Phosphoinositides I: Enzymes of Synthesis and Degradation

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Publisher : Springer Science & Business Media
ISBN 13 : 940073011X
Total Pages : 361 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositides I: Enzymes of Synthesis and Degradation

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Publisher : Springer
ISBN 13 : 9789400730113
Total Pages : 356 pages
Book Rating : 4.7/5 (31 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer. This book was released on 2012-03-14 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositides

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (21 download)

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Book Synopsis Phosphoinositides by : Dr. Tamas Balla

Download or read book Phosphoinositides written by Dr. Tamas Balla and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phosphoinositides I: Enzymes of Synthesis and Degradation

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9400730128
Total Pages : 362 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Biology of Phosphoinositides

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Publisher : Oxford University Press, USA
ISBN 13 : 9780199637645
Total Pages : 372 pages
Book Rating : 4.6/5 (376 download)

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Book Synopsis Biology of Phosphoinositides by : Shamshad Cockcroft

Download or read book Biology of Phosphoinositides written by Shamshad Cockcroft and published by Oxford University Press, USA. This book was released on 2000 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the current opinions on lipid signalling research with an emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate, but in the light of recent research it has become apparent that any work in this area must include the two, as this book does. In the text, control of synthesis, translocation, and degradation of phosphoinositides is given extensive coverage; there is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation-state of membrane proteins; the regulation of phospholipase C, phospholipase D, the phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth.

Plant Lipid Metabolism

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Publisher : Springer Science & Business Media
ISBN 13 : 9401583943
Total Pages : 598 pages
Book Rating : 4.4/5 (15 download)

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Book Synopsis Plant Lipid Metabolism by : J.C. Kader

Download or read book Plant Lipid Metabolism written by J.C. Kader and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of papers that comprehensively describe the major areas of research on lipid metabolism of plants. State-of-the-art knowledge about research on fatty acid and glycerolipid biosynthesis, isoprenoid metabolism, membrane structure and organization, lipid oxidation and degradation, lipids as intracellular and extracellular messengers, lipids and environment, oil seeds and gene technology is reviewed. The different topics covered show that modern tools of plant cellular and molecular biology, as well as molecular genetics, have been recently used to characterize several key enzymes of plant lipid metabolism (in particular, desaturases, thioesterases, fatty acid synthetase) and to isolate corresponding cDNAs and genomic clones, allowing the use of genetic engineering methods to modify the composition of membranes or storage lipids. These findings open fascinating perspectives, both for establishing the roles of lipids in membrane function and intracellular signalling and for adapting the composition of seed oil to the industrial needs. This book will be a good reference source for research scientists, advanced students and industrialists wishing to follow the considerable progress made in recent years on plant lipid metabolism and to envision the new opportunities offered by genetic engineering for the development of novel oil seeds.

Encyclopedia of Signaling Molecules

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Publisher : Springer
ISBN 13 : 9781493968008
Total Pages : 6330 pages
Book Rating : 4.9/5 (68 download)

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Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Molecular Biology of the Male Reproductive System

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Publisher : Elsevier
ISBN 13 : 008091764X
Total Pages : 502 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Molecular Biology of the Male Reproductive System by : David de Kretser

Download or read book Molecular Biology of the Male Reproductive System written by David de Kretser and published by Elsevier. This book was released on 2012-12-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. - Provides up-to-date reviews of the molecular and cellular biology of male reproduction - Includes chapters on the developmental biology of the testes - Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes

Cellular and Molecular Biology of Bone

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Publisher : Academic Press
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cellular and Molecular Biology of Bone by : Masaki Noda

Download or read book Cellular and Molecular Biology of Bone written by Masaki Noda and published by Academic Press. This book was released on 1993-09-13 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death and resorption.

Handbook of Cell Signaling

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Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3188 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field

Phosphoinositides II: The Diverse Biological Functions

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Publisher : Springer Science & Business Media
ISBN 13 : 9400730152
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides II: The Diverse Biological Functions by : Tamas Balla

Download or read book Phosphoinositides II: The Diverse Biological Functions written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-02-28 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Abscisic Acid in Plants

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Publisher : Academic Press
ISBN 13 : 0081026218
Total Pages : 386 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Abscisic Acid in Plants by :

Download or read book Abscisic Acid in Plants written by and published by Academic Press. This book was released on 2019-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abscisic Acid in Plants, Volume 92, the latest release in the Advances in Botanical Research series, is a compilation of the current state-of-the-art on the topic. Chapters in this new release comprehensively describe latest knowledge on how ABA functions as a plant hormone. They cover topics related to molecular mechanisms as well as the biochemical and chemical aspects of ABA action: hormone biosynthesis, catabolism, transport, perception, signaling in plants, seeds and in response to biotic and abiotic stresses, hormone evolution and chemical biology, and much more. Presents the latest release in the Advances in Botanical Research series Provides an Ideal resource for post-graduates and researchers in the plant sciences, including plant physiology, plant genetics, plant biochemistry, plant pathology, and plant evolution Contains contributions from internationally recognized authorities in their respective fields

Biochemistry of Lipids, Lipoproteins and Membranes

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Publisher : Elsevier
ISBN 13 : 0444634495
Total Pages : 625 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Biochemistry of Lipids, Lipoproteins and Membranes by : Neale Ridgway

Download or read book Biochemistry of Lipids, Lipoproteins and Membranes written by Neale Ridgway and published by Elsevier. This book was released on 2015-07-24 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Non-Canonical Autophagy

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Publisher : Academic Press
ISBN 13 : 0128209119
Total Pages : 184 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Non-Canonical Autophagy by : Giulia Petroni

Download or read book Non-Canonical Autophagy written by Giulia Petroni and published by Academic Press. This book was released on 2021-04-21 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development

Phosphoinositides and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9400750242
Total Pages : 322 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides and Disease by : Marco Falasca

Download or read book Phosphoinositides and Disease written by Marco Falasca and published by Springer Science & Business Media. This book was released on 2012-10-21 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

MRCOG Part One

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Publisher : Cambridge University Press
ISBN 13 : 1107667135
Total Pages : 557 pages
Book Rating : 4.1/5 (76 download)

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Book Synopsis MRCOG Part One by : Alison Fiander

Download or read book MRCOG Part One written by Alison Fiander and published by Cambridge University Press. This book was released on 2016-10-13 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: