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Polymetallic Lanthanide Complexes For Application In Luminescence And Magnetic Resonance Imaging
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Book Synopsis Polymetallic Lanthanide Complexes for Application in Luminescence and Magnetic Resonance Imaging by : Matteo Placido Placidi
Download or read book Polymetallic Lanthanide Complexes for Application in Luminescence and Magnetic Resonance Imaging written by Matteo Placido Placidi and published by . This book was released on 2009 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polymetallic Lanthanides Complexes for Application in Luminescence and Magnetic Resonance Imaging by : Matteo Placido Placidi
Download or read book Polymetallic Lanthanides Complexes for Application in Luminescence and Magnetic Resonance Imaging written by Matteo Placido Placidi and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Complexes for Luminescent Materials and the Magnetic Resonance Imaging (MRI) Contrast Agents by : ZhiHang Chen
Download or read book Lanthanide Complexes for Luminescent Materials and the Magnetic Resonance Imaging (MRI) Contrast Agents written by ZhiHang Chen and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Luminescent Sensors by : Cong Li
Download or read book Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Luminescent Sensors written by Cong Li and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Luminescent Sensors" by Cong, Li, 李聰, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled LANTHANIDE COMPLEXES FOR MAGNETIC RESONANCE IMAGING (MRI) CONTRAST AGENTS AND LUMINESCENT SENSORS Submitted by Li Cong for the degree of Doctor of Philosophy at The University of Hong Kong in June 2004 Magnetic resonance imaging (MRI) and bioluminescence imaging are widely used in medical diagnosis. There is a need to develop MRI contrast agents and 3+ 3+ luminescence sensors with higher sensitivity and specificity. Novel Gd and Tb complexes endowed with different functionalities have been synthesized and studied. In this work, a series of general and straightforward methods for the preparation of mono, 1,4 bis and tris N-alkylation of cyclen in high yields and with unprecedented regioselectivity were developed. These protocols are useful in introducing different functional groups to the 1,4,7,10-tetraazacyclododecane (cyclen) in a single step without the use of unnecessary protecting groups. For example, the functionalised 1,4,7-tris-(acetic acid)-1,4,7,10-tetraazacyclododecane (DO3A) derivatives that used to be prepared by multiple steps can now be achieved in two simple steps with attractive features such as high yield, operational convenience and cost economy. 3+ The novel mononuclear Gd polyaminocarboxylates based on cyclen, GdL1- GdL7, were synthesized. Functional groups, such as crown ethers with different ring sizes, β-D-glucopyranose, guanidinium and quinine alkylated diaza-18C6, were introduced into these complexes to achieve target-specificity. The synthesis, structural 1 13 characterization measured by single crystal X-ray analysis, H and C NMR, ESI-MS, HRFAB-MS and elemental analysis, luminescence-lifetime measurements, the relaxometric investigations of the complexes by nuclear magnetic resonance 17 dispersion (NMRD) profiles, variable-temperature O NMR transverse relaxation and pH dependence relaxivity, in vivo MRI studies and in vitro toxicity studies were 3+ discussed. Relaxivities of the four Gd complexes, GdL1, GdL3, GdL5 and GdL6 -1 -1 -1 -1 are in the descending order of GdL1 (9.65 mM s ) > GdL3 (9.36 mM s ) > GdL6 -1 -1 -1 -1 (7.34 mM s ) > GdL5 (3.75 mM s ) measured at 20 MHz and 25C. Compared to -1 -1 the commercially available contrast agents [Gd(DOTA)(H O)] (4.74 mM s ) and -1 -1 [Gd(DO3A)(H O) ] (5.72 mM s ) with two bound water molecules, GdL1, GdL3 2 2 and GdL6 showed much higher relaxivity. The most striking result is the water molecule exchange lifetime of GdL1, which was measured as 55 ns, very close to the optimum value of 20-30 ns in theory. GdL1, GdL3 and GdL6 also demonstrated outstanding performances in the MRI studies based on small animals. The maximal renal and hepatic intensity enhancements (IE) induced by GdL1 were 200% and 105% respectively above the control level, and much higher than those of Gd-DOTA at 123% and 70%. Moreover, GdL1 and GdL3 afforded much longer resident lifetimes in the kidney cortex and liver parenchyma. It is noteworthy that GdL1 showed obvious target-specificity to liver tissue. The maximal hepatic IE induced by GdL1 with low dosage (90%, 0.03 mmol/kg) is even higher than that of Gd-DOTA with three times dosage (70%, 0.1 mmol/kg). Furthermore, an in vitro MTT assay confirmed that the cytotoxicity of GdL1 is quite low even at high concentration (10 mM). The luminescent properties of TbL1, TbL3 and TbL7 were investigated in aqueous solution. TbL
Book Synopsis Highly Luminescent Lanthanide Complexes with Specific Coordination Structures by : Kohei Miyata
Download or read book Highly Luminescent Lanthanide Complexes with Specific Coordination Structures written by Kohei Miyata and published by Springer Science & Business Media. This book was released on 2014-04-08 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis deals with strongly luminescent lanthanide complexes having novel coordination structures. Luminescent lanthanide complexes are promising candidates as active materials for EL devices, lasers, and bio-sensing applications. The organic ligands in lanthanide complexes control geometrical and vibrational frequency structures that are closely related to the luminescent properties. In most of the previous work, however, lanthanide complexes have high-vibrational frequency C–H units close to the metal center for radiationless transition. In this thesis, the luminescent properties of lanthanide complexes with low-vibrational frequency C–F and P=O units are elucidated in terms of geometrical, vibrational, and chemical structures. The author also describes lanthanide coordination polymers with both high thermal stability (decomposition point > 300°C) and strong-luminescent properties (emission quantum yield > 80%). The author believes that novel studies on the characteristic structures and photophysical properties of lanthanide complexes may open up a frontier field in photophysical, coordination and material chemistry.
Book Synopsis Assembled Lanthanide Complexes with Advanced Photophysical Properties by : Yuichi Hirai
Download or read book Assembled Lanthanide Complexes with Advanced Photophysical Properties written by Yuichi Hirai and published by Springer. This book was released on 2018-04-07 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis provides essential information on the systematic design of assembled lanthanide complexes for functional luminescent materials. It discusses the relationships between assembled structures and photo, thermal, and mechanical properties on the basis of crystallography, spectroscopy, and thermodynamics. The described guidelines for assembled structures will be extremely valuable, both for industrial applications and for readers’ fundamental understanding of solid-state photophysics and materials chemistry. Luminescent lanthanide complexes are promising candidates for lighting devices, lasers, and bio-probes owing to their line-like and long-lived emission arising from characteristic 4f–4f transitions. Low-vibrational and asymmetrical coordination structures around lanthanide ions have been introduced to achieve strong luminescence, using specific organic ligands. Recently, assembled lanthanide complexes including coordination polymers and metal organic frameworks have increasingly attracted attention as a new class of luminescent materials offering thermal stability and color tunability. However, improving the luminescence efficiencies of these compounds remains a challenge, and specific molecular designs to control assembled structures and yield additional physical properties have not been established. The author provides a group of bent-angled bridging ligands to boost photoluminescence efficiency, and successfully introduces for the first time glass formability and strong triboluminescence properties.
Book Synopsis Lanthanide Complexes for Luminescent Materials and the Magnetic Resonance Imaging (MRI) Contrast Agents by : Zhihang Chen
Download or read book Lanthanide Complexes for Luminescent Materials and the Magnetic Resonance Imaging (MRI) Contrast Agents written by Zhihang Chen and published by . This book was released on 2008 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Probes in Life, Chemical, and Earth Sciences by : J.-C. G. Bünzli
Download or read book Lanthanide Probes in Life, Chemical, and Earth Sciences written by J.-C. G. Bünzli and published by . This book was released on 1989 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lanthanide elements were first used some thirty years ago in the optical glass industry, followed shortly by their use as NMR shift reagents in organic chemistry. Since then, the application of lanthanides in studies of organic and biochemical systems by use of their NMR and spectroscopic properties has created a rapidly growing interest in the physics and chemistry of these elements. Their use in industrial catalysts, electronic and optical components, high-temperature superconductors, in medicine as X-ray intensifying materials, relaxation agents for imaging techniques or radioisotopes for pharmaceutical applications, have combined with their utilisation in science as probes of a wide variety of phenomena giving them a prominent place in modern science. In this book, leading experts describe the various facets of the application of lanthanides as probes in life, chemical and earth sciences. The aim is to provide guidance to scientists who may wish to use the unique advantages of lanthanide probes in their own fields.To supplement the chapters on the basic concepts of the application of lanthanides, chapters are provided on the basic chemistry of these elements and on the synthetic and analytical aspects of lanthanides and their compounds. The book thus provides a great deal of useful information which will no doubt assist scientists in using these fascinating and valuable elements in their research.
Book Synopsis Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Luminescent Sensors by : Cong Li (Ph.D.)
Download or read book Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Luminescent Sensors written by Cong Li (Ph.D.) and published by . This book was released on 2004 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents by : Pui-Ling Tong
Download or read book Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents written by Pui-Ling Tong and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents" by 湯佩玲, Pui-ling, Tong, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4257621 Subjects: Magnetic resonance imaging Lanthanum compounds Contrast media
Book Synopsis Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Fluorescence Probes by : Ho-Hon Arthur Leung
Download or read book Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Fluorescence Probes written by Ho-Hon Arthur Leung and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Fluorescence Probes" by Ho-hon, Arthur, Leung, 梁浩瀚, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: In this work, novel Gd(III) complexes endowed with non-steroidal anti-inflammatory drugs (NSAIDs) were synthesised and their targeting properties towards sites of inflammation were studied in U87 xenograft and rheumatoid arthritis animal models. The Tb(III) analogues were also synthesised and their photophysical properties were studied. Six new Gd(III) DO3A-amide complexes bearing different linkers, ethylenediamine (GdL1), hexamethylenediamine (GdL2), 2,2'-oxydiethylamine (GdL3), 4,7,10-trioxa-1,13-tridecanediamine (GdL4), trans-1,4-cyclohexanediamine (GdL5), and 1,4-phenylenediamine (GdL6) were incorporated to mefenamic acid (MA) moiety, a common NSAID. The syntheses, relaxometric properties by NMR techniques, hydration number determinations by luminescence lifetime measurements, lipophilicities by UV-Vis spectrometry, serum albumin binding properties by tryptophan emission-quenching experiments, cytotoxicities by MTT assay, cellular uptake properties; MRI scans on U87 sxenograft and rheumatoid arthritis animal models, and biodistributions of these new complexes were discussed. GdL1-L6 possess one bound water molecule and GdL2-L5 show higher relaxivities than Gd-DOTA (4.21 mM?1s?1, 300 MHz, 25oC), a clinically used MRI contrast agent (CA). The relaxivities at 300 and 400 MHz respectively at 25oC are in the descending order of GdL4 (5.70 and 4.87 mM?1?1) > GdL3 (4.94 and 4.07 mM?1s?1) > GdL2 (4.60 and 4.07 mM?1s?1) > GdL5 (4.41 and 4.12 mM?1s?1) > GdL6 (3.98 and 3.31 mM?1s?1) > GdL1 (3.96 and 3.56 mM?1s?1). GdL1-L5 show low cytotoxicities towards HeLa cells at 1000 μM. The MRI scans of GdL1-L6 on U87 xenograft show strong intensity boost immediately after administration. The intensity enhancements persist for more than 90 mins and complete clearances are found after 24 h post-administration. Their MRI scans on arthritis model also show prolonged retention. It is concluded that the retention is related to the targeting on inflammatory mediators of the complexes. All complexes show superior retention and intensity enhancements in kidney, liver, tumour and arthritis joint than Gd-DOTA. GdL1-L6 are therefore potential candidates as universal MRI CAs. Three new Gd(III) DO3A-amide complexes bearing respectively benzoic acid (GdL7), salicylic acid (GdL8), and methylated salicylic acid (GdL9), one known Gd(III) DTPA-bissalicylic acid (GdL10) complex and one new Gd(III) DTPA-bismethylated salicylic acid (GdL11) were synthesised and investigated. Their syntheses, relaxivities, hydration numbers, pH dependent photophysical properties, cytotoxicities, cellular uptake properties and MRI scans on arthritis rat model were discussed. All GaL7-L11 possess one bound water molecule and show lower relaxivities than Gd-DOTA. The relaxivities at 300 MHz at 25oC are in the descending order of GdL10 (3.64 mM?1s?1) > GdL9 (3.53 mM?1s?1) > GdL11 (2.69 mM?1s?1) > GdL8 (2.10 mM?1s?1) > GdL7 (1.99 mM?1s?1). Their Tb(III) analogue (TbL7-L11) show pH dependent UV-Vis and photoluminescence spectra which are consequences of protonation or deprotonation of the carboxylic acid, hydroxyl and amide groups. It is concluded that the pH change alters energy transfer efficiency and the ligand triplet energy level. GdL7-L11 show low cytotoxicities in MTT assay. Specifically, GdL8 is examined on arthritis rat model to give a comparable intensity at the arthritis joint to Gd-DOTA but
Book Synopsis Design and Synthesis of Novel Lanthanide Chelates for Use in Magnetic Resonance Imaging (MRI). by : Graeme James Stasiuk
Download or read book Design and Synthesis of Novel Lanthanide Chelates for Use in Magnetic Resonance Imaging (MRI). written by Graeme James Stasiuk and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis reports a series of novel Ln-DO3A based complexes, modulation of emission intensity (Eu and Tb) has been achieved and relaxivity, r1, (Gd) has been shown. Propargyl-appended lanthanide complexes derived from DO3A, has a hydration state, q = 2. They undergo Cu(I) catalysed cycloaddition reactions with azides to form 1,2,3-triazole appended complexes: coordination of one of the triazole nitrogen atoms to the metal centre changes the local coordination environment and luminescence studies indicate a hydration state of q = 1. Propargyl-appended Ln(III) complexes show unanticipated reactivity towards NaN3 in the Cu(I) catalysed 'click' reaction yielding an unsubstituted 1,2,3-triazole. The resulting Eu(III) complex exhibits pH-responsive 1H NMR and Ln(III) luminescence behaviour in the physiological pH range, consistent with deprotonation of the NH-acidic bound triazole. The coordination mode of the NH-triazole switches from NH-triazole bound in a pyridinic manner to bound in an anionic manner as a triazolide, while retaining a q = 1. This was demonstrated in luminescent studies of Eu(III) and Tb(III) complexes with a pKa ~ 7.5. Relaxation measurements on the Gd(III) analogue show a q =1 throughout the pH range, i.e. no change in hydration state. To overcome the unanticipated reactivity of NaN3 with propargyl-appended Ln(III) complexes, p-ethynylbenzyl-appended Ln(III) complexes were synthesised. These show promise as precursors for multimeric, self-associating and d-f hybrid complexes, via the Cu(I) catalysed cycloaddition or 'click' reaction. Luminescent studies show evidence of the formation of 1,2,3-triazoles that do not bind to the Ln(III) metal centre, with a hydration state q =1. These complexes have been applied in the synthesis of multimeric, self-associating and d-f hybrid compounds. Uridine was attached to a EuDO3A chelate via four different linkers. These complexes are precursors for an accumulation and activation strategy, developed as enzyme activated contrast agents. Neutral q = 1 Eu(III) uridine-DO3A based complexes were successfully synthesised and linked via a propyl, amide or 1,2,3-triazole unit.
Book Synopsis Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Fluorescence Probes by : Ho-hon Leung (Arthur)
Download or read book Lanthanide Complexes for Magnetic Resonance Imaging (MRI) Contrast Agents and Fluorescence Probes written by Ho-hon Leung (Arthur) and published by . This book was released on 2011 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Complexes Containing Macrocyclic Ligands for Magnetic Resonance Imaging Contrast Agents by : Kam-Cheung Wong
Download or read book Lanthanide Complexes Containing Macrocyclic Ligands for Magnetic Resonance Imaging Contrast Agents written by Kam-Cheung Wong and published by . This book was released on 2017-01-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lanthanide Single Molecule Magnets by : Jinkui Tang
Download or read book Lanthanide Single Molecule Magnets written by Jinkui Tang and published by Springer. This book was released on 2015-04-24 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book begins by providing basic information on single-molecule magnets (SMMs), covering the magnetism of lanthanide, the characterization and relaxation dynamics of SMMs and advanced means of studying lanthanide SMMs. It then systematically introduces lanthanide SMMs ranging from mononuclear and dinuclear to polynuclear complexes, classifying them and highlighting those SMMs with high barrier and blocking temperatures – an approach that provides some very valuable indicators for the structural features needed to optimize the contribution of an Ising type spin to a molecular magnet. The final chapter presents some of the newest developments in the lanthanide SMM field, such as the design of multifunctional and stimuli-responsive magnetic materials as well as the anchoring and organization of the SMMs on surfaces. In addition, the crystal structure and magnetic data are clearly presented with a wealth of illustrations in each chapter, helping newcomers and experts alike to better grasp ongoing trends and explore new directions. Jinkui Tang is a professor at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. Peng Zhang is currently pursuing his PhD at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, with a specific focus on the molecular magnetism of lanthanide compounds under the supervision of Prof. Jinkui Tang.
Book Synopsis Lanthanide Complexes Containing Macrocyclic Ligands for Magnetic Resonance Imaging Contrast Agents by : Kam-cheung Wong (Ph. D.)
Download or read book Lanthanide Complexes Containing Macrocyclic Ligands for Magnetic Resonance Imaging Contrast Agents written by Kam-cheung Wong (Ph. D.) and published by . This book was released on 2009 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Structural and Chemical Analysis of Lanthanide Complexes for Use as Contrast Agents in Magnetic Resonance Imaging Scans by : Janene M. O'Donnell
Download or read book A Structural and Chemical Analysis of Lanthanide Complexes for Use as Contrast Agents in Magnetic Resonance Imaging Scans written by Janene M. O'Donnell and published by . This book was released on 1995 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
