Precision Medicine in Diabetes

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Publisher : Springer Nature
ISBN 13 : 3030989275
Total Pages : 340 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Precision Medicine in Diabetes by : Rita Basu

Download or read book Precision Medicine in Diabetes written by Rita Basu and published by Springer Nature. This book was released on 2022-05-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing clarity to the emerging model of precision medicine within the diabetes field, and expanding upon how it will lead to the development of specifically tailored treatment for patients and even macro strategies in public health, this unique book explores the realm of biomarkers in the era of big data. Various experts in their respective areas discuss the current practice to illuminate how creating a more discreet profile of patients and even substratum of populations will lead to more refined therapies targeted towards the phenotype and genotype of the patient. Embracing a multidisciplinary team science approach, this book demonstrates how precision medicine in diabetes can mine a web of data toward diabetes risk stratification and treatment options. The authors skillfully articulate how the construction of various prediction-based models can revolutionize clinical decision-making, and they examine the challenges and pitfalls of integrating disparate sources of information and how the collection of data and cooperation among stakeholders will be key to the future of precision medicine in diabetes treatment. Topics include personalized approaches to the management of both type 1 and type 2 diabetes, various macro and microvascular complications of diabetes, inpatient management of glycemia, nutrition, exercise, advances in diabetes technology and others. Ideal for clinical endocrinologists and other professionals involved in the management of diabetes and its complications, Precision Medicine in Diabetes is first of its kind to address this paradigm-shifting topic in a comprehensive way.

Personalized Predictive Modeling in Type 1 Diabetes

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Publisher : Academic Press
ISBN 13 : 0128051469
Total Pages : 253 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Personalized Predictive Modeling in Type 1 Diabetes by : Eleni I. Georga

Download or read book Personalized Predictive Modeling in Type 1 Diabetes written by Eleni I. Georga and published by Academic Press. This book was released on 2017-12-11 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures. Describes fundamentals of modeling techniques as applied to glucose control Covers model selection process and model validation Offers computer code on a companion website to show implementation of models and algorithms Features the latest developments in the field of diabetes predictive modeling

Toward Precision Medicine

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Publisher : National Academies Press
ISBN 13 : 0309222222
Total Pages : 142 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Toward Precision Medicine by : National Research Council

Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Precision Medicine in Type 2 Diabetes

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Precision Medicine in Type 2 Diabetes by : J. Dennis

Download or read book Precision Medicine in Type 2 Diabetes written by J. Dennis and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM

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Publisher : Springer Science & Business Media
ISBN 13 : 9400759711
Total Pages : 549 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM by : Mahmood S. Mozaffari

Download or read book New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM written by Mahmood S. Mozaffari and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended to provide up-to-date and emerging information in the field of diabetes mellitus with a focus on preventive, predictive and personalized medicine.

Progress and Challenges in Precision Medicine

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Publisher : Academic Press
ISBN 13 : 0128095024
Total Pages : 346 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Progress and Challenges in Precision Medicine by : Mukesh Verma

Download or read book Progress and Challenges in Precision Medicine written by Mukesh Verma and published by Academic Press. This book was released on 2016-12-22 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Advancing Precision Medicine in Type 2 Diabetes Through Machine Learning

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Publisher :
ISBN 13 : 9789180697811
Total Pages : 0 pages
Book Rating : 4.6/5 (978 download)

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Book Synopsis Advancing Precision Medicine in Type 2 Diabetes Through Machine Learning by : Moa Lugner

Download or read book Advancing Precision Medicine in Type 2 Diabetes Through Machine Learning written by Moa Lugner and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Economic Evaluations of Precision Medicine: Case Studies in Diabetes

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Economic Evaluations of Precision Medicine: Case Studies in Diabetes by :

Download or read book Economic Evaluations of Precision Medicine: Case Studies in Diabetes written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Individualized Care

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Publisher : Springer
ISBN 13 : 331989899X
Total Pages : 232 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis Individualized Care by : Riitta Suhonen

Download or read book Individualized Care written by Riitta Suhonen and published by Springer. This book was released on 2018-08-22 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed book is based on more than 20 years of researches on patient individuality, care and services of the continuously changing healthcare system. It describes how research results can be used to respond to challenges on individuality in healthcare systems. Service users’, patients’ or clients’ point of views on care and health services are urgently needed. This book describes the conceptualisation of the individualized nursing care phenomenon and the process development of the measuring instruments of that phenomenon in different contexts. It describes results from a variety of clinical contexts about individualized nursing care and explains factors associated with the perceptions and delivery of individualized nursing care from different point of views. This book may appeal to clinicians, nurses practitioners and researchers from many fields.

Precision Medicine and Artificial Intelligence

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Publisher : Academic Press
ISBN 13 : 032385432X
Total Pages : 300 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Precision Medicine and Artificial Intelligence by : Michael Mahler

Download or read book Precision Medicine and Artificial Intelligence written by Michael Mahler and published by Academic Press. This book was released on 2021-03-12 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

The Patient Equation

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Publisher : John Wiley & Sons
ISBN 13 : 111975576X
Total Pages : 288 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis The Patient Equation by : Glen de Vries

Download or read book The Patient Equation written by Glen de Vries and published by John Wiley & Sons. This book was released on 2020-07-23 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: How the data revolution is transforming biotech and health care, especially in the wake of COVID-19—and why you can’t afford to let it pass you by We are living through a time when the digitization of health and medicine is becoming a reality, with new abilities to improve outcomes for patients as well as the efficiency and success of the organizations that serve them. In The Patient Equation, Glen de Vries presents the history and current state of life sciences and health care as well as crucial insights and strategies to help scientists, physicians, executives, and patients survive and thrive, with an eye toward how COVID-19 has accelerated the need for change. One of the biggest challenges facing biotech, pharma, and medical device companies today is how to integrate new knowledge, new data, and new technologies to get the right treatments to the right patients at precisely the right times—made even more profound in the midst of a pandemic and in the years to come. Drawing on the fascinating stories of businesses and individuals that are already making inroads—from a fertility-tracking bracelet changing the game for couples looking to get pregnant, to an entrepreneur reinventing the treatment of diabetes, to Medidata's own work bringing clinical trials into the 21st century—de Vries shares the breakthroughs, approaches, and practical business techniques that will allow companies to stay ahead of the curve and deliver solutions faster, cheaper, and more successfully—while still upholding the principles of traditional therapeutic medicine and reflecting the current environment. How new approaches to cancer and rare diseases are leading the way toward precision medicine What data and digital technologies enable in the building of robust, effective disease management platforms Why value-based reimbursement is changing the business of life sciences How the right alignment of incentives will improve outcomes at every stage of the patient journey Whether you're a scientist, physician, or executive, you can't afford to let the moment pass: understand the landscape with this must-read roadmap for success—and see how you can change health care for the better.

Precision Medicine in Clinical Practice

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Publisher : Springer Nature
ISBN 13 : 9811950822
Total Pages : 259 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Precision Medicine in Clinical Practice by : Mandana Hasanzad

Download or read book Precision Medicine in Clinical Practice written by Mandana Hasanzad and published by Springer Nature. This book was released on 2022-09-30 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides complete information on the cornerstones of precision medicine through the omics approach. Clinical applications of genomics and precision medicine have progressed from a theoretical wish list to an impactful force in medical practice.Step-by-step descriptions are provided from basics to the future application and its benefit in clinical practice. Precision medicine aims to personalize health care by tailoring decisions and treatments to each individual in every possible way. Precision medicine includes pharmacogenomics. Essential information is provided on the role of precision medicine and pharmacogenomics in the clinical practice of cancer, cardiovascular disease, diabetes, psychiatric disease, and also the importance for healthcare professionals. This book will assist the practitioners how to integrate precision medicine and pharmacogenomics data into their clinical practice. It is hoped that physicians, pharmacists, and scientists with basic scientific knowledge of precision medicine will findthis book useful.

Pharmacogenomics in Drug Discovery and Development

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Publisher : Springer Nature
ISBN 13 : 107162573X
Total Pages : 618 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Pharmacogenomics in Drug Discovery and Development by : Qing Yan

Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Springer Nature. This book was released on 2022-09-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

From Pharmacogenetics to Gene Expression

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis From Pharmacogenetics to Gene Expression by : Guadalupe Ortiz-Lopez

Download or read book From Pharmacogenetics to Gene Expression written by Guadalupe Ortiz-Lopez and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately 25,Äì60% of patients show specific pharmacological responses to a particular drug. We call this interindividual variability (IV) response to drugs affecting their efficacy and the appearance of side effects in individuals. This IV may be due to multifactorial components such as genetic factors (single nucleotide polymorphisms, SNPs; and copy number variations, CNV), environmental stimuli, epigenetic modulation, disease/health conditions, or drug interactions, among others. Therefore, these factors can influence the response to the drug by modifying absorption, metabolism, pharmacokinetics (PK), and pharmacodynamics (PD), causing the loss of treatment efficacy or leading to adverse drug reactions with negative consequences for patients. The knowledge in pharmacogenetics (study of pharmacological consequences of single gene mutations) and pharmacogenomics (study of the influence of many gene or gene patterns in the reponse to drugs), disciplines that seek to predict how a specific individual responds to the administration of a particular drug, has advanced by leaps and bounds thanks to ,Äúomics,Äù technologies. Nonetheless, despite, the development of next-generation sequencing platforms and the mapping of the human genome have transformed the field of pharmacogenetics, the translational into clinical practice has been slow. Therefore, identification of SNPs that could affect the expression of pharmacogenes in order to make associations with PK and PD will improve our understanding of genetic effects on drug efficacy and transfer it to the clinic. Type 2 diabetes (T2D) represents a national public health problem, not only because of the high frequency of the disease reported worldwide, but also because of the poor adherence to therapeutic management, whose causes have not yet been clarified. One of the challenges in the management of diseases to reach optimal treatment is the complex genetic background. Hence, the integration of multiple levels of pharmacological information, including variation in gene sequence, impact in drug response, and function of drug targets, could help us to predict sources of interpatient variability in drug effects, laying the basis for precision therapy. Thus, the present chapter aims to collect all the available data about genetic variations in pharmacogenes affecting drug response in T2D and integrate it with their effect on gene expression to elucidate their impact in pharmacological efficacy.

Genomic and Precision Medicine

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Publisher : Academic Press
ISBN 13 : 0128006544
Total Pages : 372 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genomic and Precision Medicine by : Geoffrey S. Ginsburg

Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2017-03-30 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. Presents a comprehensive volume for primary care providers Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine Includes a current overview on major opportunities for genomic and personalized medicine in practice Highlights case studies that illustrate the practical use of genomics in the management in patients

Relevance of Health Literacy to Precision Medicine

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Publisher : National Academies Press
ISBN 13 : 0309447356
Total Pages : 125 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Relevance of Health Literacy to Precision Medicine by : National Academies of Sciences, Engineering, and Medicine

Download or read book Relevance of Health Literacy to Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-04 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: On January 20, 2015, President Obama announced the Precision Medicine Initiative (PMI) in his State of the Union address. The PMI, by developing new approaches for detecting, measuring, and analyzing a wide range of biomedical information including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters, is intended to enable a new era of medicine in which researchers, providers, and patients work together to develop individualized care. Part of this effort included the creation of a national, large-scale research participant group, or cohort. The PMI Cohort Program is aimed at extending precision medicine to many diseases, including both rare and common diseases such as diabetes, heart disease, Alzheimer's disease, obesity, and mental illnesses such as depression, bipolar disorder, and schizophrenia, by building a national research cohort of 1 million or more U.S. participants. An important challenge to assembling the PMI Cohort will be to reach individuals who are socioeconomically disadvantaged. Individuals who are socioeconomically disadvantaged have lower health literacy; often belong to racial, ethnic, and minority communities; and are often less likely to participate in research studies and biorepositories. To explore possible strategies and messaging designs, the Roundtable on Health Literacy formed an ad hoc committee charged with planning and conducting a 1-day public workshop on the intersection of health literacy and precision medicine. The workshop participants discussed a variety of topics including an overview of precision medicine and its potential, the relevance of health literacy to the success of precision medicine efforts, and perspectives and understanding of different groups, such as health care providers, consumers, and insurers. This publication summarizes the presentations and discussions from the workshop.

Monogenic Diabetes: Implementation of Translational Genomic Research Towards Precision Medicine

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Monogenic Diabetes: Implementation of Translational Genomic Research Towards Precision Medicine by :

Download or read book Monogenic Diabetes: Implementation of Translational Genomic Research Towards Precision Medicine written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: