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Prescriptions For Working Statisticians
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Book Synopsis Prescriptions for Working Statisticians by : Albert Madansky
Download or read book Prescriptions for Working Statisticians written by Albert Madansky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first course in statistics, no matter how "good" or "long" it is, typically covers inferential procedures which are valid only if a number of preconditions are satisfied by the data. For example, students are taught about regression procedures valid only if the true residuals are independent, homoscedastic, and normally distributed. But they do not learn how to check for indepen dence, homoscedasticity, or normality, and certainly do not learn how to adjust their data and/or model so that these assumptions are met. To help this student out! I designed a second course, containing a collec tion of statistical diagnostics and prescriptions necessary for the applied statistician so that he can deal with the realities of inference from data, and not merely with the kind of classroom problems where all the data satisfy the assumptions associated with the technique to be taught. At the same time I realized that I was writing a book for a wider audience, namely all those away from the classroom whose formal statistics education ended with such a course and who apply statistical techniques to data.
Book Synopsis Statistical Thinking for Non-Statisticians in Drug Regulation by : Richard Kay
Download or read book Statistical Thinking for Non-Statisticians in Drug Regulation written by Richard Kay and published by John Wiley & Sons. This book was released on 2014-10-23 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.
Book Synopsis Statistical Issues in Drug Development by : Stephen S. Senn
Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.
Book Synopsis Probability for Statisticians by : Galen R. Shorack
Download or read book Probability for Statisticians written by Galen R. Shorack and published by Springer Science & Business Media. This book was released on 2006-05-02 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: The choice of examples used in this text clearly illustrate its use for a one-year graduate course. The material to be presented in the classroom constitutes a little more than half the text, while the rest of the text provides background, offers different routes that could be pursued in the classroom, as well as additional material that is appropriate for self-study. Of particular interest is a presentation of the major central limit theorems via Steins method either prior to or alternative to a characteristic function presentation. Additionally, there is considerable emphasis placed on the quantile function as well as the distribution function, with both the bootstrap and trimming presented. The section on martingales covers censored data martingales.
Book Synopsis Statistical Thinking for Non-Statisticians in Drug Regulation by : Richard Kay
Download or read book Statistical Thinking for Non-Statisticians in Drug Regulation written by Richard Kay and published by John Wiley & Sons. This book was released on 2022-11-29 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: STATISTICAL THINKING FOR NON-STATISTICIANS IN DRUG REGULATION Statistical methods in the pharmaceutical industry are accepted as a key element in the design and analysis of clinical studies. Increasingly, the medical and scientific community are aligning with the regulatory authorities and recognizing that correct statistical methodology is essential as the basis for valid conclusions. In order for those correct and robust methods to be successfully employed there needs to be effective communication across disciplines at all stages of the planning, conducting, analyzing and reporting of clinical studies associated with the development and evaluation of new drugs and devices. Statistical Thinking for Non-Statisticians in Drug Regulation provides a comprehensive in-depth guide to statistical methodology for pharmaceutical industry professionals, including physicians, investigators, medical science liaisons, clinical research scientists, medical writers, regulatory personnel, statistical programmers, senior data managers and those working in pharmacovigilance. The author’s years of experience and up-to-date familiarity with pharmaceutical regulations and statistical practice within the wider clinical community make this an essential guide for the those working in and with the industry. The third edition of Statistical Thinking for Non-Statisticians in Drug Regulation includes: A detailed new chapter on Estimands in line with the 2019 Addendum to ICH E9 Major new sections on topics including Combining Hierarchical Testing and Alpha Adjustment, Biosimilars, Restricted Mean Survival Time, Composite Endpoints and Cumulative Incidence Functions, Adjusting for Cross-Over in Oncology, Inverse Propensity Score Weighting, and Network Meta-Analysis Updated coverage of many existing topics to reflect new and revised guidance from regulatory authorities and author experience Statistical Thinking for Non-Statisticians in Drug Regulation is a valuable guide for pharmaceutical and medical device industry professionals, as well as statisticians joining the pharmaceutical industry and students and teachers of drug development.
Book Synopsis Monte Carlo Statistical Methods by : Christian Robert
Download or read book Monte Carlo Statistical Methods written by Christian Robert and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have sold 4300 copies worldwide of the first edition (1999). This new edition contains five completely new chapters covering new developments.
Book Synopsis Statistics As Principled Argument by : Robert P. Abelson
Download or read book Statistics As Principled Argument written by Robert P. Abelson and published by Psychology Press. This book was released on 2012-09-10 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this illuminating volume, Robert P. Abelson delves into the too-often dismissed problems of interpreting quantitative data and then presenting them in the context of a coherent story about one's research. Unlike too many books on statistics, this is a remarkably engaging read, filled with fascinating real-life (and real-research) examples rather than with recipes for analysis. It will be of true interest and lasting value to beginning graduate students and seasoned researchers alike. The focus of the book is that the purpose of statistics is to organize a useful argument from quantitative evidence, using a form of principled rhetoric. Five criteria, described by the acronym MAGIC (magnitude, articulation, generality, interestingness, and credibility) are proposed as crucial features of a persuasive, principled argument. Particular statistical methods are discussed, with minimum use of formulas and heavy data sets. The ideas throughout the book revolve around elementary probability theory, t tests, and simple issues of research design. It is therefore assumed that the reader has already had some access to elementary statistics. Many examples are included to explain the connection of statistics to substantive claims about real phenomena.
Book Synopsis Statistical Methods: The Geometric Approach by : David J. Saville
Download or read book Statistical Methods: The Geometric Approach written by David J. Saville and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel exposition of the analysis of variance and regression. The key feature here is that these tools are viewed in their natural mathematical setting - the geometry of finite dimensions. This is because geometry clarifies the basic statistics and unifies the many aspects of analysing variance and regression.
Book Synopsis Randomization, Bootstrap and Monte Carlo Methods in Biology by : Bryan F.J. Manly
Download or read book Randomization, Bootstrap and Monte Carlo Methods in Biology written by Bryan F.J. Manly and published by CRC Press. This book was released on 2020-07-21 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern computer-intensive statistical methods play a key role in solving many problems across a wide range of scientific disciplines. Like its bestselling predecessors, the fourth edition of Randomization, Bootstrap and Monte Carlo Methods in Biology illustrates a large number of statistical methods with an emphasis on biological applications. The focus is now on the use of randomization, bootstrapping, and Monte Carlo methods in constructing confidence intervals and doing tests of significance. The text provides comprehensive coverage of computer-intensive applications, with data sets available online. Features Presents an overview of computer-intensive statistical methods and applications in biology Covers a wide range of methods including bootstrap, Monte Carlo, ANOVA, regression, and Bayesian methods Makes it easy for biologists, researchers, and students to understand the methods used Provides information about computer programs and packages to implement calculations, particularly using R code Includes a large number of real examples from a range of biological disciplines Written in an accessible style, with minimal coverage of theoretical details, this book provides an excellent introduction to computer-intensive statistical methods for biological researchers. It can be used as a course text for graduate students, as well as a reference for researchers from a range of disciplines. The detailed, worked examples of real applications will enable practitioners to apply the methods to their own biological data.
Book Synopsis Linear Models for Multivariate, Time Series, and Spatial Data by : Ronald Christensen
Download or read book Linear Models for Multivariate, Time Series, and Spatial Data written by Ronald Christensen and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a self-contained companion volume to the authors book "Plane Answers to Complex Questions: The Theory of Linear Models". It provides introductions to several topics related to linear model theory: multivariate linear models, discriminant analysis, principal components, factor analysis, time series in both the frequency and time domains, and spatial data analysis (geostatistics). The purpose of this volume is to use the three fundamental ideas of best linear prediction, projections, and Mahalanobis' distance to exploit their properties in examining multivariate, time series and spatial data. Ronald Christensen is Professor of Statistics at the University of New Mexico, and is recognised internationally as an expert in the theory and application of linear models.
Download or read book Probability written by Jim Pitman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a text for a one-quarter or one-semester course in probability, aimed at students who have done a year of calculus. The book is organised so a student can learn the fundamental ideas of probability from the first three chapters without reliance on calculus. Later chapters develop these ideas further using calculus tools. The book contains more than the usual number of examples worked out in detail. The most valuable thing for students to learn from a course like this is how to pick up a probability problem in a new setting and relate it to the standard body of theory. The more they see this happen in class, and the more they do it themselves in exercises, the better. The style of the text is deliberately informal. My experience is that students learn more from intuitive explanations, diagrams, and examples than they do from theorems and proofs. So the emphasis is on problem solving rather than theory.
Book Synopsis Probability Theory by : Yuan Shih Chow
Download or read book Probability Theory written by Yuan Shih Chow and published by Springer Science & Business Media. This book was released on 2012-11-28 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprising the major theorems of probability theory and the measure theoretical foundations of the subject, the main topics treated here are independence, interchangeability, and martingales. Particular emphasis is placed upon stopping times, both as tools in proving theorems and as objects of interest themselves. No prior knowledge of measure theory is assumed and a unique feature of the book is the combined presentation of measure and probability. It is easily adapted for graduate students familiar with measure theory using the guidelines given. Special features include: - A comprehensive treatment of the law of the iterated logarithm - The Marcinklewicz-Zygmund inequality, its extension to martingales and applications thereof - Development and applications of the second moment analogue of Walds equation - Limit theorems for martingale arrays; the central limit theorem for the interchangeable and martingale cases; moment convergence in the central limit theorem - Complete discussion, including central limit theorem, of the random casting of r balls into n cells - Recent martingale inequalities - Cram r-L vy theorem and factor-closed families of distributions.
Book Synopsis Statistics and Finance by : David Ruppert
Download or read book Statistics and Finance written by David Ruppert and published by Springer. This book was released on 2014-02-26 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book emphasizes the applications of statistics and probability to finance. The basics of these subjects are reviewed and more advanced topics in statistics, such as regression, ARMA and GARCH models, the bootstrap, and nonparametric regression using splines, are introduced as needed. The book covers the classical methods of finance and it introduces the newer area of behavioral finance. Applications and use of MATLAB and SAS software are stressed. The book will serve as a text in courses aimed at advanced undergraduates and masters students. Those in the finance industry can use it for self-study.
Book Synopsis Basic Principles of Structural Equation Modeling by : Ralph O. Mueller
Download or read book Basic Principles of Structural Equation Modeling written by Ralph O. Mueller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last two decades, structural equation modeling (SEM) has emerged as a powerful multivariate data analysis tool in social science research settings, especially in the fields of sociology, psychology, and education. Although its roots can be traced back to the first half of this century, when Spearman (1904) developed factor analysis and Wright (1934) introduced path analysis, it was not until the 1970s that the works by Karl Joreskog and his associates (e. g. , Joreskog, 1977; Joreskog and Van Thillo, 1973) began to make general SEM techniques accessible to the social and behavioral science research communities. Today, with the development and increasing avail ability of SEM computer programs, SEM has become a well-established and respected data analysis method, incorporating many of the traditional analysis techniques as special cases. State-of-the-art SEM software packages such as LISREL (Joreskog and Sorbom, 1993a,b) and EQS (Bentler, 1993; Bentler and Wu, 1993) handle a variety of ordinary least squares regression designs as well as complex structural equation models involving variables with arbitrary distributions. Unfortunately, many students and researchers hesitate to use SEM methods, perhaps due to the somewhat complex underlying statistical repre sentation and theory. In my opinion, social science students and researchers can benefit greatly from acquiring knowledge and skills in SEM since the methods-applied appropriately-can provide a bridge between the theo retical and empirical aspects of behavioral research.
Book Synopsis Plane Answers to Complex Questions by : Ronald Christensen
Download or read book Plane Answers to Complex Questions written by Ronald Christensen and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Plane Answers has many additions and a couple of deletions. New material includes additional illustrative examples in Ap pendices A and B and Chapters 2 and 3, as well as discussions of Bayesian estimation, near replicate lack of fit tests, testing the independence assump tion, testing variance components, the interblock analysis for balanced in complete block designs, nonestimable constraints, analysis of unreplicated experiments using normal plots, tensors, and properties of Kronecker prod ucts and Vee operators. The book contains an improved discussion of the relation between ANOVA and regression, and an improved presentation of general Gauss-Markov models. The primary material that has been deleted are the discussions of weighted means and of log-linear models. The mate rial on log-linear models was included in Christensen (1990b), so it became redundant here. Generally, I have tried to clean up the presentation of ideas wherever it seemed obscure to me. Much of the work on the second edition was done while on sabbatical at the University of Canterbury in Christchurch, New Zealand. I would par ticularly like to thank John Deely for arranging my sabbatical. Through their comments and criticisms, four people were particularly helpful in con structing this new edition. I would like to thank Wes Johnson, Snehalata Huzurbazar, Ron Butler, and Vance Berger.
Book Synopsis Modeling, Analysis, Design, and Control of Stochastic Systems by : V. G. Kulkarni
Download or read book Modeling, Analysis, Design, and Control of Stochastic Systems written by V. G. Kulkarni and published by Springer. This book was released on 2014-01-13 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introductory level text on stochastic modelling, suited for undergraduates or graduates in actuarial science, business management, computer science, engineering, operations research, public policy, statistics, and mathematics. It employs a large number of examples to show how to build stochastic models of physical systems, analyse these models to predict their performance, and use the analysis to design and control them. The book provides a self-contained review of the relevant topics in probability theory: In discrete and continuous time Markov models it covers the transient and long term behaviour, cost models, and first passage times; under generalised Markov models, it covers renewal processes, cumulative processes and semi-Markov processes. All the material is illustrated with many examples, and the book emphasises numerical answers to the problems. A software package called MAXIM, which runs on MATLAB, is available for downloading.
Book Synopsis Applied Multivariate Data Analysis by : J.D. Jobson
Download or read book Applied Multivariate Data Analysis written by J.D. Jobson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: An easy to read survey of data analysis, linear regression models and analysis of variance. The extensive development of the linear model includes the use of the linear model approach to analysis of variance provides a strong link to statistical software packages, and is complemented by a thorough overview of theory. It is assumed that the reader has the background equivalent to an introductory book in statistical inference. Can be read easily by those who have had brief exposure to calculus and linear algebra. Intended for first year graduate students in business, social and the biological sciences. Provides the student with the necessary statistics background for a course in research methodology. In addition, undergraduate statistics majors will find this text useful as a survey of linear models and their applications.
