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Phosphatase Modulators
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Book Synopsis Phosphatase Modulators by : José Luis Millán
Download or read book Phosphatase Modulators written by José Luis Millán and published by Humana Press. This book was released on 2013-07-17 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Book Synopsis Phosphatase Modulators by : José Luis Millán
Download or read book Phosphatase Modulators written by José Luis Millán and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Book Synopsis Development of Allosteric PFKFB3 Phosphatase Modulators by : Helena Macut
Download or read book Development of Allosteric PFKFB3 Phosphatase Modulators written by Helena Macut and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Miklós Bodanszky Award Lecture: Advances in the Selective Targeting of Protein Phosphatase-1 and Phosphatase-2A with Peptides by : Maja Köhn
Book Synopsis Protein Tyrosine Phosphatase PTPRR Isoforms: Modulators of Neuronal Growth Factor Signalling by : Yvet Elisabeth Noordman
Download or read book Protein Tyrosine Phosphatase PTPRR Isoforms: Modulators of Neuronal Growth Factor Signalling written by Yvet Elisabeth Noordman and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterisation and Modulation of the Phosphatase Activity of Phosphatase of Regenerating Liver-3 (PRL-3) and SH2 Containing Protein Tyrosine Phosphatase 2 (SHP2) by : Judith Weyershäuser
Download or read book Characterisation and Modulation of the Phosphatase Activity of Phosphatase of Regenerating Liver-3 (PRL-3) and SH2 Containing Protein Tyrosine Phosphatase 2 (SHP2) written by Judith Weyershäuser and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Erythrocyte Acid Phosphatase Function and Activity Modulation by Purines by : Elaine Mansfield
Download or read book Erythrocyte Acid Phosphatase Function and Activity Modulation by Purines written by Elaine Mansfield and published by . This book was released on 1982 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of Nocturnin Phosphatase Activity Through the Disordered Amino Terminus by : Anushka Christobel Wickramaratne
Download or read book Modulation of Nocturnin Phosphatase Activity Through the Disordered Amino Terminus written by Anushka Christobel Wickramaratne and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical and Biochemical Modulation of PRL-3 Phosphatase Activity by : Birgit Höger
Download or read book Chemical and Biochemical Modulation of PRL-3 Phosphatase Activity written by Birgit Höger and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Book Synopsis Transduction Mechanisms in Cellular Signaling by : Edward A. Dennis
Download or read book Transduction Mechanisms in Cellular Signaling written by Edward A. Dennis and published by Academic Press. This book was released on 2011-04-04 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
Book Synopsis Protein Phosphatase Modulation of Somatostatin Receptor Signaling in the Mouse Hippocampus by :
Download or read book Protein Phosphatase Modulation of Somatostatin Receptor Signaling in the Mouse Hippocampus written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of SHP-1 Tyrosine Phosphatase in Modulating Lymphocyte Signaling Cascades by : Ally-Khan B. Somani
Download or read book The Role of SHP-1 Tyrosine Phosphatase in Modulating Lymphocyte Signaling Cascades written by Ally-Khan B. Somani and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of phosphatases in regulating intracellular signaling has recently been realized by the identification and characterization of various families of phosphatases. In particular, the protein tyrosine phosphatases occupy a prominent role in regulating protein tyrosine kinase mediated signaling events. In this regard, the SH2 domain containing cytosolic protein tyrosine phosphatase SHP-1 has been implicated in the downregulation of signaling cascades in haemopoietic cells. Herein, we report that SHP-1 can directly regulate the Src protein tyrosine kinase p60 c-Src. We have demonstrated that Src isolated from platelets and T cells is preferentially dephosphorylated at its inhibitory phosphotyrosine site by the SHP-1 tyrosine phosphatase. This represents the first biochemical evidence that SHP-1 can also function as a positive signal regulator. Furthermore, we have also tried to elucidate the role of SHP-1 in the signaling of the surface comodulators CD19 and CD5, on B and T cells respectively. With respect to SHP-1 and CD19 signaling, we demonstrate an indirect role for SHP-1 and present data revealing the capacity of SHP-1 to dephosphorylate the Lyn autophosphorylation site. This data provides strong evidence that SHP-1 functions also include the negative regulation of the Lyn kinase activation in B cells. Finally, given the recent biochemical evidence for CD5 and SHP-1 interaction, we investigated the biochemical and physiological relevance of the two signaling proteins in the context of T cell development and activation. By utilizing HY-TCR and HY-TCR CD5 over-expressing transgenic mice crossed with the SHP-1 deficient motheaten mice, we first examined the role of SHP-1 in T cell development. Herein we report that SHP-1 function also includes the down regulation of both positive and negative T cell selection. With respect to CD5, we report that although CD5 can down modulate the T cell selection process, our findings suggest that this can be achieved independent of SHP-1. Taken together, these studies provide novel insights into the mechanisms whereby SHP-1 modulates antigen receptor signaling. SHP-1, by virtue of its ability to regulate protein tyrosine kinase activity and membrane co-receptors represents a protein tyrosine phosphatase occupying a pivotal role in the translation of antigen receptor signals to such biological outcomes as proliferation, transformation, and selection.
Book Synopsis Biochemistry of Smooth Muscle Contraction by : Michael Barany
Download or read book Biochemistry of Smooth Muscle Contraction written by Michael Barany and published by Elsevier. This book was released on 1996-01-04 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
Book Synopsis Phosphate Metabolism by : Shaul Massry
Download or read book Phosphate Metabolism written by Shaul Massry and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Book Synopsis Neurotransmitter Transporters by : Maarten E. A. Reith
Download or read book Neurotransmitter Transporters written by Maarten E. A. Reith and published by Springer Science & Business Media. This book was released on 1996-10-01 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of recent advances made in characterizing neurotransmitter transporters-including their imaging in the living brain-and in elucidating the processes underlying biological transport. The expert contributors present up-to-date findings on the molecular cloning of transporters and on neurotransmitter families both in plasma membranes and in storage vesicles. They also provide essential information on the structure-activity relationships for a multitude of recently synthesized dopamine uptake blockers, on transporter changes in the context of human drug abuse, and on the role of transporters in the action of uptake blockers in vivo. The book opens the new frontier of transporters research, authoritatively presenting new insights into their roles in such diseases as brain ischemia and ALS, and into their involvement as targets for antidepressants, antiepileptics, drugs of abuse, and neurotoxins.
Book Synopsis Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function and Phosphorylation by a Single Nucleotide Polymorphism C.521 T]C and Protein Kinase/phosphatase Modulators by : Alexandra Rose Crowe
Download or read book Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function and Phosphorylation by a Single Nucleotide Polymorphism C.521 T]C and Protein Kinase/phosphatase Modulators written by Alexandra Rose Crowe and published by . This book was released on 2019 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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