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Phosphodiesterase Methods And Protocols
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Book Synopsis Phosphodiesterase Methods and Protocols by : Claire Lugnier
Download or read book Phosphodiesterase Methods and Protocols written by Claire Lugnier and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs.
Book Synopsis Receptor Binding Techniques by : Anthony P. Davenport
Download or read book Receptor Binding Techniques written by Anthony P. Davenport and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy transfer, and quantitative analysis of receptor mRNA by TaqMan PCR. These book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified.
Book Synopsis Human Retrovirus Protocols by : Tuofu Zhu
Download or read book Human Retrovirus Protocols written by Tuofu Zhu and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge collection of basic and state-of-the-art methods optimized for investigating the molecular biology of this class of retrovirus. These readily reproducible techniques range from methods for the isolation and detection of human retroviruses to cutting-edge methods for exploring the interplay between the viruses and the host. Here, the researcher will find up-to-date techniques for the isolation and propagation of HIV, HTLV, and foamy virus from a variety of sources. There are also assays for determining the cell tropism of HIV-1, the coreceptor usage of HIV-1, and human gene expression with HIV-1 infection by microarrays, as well as for phenotyping HIV-1 infected monocytes and examining their fitness. Highlights include the detection and quantification of HIV-1 in resting CD4+, a new cloning system for making recombinent virus, cDNA microarrays, and the determination of genetic polymorphisms in two recently identified HIV-1 co-factors that are critical for HIV-1 infection.
Book Synopsis Cell Imaging Techniques by : Douglas J. Taatjes
Download or read book Cell Imaging Techniques written by Douglas J. Taatjes and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: A diverse collection of state-of-the-art methods for the microscopic imaging of cells and molecules. The authors cover a wide spectrum of complimentary techniques, including such methods as fluorescence microscopy, electron microscopy, atomic force microscopy, and laser scanning cytometry. Additional readily reproducible protocols on confocal scanning laser microscopy, quantitative computer-assisted image analysis, laser-capture microdissection, microarray image scanning, near-field scanning optical microscopy, and reflection contrast microscopy round out this eclectic collection of cutting-edge imaging techniques now available. The authors also discuss preparative methods for particles and cells by transmission electron microscopy.
Book Synopsis Peptide Synthesis and Applications by : John Howl
Download or read book Peptide Synthesis and Applications written by John Howl and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hands-on experts describe in step-by-step detail the key methodologies of contemporary peptide synthesis and illustrate their numerous applications. The techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.
Book Synopsis Hormone Assays in Biological Fluids by : Michael J. Wheeler
Download or read book Hormone Assays in Biological Fluids written by Michael J. Wheeler and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert researchers who have developed and applied significant new assays describe in step-by-step detail a variety of methods for measuring a broad variety of hormones, related peptides, and synthetic steroids in various biological fluids. The hormones measured range from glucocorticoids in biological fluids, urinary steroids, aldosterone in blood, and plasma renin activity, to gut hormones in plasma, melatonin, prolactin, 6-sulfatoxymelatonin, and androgens in blood, saliva, and hair. The emphasis is on noncommercial assays so that investigators can set up novel methods suited to their special needs. Commercial assays are also described for comparative purposes. Tutorials on radioimmunoassay, gas chromatography-mass spectrometry, high-performance liquid chromatography, and PCR techniques help the reader to choose the best method for his or her purpose.
Book Synopsis Vertebrate Phototransduction and the Visual Cycle by : Krzysztof Palczewski
Download or read book Vertebrate Phototransduction and the Visual Cycle written by Krzysztof Palczewski and published by Academic Press. This book was released on 2000 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Applications of PCR by : Y. M. Dennis Lo
Download or read book Clinical Applications of PCR written by Y. M. Dennis Lo and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this updated second edition, leading researchers apply molecular diagnostics to the many recent advances that have occurred in polymerase chain reaction( PCR)-based technologies. Highlights include real-time PCR, which allows the technique to be performed in a quantitative manner with improved sensitivity, robustness, and resilience to carryover contamination, mass spectrometric analysis of nucleic acids, and circulating cell-free nucleic acids in plasma. The authors apply these innovations to a broad spectrum of applications, including gene expression, methylation, trace molecule, gene dosage, and single cell analysis.
Book Synopsis Cyclic Nucleotide Phosphodiesterases in Health and Disease by : Joseph A. Beavo
Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Book Synopsis Control of Higher–Dimensional PDEs by : Thomas Meurer
Download or read book Control of Higher–Dimensional PDEs written by Thomas Meurer and published by Springer Science & Business Media. This book was released on 2012-08-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph presents new model-based design methods for trajectory planning, feedback stabilization, state estimation, and tracking control of distributed-parameter systems governed by partial differential equations (PDEs). Flatness and backstepping techniques and their generalization to PDEs with higher-dimensional spatial domain lie at the core of this treatise. This includes the development of systematic late lumping design procedures and the deduction of semi-numerical approaches using suitable approximation methods. Theoretical developments are combined with both simulation examples and experimental results to bridge the gap between mathematical theory and control engineering practice in the rapidly evolving PDE control area. The text is divided into five parts featuring: - a literature survey of paradigms and control design methods for PDE systems - the first principle mathematical modeling of applications arising in heat and mass transfer, interconnected multi-agent systems, and piezo-actuated smart elastic structures - the generalization of flatness-based trajectory planning and feedforward control to parabolic and biharmonic PDE systems defined on general higher-dimensional domains - an extension of the backstepping approach to the feedback control and observer design for parabolic PDEs with parallelepiped domain and spatially and time varying parameters - the development of design techniques to realize exponentially stabilizing tracking control - the evaluation in simulations and experiments Control of Higher-Dimensional PDEs — Flatness and Backstepping Designs is an advanced research monograph for graduate students in applied mathematics, control theory, and related fields. The book may serve as a reference to recent developments for researchers and control engineers interested in the analysis and control of systems governed by PDEs.
Book Synopsis Applications of Symmetry Methods to Partial Differential Equations by : George W. Bluman
Download or read book Applications of Symmetry Methods to Partial Differential Equations written by George W. Bluman and published by Springer Science & Business Media. This book was released on 2009-10-30 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an acessible book on the advanced symmetry methods for differential equations, including such subjects as conservation laws, Lie-Bäcklund symmetries, contact transformations, adjoint symmetries, Nöther's Theorem, mappings with some modification, potential symmetries, nonlocal symmetries, nonlocal mappings, and non-classical method. Of use to graduate students and researchers in mathematics and physics.
Book Synopsis Handbook of Nonlinear Partial Differential Equations, Second Edition by : Andrei D. Polyanin
Download or read book Handbook of Nonlinear Partial Differential Equations, Second Edition written by Andrei D. Polyanin and published by CRC Press. This book was released on 2016-04-19 with total page 1878 pages. Available in PDF, EPUB and Kindle. Book excerpt: New to the Second Edition More than 1,000 pages with over 1,500 new first-, second-, third-, fourth-, and higher-order nonlinear equations with solutions Parabolic, hyperbolic, elliptic, and other systems of equations with solutions Some exact methods and transformations Symbolic and numerical methods for solving nonlinear PDEs with MapleTM, Mathematica®, and MATLAB® Many new illustrative examples and tables A large list of references consisting of over 1,300 sources To accommodate different mathematical backgrounds, the authors avoid wherever possible the use of special terminology. They outline the methods in a schematic, simplified manner and arrange the material in increasing order of complexity.
Book Synopsis G Protein Pathways, Part C: Effector Mechanisms by :
Download or read book G Protein Pathways, Part C: Effector Mechanisms written by and published by Elsevier. This book was released on 2001-10-15 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third volume in the trio covering G proteins, features integrated approaches to studying G proteins. Methods pertaining to signaling mechanisms are presented, including theoretical and modeling approaches, biochemistry and molecular biology, and cell biology and physiology. The techniques for studying the structure and function of G proteins are important not only to those with specific research interests in them, but also endocrinologists and pharmacologists conducting research on signaling mechanisms that are increasingly understood to interact with G proteins.
Book Synopsis Handbook of Object Novelty Recognition by :
Download or read book Handbook of Object Novelty Recognition written by and published by Academic Press. This book was released on 2018-11-16 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Object Novelty Recognition, Volume 26, synthesizes the empirical and theoretical advances in the field of object recognition and memory that have occurred since the development of the spontaneous object recognition task. The book is divided into four sections, covering vision and perception of object features and attributions, definitions of concepts that are associated with object recognition, the influence of brain lesions and drugs on various memory functions and processes, and models of neuropsychiatric disorders based on spontaneous object recognition tasks. A final section covers genetic and developmental studies and gender and hormone studies. - Details the brain structures and the neural circuits that underlie memory of objects, including vision and olfaction - Provides a thorough description of the object novelty recognition task, variations on the basic task, and methods and techniques to help researchers avoid common pitfalls - Assists researchers in understanding all aspects of object memory, conducting object novelty recognition tests, and producing reliable, reproducible results
Book Synopsis Adaptive Multilevel Solution of Nonlinear Parabolic PDE Systems by : Jens Lang
Download or read book Adaptive Multilevel Solution of Nonlinear Parabolic PDE Systems written by Jens Lang and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowadays there is an increasing emphasis on all aspects of adaptively gener ating a grid that evolves with the solution of a PDE. Another challenge is to develop efficient higher-order one-step integration methods which can handle very stiff equations and which allow us to accommodate a spatial grid in each time step without any specific difficulties. In this monograph a combination of both error-controlled grid refinement and one-step methods of Rosenbrock-type is presented. It is my intention to impart the beauty and complexity found in the theoretical investigation of the adaptive algorithm proposed here, in its realization and in solving non-trivial complex problems. I hope that this method will find many more interesting applications. Berlin-Dahlem, May 2000 Jens Lang Acknowledgements I have looked forward to writing this section since it is a pleasure for me to thank all friends who made this work possible and provided valuable input. I would like to express my gratitude to Peter Deuflhard for giving me the oppor tunity to work in the field of Scientific Computing. I have benefited immensly from his help to get the right perspectives, and from his continuous encourage ment and support over several years. He certainly will forgive me the use of Rosenbrock methods rather than extrapolation methods to integrate in time.
Book Synopsis Cell Physiology Source Book by : Nicholas Sperelakis
Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Book Synopsis Adaptive Methods for Partial Differential Equations by : Ivo Babushka
Download or read book Adaptive Methods for Partial Differential Equations written by Ivo Babushka and published by SIAM. This book was released on 1989-01-01 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Proceedings of the Workshop on Adaptive Computational Methods for Partial Differential Equations, Rensselaer Polytechnic Institute, October 13-15, 1988"--T.p. verso.
