Polyamine Cell Signaling

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Polyamine Cell Signaling

Author : Jian-Ying Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1597451452
Total Pages : 490 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Polyamine Cell Signaling by : Jian-Ying Wang

Download or read book Polyamine Cell Signaling written by Jian-Ying Wang and published by Springer Science & Business Media. This book was released on 2007-11-19 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.

Polyamines

Author : Tomonobu Kusano
Publisher : Springer
ISBN 13 : 443155212X
Total Pages : 336 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Polyamines by : Tomonobu Kusano

Download or read book Polyamines written by Tomonobu Kusano and published by Springer. This book was released on 2015-01-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.

Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Author : Tracy Murray-Stewart
Publisher : MDPI
ISBN 13 : 3039211528
Total Pages : 240 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Polyamine Metabolism in Disease and Polyamine-Targeted Therapies by : Tracy Murray-Stewart

Download or read book Polyamine Metabolism in Disease and Polyamine-Targeted Therapies written by Tracy Murray-Stewart and published by MDPI. This book was released on 2019-10-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.

Polyamine Protocols

Author : David M. L. Morgan
Publisher : Springer Science & Business Media
ISBN 13 : 1592595650
Total Pages : 173 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Polyamine Protocols by : David M. L. Morgan

Download or read book Polyamine Protocols written by David M. L. Morgan and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique collection of hands-on enzyme assay techniques to study polyamines and their function. The techniques range from assay methods for enzymes of polyamine biosynthesis and catabolism to measurements of polyamines, polyamine transport, and polyamine effects on cell growth. The methods are presented by leading researchers who have perfected them to a high art, and include clear, step-by-step instructions with numerous hints and tips to ensure readily reproducible results.

A Guide to the Polyamines

Author : Seymour Stanley Cohen
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 632 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A Guide to the Polyamines by : Seymour Stanley Cohen

Download or read book A Guide to the Polyamines written by Seymour Stanley Cohen and published by Oxford University Press, USA. This book was released on 1998 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The polyamines are ubiquitous and essential organic cations in prokaryotic and eukaryotic cells. This book is a comprehensive survey of the development of knowledge of their physiological and structural roles. Currently, the genetic and regulatory determinants of the amines and their cellular composition are being explored actively as parameters of normal physiology and aberrant pathologies. Cancer, virus infection, and protozoan parasitism are major examples of the later groups. Studies of the control of polyamine metabolism are providing important therapeutic leads. Further, the structural roles of the amines are being determined at molecular levels, contributing to the understanding of polynucleotide and protein organization and interaction, as well as to the solution of problems of genome transfer. These subjects describe a burgeoning biochemical area involving compounds whose roles in cytoplasmic and nuclear function include numerous aspects of organelle structure, polymer synthesis, and interactions.

Polyamines

Author : Anthony E. Pegg
Publisher : Humana Press
ISBN 13 : 9781493958399
Total Pages : 523 pages
Book Rating : 4.9/5 (583 download)

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Book Synopsis Polyamines by : Anthony E. Pegg

Download or read book Polyamines written by Anthony E. Pegg and published by Humana Press. This book was released on 2016-08-23 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.

Regulation of Gastrointestinal Mucosal Growth

Author : Rao N. Jaladanki
Publisher : Biota Publishing
ISBN 13 : 1615047352
Total Pages : 150 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Regulation of Gastrointestinal Mucosal Growth by : Rao N. Jaladanki

Download or read book Regulation of Gastrointestinal Mucosal Growth written by Rao N. Jaladanki and published by Biota Publishing. This book was released on 2016-11-30 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 9781420044157
Total Pages : 350 pages
Book Rating : 4.0/5 (441 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

Protective Chemical Agents in the Amelioration of Plant Abiotic Stress

Author : Aryadeep Roychoudhury
Publisher : John Wiley & Sons
ISBN 13 : 111955165X
Total Pages : 704 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Protective Chemical Agents in the Amelioration of Plant Abiotic Stress by : Aryadeep Roychoudhury

Download or read book Protective Chemical Agents in the Amelioration of Plant Abiotic Stress written by Aryadeep Roychoudhury and published by John Wiley & Sons. This book was released on 2020-05-20 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the chemical agents that protect plants from various environmental stressors Protective Chemical Agents in the Amelioration of Plant Abiotic Stress offers a guide to the diverse chemical agents that have the potential to mitigate different forms of abiotic stresses in plants. Edited by two experts on the topic, the book explores the role of novel chemicals and shows how using such unique chemical agents can tackle the oxidative damages caused by environmental stresses. Exogenous application of different chemical agents or chemical priming of seeds presents opportunities for crop stress management. The use of chemical compounds as protective agents has been found to improve plant tolerance significantly in various crop and non-crop species against a range of different individually applied abiotic stresses by regulating the endogenous levels of the protective agents within plants. This important book: Explores the efficacy of various chemical agents to eliminate abiotic stress Offers a groundbreaking look at the topic and reviews the most recent advances in the field Includes information from noted authorities on the subject Promises to benefit agriculture under stress conditions at the ground level Written for researchers, academicians, and scientists, Protective Chemical Agents in the Amelioration of Plant Abiotic Stress details the wide range of protective chemical agents, their applications, and their intricate biochemical and molecular mechanism of action within the plant systems during adverse situations.

The Genus Yersinia:

Author : Robert D. Perry
Publisher : Springer Science & Business Media
ISBN 13 : 0387721231
Total Pages : 454 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis The Genus Yersinia: by : Robert D. Perry

Download or read book The Genus Yersinia: written by Robert D. Perry and published by Springer Science & Business Media. This book was released on 2007-09-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.

Polyamines in Cancer

Author : Kenji Nishioka
Publisher : Landes Bioscience
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Polyamines in Cancer by : Kenji Nishioka

Download or read book Polyamines in Cancer written by Kenji Nishioka and published by Landes Bioscience. This book was released on 1996 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polyamine-Containing DNA Fragments

Author : V. F. Zarytova
Publisher : Nova Biomedical Books
ISBN 13 : 9781617283468
Total Pages : 84 pages
Book Rating : 4.2/5 (834 download)

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Book Synopsis Polyamine-Containing DNA Fragments by : V. F. Zarytova

Download or read book Polyamine-Containing DNA Fragments written by V. F. Zarytova and published by Nova Biomedical Books. This book was released on 2010-12-30 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyamines are known to play an essential role in living organisms, where they act as metabolic regulators, in cell proliferation and differentiation, and as stabilising agents of nucleic acid structure and conformation. Polyamines are also known to protect DNA from damage caused by external agents, such as reactive oxygen species or radiation. The essential role of polyamines for maintaining cell growth has been widely documented. Polyamines can stabilise double- and triplex-stranded DNAs. Furthermore, polyamines and their derivatives can be used as condensing agents to package genes of interest for efficient transfection into living cells. This book discusses aspects concerning polyamines and nucleic acid fragments including the synthesis of covalent polyamine-oligonucleotide conjugates, the preparation of DNA arrays using polyamines, and the use of polyamines as vehicles to deliver nucleic acids into cells.

DNA Methylation and Complex Human Disease

Author : Michel Neidhart
Publisher : Academic Press
ISBN 13 : 0127999205
Total Pages : 552 pages
Book Rating : 4.1/5 (279 download)

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Book Synopsis DNA Methylation and Complex Human Disease by : Michel Neidhart

Download or read book DNA Methylation and Complex Human Disease written by Michel Neidhart and published by Academic Press. This book was released on 2015-08-11 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Inhibition of Polyamine Metabolism

Author : Peter McCann
Publisher : Elsevier
ISBN 13 : 0323152325
Total Pages : 388 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Inhibition of Polyamine Metabolism by : Peter McCann

Download or read book Inhibition of Polyamine Metabolism written by Peter McCann and published by Elsevier. This book was released on 2012-12-02 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis inhibitors. The book is comprised of chapters which describe the compounds which are in use; the rationale for the design of such inhibitors; their synthesis and action; their biological effects on mammalian cells and tissues, plants, and microorganisms including protozoal parasites; and a review of the clinical experience with these inhibitors. The major beneficial effect which the wide availability of these inhibitors has had on the field of polyamine research in general is likewise demonstrated. Biochemists, pharmacologist, and cellular physiologists will find this text very useful.

Amino Acids in Nutrition and Health

Author : Guoyao Wu
Publisher : Springer Nature
ISBN 13 : 303074180X
Total Pages : 227 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Amino Acids in Nutrition and Health by : Guoyao Wu

Download or read book Amino Acids in Nutrition and Health written by Guoyao Wu and published by Springer Nature. This book was released on 2021-07-12 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.

Annual Plant Reviews, The Plant Hormone Ethylene

Author : Michael T. McManus
Publisher : John Wiley & Sons
ISBN 13 : 111822311X
Total Pages : 433 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Annual Plant Reviews, The Plant Hormone Ethylene by : Michael T. McManus

Download or read book Annual Plant Reviews, The Plant Hormone Ethylene written by Michael T. McManus and published by John Wiley & Sons. This book was released on 2012-02-08 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The plant hormone ethylene is one of the most important, being one of the first chemicals to be determined as a naturally-occurring growth regulator and influencer of plant development. It was also the first hormone for which significant evidence was found for the presence of receptors. This important new volume in Annual Plant Reviews is broadly divided into three parts. The first part covers the biosynthesis of ethylene and includes chapters on S-adenosylmethionine and the formation and fate of ACC in plant cells. The second part of the volume covers ethylene signaling, including the perception of ethylene by plant cells, CTR proteins, MAP kinases and EIN2 / EIN3. The final part covers the control by ethylene of cell function and development, including seed development, germination, plant growth, cell separation, fruit ripening, senescent processes, and plant-pathogen interactions. The Plant Hormone Ethylene is an extremely valuable addition to Wiley-Blackwell's Annual Plant Reviews. With contributions from many of the world's leading researchers in ethylene, and edited by Professor Michael McManus of Massey University, this volume will be of great use and interest to a wide range of plant scientists, biochemists and chemists. All universities and research establishments where plant sciences, biochemistry, chemistry, life sciences and agriculture are studied and taught should have access to this important volume.

Epigenetics of Aging and Longevity

Author : Alexey Moskalev
Publisher : Academic Press
ISBN 13 : 012811083X
Total Pages : 544 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Epigenetics of Aging and Longevity by : Alexey Moskalev

Download or read book Epigenetics of Aging and Longevity written by Alexey Moskalev and published by Academic Press. This book was released on 2017-11-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan