Protein And Peptide Nanoparticles For Drug Delivery

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Protein and Peptide Nanoparticles for Drug Delivery

Author :
Publisher : Academic Press
ISBN 13 : 012802870X
Total Pages : 386 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Protein and Peptide Nanoparticles for Drug Delivery by :

Download or read book Protein and Peptide Nanoparticles for Drug Delivery written by and published by Academic Press. This book was released on 2015-03-26 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in application of powerful techniques in a wide bioscience area Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

Peptide and Protein Delivery

Author : Chris Van Der Walle
Publisher : Academic Press
ISBN 13 : 0123849365
Total Pages : 381 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Peptide and Protein Delivery by : Chris Van Der Walle

Download or read book Peptide and Protein Delivery written by Chris Van Der Walle and published by Academic Press. This book was released on 2011-05-12 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Nanotechnology in Drug Delivery

Author : Saurabh Bhatia
Publisher : CRC Press
ISBN 13 : 1315342065
Total Pages : 296 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Nanotechnology in Drug Delivery by : Saurabh Bhatia

Download or read book Nanotechnology in Drug Delivery written by Saurabh Bhatia and published by CRC Press. This book was released on 2017-03-03 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important new book provides the fundamental understanding of the peptide and protein drug delivery systems with a special focus on their nanotechnology applications. Addressing an increasing interest in peptide and protein drug delivery systems in both academic and industrial circles worldwide, this book fills the need for a comprehensive review and assessment of conventional and nonconventional routes of administration.

Peptide and Protein Drug Delivery

Author : Vincent Lee
Publisher : CRC Press
ISBN 13 : 9780824778965
Total Pages : 916 pages
Book Rating : 4.7/5 (789 download)

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Book Synopsis Peptide and Protein Drug Delivery by : Vincent Lee

Download or read book Peptide and Protein Drug Delivery written by Vincent Lee and published by CRC Press. This book was released on 1990-11-19 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai

Trends and Future Perspectives in Peptide and Protein Drug Delivery

Author : Vincent Lee
Publisher : CRC Press
ISBN 13 : 9783718656417
Total Pages : 400 pages
Book Rating : 4.6/5 (564 download)

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Book Synopsis Trends and Future Perspectives in Peptide and Protein Drug Delivery by : Vincent Lee

Download or read book Trends and Future Perspectives in Peptide and Protein Drug Delivery written by Vincent Lee and published by CRC Press. This book was released on 1995-02-01 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

Peptide and Protein Drug Delivery Using Polysaccharides

Author : Aakanchha Jain
Publisher : Elsevier
ISBN 13 : 0443189269
Total Pages : 331 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Peptide and Protein Drug Delivery Using Polysaccharides by : Aakanchha Jain

Download or read book Peptide and Protein Drug Delivery Using Polysaccharides written by Aakanchha Jain and published by Elsevier. This book was released on 2023-10-10 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection

Protein and Peptide Drug Delivery

Author : Nitai Charan Giri
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Protein and Peptide Drug Delivery by : Nitai Charan Giri

Download or read book Protein and Peptide Drug Delivery written by Nitai Charan Giri and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein and peptide-based drugs have great potential applications as therapeutic agents since they have higher efficacy and lower toxicity than chemical drugs. However, difficulty with their delivery has limited their use. In particular, their oral bioavailability is very low, and the transdermal delivery faces absorption limitations. Therefore, most of the protein and peptide-based drugs are administered by the parenteral route. However, this route also has some problems, such as patient discomfort, especially for pediatric use. Extensive research has been performed over the past few decades to develop protein and peptide delivery systems that circumvent the problems mentioned above. Various strategies that have been employed during this time include nanoparticle carriers, absorption enhancers, enzyme inhibitors, mucoadhesive polymers, and chemical modification of protein or peptide structures. However, most of these strategies are focused on the delivery of proteins or peptides via the oral route since it is the most preferred route considering its high level of patient acceptance, long-term compliance, and simplicity. However, other routes of administration such as transdermal, nasal, pulmonary can also be attractive alternatives for protein and peptide delivery. This chapter will discuss the most effective approaches used to develop protein and peptide drug delivery systems.

Drug Delivery Systems

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
ISBN 13 : 1588298914
Total Pages : 255 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Drug Delivery Systems by : Kewal K. Jain

Download or read book Drug Delivery Systems written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Delivery Of Protein And Peptide Drugs In Cancer

Author : Vladimir P Torchilin
Publisher : World Scientific
ISBN 13 : 1783260009
Total Pages : 392 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Delivery Of Protein And Peptide Drugs In Cancer by : Vladimir P Torchilin

Download or read book Delivery Of Protein And Peptide Drugs In Cancer written by Vladimir P Torchilin and published by World Scientific. This book was released on 2006-04-05 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells.This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy.Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences.

Peptide and Protein Interaction with Membrane Systems

Author : Sara Bobone
Publisher : Springer
ISBN 13 : 3319064347
Total Pages : 147 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Peptide and Protein Interaction with Membrane Systems by : Sara Bobone

Download or read book Peptide and Protein Interaction with Membrane Systems written by Sara Bobone and published by Springer. This book was released on 2014-05-31 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.

Intracellular Delivery

Author : Aleš Prokop
Publisher : Springer Science & Business Media
ISBN 13 : 9400712480
Total Pages : 871 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Intracellular Delivery by : Aleš Prokop

Download or read book Intracellular Delivery written by Aleš Prokop and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.

Artificial Protein and Peptide Nanofibers

Author : Gang Wei
Publisher : Woodhead Publishing
ISBN 13 : 0081028512
Total Pages : 504 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Artificial Protein and Peptide Nanofibers by : Gang Wei

Download or read book Artificial Protein and Peptide Nanofibers written by Gang Wei and published by Woodhead Publishing. This book was released on 2020-07-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization, and Applications provides comprehensive knowledge of the preparation, modification and applications of protein and peptide nanofibers. The book reviews the synthesis and strategies necessary to create protein and peptide nanofibers, such as self-assembly (including supramolecular assembly), electrospinning, template synthesis, and enzymatic synthesis. Then, the key chemical modification and molecular design methods are highlighted that can be utilized to improve the bio-functions of these synthetic fibers. Finally, fabrication methods for key applications, such as sensing, drug delivery, imaging, tissue engineering and electronic devices are reviewed. This book will be an ideal resource for those working in materials science, polymer science, chemical engineering, nanotechnology and biomedicine. Reviews key chemical modification and molecular design methods to improve the bio-functions of synthetic peptide and protein nanofibers Discusses the most important synthesis strategies, including supramolecular assembly, electrospinning, template synthesis and enzymatic synthesis Provides information on fabrication of nanofibers for key applications such as sensing, imaging, drug delivery and tissue engineering

Protein-Nanoparticle Interactions

Author : Masoud Rahman
Publisher : Springer Science & Business Media
ISBN 13 : 3642375553
Total Pages : 95 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Protein-Nanoparticle Interactions by : Masoud Rahman

Download or read book Protein-Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.

Cancer Theranostics

Author : Xiaoyuan Chen
Publisher : Academic Press
ISBN 13 : 0124078842
Total Pages : 543 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Cancer Theranostics by : Xiaoyuan Chen

Download or read book Cancer Theranostics written by Xiaoyuan Chen and published by Academic Press. This book was released on 2014-03-20 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Peptide and Protein Drug Delivery

Author :
Publisher : Munksgaard International Publishers
ISBN 13 :
Total Pages : 492 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Peptide and Protein Drug Delivery by :

Download or read book Peptide and Protein Drug Delivery written by and published by Munksgaard International Publishers. This book was released on 1998 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Delivery Technologies for Biopharmaceuticals

Author : Lene Jorgensen
Publisher : John Wiley & Sons
ISBN 13 : 0470688408
Total Pages : 442 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Delivery Technologies for Biopharmaceuticals by : Lene Jorgensen

Download or read book Delivery Technologies for Biopharmaceuticals written by Lene Jorgensen and published by John Wiley & Sons. This book was released on 2009-10-23 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Oral Delivery of Therapeutic Peptides and Proteins

Author : Puneet Tyagi
Publisher : Elsevier
ISBN 13 : 0128210613
Total Pages : 316 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Oral Delivery of Therapeutic Peptides and Proteins by : Puneet Tyagi

Download or read book Oral Delivery of Therapeutic Peptides and Proteins written by Puneet Tyagi and published by Elsevier. This book was released on 2022-08-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development