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Pre Referral Rectal Artesunate To Prevent Death And Disability In Severe Malaria
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Book Synopsis Pre-referral treatment with rectal artesunate of children with suspected severe malaria by : World Health Organization
Download or read book Pre-referral treatment with rectal artesunate of children with suspected severe malaria written by World Health Organization and published by World Health Organization. This book was released on 2023-11-07 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The use of rectal artesunate as a pre-referral treatment for severe Plasmodium falciparum malaria, 2023 update by : World Health Organization
Download or read book The use of rectal artesunate as a pre-referral treatment for severe Plasmodium falciparum malaria, 2023 update written by World Health Organization and published by World Health Organization. This book was released on 2023-07-04 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2021, preliminary results of observational studies from the Community Access to Rectal Artesunate for Malaria (CARAMAL) project did not confirm the mortality impact observed in the controlled trial in 2009. Consequently, in January 2022, WHO released an information note on rectal artesunate (RAS), suggesting immediate risk mitigation measures. To provide clarity on the evidence, WHO subsequently convened independent experts to conduct a formal evidence review of the data from the CARAMAL project, as well as data from other studies evaluating the deployment of pre-referral RAS at programmatic level. The outcomes of the review, including results of additional analyses undertaken by the WHO appointed experts, form the basis of this updated information note on the use of RAS as a pre-referral treatment for severe Plasmodium falciparum malaria.
Book Synopsis The use of rectal artesunate as a pre-referral treatment for severe P. falciparum malaria by :
Download or read book The use of rectal artesunate as a pre-referral treatment for severe P. falciparum malaria written by and published by World Health Organization. This book was released on 2022-01-28 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO Malaria Policy Advisory Group (MPAG) recently reviewed the evidence from a large-scale study in 3 African countries deploying rectal artesunate under real-life conditions. This information note shares the findings of the study and possible implications for the use of RAS as pre-referral treatment for severe malaria, and makes concrete recommendations for countries to consider. The WHO Global Malaria Programme, in consultation with other relevant departments, will conduct a formal evidence review and develop detailed guidance on the conditions under which the use of this tool can be implemented safely and effectively. Such guidance will be shared with countries as soon as it becomes available.
Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Book Synopsis Saving Lives, Buying Time by : Institute of Medicine
Download or read book Saving Lives, Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Book Synopsis Technical consultation to review the effectiveness of rectal artesunate used as pre-referral treatment of severe malaria in children by : World Health Organization
Download or read book Technical consultation to review the effectiveness of rectal artesunate used as pre-referral treatment of severe malaria in children written by World Health Organization and published by World Health Organization. This book was released on 2023-06-21 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document is the report of a WHO technical consultation of independent experts convened in October 2022. The aim of the consultation was to conduct a formal evidence review of several studies evaluating the effectiveness of rectal artesunate (RAS) as a pre-referral treatment for severe malaria. In addition to the study published under the Community Access to Rectal Artesunate for Malaria Project, the review included other studies from early-use countries deploying RAS at the programmatic level. The main objective of the technical consultation was to support the development of guidance for the safe and effective implementation of this intervention based on the evidence from areas where RAS has already been implemented.
Book Synopsis Principles of Medicine in Africa by : David Mabey
Download or read book Principles of Medicine in Africa written by David Mabey and published by Cambridge University Press. This book was released on 2013-01-17 with total page 929 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essential text for all healthcare professionals wanting a complete, up-to-date practical reference book on medicine in Africa.
Book Synopsis Guidelines for the Treatment of Malaria. Third Edition by : World Health Organization
Download or read book Guidelines for the Treatment of Malaria. Third Edition written by World Health Organization and published by World Health Organization. This book was released on 2015-08-13 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria remains an important cause of illness and death in children and adults in countries in which it is endemic. Malaria control requires an integrated approach including prevention (primarily vector control) and prompt treatment with effective antimalarial agents. Malaria case management consisting of prompt diagnosis and effective treatment remains a vital component of malaria control and elimination strategies. Since the publication of the first edition of the Guidelines for the treatment of malaria in 2006 and the second edition in 2010 all countries in which P. falciparum malaria is endemic have progressively updated their treatment policy from use of ineffective monotherapy to the currently recommended artemisinin-based combination therapies (ACT). This has contributed substantially to current reductions in global morbidity and mortality from malaria. Unfortunately resistance to artemisinins has arisen recently in P. falciparum in South-East Asia which threatens these gains. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on a firmer evidence base for most antimalarial drugs and in addition include recommendation on the use of drugs to prevent malaria in groups at high risk. The Guidelines provide a framework for designing specific detailed national treatment protocols taking into account local patterns of resistance to antimalarial drugs and health service capacity. It provides recommendations on treatment of uncomplicated and severe malaria in all age groups all endemic areas in special populations and several complex situations. In addition on the use of antimalarial drugs as preventive therapy in healthy people living in malaria-endemic areas who are high risk in order to reduce morbidity and mortality from malaria. The Guidelines are designed primarily for policy-makers in ministries of health who formulate country-specific treatment guidelines. Other groups that may find them useful include health professionals and public health and policy specialists that are partners in health or malaria control and the pharmaceutical industry. The treatment recommendations in the main document are brief; for those who wish to study the evidence base in more detail a series of annexes is provided with references to the appropriate sections of the main document.
Book Synopsis Treatment and Prevention of Malaria by : Henry M. Staines
Download or read book Treatment and Prevention of Malaria written by Henry M. Staines and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
Download or read book Neonatal Formulary written by Edmund Hey and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its sixth edition, the Neonatal Formulary continues to provide advice on the safe use of drugs commonly given to babies during labor, delivery and the first month of life. In addition to the 230 monographs featured in the previous edition, 6 new drugs were added and all references have been updated. An accompanying website offers regular updates and electronic cross-links to a wide range of other useful information for neonatologists and neonatal nurses, hospital pharmacists, obstetric staff or general practitioners. For easy access, the whole text is also available for purchase in a PDA format.
Book Synopsis The Use of Artemisinin Derivative Suppositories as Life-Saving Remedy for Critical Malaria Patients by : Renu Tripathi
Download or read book The Use of Artemisinin Derivative Suppositories as Life-Saving Remedy for Critical Malaria Patients written by Renu Tripathi and published by Cambridge Scholars Publishing. This book was released on 2021-03-01 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details antimalarial suppositories proposed for emergency life-saving treatment of children and adults suffering from severe and cerebral malaria. It stresses the importance of emergency antimalarial therapy to save the lives of patients who cannot take oral antimalarial treatment in rural areas where modern, life-saving therapy is not available. It considers the use of suppositories and oral treatment for MDR malarias, the control of MDR malaria infections, drug discovery, safe delivery, and drug resistant malaria.
Book Synopsis Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy by : Qigui Li
Download or read book Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy written by Qigui Li and published by Bentham Science Publishers. This book was released on 2015-06-04 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.
Book Synopsis Updates in Tropical Medicine, An Issue of Infectious Disease Clinics of North America by : Michael Libman
Download or read book Updates in Tropical Medicine, An Issue of Infectious Disease Clinics of North America written by Michael Libman and published by Elsevier Health Sciences. This book was released on 2019-02-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: With consultation of Dr. Helen Boucher, Drs. Libman and Younsouni have put together an issue that provides current updates on a wide range of topics in tropical medicine. They have enlisted top experts from around the world to offer their expertise on state-of-the-art diagnosis, treatment, and management. The clinical reviews in this issue are devoted to: Tropical Diseases: Definition, Geographic Distribution, Transmission, and Classification; Venomous Bites, Stings, and Poisoning; What’s New in Management in the Management of Malaria; Human African Trypanosomiasis; American Trypanosomiasis; Leishmaniasis – Recent Developments in the Diagnosis and Management; Enteric Infections: New Paradigms for Causality and Key Pathogens; Enteric Infections: New Paradigms for Morbidity; Strongyloides, the Neglected NTD: Current Concepts for Screening, Diagnosis, and Treatment; Cysticercosis: State-of the Art Management; Arboviruses and Viral Hemorrhagic Fevers; Laboratory Diagnosis of Tropical Infections; Diagnostics During Public Health Emergencies: Lessons from Ebola and Zika; Antimicrobial Resistance; Migration Medicine in 2018; and Richettsiosis: Practical Update. Readers will come away with the information they need to make clinical decisions with confidence.
Book Synopsis Frontiers in Anti-Infective Drug Discovery by : Atta -ur- Rahman
Download or read book Frontiers in Anti-Infective Drug Discovery written by Atta -ur- Rahman and published by Bentham Science Publishers. This book was released on 2017-08-11 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships.
Book Synopsis Neonatal Formulary by : Sean Ainsworth
Download or read book Neonatal Formulary written by Sean Ainsworth and published by Oxford University Press. This book was released on 2020-03-13 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neonatal Formulary provides comprehensive guidance on the safe use of the drugs prescribed during pregnancy and commonly given to babies during labour and delivery, as well as during lactation and the first year of life. Treating the journey from pregnancy to parenthood as a continuous event, the new edition contains updated information on how the drugs affect both mother and baby. The first part of the book focuses on drug storage, drug licensing, and drug prescribing. In addition, it explains to why the metabolism of drugs differs in premature and sick infants, and why the practice of extrapolating doses from adult studies is unsafe. Patient safety, excipients, and therapies that affect drugs are also covered. Part 2 consists of monographs for over 250 drugs that may find use in the neonatal unit, and possibly outside it. Each monograph is divided into sections covering use, pharmacology, treatment, drug interactions or other administration, information, supply and administration, and references. The monographs are evidence-based and include links to the Cochrane Database of Systematic Reviews, and national guidelines. The third part presents information on additional drugs, and groups of drugs, that are often taken by mothers during pregnancy, labour, or during breast feeding. The drugs discussed in this section all affect the foetus or infant. Containing far more detail than is available in the British National Formulary for Children, and with additional online material featuring updates related to specific drugs and dosing, Neonatal Formulary is an essential guide for neonatologists, neonatal nurses, hospital pharmacists, obstetric staff, advanced nurse practitioners and for all health care professionals caring for pregnant women and their infants in the first year of life.
Book Synopsis Guidelines for the Treatment of Malaria by : World Health Organization
Download or read book Guidelines for the Treatment of Malaria written by World Health Organization and published by World Health Organization. This book was released on 2010 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.
Book Synopsis Principles of Medicine in Africa by : David Mabey
Download or read book Principles of Medicine in Africa written by David Mabey and published by Cambridge University Press. This book was released on 2013-01-17 with total page 929 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Medicine in Africa combines classical clinical medicine with a rich understanding of the major environmental and cultural influences on health and disease, providing comprehensive guidance for anyone intending to practise medicine in Africa. Disease is presented in the context of family and culture, and the effects of inequality and problems of limited resources are addressed. The authors have a wealth of experience in front line healthcare and provide practical, evidence-based management guidelines for all the common and less common conditions likely to be encountered. This fourth edition has been thoroughly updated to incorporate the latest research findings and management guidelines. It includes an expanded section on maternal and child health, but careful editing has generated a slimmer volume, whilst retaining all of the essential content. This is the one essential text for medical students and healthcare professionals wanting a complete and up-to-date reference book on medicine in Africa.
