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Pharmacogenomics In Admixed Populations
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Book Synopsis Pharmacogenomics in Admixed Populations by : Dr. G. Suarez-Kurtz
Download or read book Pharmacogenomics in Admixed Populations written by Dr. G. Suarez-Kurtz and published by CRC Press. This book was released on 2007-08-03 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs
Book Synopsis Pharmacogenomics in Admixed Populations by : Guilherme Suarez-Kurtz
Download or read book Pharmacogenomics in Admixed Populations written by Guilherme Suarez-Kurtz and published by CRC Press. This book was released on 2007 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ethnic specificity has become an integral part of research in the overlapping sciences of pharmacogenetics and pharmacogenomics. Pharmacogenomics in Admixed Populations was conceived to compile pharmacogenetic/-genomic (PGx) data from peoples of four continents: Africa, America, Asia and Oceania, where admixture and population stratification occurs in distinct patterns. The organization of this book was formed by a population PGx perspective: an initial review of the evolution of human genetic diversity leads into a series of chapters dealing with the population structure, and the PGx profiles, of various peoples selected on the basis of continents, countries or particular sub-groups within a continent or country.
Book Synopsis Pharmacogenomics by : Yui-Wing Francis Lam
Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2013-02-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. - Multi-contributed book and chapters are written by contributors who are experts in their field - Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be - Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications - Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
Book Synopsis Pharmacogenomics in Psychiatry by : M. Schwab
Download or read book Pharmacogenomics in Psychiatry written by M. Schwab and published by Karger Medical and Scientific Publishers. This book was released on 2010-06-25 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research.Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.
Book Synopsis The Evolution and Genetics of Latin American Populations by : Francisco M. Salzano
Download or read book The Evolution and Genetics of Latin American Populations written by Francisco M. Salzano and published by Cambridge University Press. This book was released on 2005-11-10 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genetic make-up of Latin America is a reflection of successive waves of colonization and immigration. There have been few works dealing with the biology of human populations at a continental scale, and while much data is available on the genetics of Latin American populations, most information remains scattered throughout the literature. This volume examines Latin American human populations in relation to their origins, environment, history, demography and genetics, drawing on aspects of nutrition, physiology, and morphology for an integrated and multidisciplinary approach. The result is a fascinating account of a people characterized by a turbulent history, marked heterogeneity, and unique genetic traits.
Book Synopsis 10 Years of Pharmacogenetics and Pharmacogenomics by : Jose Agundez
Download or read book 10 Years of Pharmacogenetics and Pharmacogenomics written by Jose Agundez and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the mechanisms by which genetic variations influence drug effects and adverse drug events, and cover basic research, clinical translation, applications in drug development and regulatory issues related to this field. Also, studies addressing the role of other factors such as epigenetics, phenotypic factors or drug-drug interactions on drug pharmacokinetics or pharmacodynamics are welcome. The editorial board is composed of 34 Associate Editors which, together with the Guest Associate Editors and the Reviewer Editors, constitute a team of nearly 340 leading experts in the field of Pharmacogenetics and Pharmacogenomics. This guarantees high quality in the reviewing process as well as short review times. A look back: 10 years of Frontiers in Pharmacogenetics & Pharmacogenomics (Continued in eBook)
Book Synopsis New Research on Pharmacogenetics by : Linda P. Barnes
Download or read book New Research on Pharmacogenetics written by Linda P. Barnes and published by Nova Publishers. This book was released on 2007 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study of genetic variation that gives rise to differing response to drugs, while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics considers one or at most a few genes of interest, while pharmacogenomics considers the entire genome. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. This new book presents leading-edge research in this dynamic field.
Book Synopsis Pharmacogenomics by : Yui-Wing Francis Lam
Download or read book Pharmacogenomics written by Yui-Wing Francis Lam and published by Academic Press. This book was released on 2018-11-27 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations.With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. - Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics - Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing - Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion
Book Synopsis Genomics Applications for the Developing World by : Karen E. Nelson
Download or read book Genomics Applications for the Developing World written by Karen E. Nelson and published by Springer Science & Business Media. This book was released on 2012-05-10 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book evolved from the editors strong belief that the information and new developments that were evolving from the rapidly growing field of genomics and that are happening primarily in the developed world have not happened at a parallel rate in the developing world. One would have hoped that by now the technologies and approaches would have been adapted on a far greater scale. In addition to this, the associated information is not always easily accessible, and is not disseminated in a format that can become a useful reference for scientists, students and others who reside in developing countries.
Book Synopsis Concepts in Pharmacogenomics by : Martin M. Zdanowicz
Download or read book Concepts in Pharmacogenomics written by Martin M. Zdanowicz and published by ASHP. This book was released on 2010 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.
Book Synopsis Genomics in Aquaculture to Better Understand Species Biology and Accelerate Genetic Progress by : José Manuel Yáñez
Download or read book Genomics in Aquaculture to Better Understand Species Biology and Accelerate Genetic Progress written by José Manuel Yáñez and published by Frontiers Media SA. This book was released on 2016-09-15 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a global perspective aquaculture is an activity related to food production with large potential for growth. Considering a continuously growing population, the efficiency and sustainability of this activity will be crucial to meet the needs of protein for human consumption in the near future. However, for continuous enhancement of the culture of both fish and shellfish there are still challenges to overcome, mostly related to the biology of the cultured species and their interaction with (increasingly changing) environmental factors. Examples of these challenges include early sexual maturation, feed meal replacement, immune response to infectious diseases and parasites, and temperature and salinity tolerance. Moreover, it is estimated that less than 10% of the total aquaculture production in the world is based on populations genetically improved by means of artificial selection. Thus, there is considerable room for implementing breeding schemes aimed at improving productive traits having significant economic impact. By far the most economically relevant trait is growth rate, which can be efficiently improved by conventional genetic selection (i.e. based on breeding values of selection candidates). However, there are other important traits that cannot be measured directly on selection candidates, such as resistance against infectious and parasitic agents and carcass quality traits (e.g. fillet yield and meat color). However, these traits can be more efficiently improved using molecular tools to assist breeding programs by means of marker-assisted selection, using a few markers explaining a high proportion of the trait variation, or genomic selection, using thousands of markers to estimate genomic breeding values. The development and implementation of new technologies applied to molecular biology and genomics, such as next-generation sequencing methods and high-throughput genotyping platforms, are allowing the rapid increase of availability of genomic resources in aquaculture species. These resources will provide powerful tools to the research community and will aid in the determination of the genetic factors involved in several biological aspects of aquaculture species. In this regard, it is important to establish discussion in terms of which strategies will be more efficient to solve the primary challenges that are affecting aquaculture systems around the world. The main objective of this Research Topic is to provide a forum to communicate recent research and implementation strategies in the use of genomics in aquaculture species with emphasis on (1) a better understanding of fish and shellfish biological processes having considerable impact on aquaculture systems; and (2) the efficient incorporation of molecular information into breeding programs to accelerate genetic progress of economically relevant traits.
Book Synopsis Immunopharmacogenomics by : Yusuke Nakamura
Download or read book Immunopharmacogenomics written by Yusuke Nakamura and published by Springer. This book was released on 2015-09-18 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.
Download or read book Pharmacogenetics written by and published by Academic Press. This book was released on 2018-05-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenetics, Volume 83, the newest volume in the Advances in Pharmacology series, presents a variety of chapters and the best authors in the field, with this release highlighting regulatory perspectives, the implementation of pharmacogenetics in everyday clinical setting, imaging in pharmacogenetics, pharmacoepidemiology in pharmacogenetics, epigenetics and micro RNA in pharmacogenetics, ethnicity in pharmacogenetics, pediatric pharmacogenetics, pharmacogenetics and adverse drug reactions, and cytochrome P450 pharmacogenetics amongst other important topics. This series presents an essential resource for pharmacologists, immunologists, and biochemists alike. - Includes the authority and expertise of leading contributors in pharmacology as sourced from an international board of authors - Presents the latest release in the Advances in Pharmacology series
Book Synopsis Bioinformatics Tools for Detection and Clinical Interpretation of Genomic Variations by : Ali Samadikuchaksaraei
Download or read book Bioinformatics Tools for Detection and Clinical Interpretation of Genomic Variations written by Ali Samadikuchaksaraei and published by BoD – Books on Demand. This book was released on 2019-09-04 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic variations and phenotypic diversity are closely linked and form the underlying mechanism for development of many human diseases. This book addresses the methods of detection, analysis, and interpretation of genomic variations in clinically relevant scenarios. If your research or clinical practice involves handling of genomic sequencing data, this book is for you. Topics covered include: methods for identifying genetic diversity, the workflow for analyzing whole exome and whole genome sequencing data, local ancestry deconvolution models, the value of molecular patterns and pattern biomarkers in cancer diagnosis and prognosis, and genotyping and profiling resistance-associated variants of hepatitis C. If your research or clinical practice involves handling of genomic sequencing data, this book is for you.
Book Synopsis Severe Asthma in Children and Adolescents by : Erick Forno
Download or read book Severe Asthma in Children and Adolescents written by Erick Forno and published by Springer Nature. This book was released on 2019-11-13 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with a comprehensive review of severe asthma in children and adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical presentation, diagnosis and treatment. Written by leaders in the field, chapter discussions draw on the mechanisms driving the disease, genetics, multidisciplinary approaches, immunomodulators, and other important aspects in the management of the disease. Severe Asthma in Children and Adolescents: Mechanisms and Management is designed to be a practical guide, opening with an introduction on the epidemiology of severe childhood asthma, as well as a discussion of special considerations of the disease unique to the preschool-aged patient. The distinctions between the diagnosis and management of asthma in young children of various ages, and specific approaches for the adolescent with severe asthma, including the transition into adult care are then addressed. Finally, the book closes with a discussion on the current state and future avenues for severe asthma research. Severe Asthma in Children and Adolescents is an indispensable reference for the healthcare professional, for basic and translational researchers, as well as for students, residents and fellows.
Book Synopsis Pharmacogenomics by : Howard L. McLeod
Download or read book Pharmacogenomics written by Howard L. McLeod and published by . This book was released on 2009-01-01 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics offers the opportunity for clinicians to dramatically improve the health outcomes of millions of patients receiving drug therapy. However, this opportunity is tempered by the challenge of learning the seemingly limitless amount of genetic information assembled during the past decade, with new knowledge developing rapidly. ACCP has developed this textbook to assist clinicians in meeting this challenge. The enhanced second edition, written by leaders in pharmacogenomics from different practice areas, disciplines, and research environments, combines the basics of pharmacogenomics with disease-specific applications to give students and practitioners a solid foundation for understanding the basic science of pharmacogenomics and the skills for integrating pharmacogenomics into daily clinical practice.
Book Synopsis Racial Identities, Genetic Ancestry, and Health in South America by : S. Gibbon
Download or read book Racial Identities, Genetic Ancestry, and Health in South America written by S. Gibbon and published by Springer. This book was released on 2011-11-15 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The edited collection brings together social and biological anthropology scholars, biologists, and geneticists to examine the interface between Genetic Admixture, Identity and Health, directly contributing to an emerging field of 'bio-cultural anthropology.
