Proteases Of Infectious Agents

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Proteases of Infectious Agents

Author : Ben Dunn
Publisher : Elsevier
ISBN 13 : 0080525741
Total Pages : 301 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Proteases of Infectious Agents by : Ben Dunn

Download or read book Proteases of Infectious Agents written by Ben Dunn and published by Elsevier. This book was released on 1999-07-01 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. Includes information on the basic biology and function of proteases Provides global survey of current research efforts in protease inhibitors Illustrates how structure-based drug design targets effective and selective compounds Highlights important diseases that provide economically important targets Describes the role of proteases as important new targets for drug discovery

Viral Proteases and Their Inhibitors

Author : Satya Prakash Gupta
Publisher : Academic Press
ISBN 13 : 0128096829
Total Pages : 518 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Viral Proteases and Their Inhibitors by : Satya Prakash Gupta

Download or read book Viral Proteases and Their Inhibitors written by Satya Prakash Gupta and published by Academic Press. This book was released on 2017-07-03 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

Author : Theresa Coetzer
Publisher : Academic Press
ISBN 13 : 9780323918015
Total Pages : 472 pages
Book Rating : 4.9/5 (18 download)

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Book Synopsis Proteolytic Enzymes and their Inhibitors in Infectious Pathogens by : Theresa Coetzer

Download or read book Proteolytic Enzymes and their Inhibitors in Infectious Pathogens written by Theresa Coetzer and published by Academic Press. This book was released on 2023-01-15 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection. Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery. Discusses proteolytic enzymes of parasites, bacteria, and viruses arranged by peptide bond cleavage classes, for improved integration of information across the infectious organisms Includes information on the structure and interaction with proteases of macromolecular protease inhibitors, and how these structures can be engineered to provide more potent and specific protease inhibitors Provides instructions in methods and technologies to identify physiological protease substrates, their cleavage specificities, and inhibitors Features rich illustrations and diagrams of core concepts, including informative three-dimensional protein structures and molecular interactions

Viral Proteases and Antiviral Protease Inhibitor Therapy

Author : Uwe Lendeckel
Publisher : Springer Science & Business Media
ISBN 13 : 9048123488
Total Pages : 139 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel

Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Proteases in Health and Disease

Author : Sajal Chakraborti
Publisher : Springer Science & Business Media
ISBN 13 : 1461492335
Total Pages : 407 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Proteases in Health and Disease by : Sajal Chakraborti

Download or read book Proteases in Health and Disease written by Sajal Chakraborti and published by Springer Science & Business Media. This book was released on 2013-12-04 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Viral Proteases and Antiviral Protease Inhibitor Therapy

Author : Uwe Lendeckel
Publisher : Springer
ISBN 13 : 9789048123759
Total Pages : 132 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Viral Proteases and Antiviral Protease Inhibitor Therapy by : Uwe Lendeckel

Download or read book Viral Proteases and Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and published by Springer. This book was released on 2009-08-29 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Plant Proteases

Author : Mercedes Diaz-Mendoza
Publisher : Frontiers Media SA
ISBN 13 : 2889633993
Total Pages : 157 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Plant Proteases by : Mercedes Diaz-Mendoza

Download or read book Plant Proteases written by Mercedes Diaz-Mendoza and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

Encyclopedia of Molecular Pharmacology

Author : Stefan Offermanns
Publisher : Springer Science & Business Media
ISBN 13 : 3540389164
Total Pages : 1515 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protease Inhibitors in AIDS Therapy

Author : Richard C. Ogden
Publisher : CRC Press
ISBN 13 : 9780824704612
Total Pages : 328 pages
Book Rating : 4.7/5 (46 download)

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Book Synopsis Protease Inhibitors in AIDS Therapy by : Richard C. Ogden

Download or read book Protease Inhibitors in AIDS Therapy written by Richard C. Ogden and published by CRC Press. This book was released on 2001-01-24 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Details the evolution of HIV protease inhibitors from molecular development through medical applications! Considering the latest class of revolutionary drugs fighting against HIV infection and AIDS, this comprehensive reference thoroughly examines the development and properties of HIV protease inhibitors from clinical and scientific perspectives, discussing how protease inhibitors changed the FDA approval process-enhancing the collaboration between regulatory authorities and drug developers. Spotlights protease inhibitors as the cornerstone drugs of the first HAART regimens-key components of long-term viral suppression and immune restoration, and in secondary and tertiary regimens! Evaluating protease inhibitors as therapeutic options and research tools, Protease Inhibitors in AIDS Therapy reviews the impact of advances in recombinant DNA technology for understanding and treating HIV and AIDS highlights a variety of strategies and techniques for drug discovery and development illustrated by success stories of pharmaceutical companies and biotechnology start-up firms summarizes the pharmacokinetics, metabolism, and drug interactions of protease inhibitors details preliminary clinical studies on oral bioavailability, pharmacokinetic profiling, efficacy, resistance, and tolerability describes available efficacy data for marketed inhibitors and those in clinical development reports on efforts to manage antiviral resistance in the clinic and improve patient adherence to complex drug therapy and more! Containing more than 600 helpful literature references, drawings, photographs, and tables, Protease Inhibitors in AIDS Therapy serves for an essential reference for infectious disease specialists, epidemiologists, virologists, immunologists, pharmacologists, medicinal chemists and biochemists, microbiologists, hematologists, hepatologists, and medical students in these disciplines.

Pseudomonas aeruginosa as an Opportunistic Pathogen

Author : Mario Campa
Publisher : Springer
ISBN 13 : 9781461363248
Total Pages : 0 pages
Book Rating : 4.3/5 (632 download)

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Book Synopsis Pseudomonas aeruginosa as an Opportunistic Pathogen by : Mario Campa

Download or read book Pseudomonas aeruginosa as an Opportunistic Pathogen written by Mario Campa and published by Springer. This book was released on 2012-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Inflammation, 4 Volume Set

Author : Jean-Marc Cavaillon
Publisher : John Wiley & Sons
ISBN 13 : 3527338993
Total Pages : 1818 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon

Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.

Mechanisms of Catalysis

Author :
Publisher : Academic Press
ISBN 13 : 0080865968
Total Pages : 471 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Mechanisms of Catalysis by :

Download or read book Mechanisms of Catalysis written by and published by Academic Press. This book was released on 1991-01-28 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Discovery of Covalent, Allosteric, Or Orthosteric Protease Inhibitors of Infectious Viruses

Author : Ittipat Meewan
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis Discovery of Covalent, Allosteric, Or Orthosteric Protease Inhibitors of Infectious Viruses by : Ittipat Meewan

Download or read book Discovery of Covalent, Allosteric, Or Orthosteric Protease Inhibitors of Infectious Viruses written by Ittipat Meewan and published by . This book was released on 2021 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over several centuries, infectious diseases caused by viruses have been a serious threat for human health globally. Even though the numbers new highly effective antiviral drugs or vaccines have been developed for the treatment rapidly, but there are plenty of newly emerge viruses that have no proper specific treatment. In addition, the reemergence of new drug resistance viral strain is a huge challenge for drug development. This dissertation presents studies the therapeutic approach of major infectious viral diseases by proper drug target selection, design of small molecules, and test the effectiveness of small molecules experimentally. In chapter 1, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against three key proteases in The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) replication including Main Protease (Mpro), SARS CoV-2 Papain Like Protease (PLpro), and human cathepsin L. The use of thiuram disulfide and dithiobis-(thioformate) covalent inhibitor warheads was inspired by disulfiram, a currently prescribed drug commonly used to treat chronic alcoholism that at the present time is in Phase 2 clinical trials against SARS-CoV-2. At the maximal allowed dose, disulfiram is associated with adverse effects. We found a few compounds that were more potent than disulfiram in the enzymatic assays against SARS-CoV-2 Mpro, SARS-CoV-2 PLpro, and human cathepsin L. The identified protease inhibitors in this series were also tested against SARS CoV-2 in a cell-based and toxicity assay and were shown to have similar or greater antiviral effect than Disulfiram. In chapter 2, we identified a novel transient deep and hydrophobic pocket of the "super-open" conformation of Zika virus (ZIKV) NS2B-NS3 protease and targeted it to overcome the limitations of the orthosteric inhibitors. We applied virtual docking screening of approximately 7 million compounds against the novel allosteric site and found seven candidates. Six out of seven top candidates selected by the docking screen inhibited ZIKV NS2B-NS3 protease proteolytic activity at low micromolar concentrations, as well as suppressing viral replication. In chapter 3, we discovered the novel class of small molecules based on a tryptophan derivative scaffold identified as hepatitis C (HCV) NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. We selected the compounds that the predicted binding poses not affected by the most frequent mutations in the active site. The top compounds had a comparable inhibition profile for the common mutant HCV GT1b D168A and the wild-type enzyme. The top three inhibitors were also tested against four human serine proteases and were shown to be specific to the viral protease. The fluorescence-based cell viability assay demonstrated a sufficient therapeutic range for the top three candidates.

Regulated Proteolysis in Microorganisms

Author : David A. Dougan
Publisher : Springer Science & Business Media
ISBN 13 : 9400759401
Total Pages : 338 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Regulated Proteolysis in Microorganisms by : David A. Dougan

Download or read book Regulated Proteolysis in Microorganisms written by David A. Dougan and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker’s yeast Saccharomyces cerevisiae).

The Cancer Degradome

Author : Dylan Edwards
Publisher : Springer Science & Business Media
ISBN 13 : 0387690573
Total Pages : 921 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis The Cancer Degradome by : Dylan Edwards

Download or read book The Cancer Degradome written by Dylan Edwards and published by Springer Science & Business Media. This book was released on 2008-09-16 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; and many other relevant subjects, including new approaches to targeting proteolysis for therapy.

Handbook of Antimicrobial Resistance

Author : Matthias Gotte
Publisher : Springer
ISBN 13 : 9781493906932
Total Pages : 0 pages
Book Rating : 4.9/5 (69 download)

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Book Synopsis Handbook of Antimicrobial Resistance by : Matthias Gotte

Download or read book Handbook of Antimicrobial Resistance written by Matthias Gotte and published by Springer. This book was released on 2018-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.