Author : Esteban Jimenez Arrieta
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)
Book Synopsis Prepartum Modulation of Systemic Inflammation in High-Priority Dairy Cow Groups by : Esteban Jimenez Arrieta
Download or read book Prepartum Modulation of Systemic Inflammation in High-Priority Dairy Cow Groups written by Esteban Jimenez Arrieta and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dairy cows experience multiple physiological challenges throughout the peripartum period which leads to a correct transition from a gestational non-lactational state to a non-gestational lactational one. Under proper management, these animals can adapt their metabolism to ensure a proper transition. However, over-conditioned cows and nulliparous animals are more prone to experience maladaptations to these physiological challenges and should be categorized as high-priority cow groups. These maladaptations in turn increase the risk of experiencing postpartum diseases, compromise the productive and reproductive performance of the animal in the following lactation, and lead to important economic losses in dairy farms. Several scientific studies have proposed that using nonsteroidal anti-inflammatory drugs (NSAID), during the transition period, can support dairy cows to overcome those maladaptations, improving their welfare and overall performance. The objectives of this thesis were to assess the effect of single oral administration of acetylsalicylic acid (ASA) on dairy cows at -14 days relative to calving (d.r.c) on 1) systemic inflammation and metabolic stress during the transition period; 2) milk components, milk quality and daily milk yield (100 days in milk; DIM) and 3) incidence of clinical health events and culling rate during the first 60 DIM and 4) reproductive performance during 300 DIM. The research was performed on Holstein dairy cows from a commercial farm in central Pennsylvania. At 21 days before the expected parturition date, cows were blocked by parity (Nulliparous [NUL] and Parous [PAR]) and body condition score (BCS; BCS>=3.75 pts = Over-conditioned [OVER]; BCS 3-3.5 pts = Optimal conditioned [OPT]) and randomly allocated into one of two treatment groups: ASA (n= 304): cows received one oral administration with 4 boluses of acetylsalicylic acid (200mg/kg; 125g/d; Sparhawk Laboratories, Inc., KS, US); and 2) PLC (n= 303): cows received one oral administration with 4 gelatin boluses filled with water. The treatment was administrated one week later. Blood samples were collected weekly from enrollment until 21 days in milk (DIM). Serum was analyzed to determine the concentration of haptoglobin (HP), non-esterified fatty acids (NEFA), and [beta]-hydroxybutyrate (BHB). Clinical metritis and subclinical ketosis were assessed at 7±3, 14±3 and 21±3 DIM. Health events during the first 60 DIM, reproductive performance, and milk production were collected from on-farm computer records. Parous cows treated with ASA had lower BCS at calving, 7±3, 14±3, and 21±3 DIM compared to multiparous cows treated with PLC (p
