Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations

Download Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations full books in PDF, epub, and Kindle. Read online Physiology Biochemistry And Pharmacology Of Transporters For Organic Cations ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations

Author : Giuliano Ciarimboli
Publisher : MDPI
ISBN 13 : 3036505628
Total Pages : 248 pages
Book Rating : 4.0/5 (365 download)

DOWNLOAD NOW!

Book Synopsis Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations by : Giuliano Ciarimboli

Download or read book Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations written by Giuliano Ciarimboli and published by MDPI. This book was released on 2021-06-24 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations

Author : Giuliano Ciarimboli
Publisher :
ISBN 13 : 9783036505633
Total Pages : 248 pages
Book Rating : 4.5/5 (56 download)

DOWNLOAD NOW!

Book Synopsis Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations by : Giuliano Ciarimboli

Download or read book Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations written by Giuliano Ciarimboli and published by . This book was released on 2021 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they allow many neurotransmitters (e.g., histamine and serotonin) and many drugs (e.g., trospium and tofacitinib) to permeate the plasma membrane. Therefore, transporters for organic cations can modulate the action of neurotransmitters and drugs, having in this way important physiological and pharmacological implications. These aspects are illustrated in original works and reviews presented in this book. Using a system biology approach, the global significance of different transporters working together has been illustrated. Regulation mechanisms determining their expression in specific organs and modulating their function are also described in this book, also concerning their role for special drug toxicities. Such an aspect is also discussed in relationship to mutations (single nucleotide polymorphisms) of transporters for organic cations. Finally, the translational value of studies performed in flies, mice, and rats is discussed. Therefore, this book offers integrative information on transporters for organic cations, which may be of interest to beginners and specialized scientists in this field.

Organic Cation Transporters

Author : Giuliano Ciarimboli
Publisher : Springer
ISBN 13 : 3319237934
Total Pages : 276 pages
Book Rating : 4.3/5 (192 download)

DOWNLOAD NOW!

Book Synopsis Organic Cation Transporters by : Giuliano Ciarimboli

Download or read book Organic Cation Transporters written by Giuliano Ciarimboli and published by Springer. This book was released on 2015-12-17 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Organic Cation Transporters in the Central Nervous System

Author : Lynette C. Daws
Publisher : Springer Nature
ISBN 13 : 3030829847
Total Pages : 333 pages
Book Rating : 4.0/5 (38 download)

DOWNLOAD NOW!

Book Synopsis Organic Cation Transporters in the Central Nervous System by : Lynette C. Daws

Download or read book Organic Cation Transporters in the Central Nervous System written by Lynette C. Daws and published by Springer Nature. This book was released on 2021-10-27 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com

Reviews of Physiology, Biochemistry and Pharmacology

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540452079
Total Pages : 168 pages
Book Rating : 4.5/5 (44 download)

DOWNLOAD NOW!

Book Synopsis Reviews of Physiology, Biochemistry and Pharmacology by :

Download or read book Reviews of Physiology, Biochemistry and Pharmacology written by and published by Springer Science & Business Media. This book was released on 2007-05-02 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: H. Wegele, L. Müller, and J. Buchner: Hsp70 and Hsp90 - A Relay Team for Protein Folding R. Schülein: The Early Stages of the Intracellular Transport of Membrane Proteins: Clinical and Pharmacological Implications L. Schild: The Epithelial Sodium Channel: From Molecule to Disease.

Reviews of Physiology, Biochemistry and Pharmacology

Author :
Publisher : Springer
ISBN 13 : 9783662310755
Total Pages : 162 pages
Book Rating : 4.3/5 (17 download)

DOWNLOAD NOW!

Book Synopsis Reviews of Physiology, Biochemistry and Pharmacology by :

Download or read book Reviews of Physiology, Biochemistry and Pharmacology written by and published by Springer. This book was released on 2014-08-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance

Author : Jurgen Brockmoller
Publisher : Frontiers Media SA
ISBN 13 : 2889740293
Total Pages : 145 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!

Book Synopsis Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance by : Jurgen Brockmoller

Download or read book Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance written by Jurgen Brockmoller and published by Frontiers Media SA. This book was released on 2022-01-12 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient. Apparently, the lack of OCT1 do not lead to apparent substantial pathological changes in these individuals. It thus appears that this transporter is not essential to human life, but does it means that OCT1 is irrelevant? In the last 25 years since the first cloning of this transporter, data on its pharmacological and physiological relevance is steadily accumulating. Numerous clinically relevant drugs (e.g. metformin, morphine, fenoterol, sumatriptan, tramadol and tropisetron) have been shown to be substrates of OCT1, and OCT1 deficiency has been shown to affect the pharmacokinetics, efficacy, or toxicity of these drugs. Also vitamin B1 has been shown to be a substrate of OCT1, and in genetically modified mice OCT1 substantially modulated hepatic lipid metabolism, total body fat and systemic glucose and lipid concentrations. Still, numerous important questions remain unsolved: For which drugs, toxins, or other endogenous or exogenous substances is OCT1 relevant? How can we predict the relevance of OCT1 from in vitro studies? What determines the substrate selectivity of OCT1 in comparison to other transporters or transport processes for organic cations? What regulates the expression of OCT1 in the liver and possibly in other tissues? What is the impact of OCT1 variation in different areas of medicine, including the therapies for cancer as well as for pulmonary, cardiovascular, or neurological diseases? How can evolutionary biology contribute to a better understanding of the roles of OCT1? And, importantly, what types of research are likely to significantly further the knowledge on OCT1 in the next decades?

Renal Transport of Organic Substances

Author : R. Greger
Publisher : Springer Science & Business Media
ISBN 13 : 3642681476
Total Pages : 325 pages
Book Rating : 4.6/5 (426 download)

DOWNLOAD NOW!

Book Synopsis Renal Transport of Organic Substances by : R. Greger

Download or read book Renal Transport of Organic Substances written by R. Greger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of reviews on the renal transport of organic substances. The first chapters deal with general aspects of the topic. The following articles treat the present knowledge on the renal trans port of specific compounds or classes of organic substances, whereas the fmal chapter on comparative physiology deals with the renal trans port of organic substances in non-mammalian vertebrates. The articles of this volume were presented in an abbreviated form as introductory lectures at a recent Symposium on Renal Transport of Organic Substances. This conference was organized by Prof. Deetjen and the editors, and was held in Innsbruck, Austria, in July 1980 at the Department of Physiology of the University of Innsbruck. During this conference the authors of the free communications (published as abstracts ill Renal Physiology, 2 (3), pp 135-166 (1980) as well as Drs. C. Gottschalk, T. Hoshi, K.C. Huang, J.P. Kokko, Ch. de Rouffignac, K. Scharer, BM. Schmidt-Nielsen, and J.A. Young, who acted as chair persons at the meeting, were invaluable contributors to the discussions of the topics reviewed in this volume. We hope that the book will be of value to nephrologists, to renal physiologists, and to those who are involved in teaching physiology, pharmacology, and internal medicine.

Membrane Transporters as Drug Targets

Author : Gordon L. Amidon
Publisher : Springer Science & Business Media
ISBN 13 : 0306468123
Total Pages : 547 pages
Book Rating : 4.3/5 (64 download)

DOWNLOAD NOW!

Book Synopsis Membrane Transporters as Drug Targets by : Gordon L. Amidon

Download or read book Membrane Transporters as Drug Targets written by Gordon L. Amidon and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters. There will be an emphasis on transporters as molecular targets for drug delivery and disposition in the body.

Transporters as Drug Carriers

Author : Gerhard F. Ecker
Publisher : LibreDigital
ISBN 13 : 9783527627431
Total Pages : 416 pages
Book Rating : 4.6/5 (274 download)

DOWNLOAD NOW!

Book Synopsis Transporters as Drug Carriers by : Gerhard F. Ecker

Download or read book Transporters as Drug Carriers written by Gerhard F. Ecker and published by LibreDigital. This book was released on 2009-09-03 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

Advanced Drug Delivery

Author : Ashim Mitra
Publisher : John Wiley & Sons
ISBN 13 : 1118662849
Total Pages : 844 pages
Book Rating : 4.1/5 (186 download)

DOWNLOAD NOW!

Book Synopsis Advanced Drug Delivery by : Ashim Mitra

Download or read book Advanced Drug Delivery written by Ashim Mitra and published by John Wiley & Sons. This book was released on 2013-08-26 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders

Author :
Publisher : Academic Press
ISBN 13 : 0128003383
Total Pages : 512 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders by :

Download or read book Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders written by and published by Academic Press. This book was released on 2014-10-21 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Reviews of Physiology, Biochemistry and Pharmacology 146

Author : M.A. Jakupec
Publisher : Springer Science & Business Media
ISBN 13 : 3540002286
Total Pages : 223 pages
Book Rating : 4.5/5 (4 download)

DOWNLOAD NOW!

Book Synopsis Reviews of Physiology, Biochemistry and Pharmacology 146 by : M.A. Jakupec

Download or read book Reviews of Physiology, Biochemistry and Pharmacology 146 written by M.A. Jakupec and published by Springer Science & Business Media. This book was released on 2003-03-25 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume of Reviews of Physiology there are three outstanding contributions, the first on Selenium-containing proteins in mammals and other forms of life, and the second on constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0 and the third on Chloroplast quest: a journey from the cytosol into the chloroplast and beyond.

A New Era of Catecholamines in the Laboratory and Clinic

Author : Lee E. Eiden
Publisher : Academic Press
ISBN 13 : 012411539X
Total Pages : 500 pages
Book Rating : 4.1/5 (241 download)

DOWNLOAD NOW!

Book Synopsis A New Era of Catecholamines in the Laboratory and Clinic by : Lee E. Eiden

Download or read book A New Era of Catecholamines in the Laboratory and Clinic written by Lee E. Eiden and published by Academic Press. This book was released on 2013-09-17 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology presents catecholamine symposium proceedings. Chapters cover such topics as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. - Presents catecholamine symposium proceedings - Chapters cover a variety of topics such as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters - With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Pharmacology

Author : Miles Hacker
Publisher : Academic Press
ISBN 13 : 0080919227
Total Pages : 607 pages
Book Rating : 4.0/5 (89 download)

DOWNLOAD NOW!

Book Synopsis Pharmacology by : Miles Hacker

Download or read book Pharmacology written by Miles Hacker and published by Academic Press. This book was released on 2009-06-19 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. - Uses individual drugs to explain molecular actions - Full color art program explains molecular and chemical concepts graphically - Logical structure reflecting the current state of pharmacology and translational research - Covers such intricacies as drug resistance and cell death - Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Drug Interactions in Infectious Diseases

Author : Stephen C. Piscitelli
Publisher : Springer Science & Business Media
ISBN 13 : 1617792136
Total Pages : 698 pages
Book Rating : 4.6/5 (177 download)

DOWNLOAD NOW!

Book Synopsis Drug Interactions in Infectious Diseases by : Stephen C. Piscitelli

Download or read book Drug Interactions in Infectious Diseases written by Stephen C. Piscitelli and published by Springer Science & Business Media. This book was released on 2011-09-08 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The third edition features five new chapters that cover material not addressed in previous editions. These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide and ketolide agents. A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development. These chapters address material that cannot be retrieved easily in the medical literature. The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references. The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions. Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation. This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features • Definitive reference source of up-to-date information on antimicrobial drug interactions • Informative tables on the degree of interaction for specific antimicrobial agents • In-depth discussion of mechanisms and potential mechanistic pathways of interaction • New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents • New chapter on probe-cocktail studies as a research tool to study drug-drug interactions • Inclusion of new antimicrobial agents and their associated drug interactions • First rate chapters on study design and analysis, and drug-food interactions • A fresh perspective on drug-cytokine interactions • Authoritative chapter on regulatory considerations of drug interactions during drug development

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

DOWNLOAD NOW!

Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.