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Point Of Care And High Density Array Electrochemical Biosensors
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Book Synopsis Point-of-Care and High-Density Array Electrochemical Biosensors by : Alexander Chuan Sun
Download or read book Point-of-Care and High-Density Array Electrochemical Biosensors written by Alexander Chuan Sun and published by . This book was released on 2018 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of numerous advances towards miniaturization in several diverse fields including chemistry, nanofabrication, microfluidics, and electronics, point-of-care (PoC) biosensors have become a promising tool to combat the most life-threatening and expensive health issues affecting the world today. PoC technology helps solve these problems by allowing for diagnostic tools typically restricted to centralized facilities to be brought closer to the point of diagnosis for faster and more frequent testing in both clinical and remote settings. While many biosensor types exist, electrochemical-based detection has the advantage that it is inherently compatible with circuits, requiring only electrodes for transduction, allowing it fully to benefit from both Moore's Law scaling and the well-established semiconductor manufacturing industry to produce miniaturized, cost-effective, and portable devices. However, there has been a lack of successful PoC electrochemical platforms capable of running multiple diagnostic tests or multi-analyte assays due to the difficultly of balancing power and area constraints of the circuitry with maintaining the required sensitivity. Therefore, in this dissertation, the circuit and system design of two electrochemical biosensor platforms are presented that explore the challenges of implementing both multi-technique and multi-analyte biosensors at the PoC. The first is a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone technologies to enable personal health monitoring. By repurposing components from one mode to the next, the biosensor is able to efficiently reconfigure itself into three different measurement modes allowing it to run a variety of assays. Each distinct mode is able to match the performance of state-of-the-art single technique biosensors, while all being integrated onto a single device at a fraction of the size. The 3.9x1.65 cm2 module was used with a modular smartphone for a variety of real-world point-of-care applications. Scaling the sensors further for high-density multi-analyte testing, a 4,096-pixel electrochemical biosensor array in 180 nm CMOS is presented. It uses a coulostatic discharge sensing technique and interdigitated electrode (IDE) geometry design to reduce the size of the readout circuitry. Each biopixel contains an IDE with a 13 aA low-leakage readout circuit directly underneath. Compared to standard electrodes, the implemented IDEs along with their inherent 3-D trenches achieve an amplification factor of 10.5x from redox cycling. The array's sensor density is comparable to state-of-the-art arrays, all without augmenting the sensors with complex post-processing. The simultaneous detection of anti-Rubella and anti-Mumps antibodies in human serum is demonstrated.
Book Synopsis Electrochemical Biosensors by : Serge Cosnier
Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Book Synopsis Point-of-Care Biosensors for Infectious Diseases by : Sushma Dave
Download or read book Point-of-Care Biosensors for Infectious Diseases written by Sushma Dave and published by John Wiley & Sons. This book was released on 2023-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Point-of-Care Biosensors for Infectious Diseases Comprehensive resource covering key developments in biosensor-based diagnostics for infectious diseases With its overview of currently available technologies, Point-of-Care Biosensors for Infectious Diseases serves as a starting point for the successful development and application of pathogen biosensors in a point-of-care setting. Here, expert authors review current challenges in pathogen detection and the selection of suitable biomarkers, detail currently available biosensor platforms including electrochemical, piezoelectric, magnetic, and optical sensors, and cover technology development for point-of-care biosensors for viral, bacterial, and parasitic infections. Point-of-Care Biosensors for Infectious Diseases covers key topics such as: Fundamentals of biosensor detection, with a focus on optical and electrochemical techniques Organic and inorganic based nanomaterials for healthcare diagnostics Strategies for miniaturizing biosensor devices, and state-of-the-art integrated sensing platforms Latest trends in point-of-care biosensing systems to detect, diagnose, and monitor infectious diseases Providing comprehensive coverage of the subject, Point-of-Care Biosensors for Infectious Diseases is an excellent reference for all developers, researchers, and technology managers in the areas of molecular diagnosis, infectious diseases, biosensors, and related fields.
Book Synopsis Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics by : Gorachand Dutta
Download or read book Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics written by Gorachand Dutta and published by Springer Nature. This book was released on 2022-12-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare.
Book Synopsis Hypersensitive Electrochemical Biosensors Based on Nanowell Array Structures for Point of Care Technology by : JuKyung Lee
Download or read book Hypersensitive Electrochemical Biosensors Based on Nanowell Array Structures for Point of Care Technology written by JuKyung Lee and published by . This book was released on 2016 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are sensitive indicators of pathogenic processes and pharmaceutical responses. Most of these biomarkers are present in the body with extremely low concentration and should be accurately and continually monitored to evaluate the dynamic physiological responses upon exposure to pathogens or drugs. However, conventional assays such as Enzyme linked immuno-sorbent assay (ELISA) and mass spectrometry can only take static and one time measurements, the process is long, expensive, and requires specialist equipment. Therefore, there is need for an advanced sensing system that is cost-effective, portable, and capable of simultaneously detecting very low levels of specific biomarkers with stable and reusable point of care technology (POCT). The goal of this thesis is to develop hyper sensitive biosensors based on electrochemical detection to recognize analytes a using nanowell array (NWA) electrode technology. NWA electrodes have been shown to enable faster detection of biomolecules with reproducibility much better than other approaches. In this thesis, I used fabricated a NWA on a 6-inch Si wafer by krypton-fluoride (KrF) stepper semiconductor process in order to develop NWA sensor through a combination of low cost and high throughput nano-pattern. Finally 57 uniform and homogeneous NWA electrodes were obtained on a 6-inch wafer. Second, to validate this NWA as a biosensor, several biomarkers were detected and monitored. In this part, first, NWA as immunosensor, antibody was immobilized on the NWA, and alkaline phosphatase (ALP) for bone monitoring and stress induced protein 1 (STIP-1) as ovarian cancer monitoring were used as antigen. Specific current and impedance were measured to quantify these analytes binding to the electrode. The Limit of detection (LOD) and the sensitivity & selectivity is highly increased compared with conventional micro-sized electrodes with reducing non-specific binding. Finally, these results suggest that wafer-scale NWA biosensor is useful for sensing application field for point of care technology because their structure provides for an advantage for detecting molecular binding events.
Book Synopsis Electrochemical Biosensors for Whole Blood Analysis by : Fan Xia
Download or read book Electrochemical Biosensors for Whole Blood Analysis written by Fan Xia and published by Springer Nature. This book was released on 2023-10-02 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates recent advances in developing sensitive and selective electrochemical biosensors for their whole blood application. Known to be a cutting-edge and fast-growing technology, electrochemical biosensors demonstrate their potential in laboratories, industries, and healthcare to achieve specific and direct target detection in complex media, and have become an emerging technology for guiding personalized medicine. The book first demonstrates methods and models to cover the detection of a variety of target molecules in whole blood, including ions, small molecules, nucleic acids, proteins, cells, etc. Then, it provides comments on various detection strategies employed to improve sensors' sensitivity, specificity, selectivity, and reproducibility as well as presenting the laws and principles. In addition, it summarizes achievements and challenges from recent years. Finally, it provides future perspectives and opportunities in electrochemical biosensors including point of care detection, molecular diagnostics and the integration of this sensor platform with multidisciplinary technologies, towards the ultimate goal of personalized medicine. The book integrates abundant viewpoints from multiple sciences and is helpful and valuable to a wide readership in the various fields of biochemistry, biophysics, bioengineering, and pharmaceutics.
Book Synopsis Medical Biosensors for Point of Care (POC) Applications by : Roger Narayan
Download or read book Medical Biosensors for Point of Care (POC) Applications written by Roger Narayan and published by Woodhead Publishing. This book was released on 2016-08-21 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications Includes contributions from leading international researchers with extensive experience in developing medical biosensors Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care
Book Synopsis Electrochemical Sensors, Biosensors and their Biomedical Applications by : Xueji Zhang
Download or read book Electrochemical Sensors, Biosensors and their Biomedical Applications written by Xueji Zhang and published by Academic Press. This book was released on 2011-04-28 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book broadly reviews the modem techniques and significant applications of chemical sensors and biosensors. Chapters are written by experts in the field – including Professor Joseph Wang, the most cited scientist in the world and renowned expert on sensor science who is also co-editor. Each chapter provides technical details beyond the level found in typical journal articles, and explores the application of chemical sensors and biosensors to a significant problem in biomedical science, also providing a prospectus for the future.This book compiles the expert knowledge of many specialists in the construction and use of chemical sensors and biosensors including nitric oxide sensors, glucose sensors, DNA sensors, hydrogen sulfide sensors, oxygen sensors, superoxide sensors, immuno sensors, lab on chip, implatable microsensors, et al. Emphasis is laid on practical problems, ranging from chemical application to biomedical monitoring and from in vitro to in vivo, from single cell to animal to human measurement. This provides the unique opportunity of exchanging and combining the expertise of otherwise apparently unrelated disciplines of chemistry, biological engineering, and electronic engineering, medical, physiological. Provides user-oriented guidelines for the proper choice and application of new chemical sensors and biosensors Details new methodological advancements related to and correlated with the measurement of interested species in biomedical samples Contains many case studies to illustrate the range of application and importance of the chemical sensors and biosensors
Book Synopsis Novel Approaches in Biosensors and Rapid Diagnostic Assays by : Zvi Liron
Download or read book Novel Approaches in Biosensors and Rapid Diagnostic Assays written by Zvi Liron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the medical, food, and environmental fields there is a continuous demand for inexpensive and sensitive analytical devices that are reliable, rapid, capable of high-throughput screening, and have low cost per test unit. Small and portable biosensor devices are designed to fulfill most of these requirements, and can be used in laboratory and on-site field testing. This volume discusses major issues in optical, acoustic and electrochemical-based biosensors, biochips, sensing recognition elements, and biosensors for medical and environmental applications. The papers presented at the conference represent basic and applied research studies in the fields of diagnostic assays and biosensor development. Novel technologies, such as arrays of sensors using high-density fiber optics to sense labeled or unlabeled oligonucleotides, and patterned arrays of recognition elements, demonstrated the capability of biosensors to analyze multiple analytes.
Book Synopsis Emerging Trends in Expert Applications and Security by : Vijay Singh Rathore
Download or read book Emerging Trends in Expert Applications and Security written by Vijay Singh Rathore and published by Springer Nature. This book was released on with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Electrochemistry of Nucleic Acids and Proteins by : E. Palecek
Download or read book Electrochemistry of Nucleic Acids and Proteins written by E. Palecek and published by Elsevier. This book was released on 2005-12-19 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA (sometimes referred to as the molecule of life), is the most interesting and most important of all molecules. Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics is devoted to the electrochemistry of DNA and RNA and to the development of sensors for detecting DNA damage and DNA hybridization. Volume 1, in the brand new series Perspectives in Bioanalysis, looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century. * Covers highly sophisticated methods of electrochemical analysis of nucleic acids and proteins * Summarises the present state of electrochemical analysis of nucleic acids and proteins * Includes future trends in the electrochemical analysis in genomics and proteomics
Book Synopsis Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis by : Pranjal Chandra
Download or read book Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis written by Pranjal Chandra and published by Springer. This book was released on 2017-12-30 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent research on cancer detection methods based on nanobiosensors, which offer ultrasensitive point-of-care diagnosis. Several methods for diagnosing cancer have been discovered and many more are currently being developed. Conventional clinical approaches to detecting cancers are based on a biopsy followed by histopathology, or on the use of biomarkers (protein levels or nucleic acid content). Biopsy is the most widely used technique; however, it is an invasive technique and is not always applicable. Furthermore, biomarker-based detection cannot be relied on when the biomarkers are present in an extremely low concentration in the body fluids and in malignant tissues. Thus, in recent years highly sensitive and robust new cancer diagnosis techniques have been developed for clinical application, and may offer an alternative strategy for cancer diagnosis. As such, this book gathers the latest point-of-care cancer diagnostic methods and protocols based on biomedical sensors, microfluidics, and integrated systems engineering. It also discusses recent developments and diagnostics tests that can be conducted outside the laboratory in remote areas. These technologies include electrochemical sensors, paper-based microfluidics, and other kit-based diagnostic methods that can be adapted to bring cancer detection and diagnostics to more remote settings around the globe. Overall, the book provides students, researchers, and clinicians alike a comprehensive overview of interdisciplinary approaches to cancer diagnosis.
Book Synopsis Nanostructured Electrochemical Biosensors by : Brian Lam
Download or read book Nanostructured Electrochemical Biosensors written by Brian Lam and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Electrochemical Biosensors by : Ali A. Ensafi
Download or read book Electrochemical Biosensors written by Ali A. Ensafi and published by Elsevier. This book was released on 2019-07-25 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. Describes several electrochemical methods used as detection techniques with biosensors Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more
Book Synopsis Modern Techniques in Biosensors by : Gorachand Dutta
Download or read book Modern Techniques in Biosensors written by Gorachand Dutta and published by Springer Nature. This book was released on 2021-01-04 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on recent advances and different research issues in the biosensor technology and also presents theoretical, methodological, well-established and validated empirical work dealing with the technology. The book addresses challenges for the development of a point-of-care test platform. The book also describes printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive, multiplex detection of disease biomarkers in real samples. It aims to overcome existing barriers for Lab-on-a-Chip commercialization (lack of cost effective mass manufacturing methods, self-contained, fully autonomous operation and user-friendliness). Different advanced techniques including electrochemical, optical, mass, colorimetric and signal amplification strategies describe early stage disease diagnosis. The book gathers scientific and technological novelties and advancements already developed or under development in the academic and research communities. It covers a vast audience from basic science to engineering and technology experts and learners.
Book Synopsis Recognition Receptors in Biosensors by : Mohammed Zourob
Download or read book Recognition Receptors in Biosensors written by Mohammed Zourob and published by Springer Science & Business Media. This book was released on 2010-01-08 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.
Book Synopsis Functionalized Nanomaterial-Based Electrochemical Sensors by : Chaudhery Mustansar Hussain
Download or read book Functionalized Nanomaterial-Based Electrochemical Sensors written by Chaudhery Mustansar Hussain and published by Woodhead Publishing. This book was released on 2022-01-11 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanomaterial-Based Electrochemical Sensors: Principles, Fabrication Methods, and Applications provides a comprehensive overview of materials, functionalized interfaces, fabrication strategies and application areas. Special attention is given to the remaining challenges and opportunities for commercial realization of functionalized nanomaterial-based electrochemical sensors. An assortment of nanomaterials has been investigated for their incorporation into electrochemical sensors. For example, carbon- based nanomaterials (carbon nanotube, graphene and carbon fiber), noble metals (Au, Ag and Pt), polymers (nafion, polypyrrole) and non-noble metal oxides (Fe2O3, NiO, and Co3O4). The most relevant materials are discussed in the book with an emphasis on their evaluation of their realization in commercial applications. Application areas touched on include the environment, food and medicine industries. Health, safety and regulation considerations are touched on, along with economic and commercialization trends. Introduces the principles of nanomaterials for electrochemical sensing applications Reviews the most relevant fabrication strategies for functionalized nanomaterial-based electrochemical sensing platforms Discusses considerations for the commercial realization of functionalized nanomaterial-based electrochemical sensors in the environment, food and point-of-care applications
