Multiple Sclerosis

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Publisher : National Academies Press
ISBN 13 : 0309072859
Total Pages : 457 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Multiple Sclerosis by : Institute of Medicine

Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Magnetic Resonance Spectroscopy in Multiple Sclerosis

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Publisher : Springer Science & Business Media
ISBN 13 : 884702109X
Total Pages : 180 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Magnetic Resonance Spectroscopy in Multiple Sclerosis by : M. Filippi

Download or read book Magnetic Resonance Spectroscopy in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".

Autoimmune Neurology

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Publisher : Elsevier
ISBN 13 : 0444634460
Total Pages : 569 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Autoimmune Neurology by :

Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

McAlpine's Multiple Sclerosis

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Publisher :
ISBN 13 :
Total Pages : 620 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis McAlpine's Multiple Sclerosis by : Alastair Compston

Download or read book McAlpine's Multiple Sclerosis written by Alastair Compston and published by . This book was released on 1998 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.

Primary Progressive Multiple Sclerosis

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Publisher : Springer Science & Business Media
ISBN 13 : 8847022347
Total Pages : 188 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Primary Progressive Multiple Sclerosis by : M. Filippi

Download or read book Primary Progressive Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.

Progress in Multiple Sclerosis Research

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Author :
Publisher : Nova Publishers
ISBN 13 : 9781594542848
Total Pages : 224 pages
Book Rating : 4.5/5 (428 download)

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Book Synopsis Progress in Multiple Sclerosis Research by : Frank H. Columbus

Download or read book Progress in Multiple Sclerosis Research written by Frank H. Columbus and published by Nova Publishers. This book was released on 2005 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is a life-long chronic disease diagnosed primarily in young adults. During an MS attack, inflammation occurs in areas of the white matter of the central nervous system (nerve fibres that are the site of MS lesions) in random patches called plaques. This process is followed by destruction of myelin, which insulates nerve cell fibres in the brain and spinal cord. Myelin facilitates the smooth, high-speed transmission of electrochemical messages between the brain, the spinal cord, and the rest of the body. The initial symptom of MS is often blurred or double vision, red-green colour distortion, or even blindness in one eye. Most MS patients experience muscle weakness in their extremities and difficulty with co-ordination and balance. Most people with MS also exhibit paresthesias, transitory abnormal sensory feeling such as numbness or pins and needles. Some may experience pain or loss of feeling. About half of people with MS experience cognitive impairments such as difficulties with concentration, attention, memory, and judgement. This volume presents leading research from around the globe.

Progress in Multiple Sclerosis Research

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Publisher : Springer Science & Business Media
ISBN 13 : 3642675549
Total Pages : 739 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Progress in Multiple Sclerosis Research by : H.J. Bauer

Download or read book Progress in Multiple Sclerosis Research written by H.J. Bauer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the annual meetings of the International Federation of Multiple Sclerosis Socie ties (IFMSS) the representatives of the national MS societies of numerous countries assemble for discussions and reports on work accomplished, under way, and to be undertaken in the future. In addition to publicity work, education, and patient ser vices, there has been an increasing interest in obtaining first hand, reliable, and re alistic information not only on the medical problems relevant to diagnosis, treat ment, and the management of MS, but also on progress in the difficult field of MS research. For this purpose the International Medical Advisory Board (IMAB) was founded. In the past years its members have organized a number of symposia in conjunc tion with the IFMSS meetings in New York, Copenhagen, Barcelona, Toronto, Am sterdam. The program of the G6ttingen symposium, relevant in its focus to the 1978 meeting of the IFMSS in Hannover, had the double purpose of bringing together scientists from many countries with active MS societies, and to inform the organi zers and members of these societies, and thereby also the MS patients, of problems and progress in a number of areas of MS research. The program was conceived as a survey of newer work undertaken in basic and experimental MS research and, on the clinical side, as a reassessment of the prerequisites in the diagnosis of MS, the value of laboratory tests, some therapeutic approaches, and organizational princi ples in the management of MS.

The Biology of Multiple Sclerosis

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Publisher : Cambridge University Press
ISBN 13 : 1139851063
Total Pages : 141 pages
Book Rating : 4.1/5 (398 download)

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Book Synopsis The Biology of Multiple Sclerosis by : Gregory Atkins

Download or read book The Biology of Multiple Sclerosis written by Gregory Atkins and published by Cambridge University Press. This book was released on 2012-11-08 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.

Multiple Sclerosis

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Publisher : Demos Medical Publishing
ISBN 13 : 193455927X
Total Pages : 594 pages
Book Rating : 4.9/5 (345 download)

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Book Synopsis Multiple Sclerosis by : T. Jock Murray, MD

Download or read book Multiple Sclerosis written by T. Jock Murray, MD and published by Demos Medical Publishing. This book was released on 2004-12-01 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge.

Multiple Sclerosis

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Publisher :
ISBN 13 : 9780994438133
Total Pages : 137 pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis Multiple Sclerosis by : Ian S. Zagon

Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Translational Methods for Multiple Sclerosis Research

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Publisher : Humana
ISBN 13 : 9781071612125
Total Pages : 335 pages
Book Rating : 4.6/5 (121 download)

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Book Synopsis Translational Methods for Multiple Sclerosis Research by : Sergiu Groppa

Download or read book Translational Methods for Multiple Sclerosis Research written by Sergiu Groppa and published by Humana. This book was released on 2021-08-03 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Neurodegeneration in Multiple Sclerosis

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Publisher : Springer Science & Business Media
ISBN 13 : 8847003911
Total Pages : 233 pages
Book Rating : 4.8/5 (47 download)

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Book Synopsis Neurodegeneration in Multiple Sclerosis by : M. Filippi

Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Neurotherapy

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Publisher : Elsevier
ISBN 13 : 0080922961
Total Pages : 546 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Neurotherapy by : Joost Verhaagen

Download or read book Neurotherapy written by Joost Verhaagen and published by Elsevier. This book was released on 2009-09-14 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the exciting recent progress in restorative neurology and neuroscience. The book includes chapters on major neurodegenerative disorders of the brain and the visual system, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, macular degeneration, retinitis pigmentosa, glaucoma, spinal cord trauma, and multiple sclerosis. The primary goal of the book is to give an overview of new developments in translational research and in potential therapeutic strategies, including stem cell therapy, immunotherapy, gene therapy, pharmacotherapy, neuroprostheses and deep brain stimulation. - Provides the reader with a unique overview over all aspects of new advances in the therapy of neurological and psychiatric disorders - Covers all levels of biological organization including novel molecular and cellular targets, electrophysiological, anatomical and behavioural substrates of neurodegeneration and the application of whole brain in vivo imaging - Broad focus with contributions by the top scientists worldwide in the respective disciplines

Neurobehavioral Aspects of Multiple Sclerosis

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Publisher :
ISBN 13 : 9780195054002
Total Pages : 296 pages
Book Rating : 4.0/5 (54 download)

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Book Synopsis Neurobehavioral Aspects of Multiple Sclerosis by : Stephen M. Rao

Download or read book Neurobehavioral Aspects of Multiple Sclerosis written by Stephen M. Rao and published by . This book was released on 1990 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is the most common neurological disease affecting young and middle-aged adults, and while much is known about its classic motor and sensory symptoms, it has only been during the past decade, with the advent of specialized neuropsychological test procedures and brain imaging methods, that the cognitive and behavioral changes associated with the disorder have come to be better understood. This book charts that recent progress. It provides a balanced, interdisciplinary view, covering the prevalence, range, type, and course of cognitive and affective disturbances in multiple sclerosis; the interrelationship of the neurobehavioral disturbance with brain abnormalities as visualized by neuroimaging; and the impact of cognitive and behavioral disabilities on patient rehabilitation. The book will be of value to all physicians and psychologists who deal with MS patients. It will update their knowledge of the disease and its ramifications, and will help in communicating this information to patients and their families.

Curing MS

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Publisher : Harmony
ISBN 13 : 0307420523
Total Pages : 354 pages
Book Rating : 4.3/5 (74 download)

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Book Synopsis Curing MS by : Howard L. Weiner, M.D.

Download or read book Curing MS written by Howard L. Weiner, M.D. and published by Harmony. This book was released on 2007-12-18 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: What causes multiple sclerosis? When will there be a cure? Dr. Howard Weiner has spent nearly three decades trying to find answers to the mysteries of multiple sclerosis, an utterly confounding and debilitating disease that afflicts almost half a million Americans. Curing MS is his moving, personal account of the long-term scientific quest to pinpoint the origins of the disease and to find a breakthrough treatment for its victims. Dr. Weiner has been at the cutting edge of MS research and drug development, and he describes in clear and illuminating detail the science behind the symptoms and how new drugs may hold the key to "taming the monster." From the "Twenty-one Points" of MS--a concise breakdown of the knowns and unknowns of the disease--to stories from the frontlines of laboratories and hospitals, Curing MS offers a message of hope about new treatments and makes a powerful argument that a cure can--and will--be found.

Neuroimmune Diseases

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Publisher : Springer
ISBN 13 : 3030195155
Total Pages : 822 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Neuroimmune Diseases by : Hiroshi Mitoma

Download or read book Neuroimmune Diseases written by Hiroshi Mitoma and published by Springer. This book was released on 2019-08-13 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Overcoming Multiple Sclerosis

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Publisher : ReadHowYouWant.com
ISBN 13 : 1459603877
Total Pages : 678 pages
Book Rating : 4.4/5 (596 download)

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Book Synopsis Overcoming Multiple Sclerosis by : George Jelinek

Download or read book Overcoming Multiple Sclerosis written by George Jelinek and published by ReadHowYouWant.com. This book was released on 2010-10-19 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Large Print.