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Author : Jian Zhang
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.:/5 (289 download)
Download or read book Primary Structure of the Catalytic Subunits of Bovine and Human DNA Polymerase Delta written by Jian Zhang and published by . This book was released on 1992 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stuart MacNeill
Publisher : Springer Science & Business Media
ISBN 13 : 9400745729
Total Pages : 344 pages
Book Rating : 4.4/5 (7 download)
Download or read book The Eukaryotic Replisome: a Guide to Protein Structure and Function written by Stuart MacNeill and published by Springer Science & Business Media. This book was released on 2012-08-23 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.
Author : Dietmar Schomburg
Publisher : Springer Science & Business Media
ISBN 13 : 9783540632306
Total Pages : 1098 pages
Book Rating : 4.6/5 (323 download)
Download or read book Enzyme Handbook written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 1997-09-24 with total page 1098 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of datasheets was generated from the database "BRENDA"
Author : Dietmar Schomburg
Publisher : Springer Science & Business Media
ISBN 13 : 364259025X
Total Pages : 988 pages
Book Rating : 4.6/5 (425 download)
Download or read book Enzyme Handbook 14 written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created it be comes more and more obvious that we are very limited in our ability to access functional data for the gene products -the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often sub ject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible appli cations of that knowledge in the fields of medicine, agriculture, etc .. Recent pro gress on enzyme immobilization, enzyme production, enzyme inhibition, coen zyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. It is the functional profile of an enzyme that enables a biologist of physician to analyze a metabolic pathway and its disturbance; it is the substrate specificity of an enzyme which tells an analytical biochemist how to design an assay; it is the stability, specificity and efficiency of an enzyme which determines its usefulness in the biotechnical transformation of a molecule. And the sum of all these data will have to be considered when the designer of artificial biocatalysts has to choose the optimum prototype to start with.
Author :
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ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.E/5 ( download)
Download or read book Abstracts, 21st Annual Meetings , January 25-February 8, 1992 written by and published by . This book was released on 1992 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Academy of Sciences (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1404 pages
Book Rating : 4.:/5 (319 download)
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.) and published by . This book was released on 1993 with total page 1404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
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ISBN 13 :
Total Pages : 850 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2001 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 2160 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author :
Publisher :
ISBN 13 :
Total Pages : 1212 pages
Book Rating : 4.:/5 (3 download)
Download or read book Research Awards Index written by and published by . This book was released on 1982 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 1352 pages
Book Rating : 4.E/5 ( download)
Download or read book Cambridge Scientific Biochemistry Abstracts written by and published by . This book was released on 1993 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Axel T. Brünger
Publisher : Yale University Press
ISBN 13 : 9780300054026
Total Pages : 404 pages
Book Rating : 4.0/5 (54 download)
Download or read book X-PLOR written by Axel T. Brünger and published by Yale University Press. This book was released on 1992-01-01 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-PLOR is a highly sophisticated computer program that provides an interface between theoretical foundations and experimental data in structural biology, with specific emphasis on X-ray crystallography and nuclear magnetic resonance spectroscopy in solution of large biological macro-molecules. This manual to X-PLOR Version 3.1 presents the theoretical background, syntax, and function of the program and also provides a comprehensive list of references and sample input files with comments. It is intended primarily for researchers and students in the fields of computational chemistry, structural biology, and computational molecular biology.
Author : Christopher W. Lawrence
Publisher : Springer Science & Business Media
ISBN 13 : 1468443828
Total Pages : 433 pages
Book Rating : 4.4/5 (684 download)
Download or read book Induced Mutagenesis written by Christopher W. Lawrence and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.
Author : Melvin L. DePamphilis
Publisher : CSHL Press
ISBN 13 : 0879697660
Total Pages : 814 pages
Book Rating : 4.8/5 (796 download)
Download or read book DNA Replication and Human Disease written by Melvin L. DePamphilis and published by CSHL Press. This book was released on 2006 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.
Author : Vladimir Uversky
Publisher : John Wiley & Sons
ISBN 13 : 0470618310
Total Pages : 532 pages
Book Rating : 4.4/5 (76 download)
Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2012-02-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
Author :
Publisher :
ISBN 13 :
Total Pages : 1064 pages
Book Rating : 4.E/5 ( download)
Download or read book Agrindex written by and published by . This book was released on 1995 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:
