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Post Translational Modifications Of Proteins
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Book Synopsis Posttranslational Modification of Proteins by : Christopher Walsh
Download or read book Posttranslational Modification of Proteins written by Christopher Walsh and published by Roberts and Company Publishers. This book was released on 2006 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.
Book Synopsis Post-translational Modifications of Proteins by : Christoph Kannicht
Download or read book Post-translational Modifications of Proteins written by Christoph Kannicht and published by Humana Press. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a fully up-dated and expanded practical guide to protein structure-function relationships. This important area of research is brought up-to-date by the leading scientists in the field. The compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular BiologyTM series. Comprehensive and cutting edge, the book serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.
Book Synopsis Post-Translational Modifications in Health and Disease by : Cecilio J. Vidal
Download or read book Post-Translational Modifications in Health and Disease written by Cecilio J. Vidal and published by Springer Science & Business Media. This book was released on 2010-10-13 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
Book Synopsis Protein Modificomics by : Tanveer Ali Dar
Download or read book Protein Modificomics written by Tanveer Ali Dar and published by Academic Press. This book was released on 2019-05-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
Book Synopsis Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins by : T. Shantha Raju
Download or read book Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins written by T. Shantha Raju and published by John Wiley & Sons. This book was released on 2019-03-15 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.
Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Book Synopsis Posttranslational Modification of Proteins by : Christoph Kannicht
Download or read book Posttranslational Modification of Proteins written by Christoph Kannicht and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins.
Book Synopsis Post-translational Modifications of Proteins by : John J. Harding
Download or read book Post-translational Modifications of Proteins written by John J. Harding and published by CRC Press. This book was released on 1991-12-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.
Book Synopsis Protein Bioinformatics by : Cathy H. Wu
Download or read book Protein Bioinformatics written by Cathy H. Wu and published by Humana. This book was released on 2017-02-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume introduces bioinformatics research methods for proteins, with special focus on protein post-translational modifications (PTMs) and networks. This book is organized into four parts and covers the basic framework and major resources for analysis of protein sequence, structure, and function; approaches and resources for analysis of protein PTMs, protein-protein interactions (PPIs) and protein networks, including tools for PPI prediction and approaches for the construction of PPI and PTM networks; and bioinformatics approaches in proteomics, including computational methods for mass spectrometry-based proteomics and integrative analysis for alternative splice isoforms, for functional discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory or computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein Bioinformatics: From Protein Modifications and Networks to Proteomics is a valuable resource for readers who wish to learn about state-of-the-art bioinformatics databases and tools, novel computational methods, and future trends in protein and proteomic data analysis in systems biology. This book is useful to researchers who work in the biotechnology and pharmaceutical industries, and in various academic departments, such as biological and medical sciences and computer sciences and engineering.
Book Synopsis Quality Control of Cellular Protein in Neurodegenerative Disorders by : Uddin, Md. Sahab
Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2020-02-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
Book Synopsis Co- and Post-translational Modification of Proteins by : Donald J. Graves
Download or read book Co- and Post-translational Modification of Proteins written by Donald J. Graves and published by Oxford University Press, USA. This book was released on 1994 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents the general biological principles--and the chemical and physical concepts-- needed for an understanding of the post- and co-translational modification of proteins, a fundamental topic in the science of protein biochemistry and molecular biology. Examples of the different types of modification reactions (glycosylation, phosphorylation, prenylation, etc.) are presented to illustrate specific points, and the book is intended to serve as a principles-based guide for studying the subject, whether in the classroom or research laboratory. In addition to its value as a timely overview of a broad, vitally important area, the book can be used in advanced courses on signal transduction, enzymology, and protein chemistry, or as a supplementary text for biochemistry or molecular biology.
Book Synopsis Cellular Mechanics and Biophysics by : Claudia Tanja Mierke
Download or read book Cellular Mechanics and Biophysics written by Claudia Tanja Mierke and published by Springer Nature. This book was released on 2020-10-30 with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.
Book Synopsis The Post-translational Modification of Proteins by : Syozo Tuboi
Download or read book The Post-translational Modification of Proteins written by Syozo Tuboi and published by . This book was released on 1992 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in post-translational modification reactions and discusses the significance of these reactions to cellular biology. Topics covered include identification and characterization of various types of post-translational modified proteins by ion spray MAS; sulfation and phosporylation of proteins; non-enzymatic glycation under diabetic conditions; amidation carboxymethylation and ADP-ribosylation of proteins, and enzymatic glycosylation of proteins.
Book Synopsis Proteome Research: New Frontiers in Functional Genomics by : Marc R. Wilkins
Download or read book Proteome Research: New Frontiers in Functional Genomics written by Marc R. Wilkins and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.
Book Synopsis Advances in Post-Translational Modifications of Proteins and Aging by : V. Zappia
Download or read book Advances in Post-Translational Modifications of Proteins and Aging written by V. Zappia and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains 56 contributions presented at the 1st International Symposium on Post-Translational Modifications of Proteins and Ageing, held on the Island of Ischia (Naples, Italy) from May 11 to 15, 1987, under the auspices of the University of Naples and the Italian Society of Biochemistry. The primary aim of this interdisciplinary meeting was to promote a productive exchange among scientists from different cultural areas, and to give them the opportunity to discuss problems of common interest approached from different scientific standpoints. Although a large number of studies has led to a definition of the chemical mechanisms and of the main enzymological aspects of the several post-translational modifications of proteins, we are still far away from a complete elucidation of the functional significance of such processes. As a matter of fact, it seems reasonable that the presently available experi mental approaches and models employed to investigate the biological roles are still inadequate. The search for suitable model systems was a matter of discussion during the meeting, and will be a major challenge in the future. The most frequently employed approaches to this problem thus far have been in vitro, but several proteins reported to be excellent in vitro substrates failed to show any activity when assayed in in vivo models.
Book Synopsis Biosimilars of Monoclonal Antibodies by : Cheng Liu
Download or read book Biosimilars of Monoclonal Antibodies written by Cheng Liu and published by John Wiley & Sons. This book was released on 2016-12-09 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information • Examines new technologies and strategies for improving biosimilar mAbs
Book Synopsis Posttranslational Modification of Proteins by : Christoph Kannicht
Download or read book Posttranslational Modification of Proteins written by Christoph Kannicht and published by Humana Press. This book was released on 2002-04-16 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins. Among the methods presented are those for analyzing the assignment of disulfide bond sites in proteins, protein N-glycosylation and protein O-glycosylation, and oligosaccharides present at specific single glycosylation sites in a protein. Additional powerful techniques facilitate the analysis of glycosylphosphatidylinositols, lipid modifications, protein phosphorylation and sulfation, protein methylation and acetylation, a-amidation, g-glutamate, isoaspartate, and lysine hydroxylation.
