistance written by Vinay Kumar and published by Springer Nature. This book was released on 2022-01-03 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products including potent phyto-molecules, antimicrobial peptides and endophytes effective against the drug-resistant microbes and target the main drug-resistance determinants (efflux pumps, biofilms, quorum sensing, plasmids, etc.) in these bacterial pathogens. Other exciting topics include applications of nanomaterials in tackling AMR and CRISPR-Cas based precise sequence-specific antimicrobials. This informative book is meant for students and researchers in basic and medical microbiology and biotechnology. It is also useful to public health professionals and industry experts involved in AMR research and related drug-designing.
Book Synopsis Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery by : Busi Siddhardha
Download or read book Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery written by Busi Siddhardha and published by Springer Nature. This book was released on 2020-03-28 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
Book Synopsis Toxin-Antitoxin Systems in Pseudomonas Aeruginosa by : Mina Mahmoudi: Sobhan
Download or read book Toxin-Antitoxin Systems in Pseudomonas Aeruginosa written by Mina Mahmoudi: Sobhan and published by . This book was released on 2021-05-06 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas aeruginosa is known as a persistent bacterial pathogen. Antibiotics are currently the most common bacterial treatment for related infections but cases of microbial resistance are on the rise. Toxin-Antitoxin Systems in Pseudomonas aeruginosa describes one of the most important antimicrobial targets in the bacterium species. The contributors have compiled comprehensive information on the subject. The reference initially acquaints the reader with key topics about P. aeruginosa infection including virulence factors, pathogenicity, epidemiology, laboratory diagnosis and antibiotic resistance. This is followed by detailed chapters on toxin-antitoxin systems which explain their role in the bacterial pathogenesis with reference to P. aeruginosa. The comprehensive information on the subject makes this an ideal reference for newcomers to the field of bacteriology and target discovery. Students of medical microbiology and medical professionals who are interested in the finer details of P. aeruginosa pathogenicity will also be equipped with sufficient information to join the discussion on this topic with fellow researchers.
Book Synopsis Acinetobacter by : E. Bergogne-Berezin
Download or read book Acinetobacter written by E. Bergogne-Berezin and published by CRC Press. This book was released on 2020-10-28 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acinetobacter details the clinical aspects of this bacterium responsible for many infections in hospitalized patients. This reference explains the importance of these organisms, both from the patient's viewpoint and the economic perspective, and provides clinicians with the knowledge they need to control these bacteria.
Book Synopsis Five Year Report by : United States-Japan Cooperative Medical Science Program
Download or read book Five Year Report written by United States-Japan Cooperative Medical Science Program and published by . This book was released on 1975 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens by : Axel Cloeckaert
Download or read book Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens written by Axel Cloeckaert and published by Frontiers Media SA. This book was released on 2018-01-26 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development and spread of antimicrobial resistance is the result of an evolutionary process by which microorganisms adapt to antibiotics through several mechanisms including alteration of drug target by mutation and horizontal transfer of resistance genes. The concomitant occurrence of independent antimicrobial resistance mechanisms is a serious threat to human health and has appeared in several emerging epidemic clones over the past decade in humans and also in animals. The increasing prevalence of antimicrobial drug resistance among animal and zoonotic foodborne pathogens is of particular concern for public health. In this Ebook, we gathered a collection of articles which deal with the most important aspects of the genetics of acquired antimicrobial resistance extending from medically-important resistance, emerging epidemic resistant clones, main mobile genetic elements spreading resistance, resistomes, dissemination between animals and humans, to the “One Health” concept.
Book Synopsis Mechanisms of antibiotic resistance by : Jun Lin
Download or read book Mechanisms of antibiotic resistance written by Jun Lin and published by Frontiers Media SA. This book was released on 2015-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Book Synopsis Acinetobacter Molecular Microbiology by : Ulrike Gerischer
Download or read book Acinetobacter Molecular Microbiology written by Ulrike Gerischer and published by . This book was released on 2008 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise volume reviews the most current and topical aspects of Acinetobacter genetics and molecular biology and is aimed at a readership of research scientists, graduate students and other specialists. Expert international authors have contributed chapters on diverse topics including taxonomy, lipopolysaccharides, catabolism of aromatic compounds, transformation systems, transcriptional regulation, applications in biotechnology, the molecular basis for virulence and pathogenicity, molecular epidemiology, and antibiotic resistance. This book is highly recommended for anyone involved in Aci.
Book Synopsis Antimicrobial Resistance by : World Health Organization
Download or read book Antimicrobial Resistance written by World Health Organization and published by . This book was released on 2014 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.
Book Synopsis Antibiotic Drug Resistance by : José-Luis Capelo-Martínez
Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Book Synopsis Microbiology of Waterborne Diseases by :
Download or read book Microbiology of Waterborne Diseases written by and published by Academic Press. This book was released on 2013-11-08 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
