Preventive And Predictive Genetics Towards Personalised Medicine

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Preventive and Predictive Genetics: Towards Personalised Medicine

Author : Godfrey Grech
Publisher : Springer
ISBN 13 : 3319153447
Total Pages : 388 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Preventive and Predictive Genetics: Towards Personalised Medicine by : Godfrey Grech

Download or read book Preventive and Predictive Genetics: Towards Personalised Medicine written by Godfrey Grech and published by Springer. This book was released on 2015-06-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Personalised Health Care

Author : Stefania Boccia
Publisher : Springer Nature
ISBN 13 : 3030523993
Total Pages : 135 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Personalised Health Care by : Stefania Boccia

Download or read book Personalised Health Care written by Stefania Boccia and published by Springer Nature. This book was released on 2020-11-23 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practitioners are increasingly adopting a personalised medicine approach to individually tailored patient care, especially disease diagnosis and treatment with the use of biomarkers. However, development and implementation of such approaches to chronic disease prevention need further investigation and concerted efforts for proper use in healthcare systems. This book provides high-quality, multidisciplinary knowledge from research in personalised medicine, specifically personalised prevention of chronic disease. It addresses different perspectives of prevention in the field, and is the outcome of a four-year work of the Personalized prevention of Chronic Disease (PRECeDI) Consortium, a multi-disciplinary and multi-professional team of experts. The Consortium jointly agreed to document and address the five aspects or domains of personalised medicine and prevention as individual chapters: Identification of biomarkers for the prevention of chronic disease Evaluation of predictive genomic applications Ethico-legal and policy issues surrounding personalised medicine Roles and responsibilities of stakeholders in informing healthy individuals on their genome: a sociotechnical analysis Identification of organisational models for the provision of predictive genomic applications The book focuses on the Consortium's recommendations that are derived from each of these domains based on up-to-date evidence and research that the authors write, follow, and systematically organise and report. Personalisation of health care is, eventually, a driver of innovation in research and healthcare systems. With this SpringerBrief on Personalised Health Care: Fostering Precision Medicine Advancements for Gaining Population Health Impact, the Consortium provides further evidence of the clinical validity and utility of personalised medicine with special emphasis on the prevention of chronic diseases. The book is a useful resource for policy makers, industry and healthcare professionals, scientists, technology-sector professionals, investors, citizens, and private companies that need proper advice to realise the potential of personalised medicine.

Advancing Healthcare Through Personalized Medicine

Author : Priya Hays
Publisher : Springer Nature
ISBN 13 : 3030801004
Total Pages : 755 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Advancing Healthcare Through Personalized Medicine by : Priya Hays

Download or read book Advancing Healthcare Through Personalized Medicine written by Priya Hays and published by Springer Nature. This book was released on 2021-09-27 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it helps to mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to the underlying concepts at the heart of personalized medicine. An innovative second edition, this book functions as an update to the successful first edition to include new, state-of-the-art information and advancements in the fast-paced field of personalized medicine. Chapters examine pharmacogenomics, targeted therapies, individualized diagnosis and treatment, and cancer immunotherapies. The book also features an essential discussion on how the advent of genomic technologies gives clinicians the capability to predict and diagnose disease more efficiently and offers a detailed up-to-date compilation of clinical trials in cancer leading to breakthrough therapies. The book also addresses the impact of Big Data on personalized medicine and the newfound applications of digital health and artificial intelligence. A work that advocates for a patient-centered approach, Advancing Healthcare Through Personalized Medicine, Second Edition is an invaluable text for clinicians, healthcare providers, and patients.

Rare Diseases

Author : Meral Özgüç
Publisher : Springer
ISBN 13 : 9401792143
Total Pages : 219 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Rare Diseases by : Meral Özgüç

Download or read book Rare Diseases written by Meral Özgüç and published by Springer. This book was released on 2014-09-08 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on predictive, preventative and personalized medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent “proof-of-principles” for the personalisation of healthcare systems on a global scale. Chapters look at national plans for rare disease, at biobanking, gene identification, rare cancers, virus gene therapy , induced pluripotency for cell therapy amongst other topics. There is a chapter dedicated to personalized medicine for hereditary deafness and another exploring the complexity of genotype-phenotype correlations. Specific diseases such as Fabry's, Gauchers and mitochondrial cytopathies are highlighted and we look at enzyme replacement therapy in lysosomal storage diseases. This work is part of a series, produced with the involvement of the European Association for Predictive, Preventive and Personalised Medicine. The series focusses on the concept of an integrative medical approach by PPPM. This volume is dedicated to all aspects related to the prediction, prevention and personalised treatments of rare diseases, and in doing so it explores developments relevant to all medical branches. The authors cover ethical considerations, the creation of a robust platform for professional communication, synergies with patient organisations, “doctor-patient” collaboration and a new philosophy of integrative medicine by PPPM. This volume serves as a reference source for scientific and medical centres in the field and can be used both at medical curricula and graduate level in the life sciences. Those who place a special emphasis on healthcare promotion and innovations intended to combat rare diseases, save the affected lives and enhance life quality will all find this book of great value.

Does Predictive Genetic Information Change Individual Health Behaviours? An Evaluation of Personalized Medicine in Cancer Prevention

Download Does Predictive Genetic Information Change Individual Health Behaviours? An Evaluation of Personalized Medicine in Cancer Prevention PDF Online Free

Author : Joanne Soo-Min Kim
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Does Predictive Genetic Information Change Individual Health Behaviours? An Evaluation of Personalized Medicine in Cancer Prevention by : Joanne Soo-Min Kim

Download or read book Does Predictive Genetic Information Change Individual Health Behaviours? An Evaluation of Personalized Medicine in Cancer Prevention written by Joanne Soo-Min Kim and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genomic and Personalized Medicine

Author :
Publisher : Academic Press
ISBN 13 : 0080919030
Total Pages : 669 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Genomic and Personalized Medicine by :

Download or read book Genomic and Personalized Medicine written by and published by Academic Press. This book was released on 2008-11-11 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine.Volume One Includes:Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care.Volume Two Includes:Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. - Highly Commended 2013 BMA Medical Book Award for Medicine - Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. - Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. - Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.

Can Precision Medicine Be Personal; Can Personalized Medicine Be Precise?

Author : Yechiel Michael Barilan
Publisher : Oxford University Press
ISBN 13 : 0198863462
Total Pages : 353 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Can Precision Medicine Be Personal; Can Personalized Medicine Be Precise? by : Yechiel Michael Barilan

Download or read book Can Precision Medicine Be Personal; Can Personalized Medicine Be Precise? written by Yechiel Michael Barilan and published by Oxford University Press. This book was released on 2022 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision / personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science.

Essentials of Genomic and Personalized Medicine

Author : Geoffrey S. Ginsburg
Publisher : Academic Press
ISBN 13 : 0080958117
Total Pages : 851 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Essentials of Genomic and Personalized Medicine by : Geoffrey S. Ginsburg

Download or read book Essentials of Genomic and Personalized Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2009-10-02 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. - Full color throughout - Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field - Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practic - Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

All Around Suboptimal Health

Author : Wei Wang
Publisher : Springer
ISBN 13 : 9783031468902
Total Pages : 0 pages
Book Rating : 4.4/5 (689 download)

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Book Synopsis All Around Suboptimal Health by : Wei Wang

Download or read book All Around Suboptimal Health written by Wei Wang and published by Springer. This book was released on 2024-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume demonstrates advanced strategies in biomedical sciences and healthcare focused on suboptimal health conditions in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). Potential benefits in healthcare systems and for society at large include but are not restricted to an improved life-quality of major populations and socio-economical groups, advanced professionalism of healthcare-givers and sustainable healthcare economy. Reactive medical services applied to healthcare resulted in epidemics of non-communicable diseases such as diabetes mellitus type 2 with currently about a half of billion patients registered worldwide. Far-reaching consequences are cascading co-morbidities with poor prognosis such as severe cardiovascular and neurological disorders, eye pathologies (e.g., proliferative diabetic retinopathy as the world leading cause of blindness) and several types of cancer, amongst others. Corresponding socio-economic burden is tremendous. The paradigm changes from reactive medicine to PPPM propagated by EPMA is, therefore, pivotal for advanced healthcare to improve the economy of medical services, life quality of populations and individual outcomes. To this end, individuals with suboptimal health condition comprise the target group for predictive diagnostics and cost-effective personalised treatments to protect affected individuals and sub-populations against health-to-disease transition, a window of opportunity for PPPM. This goal is of highest priority benefiting millions of people and societies at large.

Outsmart Your Genes

Author : Brandon Colby MD
Publisher : Penguin
ISBN 13 : 1101186771
Total Pages : 327 pages
Book Rating : 4.1/5 (11 download)

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Book Synopsis Outsmart Your Genes by : Brandon Colby MD

Download or read book Outsmart Your Genes written by Brandon Colby MD and published by Penguin. This book was released on 2010-04-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictive medicine is the most exciting—and potentially groundbreaking—medical development in decades. Written by Brandon Colby, MD, a leader in the fields of predictive medicine and genetic testing, Outsmart Your Genes will empower you, the reader, with a clear understanding of exactly what predictive medicine entails and how it can be used today to protect your health as well as the health of those you love. Written in straightforward, nontechnical language, Outsmart Your Genes enables everyone, even those without any background in genetics or medicine, to understand the benefits of predictive medicine. Separating myth from fact and answering all the tough questions, Outsmart Your Genes clearly explains: How the revolutionary new medical specialty called predictive medicine analyzes your genes and provides you with clear solutions to protect your health and wellbeing. What the process will entail and how simple it is. For example, the process doesn’t even require blood or use needles – instead, all that’s needed in order to run the analysis is a small amount of your saliva. What your genes can reveal about your overall health and how we can use that information to provide you with a genetically tailored plan for preventing cancer, Alzheimer's, heart disease, obesity, and many other conditions. As opposed to just generalities, specific examples are given so that you’ll know exactly how medicine will improve your life. The many ways in-which learning about your genes can help you formulate a genetically tailored nutrition and athletic plan that may help you shed those extra pounds and stay trim and fit. How predictive medicine can help both prospective and current parents protect their children against SIDS and also help minimize the impact of and most effectively treat many other childhood diseases such as autism, asthma, dyslexia, obesity, and diabetes. Why analyzing your children’s genes may provide the best chance they have to fight against diseases that may not affect them until later in life, including Alzheimer’s, many forms of cancer (such as breast cancer and skin cancer), multiple sclerosis, and even hearing loss. How groundbreaking advancements in the fields of genetic analysis, including predictive medicine panels and disease matrix technology, allow you and your physician to avoid information overload and focus only on the information most relevant to you. The important concepts you need to understand before speaking with a doctor. The top five questions you need to ask in order to assess: The credibility of the laboratory doing the testing. The types of diseases included in the test. How thoroughly the test actually evaluates your risk for each of the diseases. Whether the information is provided in a way that makes it actionable. Whether the results will be delivered in a format that is straightforward and easy to understand.

Cancer Genetics and Genomics for Personalized Medicine

Author : Il-Jin Kim
Publisher : CRC Press
ISBN 13 : 1315341107
Total Pages : 230 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Cancer Genetics and Genomics for Personalized Medicine by : Il-Jin Kim

Download or read book Cancer Genetics and Genomics for Personalized Medicine written by Il-Jin Kim and published by CRC Press. This book was released on 2017-04-11 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

Greek Medicine from Hippocrates to Galen

Author : Jacques Jouanna
Publisher : BRILL
ISBN 13 : 9004208593
Total Pages : 424 pages
Book Rating : 4.0/5 (42 download)

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Book Synopsis Greek Medicine from Hippocrates to Galen by : Jacques Jouanna

Download or read book Greek Medicine from Hippocrates to Galen written by Jacques Jouanna and published by BRILL. This book was released on 2012-07-25 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes available in English translation a selection of Jacques Jouanna's papers on Greek and Roman medicine, ranging from the early beginnings of Greek medicine to late antiquity.

Anticipation and Medicine

Author : Mihai Nadin
Publisher : Springer
ISBN 13 : 3319451421
Total Pages : 355 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Anticipation and Medicine by : Mihai Nadin

Download or read book Anticipation and Medicine written by Mihai Nadin and published by Springer. This book was released on 2016-10-22 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, practicing physicians and experts in anticipation present arguments for a new understanding of medicine. Their contributions make it clear that medicine is the decisive test for anticipation. The reader is presented with a provocative hypothesis: If medicine will align itself with the anticipatory condition of life, it can prompt the most important revolution in our time. To this end, all stakeholders—medical practitioners, patients, scientists, and technology developers—will have to engage in the conversation. The book makes the case for the transition from expensive, and only marginally effective, reactive treatment through “spare parts” (joint replacements, organ transplants) and reliance on pharmaceuticals (antibiotics, opiates) to anticipation-informed healthcare. Readers will understand why the current premise of treating various behavioral conditions (attention deficit disorder, hyperactivity, schizophrenia) through drugs has to be re-evaluated from the perspective of anticipation. In the manner practiced today, medicine generates dependence and long-lasting damage to those it is paid to help. As we better understand the nature of the living, the proactive view of healthcare, within which the science and art of healing fuse, becomes a social and political mandate.

Toward Precision Medicine

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309222222
Total Pages : 142 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Toward Precision Medicine by : National Research Council

Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Omics for Personalized Medicine

Author : Debmalya Barh
Publisher : Springer Science & Business Media
ISBN 13 : 8132211847
Total Pages : 825 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Omics for Personalized Medicine by : Debmalya Barh

Download or read book Omics for Personalized Medicine written by Debmalya Barh and published by Springer Science & Business Media. This book was released on 2013-10-14 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

An Immense New Power to Heal

Author : Lee Gutkind
Publisher : Underland Press
ISBN 13 : 9781937163068
Total Pages : 0 pages
Book Rating : 4.1/5 (63 download)

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Book Synopsis An Immense New Power to Heal by : Lee Gutkind

Download or read book An Immense New Power to Heal written by Lee Gutkind and published by Underland Press. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful completion of the Human Genome Project in 2003 created both hope and hype with regard to advancements in medical therapies. The delineation of precise genetic information suggested the possibility of predicting an individual's future health as well as the theoretical ability to intervene and fix it. Nearly a decade later, Gutkind and Kennedy (writers who are well versed in exploring both the technical and personal sides of science and medicine) chronicle the growing pains of personalized medicine, a genomic-driven, individualized type of preventive health care with uniquely targeted treatments. Interviews with researchers, patients, physicians, and others in the genomic business lead the authors to conclude that although personalized medicine has plenty of power and promise, it has a long way to go before becoming the standard of medical care. Sequencing your own genome is already quite accessible and getting cheaper all the time. Managing and making sense of vast amounts of genetic data remain daunting." (Booklist, copyright 2012, American Library Association.).--

Genomic and Personalized Medicine

Author : Geoffrey S. Ginsburg
Publisher : Academic Press
ISBN 13 : 0123822270
Total Pages : 1343 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Genomic and Personalized Medicine by : Geoffrey S. Ginsburg

Download or read book Genomic and Personalized Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2012-11-29 with total page 1343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis