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Prostaglandins And Immunity
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Book Synopsis Prostaglandins and Immunity by : James S. Goodwin
Download or read book Prostaglandins and Immunity written by James S. Goodwin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Book Synopsis Prostaglandins, Leukotrienes, and the Immune Response by : John L. Ninnemann
Download or read book Prostaglandins, Leukotrienes, and the Immune Response written by John L. Ninnemann and published by Cambridge University Press. This book was released on 1988-09-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.
Book Synopsis Prostaglandins in Cellular Biology by : Peter W. Ramwell
Download or read book Prostaglandins in Cellular Biology written by Peter W. Ramwell and published by Springer. This book was released on 1972-05 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the first of the ALZA CONFERENCE SERIES which will deal with a wide variety of topics of biomedical interest. These Conferences are planned to cover a range of subjects from the molecular level, such as drug receptor and drug membrane interactions, to the organ and organismal levels and the dynamics of drug therapy. This year's topic is "PROSTAGLANDINS." It is rapidly becoming clear that prosta glandins are of great interest and potential utility in therapeutics. An understanding of the role of prostaglandins in the regulation of cell processes should provide insight into the understanding of a variety of difficult and intransigent fields such as cancer, allergy, and transplant rejection. We hope that this Conference may focus attention on novel approaches to these areas. We wish to thank our distinguished Chairmen and guests for their attendance. The papers and dis cussions were prepared by Yvonne Hendrickson, using an ATS/360 Text-Editing System; we acknowledge with gratitude her skill, patience, and hard work. P.W.R. B.B.P.
Book Synopsis Prostaglandins and Prostaglandin Receptor Mediated Regulation of the Immune Response by :
Download or read book Prostaglandins and Prostaglandin Receptor Mediated Regulation of the Immune Response written by and published by . This book was released on 1993 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prostaglandin Regulation of Immune Responses Against Coronavirus Infections by : Rahul Vijay
Download or read book Prostaglandin Regulation of Immune Responses Against Coronavirus Infections written by Rahul Vijay and published by . This book was released on 2016 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins (PG) are ubiquitous lipid mediators that play key roles in pathophysiological responses to infections. They are considered to have both pro and anti-inflammatory roles depending upon the time of inflammation, the receptors that they bind to and the tissues that they act upon. Hence given their pleiotropic effects, a perfect balance between the pro and anti-inflammatory functions of PGs are required to ensure that a controlled timely immune response is elicited to mediate protection and to avoid immunopathology. PGD2 is one such PG that was reported to increase with age in the lungs of mice and to mediate an anti-inflammatory effect thereby blunting the immune response following Severe Acute Respiratory Syndrome - Coronavirus (SARS-CoV). Increase in PGD2 with age incapacitates respiratory dendritic cells (rDC) to migrate from lungs to the draining lymph node following SARS-CoV infection due to down regulation of CCR7 (a receptor for chemokines CCL19/21). Migration of rDCs to draining lymph nodes requires high expression of CCR7 and it's binding to CCL19/21, a chemokine that mediates migration of dendritic cells along its gradient. Although increase in levels of PGD2 might prove beneficial in high inflammatory conditions, it should be noted that high levels of such a potent anti-inflammatory mediator during the initiation of an immune response could prove detrimental. In chapter II of this thesis I show that age-related increases in oxidative stress result in the upregulation of a single phospholipase (PLA2) group II D (G2D) (PLA2G2D) with anti-inflammatory roles. PLA2G2D functions by releasing Arachidonic acid (AA) from the lipid membrane, which will be further metabolized to other pro-resolving/ anti-inflammatory lipid mediators including PGD2.
Book Synopsis Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy by : Jules E. Harris
Download or read book Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy written by Jules E. Harris and published by CRC Press. This book was released on 1994-03-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.
Book Synopsis Regulation of Immune Response by Prostaglandins by : James S. Goodwin
Download or read book Regulation of Immune Response by Prostaglandins written by James S. Goodwin and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prostaglandins and Their Precursor Substances on the Modulation of in Vivo Immunity by : Arthur Stackpoole
Download or read book Prostaglandins and Their Precursor Substances on the Modulation of in Vivo Immunity written by Arthur Stackpoole and published by . This book was released on 1986* with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunopharmacological Regulation of the Immune Response by Prostaglandins by : I. M. Orme
Download or read book Immunopharmacological Regulation of the Immune Response by Prostaglandins written by I. M. Orme and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prostaglandins in Cellular Biology by : Peter W. Ramwell
Download or read book Prostaglandins in Cellular Biology written by Peter W. Ramwell and published by Springer. This book was released on 1972-05 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the first of the ALZA CONFERENCE SERIES which will deal with a wide variety of topics of biomedical interest. These Conferences are planned to cover a range of subjects from the molecular level, such as drug receptor and drug membrane interactions, to the organ and organismal levels and the dynamics of drug therapy. This year's topic is "PROSTAGLANDINS." It is rapidly becoming clear that prosta glandins are of great interest and potential utility in therapeutics. An understanding of the role of prostaglandins in the regulation of cell processes should provide insight into the understanding of a variety of difficult and intransigent fields such as cancer, allergy, and transplant rejection. We hope that this Conference may focus attention on novel approaches to these areas. We wish to thank our distinguished Chairmen and guests for their attendance. The papers and dis cussions were prepared by Yvonne Hendrickson, using an ATS/360 Text-Editing System; we acknowledge with gratitude her skill, patience, and hard work. P.W.R. B.B.P.
Book Synopsis The Role of Prostaglandins in Regulation of I̲n̲ V̲i̲t̲r̲o̲ Cell Mediated Immunity by : Timothy L. Darrow
Download or read book The Role of Prostaglandins in Regulation of I̲n̲ V̲i̲t̲r̲o̲ Cell Mediated Immunity written by Timothy L. Darrow and published by . This book was released on 1980 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Angiogenesis in Health, Disease and Malignancy by : Ali Salajegheh
Download or read book Angiogenesis in Health, Disease and Malignancy written by Ali Salajegheh and published by Springer. This book was released on 2016-03-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine
Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Book Synopsis Prostaglandins by : Gillian M. Goodwin
Download or read book Prostaglandins written by Gillian M. Goodwin and published by Nova Science Publishers. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. They are mediators that participate in the regulation of multiple biological processes, both in health and disease. Prostaglandins contribute to the regulation of vascular tone, platelet function, and fertility. They also play key roles as inflammatory mediators and modulators of tumor biology. Although they are technically hormones, they are rarely classified as such. This book examines the biological role of prostaglandins in drug discovery, and on immune cells; the prostaglandin interchange; and the roles of prostaglandin E2 in inflammation-related cardiovascular disease as well as other related topics of import.
Book Synopsis The Biosynthesis and Actions of Prostaglandins in Insect Immune Tissues by : Hasan Tunaz
Download or read book The Biosynthesis and Actions of Prostaglandins in Insect Immune Tissues written by Hasan Tunaz and published by . This book was released on 2002 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prostaglandins and Immune Suppression in the Tumorous Aged Mouse by : Maury M. Rosenstein
Download or read book Prostaglandins and Immune Suppression in the Tumorous Aged Mouse written by Maury M. Rosenstein and published by . This book was released on 1979 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
