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Pharmacology Of Pulmonary Blood Vessels With Especial Reference To Pulmonary Hypertension And The Effects Of Endothelin
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Book Synopsis Pharmacology of Pulmonary Blood Vessels with Especial Reference to Pulmonary Hypertension and the Effects of Endothelin by : Christine Sandra Kay
Download or read book Pharmacology of Pulmonary Blood Vessels with Especial Reference to Pulmonary Hypertension and the Effects of Endothelin written by Christine Sandra Kay and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pulmonary Actions of the Endothelins by : Goldie
Download or read book Pulmonary Actions of the Endothelins written by Goldie and published by Springer. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biology of the family of endogenous autocrine peptides known as the endothelins (ETs) has been a source of intense study for researchers since 1988, following the identification of ET-l as the previously described endothelium-derived contractile factor. Initial interest focussed on the actions of the ETs in the cardiovascular system, and this remains the pri mary source of published work involving these peptides. Importantly, evi dence is mounting for a significant mediator role for ET-l in cardiovascu lar diseases including systemic hypertension and congestive heart failure. However, it was also recognized early on that the ETs exert an array of powerful actions in the respiratory tract, many of which prompted specula tion concerning mediator roles for ET-l in several lung diseases including asthma and pulmonary hypertension. In recent years the evidence for the involvement of ET-l in lung diseases has become more compelling. There is now real hope and anticipation that novel ET receptor antagonists may eventually be used therapeutically against asthma and other major lung pathologies. It is this atmosphere of excitement created by new discoveries and the increasing scientific ratio nale for a significant impact ofthe ETs in pulmonary diseases that prompt ed the creation of this book, the first on this topic. Most of the information presented relates to ET-l, which is the most widely studied member of the ET family.
Book Synopsis Pharmacotherapy of Pulmonary Hypertension by : Marc Humbert
Download or read book Pharmacotherapy of Pulmonary Hypertension written by Marc Humbert and published by Springer Science & Business Media. This book was released on 2013-10-04 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
Book Synopsis Pulmonary hypertension by : Sics Editore
Download or read book Pulmonary hypertension written by Sics Editore and published by SICS Editore. This book was released on 2014-10-01 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary hypertension (PH) denotes a state where the mean pulmonary artery pressure is 25 mmHg or higher (measured invasively via right heart catheterisation in specialist medical care). In clinical practice, echocardiography is used as a screening tool because it provides the means to indirectly estimate the pressure within the pulmonary arteries. The most common causes of increased pulmonary blood pressure are problems related to the left side of the heart (such as ventricular failure and valvular defects) and hypoxaemia caused either by lung disease or other conditions (such as COPD, pulmonary fibrosis and sleep apnoea). In these situations the increase in pulmonary blood pressure is a secondary haemodynamic phenomenon and, according to current understanding, it only plays a minor role as far as the management of the condition is concerned. At present, no evidence exists on the benefit of PH medication in the treatment of these conditions. Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are markedly rarer causes of PH, and in these conditions both pulmonary blood pressure and pulmonary vascular resistance play a major role. The principal mechanism behind PAH is an endothelial dysfunction in the small pulmonary arteries leading to an imbalance between vasoactive mediators (e.g. prostacycline, nitrous oxide and endothelin), which are responsible for the dilatation and constriction of the vessels as well as for enhancing or inhibiting vascular proliferation. Promising new drugs have been introduced during the last few years for the treatment of PAH, which improve the patient’s functional capacity and probably also the prognosis. The investigations of PH are always carried out in specialist medical care, and the diagnosis and treatment of PAH and CTEPH should be concentrated in specialist centres.
Book Synopsis Pulmonary Circulation by : Andrew J Peacock
Download or read book Pulmonary Circulation written by Andrew J Peacock and published by CRC Press. This book was released on 2011-05-27 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative, comprehensive and definitive, Pulmonary Circulation builds on the success of its previous two editions by providing practising respiratory physicians with a highly-ordered, unique reference work on the structure, function and pathophysiology of the pulmonary circulation. New for the third edition: Thoroughly revised with comprehensive coverage from diagnosis and clinical evaluation of pulmonary hypertension, to imaging techniques, disorders and treatment A new truly global team of expert editors, authors and key opinion leaders provide a wealth of detail on the latest developments and issues New chapters, such as: paediatrics, critical care, special environments including high altitude and underwater More quality chapters, authors, illustrations with thorough and thoughtful referencing make this book a contemporary essential reference text Pulmonary Circulation remains an essential resource for pulmonary hypertension specialists and should prove invaluable in all respiratory, cardiac and intensive care units.
Book Synopsis Pulmonary Hypertension by : Bradley A. Maron
Download or read book Pulmonary Hypertension written by Bradley A. Maron and published by Springer. This book was released on 2015-11-02 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the framework for a singular reference in the field of pulmonary hypertension. Pulmonary vascular disease is a complex and heterogeneous condition characterized by remodeling of distal pulmonary arterioles that increases pulmonary vascular resistance to affect cardiopulmonary hemodynamic and right ventricular function adversely, resulting in a clinical syndrome of diminished exercise tolerance, shortness of breath, and heart failure-associated morbidity and mortality. Owing to the availability of novel pulmonary circulation-selective pharmacotherapies over the previous decade, the number of pulmonary hypertension patients eligible for treatment has increased substantially. Despite this progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling. Taken together, a key educational opportunity is exposed to bridge this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension.
Book Synopsis The Pulmonary Circulation in Health and Disease by : James Will
Download or read book The Pulmonary Circulation in Health and Disease written by James Will and published by Elsevier. This book was released on 2012-12-02 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pulmonary Circulation in Health and Disease covers the proceedings of a symposium purposed to create a more complete picture of the pulmonary circulation under normal and diseased conditions through the help of an interdisciplinary group of acknowledged experts. The book is divided into seven parts. The first part discusses morphology in relation to pulmonary circulation and includes an overview of the microscopic appearance of the pulmonary artery and the innervation of the pulmonary circulation, as well as the structure and infrastructure of the pulmonary microvasculature and the changes it undergoes. The second part concerns itself with the different pharmacological studies related to pulmonary circulation. The third part goes in-depth about concepts in pulmonary hemodynamics, such as its occlusion methods, its models based on anatomic and functional data, its active distribution, and gravity nondependent distribution of pulmonary blood flow; the fourth part on the other hand discusses pulmonary blood flow and gas exchange. The fifth part discusses pulmonary endothelial cells, its mechanisms, and its properties; the sixth and seventh parts cover the mechanisms of pulmonary hypertension. The text is recommended for basic scientists studying the lung and for clinicians such as cardiologists and pulmonologists. Those interested in the effects of alterations in lung function will also find this helpful.
Book Synopsis Pulmonary Hypertension - ECAB by : Sheila Glennis Haworth
Download or read book Pulmonary Hypertension - ECAB written by Sheila Glennis Haworth and published by Elsevier Health Sciences. This book was released on 2008-12-26 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary hypertension is defined as a mean pulmonary artery pressure (mPAP) ≥25 mmHg, with Pulmonary Capillary Wedge Pressure ≤ 15 mmHg, measured by cardiac catheterization. The etiology of PH has a varied spectrum extending right from Drugs, toxins and portal hypertension to HIV, Collagen Vascular Diseases and Persistent Pulmonary Hypertension of Newborn, etc. The estimation of disease prevalence has been nearly impossible owing to the geographic distribution and economic diversity, along with significant regional variations in human development and healthcare infrastructure. A large number of patients with PH never reach the health centers capable of diagnosing the disease condition correctly. Advance pulmonary vascular disease as a result of uncorrected CHD is a major health challenge in the developing world. PH exists as a major component of many forms of cardiac and pulmonary disease. While breathlessness is the most common feature of PH, patients often also present with chest pain, syncope, fatigue, weakness and abdominal distension. The precordial signs include a right ventricular lift, accentuated pulmonary component of S2, a pansystolic murmur of Tricuspid regurgitation, a diastolic murmur of pulmonary regurgitation and a right ventricular S3. The standard diagnostic workup in developed countries includes a series of investigations to rule out the secondary causes. Additional tests are required to estimate the disease severity and plan the appropriate treatment. These include the cardiac catheterization, selective pulmonary angiography by direct injection of pulmonary arteries, high resolution CT scan, cardiac magnetic resonance, ABGs, nocturnal O2 saturation, etc. While most of the basic management is feasible in the Indian conditions, most of the newly introduced drugs are either not available or are available at costs that far exceed the paying capacity of an average citizen of a developing economy. An underdeveloped health insurance system adds further to the financial burden of the treatment. Measures like formulation of guidelines for diagnosis and treatment of PAH, educating clinicians and scientists and making medications affordable to poor patients might ensue a breakthrough in the overall management of pulmonary hypertension.
Book Synopsis Pulmonary Circulation by : Andrew J. Peacock
Download or read book Pulmonary Circulation written by Andrew J. Peacock and published by CRC Press. This book was released on 2016-03-23 with total page 1746 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment. This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society. Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.
Book Synopsis Textbook of Pulmonary Vascular Disease by : Jason X. -J. Yuan
Download or read book Textbook of Pulmonary Vascular Disease written by Jason X. -J. Yuan and published by Springer Science & Business Media. This book was released on 2011-03-24 with total page 1640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Pulmonary Vascular Diseases combines basic scientific knowledge on the pulmonary circulatory system at levels of the molecule, cell, tissue, and organ with clinical diagnosis and treatment of pulmonary vascular diseases. State-of-the-art techniques and their potential applications in research, diagnosis, and treatment of pulmonary vascular diseases are also covered.
Book Synopsis The Lung Circulation by : Domingo M. Aviado
Download or read book The Lung Circulation written by Domingo M. Aviado and published by Elsevier. This book was released on 2013-10-22 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Lung Circulation deals with important aspects of the lung circulation, with emphasis on the physiology of the pulmonary and bronchial circulation and autonomic pharmacology. Topics covered range from the role of anoxia in pulmonary circulation to reflexes arising from the pulmonary circulation and neighboring structures. The release of chemical substances from the pulmonary and bronchial circulation is also discussed. This volume is comprised of 10 chapters and begins with a review of the influence of anoxia on pulmonary circulation as well as four pertinent effects of anoxemia, namely, respiratory stimulation; cardiac stimulation; systemic vasoconstriction and vasodilatation; and pulmonary vasoconstriction and vasodilatation). The following chapters focus on the regulation of bronchial circulation; autonomic nervous control of pulmonary circulation involving acetylcholine, anticholinesterases, and atropine; and the pharmacology of sympathomimetic drugs, sympathetic blocking drugs, ganglion stimulants, and blocking drugs. The final chapter is devoted to the pharmacology of the autonomic nervous system and considers drugs that stimulate chemoreflexes arising from the lung circulation, including veratrum alkaloids. This book will appeal to physiologists and pharmacologists.
Book Synopsis Pulmonary Arterial Hypertension and Interstitial Lung Diseases by : Robert P. Baughman
Download or read book Pulmonary Arterial Hypertension and Interstitial Lung Diseases written by Robert P. Baughman and published by Springer Science & Business Media. This book was released on 2009-01-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interstitial lung disease (ILD) is a broad category of lung diseases that includes more than 150 disorders characterized by scarring or fibrosis of the lungs. In Pulmonary Arterial Hypertension and Interstitial Lung Disease: A Clinical Guide, renowned experts provide a state-of-the-art overview of the problems seen by physicians in the clinical management of ILDs. Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease and associated pulmonary hypertension. A detailed analysis of the pathology of the various interstitial lung diseases is also provided. The second part addresses specific categories of disease. Bronchiolitis, hypersensitivity pneumonitis, and other conditions are covered, and the use of inspiratory and expiratory high resolution CT scan is discussed as well. This important new text is an invaluable resource for the practicing physician who must be aware of the broad and troubling manifestations of interstitial lung disease.
Author :National Organization for Rare Disorders Publisher :Lippincott Williams & Wilkins ISBN 13 :9780781730631 Total Pages :982 pages Book Rating :4.7/5 (36 download)
Book Synopsis NORD Guide to Rare Disorders by : National Organization for Rare Disorders
Download or read book NORD Guide to Rare Disorders written by National Organization for Rare Disorders and published by Lippincott Williams & Wilkins. This book was released on 2003 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Cardiovascular Disability by : Institute of Medicine
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Book Synopsis Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension by : Toshio Nakanishi
Download or read book Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension written by Toshio Nakanishi and published by Springer Nature. This book was released on 2020-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
