Polycystic Kidney Disease

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Cystogenesis

Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Cystogenesis by : Jong Hoon Park

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Polycystic Kidney Disease

Author : Jinghua Hu
Publisher : CRC Press
ISBN 13 : 0429888953
Total Pages : 361 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Polycystic Kidney Disease by : Jinghua Hu

Download or read book Polycystic Kidney Disease written by Jinghua Hu and published by CRC Press. This book was released on 2019-10-24 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

The Cystic Kidney

Author : K.D. Gardner
Publisher : Springer Science & Business Media
ISBN 13 : 9400904576
Total Pages : 441 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Cystic Kidney by : K.D. Gardner

Download or read book The Cystic Kidney written by K.D. Gardner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about renal cysts and cystic kidneys. Its contributors have created a resource of current information in a field that once aroused only curiosity, but that now stands at the leading edge of molecular nephrology. Its authorship includes 'oldtimers', who bring the wisdom of experience, and 'newcomers', whose presence attests to the contributions made by the investigative and technological advances of the past decade. Its text is organized to carry the reader from renal cyst to cystic renal disease. Each of its chapters defines or explores a challenge or an advance. Cells that line renal cysts are diverse in structure, type, and perhaps function. The cysts themselves lie within an interstitium that is not normal and may influence cyst development and growth. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.

Renal Fibrosis: Mechanisms and Therapies

Author : Bi-Cheng Liu
Publisher : Springer
ISBN 13 : 9811388717
Total Pages : 709 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Renal Fibrosis: Mechanisms and Therapies by : Bi-Cheng Liu

Download or read book Renal Fibrosis: Mechanisms and Therapies written by Bi-Cheng Liu and published by Springer. This book was released on 2019-08-09 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Ferri's Clinical Advisor 2020 E-Book

Author : Fred F. Ferri
Publisher : Elsevier Health Sciences
ISBN 13 : 0323679773
Total Pages : 2136 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Ferri's Clinical Advisor 2020 E-Book by : Fred F. Ferri

Download or read book Ferri's Clinical Advisor 2020 E-Book written by Fred F. Ferri and published by Elsevier Health Sciences. This book was released on 2019-06-01 with total page 2136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today’s medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.

Silva's Diagnostic Renal Pathology

Author : Xin J. Zhou
Publisher : Cambridge University Press
ISBN 13 : 1316613984
Total Pages : 691 pages
Book Rating : 4.3/5 (166 download)

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Book Synopsis Silva's Diagnostic Renal Pathology by : Xin J. Zhou

Download or read book Silva's Diagnostic Renal Pathology written by Xin J. Zhou and published by Cambridge University Press. This book was released on 2017-03-02 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Chronic Kidney Disease

Author : Thomas Rath
Publisher : BoD – Books on Demand
ISBN 13 : 953513843X
Total Pages : 307 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Chronic Kidney Disease by : Thomas Rath

Download or read book Chronic Kidney Disease written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2018-02-21 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

Polycystic Kidney Disease

Author : Benjamin D. Cowley, Jr.
Publisher : Springer
ISBN 13 : 1493977849
Total Pages : 274 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Polycystic Kidney Disease by : Benjamin D. Cowley, Jr.

Download or read book Polycystic Kidney Disease written by Benjamin D. Cowley, Jr. and published by Springer. This book was released on 2018-05-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Pediatric Kidney Disease

Author : Denis F. Geary
Publisher : Springer
ISBN 13 : 3662529726
Total Pages : 1968 pages
Book Rating : 4.6/5 (625 download)

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Book Synopsis Pediatric Kidney Disease by : Denis F. Geary

Download or read book Pediatric Kidney Disease written by Denis F. Geary and published by Springer. This book was released on 2017-02-16 with total page 1968 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this valuable clinical resource offers a state of the art, comprehensive review on every clinical condition encountered in pediatric nephrology. International experts present the latest knowledge on epidemiology, diagnosis, management, and prognosis in one concise, clinically focused text, in which care has been taken to couple just the right amount of "need-to-know" basic science with practical clinical guidance that will enable the reader to make efficient, informed decisions. The topics covered include: disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, hypertension, chronic and end-stage renal disease, and renal replacement therapy. The full-color, highly visual, meticulously crafted format will ensure that the practitioner is able to source and apply information with remarkable ease.

Pediatric Nephrology

Author : Ellis D. Avner
Publisher : Springer Science & Business Media
ISBN 13 : 3540763279
Total Pages : 2059 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Pediatric Nephrology by : Ellis D. Avner

Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Polycystic Kidney Disease

Author : Xiaogang Li
Publisher :
ISBN 13 : 9780994438102
Total Pages : pages
Book Rating : 4.4/5 (381 download)

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Book Synopsis Polycystic Kidney Disease by : Xiaogang Li

Download or read book Polycystic Kidney Disease written by Xiaogang Li and published by . This book was released on 2015-11-17 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD. Section 2 covers most of the fundamental molecular and cellular mechanisms underlying PKD, and how this knowledge is contributing to the development of potential novel therapeutic agents. Finally, section 3 focuses on extra-renal or secondary complications of PKD.

Clinical Companion in Nephrology

Author : Jack Fairweather
Publisher : Springer Nature
ISBN 13 : 3030383202
Total Pages : 331 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Clinical Companion in Nephrology by : Jack Fairweather

Download or read book Clinical Companion in Nephrology written by Jack Fairweather and published by Springer Nature. This book was released on 2020-04-29 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this educational book provides an updated resource on how best to discuss and manage acute and chronic presentations of renal diseases. All chapters have been reviewed and updated to reflect changes which directly affect clinical practice and new chapters have been added including Dialysis and Poisoning, Urinalysis/Microscopy and Renal Biopsy. Chapters now include information on key clinical trials for management strategies Allowing for concise reading on specific topics this book acts as both a quick reference text and study guide. The layout has been designed in a question and answer format in order to promote self-directed learning. Images and diagrams have been further standardized and improved for the new edition and remain a key feature of the book. Clinical Companion in Nephrology, second edition, is an invaluable resource for junior doctors, medical students and renal nurses who encounter renal patients in their daily practice.

Kidney Development, Disease, Repair and Regeneration

Author : Melissa Helen Little
Publisher : Academic Press
ISBN 13 : 012800438X
Total Pages : 615 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Kidney Development, Disease, Repair and Regeneration by : Melissa Helen Little

Download or read book Kidney Development, Disease, Repair and Regeneration written by Melissa Helen Little and published by Academic Press. This book was released on 2015-08-06 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Renal Fibrosis

Author : Mohammed S. Razzaque
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805575688
Total Pages : 222 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Renal Fibrosis by : Mohammed S. Razzaque

Download or read book Renal Fibrosis written by Mohammed S. Razzaque and published by Karger Medical and Scientific Publishers. This book was released on 2003-01-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis.Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.

Why I Think about Urine

Author : Jared James Grantham
Publisher : Rockhill Books
ISBN 13 : 9781611691283
Total Pages : 282 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Why I Think about Urine by : Jared James Grantham

Download or read book Why I Think about Urine written by Jared James Grantham and published by Rockhill Books. This book was released on 2014-04-11 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this page-turner, Dr. Jared Grantham, a noted researcher with the University of Kansas Medical Center, takes the reader through his life of scientific discovery, but a life also of hardship beset by tragedy. It follows a career path that begins in Kansas, finishes in Kansas and ultimately leads to the development of a treatment for a devastating kidney disease suffered by his boyhood friend.

Chronic Renal Disease

Author : Paul L. Kimmel
Publisher : Academic Press
ISBN 13 : 0128158778
Total Pages : 1390 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chronic Renal Disease by : Paul L. Kimmel

Download or read book Chronic Renal Disease written by Paul L. Kimmel and published by Academic Press. This book was released on 2019-08-28 with total page 1390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation. Includes case studies and questions which can be used as a teaching tool for medical students and resident Provides coverage of classification and measurement, epidemiology, pathophysiology, complications of CKD, fluid/electrolyte disorders in CKD, CKD and systemic illnesses, clinical considerations, therapeutic considerations, and special considerations

Current Perspectives in Kidney Diseases

Author : G. La Manna
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318060615
Total Pages : 210 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Current Perspectives in Kidney Diseases by : G. La Manna

Download or read book Current Perspectives in Kidney Diseases written by G. La Manna and published by Karger Medical and Scientific Publishers. This book was released on 2017-05-23 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: After years of stagnation, much has been happening in the diagnosis and treatment of kidney diseases. This book contains a comprehensive review of the main developments in AKI, CKD, hemodialysis and kidney transplantation. The section on AKI deals with the key innovations in extracorporeal technologies. The section on nephrology and CKD concentrates on mineral metabolism alterations, restenosis in hemodialytic fistulas, mycophenolate mofetil as an alternative treatment for IgA nephropathy, and the genetics and progression of autosomal dominant polycystic kidney disease. The part on hemodialysis includes contributions on expanded hemodialysis, potassium profiling and home hemodialysis. Chapters on the treatment of acute antibody-mediated rejection after transplantation, pathogenesis and therapy of chronic allograft injury, and non-invasive surrogate biomarkers of acute rejection round out the subjects covered. Due to the wide variety of topics included in each section, this book is not only of interest to nephrologists, but also to professionals from related fields.